ATE282717T1 - Neuartiges verfahren zur identifizierung von klonen mit einer gewünschten biologischen eigenschaft, ausgehend von einer expressionsgenbank - Google Patents

Neuartiges verfahren zur identifizierung von klonen mit einer gewünschten biologischen eigenschaft, ausgehend von einer expressionsgenbank

Info

Publication number
ATE282717T1
ATE282717T1 AT99924858T AT99924858T ATE282717T1 AT E282717 T1 ATE282717 T1 AT E282717T1 AT 99924858 T AT99924858 T AT 99924858T AT 99924858 T AT99924858 T AT 99924858T AT E282717 T1 ATE282717 T1 AT E282717T1
Authority
AT
Austria
Prior art keywords
clones
library
desired biological
biological property
expression
Prior art date
Application number
AT99924858T
Other languages
English (en)
Inventor
Dolores Cahill
Konrad Buessow
Gerald Walter
Hans Lehrach
Original Assignee
Max Planck Gesellschaft
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Max Planck Gesellschaft filed Critical Max Planck Gesellschaft
Application granted granted Critical
Publication of ATE282717T1 publication Critical patent/ATE282717T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1086—Preparation or screening of expression libraries, e.g. reporter assays
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00351—Means for dispensing and evacuation of reagents
    • B01J2219/00387—Applications using probes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00497—Features relating to the solid phase supports
    • B01J2219/00527—Sheets
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00585—Parallel processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/0059—Sequential processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00596—Solid-phase processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/0061—The surface being organic
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00612—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports the surface being inorganic
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00632—Introduction of reactive groups to the surface
    • B01J2219/00637—Introduction of reactive groups to the surface by coating it with another layer
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00659—Two-dimensional arrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/0068—Means for controlling the apparatus of the process
    • B01J2219/00702—Processes involving means for analysing and characterising the products
    • B01J2219/00707—Processes involving means for analysing and characterising the products separated from the reactor apparatus
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718—Type of compounds synthesised
    • B01J2219/0072—Organic compounds
    • B01J2219/00722—Nucleotides
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/04—Libraries containing only organic compounds
    • C40B40/06—Libraries containing nucleotides or polynucleotides, or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B60/00—Apparatus specially adapted for use in combinatorial chemistry or with libraries
    • C40B60/14—Apparatus specially adapted for use in combinatorial chemistry or with libraries for creating libraries

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Plant Pathology (AREA)
  • Immunology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
AT99924858T 1998-04-30 1999-04-30 Neuartiges verfahren zur identifizierung von klonen mit einer gewünschten biologischen eigenschaft, ausgehend von einer expressionsgenbank ATE282717T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US7059098A 1998-04-30 1998-04-30
PCT/EP1999/002963 WO1999057311A2 (en) 1998-04-30 1999-04-30 Novel method for the identification of clones conferring a desired biological property from an expression library

Publications (1)

Publication Number Publication Date
ATE282717T1 true ATE282717T1 (de) 2004-12-15

Family

ID=22096239

Family Applications (1)

Application Number Title Priority Date Filing Date
AT99924858T ATE282717T1 (de) 1998-04-30 1999-04-30 Neuartiges verfahren zur identifizierung von klonen mit einer gewünschten biologischen eigenschaft, ausgehend von einer expressionsgenbank

Country Status (8)

Country Link
US (2) US20050244854A1 (de)
EP (1) EP1073770B1 (de)
JP (2) JP4540846B2 (de)
AT (1) ATE282717T1 (de)
AU (1) AU770540B2 (de)
CA (1) CA2326390A1 (de)
DE (2) DE69921982T2 (de)
WO (1) WO1999057311A2 (de)

Families Citing this family (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE393912T1 (de) 1998-02-04 2008-05-15 Invitrogen Corp Microarrays und ihre verwendungen
EP1198566A2 (de) * 1999-07-05 2002-04-24 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Methode mit einer hohen durchsatzrate zur selektion von interagierenden molekülen
US20020006664A1 (en) 1999-09-17 2002-01-17 Sabatini David M. Arrayed transfection method and uses related thereto
WO2001020015A1 (en) 1999-09-17 2001-03-22 Whitehead Institute For Biomedical Research Reverse transfection method
DE19957827C2 (de) * 1999-11-25 2003-06-12 Epigenomics Ag Verwendung eines Oligomer-Arrays mit PNA- und/oder DNA-Oligomeren auf einer Oberfläche
CA2408291C (en) 2000-05-04 2014-07-15 Yale University High density protein arrays for screening of protein activity
US20020055110A1 (en) * 2000-06-23 2002-05-09 Ian Tomlinson Matrix screening method
US7420030B2 (en) 2000-09-08 2008-09-02 The Board Of Regents Of The University Of Texas System Aminopeptidase A (APA) targeting peptides for the treatment of cancer
US7452964B2 (en) 2001-09-07 2008-11-18 Board Of Regents, The University Of Texas System Compositions and methods of use of targeting peptides against placenta and adipose tissues
US20040170955A1 (en) 2000-09-08 2004-09-02 Wadih Arap Human and mouse targeting peptides identified by phage display
US7981842B2 (en) 2001-06-08 2011-07-19 Panomics, Inc. Method for detecting transcription factor-protein interactions
WO2004051268A1 (en) 2002-12-03 2004-06-17 Celltech R & D Limited Assay for identifying antibody producing cells
US20040248323A1 (en) 2003-06-09 2004-12-09 Protometrix, Inc. Methods for conducting assays for enzyme activity on protein microarrays
DE102004056794B4 (de) * 2004-11-24 2010-08-26 Protagen Ag Verwendung einer Anordnung und Verfahren zur Validierung von Bindern
JP5601746B2 (ja) * 2006-03-16 2014-10-08 日本ソフトウェアマネジメント株式会社 同一の試料を用いた二段階核酸検査方法
US8536115B2 (en) * 2006-08-31 2013-09-17 Centre For Addiction And Mental Health Compositions and methods for modulating AMPA receptor-mediated excitotoxicity
WO2008092442A1 (de) 2007-02-01 2008-08-07 Protagen Aktiengesellschaft Stratifizierung und therapiesteuerung eines patienten mittels proteinbiochips
DE102007028050A1 (de) 2007-06-14 2008-12-18 Protagen Ag Hautchip
CA2698437A1 (en) 2007-09-03 2009-03-12 Protagen Ag Marker sequences for rheumatoid arthritis and use thereof
DE102007041654A1 (de) 2007-09-03 2009-07-23 Protagen Ag Markersequenzen für juvenile idiopathische Arthritis und deren Verwendung
DE102007041656A1 (de) 2007-09-03 2009-05-07 Protagen Ag Markersequenzen für rheumatoide Arthritis und deren Verwendung
DE102007041657A1 (de) 2007-09-03 2009-03-05 Protagen Ag Markersequenzen für Multiple Sklerose und deren Verwendung
DE102007062847A1 (de) 2007-12-21 2009-12-31 Protagen Ag Markersequenzen für neurodegenerative Erkrankungen und deren Verwendung
DE102008031699A1 (de) 2008-07-04 2010-01-14 Protagen Ag Markersequenzen für Prostataentzündungserkrankungen, Prostatakarzinom und deren Verwendung
EP2275568A1 (de) 2009-07-13 2011-01-19 Universitätsklinikum Regensburg Markersequenzen für Adipositas und deren Verwendung
CA2775978A1 (en) 2009-09-29 2011-04-07 Protagen Ag Marker sequences for pancreatic cancer diseases, pancreatic carcinoma and use thereof
EP2483694A1 (de) 2009-10-01 2012-08-08 Protagen AG Biomarker für morbus alzheimer
EP2437060A1 (de) 2010-10-01 2012-04-04 Protagen AG Markersequenzen für Multiple Sklerose und deren Verwendung
DE102010042359A1 (de) 2010-10-12 2012-04-12 Protagen Ag Markersequenzen für Multiple Sklerose und deren Verwendung
EP2441848A1 (de) 2010-10-12 2012-04-18 Protagen AG Markersequenzen für systemischer Lupus Erythematodes und deren Verwendung
EP2487251A1 (de) 2011-02-13 2012-08-15 Protagen AG Markersequenzen für die Diagnose von Prostatakarzinom und deren Verwendung
US10060911B2 (en) 2011-08-19 2018-08-28 Protagen Aktiengesellschaft Method for diagnosis of high-affinity binders and marker sequences
WO2013072393A2 (de) 2011-11-14 2013-05-23 Protagen Ag Neues verfahren zur identifizierung von spezifischen markersequenzen für prostatakrebs
EP2605017A1 (de) 2011-12-16 2013-06-19 Protagen AG Markersequenzen für gynäkologisches Malignom und deren Verwendung
EP2607900A1 (de) 2011-12-22 2013-06-26 Protagen AG Markersequenzen für Brustkrebs und deren Verwendung
EP2831275A1 (de) 2012-03-27 2015-02-04 Protagen AG Markersequenzen für rheumatoide arthritis
EP2644704A1 (de) 2012-03-27 2013-10-02 Protagen AG Markersequenzen für Rheumatoide Arthritis
WO2014001576A2 (en) 2012-06-30 2014-01-03 Meyer Helmut E Marker sequences for parkinson's disease and use thereof
WO2014041185A2 (en) 2012-09-17 2014-03-20 Ait Austrian Institute Of Technology Gmbh Colon cancer diagnostic method and means
EP2735875A1 (de) 2012-11-27 2014-05-28 Protagen AG Markersequenzen für Neuromyelitis optica (NMO) und Verwendungen dafür
EP2806274A1 (de) 2013-05-24 2014-11-26 AIT Austrian Institute of Technology GmbH Lungenkrebsdiagnoseverfahren und -mittel
EP2857839A1 (de) 2013-10-01 2015-04-08 AIT Austrian Institute of Technology GmbH Brustkrebsdiagnoseverfahren und -mittel
EP3910338A3 (de) 2014-02-10 2022-02-16 Oncimmune Germany GmbH Markersequenzen zur diagnose und stratifizierung von sle patienten
EP3140651B1 (de) 2014-05-09 2022-10-26 Oncimmune Germany GmbH Markersequenzen zur diagnose und stratifizierung von systemische sklerose patienten
US20190062846A1 (en) * 2016-01-29 2019-02-28 Dana-Farber Cancer Institute, Inc. Compositions and methods for screening pediatric gliomas and methods of treatment thereof
EP3214444A1 (de) 2016-03-04 2017-09-06 AIT Austrian Institute of Technology GmbH Prostatakrebs-diagnoseverfahren und -mittel
WO2017168014A1 (de) 2016-04-02 2017-10-05 Protagen Ag Markersequenzen für rheumatoide arthritis
EP3258268A1 (de) 2016-06-15 2017-12-20 Protagen AG Markersequenzen zur therapiesteuerung von patienten mit rheumatoider arthritis
CN110691509A (zh) 2017-03-28 2020-01-14 植物Arc生物技术有限公司 用于改良植物性状的方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6919211B1 (en) * 1989-06-07 2005-07-19 Affymetrix, Inc. Polypeptide arrays
EP1382386A3 (de) * 1992-02-19 2004-12-01 The Public Health Research Institute Of The City Of New York, Inc. Neue Ordnungen für Oligonukleotide und ihr Nutzen zum Sortieren, Isolieren, Sequenzierung und Manipulieren von Nukleinsäuren
US6107059A (en) * 1992-04-29 2000-08-22 Affymax Technologies N.V. Peptide library and screening method
DE4237113B4 (de) * 1992-11-03 2006-10-12 "Iba Gmbh" Peptide und deren Fusionsproteine, Expressionsvektor und Verfahren zur Herstellung eines Fusionsproteins
US6335160B1 (en) * 1995-02-17 2002-01-01 Maxygen, Inc. Methods and compositions for polypeptide engineering
US6284459B1 (en) * 1995-04-25 2001-09-04 Discovery Partners International Solid support matrices with memories and combinatorial libraries therefrom
US5763263A (en) * 1995-11-27 1998-06-09 Dehlinger; Peter J. Method and apparatus for producing position addressable combinatorial libraries
WO1997032017A1 (en) * 1996-02-26 1997-09-04 Morphosys Gesellschaft Für Proteinoptimierung Mbh Novel method for the identification of nucleic acid sequences encoding two or more interacting (poly)peptides
DE69735601T2 (de) * 1996-11-29 2007-10-18 The Board Of Trustees Of The Leland Stanford Junior University, Stanford Anordnungen von unabhängig voneinander ansteuerbaren, gestützten flüssigbilayer-membranen und ihre anwendungsverfahren
JP2002513589A (ja) * 1998-04-30 2002-05-14 マックス−プランク−ゲゼルシャフト・ツア・フェルデルング・デア・ヴィッセンシャフテン・エー・ファオ 再アレー化を伴う、発現ライブラリーのクローンを選択するための新規方法
US6190908B1 (en) * 1998-08-12 2001-02-20 The Scripps Research Institute Modulation of polypeptide display on modified filamentous phage

Also Published As

Publication number Publication date
EP1073770A2 (de) 2001-02-07
JP2010227109A (ja) 2010-10-14
DE69921982T2 (de) 2005-12-29
US20050244854A1 (en) 2005-11-03
DE1073770T1 (de) 2002-07-04
AU4136999A (en) 1999-11-23
WO1999057311A2 (en) 1999-11-11
WO1999057311A3 (en) 2000-03-30
JP2002513588A (ja) 2002-05-14
US20100152051A1 (en) 2010-06-17
AU770540B2 (en) 2004-02-26
DE69921982D1 (de) 2004-12-23
CA2326390A1 (en) 1999-11-11
EP1073770B1 (de) 2004-11-17
JP4540846B2 (ja) 2010-09-08

Similar Documents

Publication Publication Date Title
DE69921982D1 (de) Neuartiges verfahren zur identifizierung von klonen mit einer gewünschten biologischen eigenschaft, ausgehend von einer expressionsgenbank
ATE301724T1 (de) Verfahren zur positionierung von klonen mittels molekularen kaemmens
DE69838724D1 (de) Polymerase-verbessernder faktor (pef)-enthaltende extrakte, pef proteinkomplexe, isoliertes pef protein und verfahren zur reinigung und identifizierung
ATE309536T1 (de) Methoden zur verwendung von randomisierten zinkfingerprotein-bibliotheken zur identifizierung von genfunktionen
ATE343586T1 (de) Verfahren zur verwendung einer universellen bibliothek von peptid-nukleinsäuren zur optimierung der dns-hybridisierung
DE69922365D1 (de) Neue methode zur selektion von klonen einer expressionsbibliothek mittels "rearraying"
ATE305054T1 (de) Verfahren und mittel zur analyse der nukleotidsequenz von nukleinsäuren
DE60045796D1 (de) Gesamt-chromosom analyse von protein-dns wechselwirkungen
DE69834032D1 (de) Verfahren zur erkennung von nucleinsäuremolekülen codierend für (poly)peptide, welche mit zielmolekülen interagieren
ATE393912T1 (de) Microarrays und ihre verwendungen
DE69739304D1 (de) Verfahren und Zusammensetzungen zur Bestimmung von Sequenzen von Nukleinsäure-Molekülen
ATE369440T1 (de) Rationale auswahl von mutmasslichen peptiden aus identifizierten nukleotid- beziehungsweise peptidsequenzen
WO2002086081A3 (en) Methods and systems for identifying proteins
ATE223971T1 (de) Neue methoden zum auffinden von liganden- und ziel-biomolekülen
DE69831500D1 (de) Humane checkpointkinase, hcds1, zusammensetzungen und verfahren
DE69940890D1 (de) Ein verfahren zur analyse von polynukleotiden
EP0767240A3 (de) DNS Sequenzierungs- und Vorbereitungsverfahren
Dzementsei et al. Migratory and adhesive properties of Xenopus laevis primordial germ cells in vitro
ATE223491T1 (de) Verfahren zur reinigung von biomolekül- oder proteinkomplexen
EP1140978A4 (de) Methoden zur identifizierung von antigen-gensequenzen
DE69934017D1 (de) 2,6-beta-d-fruktanhydrolase enzym und verfahren zu dessen verwendung
DE69637724D1 (de) Polypeptide mit spezieller, funktioneller domäne, verfahren zu ihrer identifikation und anwendungen derselben
DE59801996D1 (de) Verfahren zur eingruppierung von sequenzen in familien
WO2001048247A3 (en) METHOD FOR GENERATION OF LONGER cDNA FRAGMENTS FROM SAGE TAGS FOR GENE IDENTIFICATION
ATE440968T1 (de) Verfahren zur diagnostizierung von aspirinunverträglichkeit

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 1073770

Country of ref document: EP

REN Ceased due to non-payment of the annual fee