JP2000505486A - ポリマー第４級アンモニウム化合物と、眼科用抗微生物剤としてのその使用 - Google Patents

ポリマー第４級アンモニウム化合物と、眼科用抗微生物剤としてのその使用

Info

Publication number: JP2000505486A
Authority: JP; Japan
Prior art keywords: weight; quaternary ammonium; present; ammonium compound; polymer
Prior art date: 1996-02-14
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Abandoned

Application number

JP09529296A

Other languages

English (en)

Japanese (ja)

Inventor

キイバ，エバン，ピー．

パーク，ジョーンサップ

Original Assignee

アルコンラボラトリーズ，インコーポレイテッド

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-02-14

Filing date

1996-02-14

Publication date

2000-05-09

1996-02-14 Application filed by アルコンラボラトリーズ，インコーポレイテッド filed Critical アルコンラボラトリーズ，インコーポレイテッド

2000-05-09 Publication of JP2000505486A publication Critical patent/JP2000505486A/ja

Status Abandoned legal-status Critical Current

Links

150000003856 quaternary ammonium compounds Chemical class 0.000 title claims abstract description 25
239000004599 antimicrobial Substances 0.000 title claims description 6
239000000203 mixture Substances 0.000 claims abstract description 24
229920000642 polymer Polymers 0.000 claims description 46
238000000034 method Methods 0.000 claims description 29
150000001450 anions Chemical class 0.000 claims description 5
230000000845 anti-microbial effect Effects 0.000 claims description 4
150000004820 halides Chemical group 0.000 claims description 4
230000000844 anti-bacterial effect Effects 0.000 claims description 3
150000001805 chlorine compounds Chemical group 0.000 claims description 3
230000001954 sterilising effect Effects 0.000 claims description 3
238000004659 sterilization and disinfection Methods 0.000 claims description 3
150000003868 ammonium compounds Chemical class 0.000 claims 3
229940126657 Compound 17 Drugs 0.000 claims 1
229940126142 compound 16 Drugs 0.000 claims 1
239000003755 preservative agent Substances 0.000 abstract description 7
239000000645 desinfectant Substances 0.000 abstract description 2
150000001875 compounds Chemical class 0.000 description 13
239000000047 product Substances 0.000 description 7
ROSDSFDQCJNGOL-UHFFFAOYSA-N Dimethylamine Chemical compound CNC ROSDSFDQCJNGOL-UHFFFAOYSA-N 0.000 description 6
239000000417 fungicide Substances 0.000 description 5
CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 4
KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 4
239000002244 precipitate Substances 0.000 description 4
230000002335 preservative effect Effects 0.000 description 4
239000011541 reaction mixture Substances 0.000 description 4
239000000243 solution Substances 0.000 description 4
FQDIANVAWVHZIR-OWOJBTEDSA-N trans-1,4-Dichlorobutene Chemical compound ClC\C=C\CCl FQDIANVAWVHZIR-OWOJBTEDSA-N 0.000 description 4
OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 description 3
230000015572 biosynthetic process Effects 0.000 description 3
KUEDAAUECWBMLW-AATRIKPKSA-N (e)-n,n,n',n'-tetramethylbut-2-ene-1,4-diamine Chemical compound CN(C)C\C=C\CN(C)C KUEDAAUECWBMLW-AATRIKPKSA-N 0.000 description 2
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
238000005481 NMR spectroscopy Methods 0.000 description 2
239000007864 aqueous solution Substances 0.000 description 2
239000000607 artificial tear Substances 0.000 description 2
239000003795 chemical substances by application Substances 0.000 description 2
239000013583 drug formulation Substances 0.000 description 2
239000004615 ingredient Substances 0.000 description 2
239000012528 membrane Substances 0.000 description 2
238000012545 processing Methods 0.000 description 2
238000000746 purification Methods 0.000 description 2
125000001453 quaternary ammonium group Chemical group 0.000 description 2
238000003756 stirring Methods 0.000 description 2
239000000126 substance Substances 0.000 description 2
238000003786 synthesis reaction Methods 0.000 description 2
230000000699 topical effect Effects 0.000 description 2
230000001988 toxicity Effects 0.000 description 2
231100000419 toxicity Toxicity 0.000 description 2
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
FPYGTMVTDDBHRP-OWOJBTEDSA-N (e)-but-2-ene-1,4-diamine Chemical compound NC\C=C\CN FPYGTMVTDDBHRP-OWOJBTEDSA-N 0.000 description 1
FJNLCHNQVJVCPY-UHFFFAOYSA-N 2-n-methoxy-2-n-methyl-4-n,6-n-dipropyl-1,3,5-triazine-2,4,6-triamine Chemical compound CCCNC1=NC(NCCC)=NC(N(C)OC)=N1 FJNLCHNQVJVCPY-UHFFFAOYSA-N 0.000 description 1
VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 1
FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
238000010521 absorption reaction Methods 0.000 description 1
125000000217 alkyl group Chemical group 0.000 description 1
238000004458 analytical method Methods 0.000 description 1
125000000129 anionic group Chemical group 0.000 description 1
230000002421 anti-septic effect Effects 0.000 description 1
230000003115 biocidal effect Effects 0.000 description 1
239000000872 buffer Substances 0.000 description 1
238000006243 chemical reaction Methods 0.000 description 1
238000004587 chromatography analysis Methods 0.000 description 1
239000008139 complexing agent Substances 0.000 description 1
229940125773 compound 10 Drugs 0.000 description 1
238000006482 condensation reaction Methods 0.000 description 1
238000012937 correction Methods 0.000 description 1
239000002537 cosmetic Substances 0.000 description 1
238000013461 design Methods 0.000 description 1
238000000502 dialysis Methods 0.000 description 1
239000003814 drug Substances 0.000 description 1
229940126534 drug product Drugs 0.000 description 1
230000000694 effects Effects 0.000 description 1
238000000921 elemental analysis Methods 0.000 description 1
230000000855 fungicidal effect Effects 0.000 description 1
230000002070 germicidal effect Effects 0.000 description 1
239000003112 inhibitor Substances 0.000 description 1
239000010985 leather Substances 0.000 description 1
239000007788 liquid Substances 0.000 description 1
238000004519 manufacturing process Methods 0.000 description 1
230000003641 microbiacidal effect Effects 0.000 description 1
229940124561 microbicide Drugs 0.000 description 1
239000002855 microbicide agent Substances 0.000 description 1
238000012986 modification Methods 0.000 description 1
230000004048 modification Effects 0.000 description 1
239000003607 modifier Substances 0.000 description 1
238000000655 nuclear magnetic resonance spectrum Methods 0.000 description 1
230000005311 nuclear magnetism Effects 0.000 description 1
239000000575 pesticide Substances 0.000 description 1
239000008194 pharmaceutical composition Substances 0.000 description 1
239000000825 pharmaceutical preparation Substances 0.000 description 1
229920002959 polymer blend Polymers 0.000 description 1
238000001556 precipitation Methods 0.000 description 1
238000002360 preparation method Methods 0.000 description 1
238000010992 reflux Methods 0.000 description 1
150000003839 salts Chemical class 0.000 description 1
238000000926 separation method Methods 0.000 description 1
239000011780 sodium chloride Substances 0.000 description 1
238000001179 sorption measurement Methods 0.000 description 1
238000001228 spectrum Methods 0.000 description 1
238000003860 storage Methods 0.000 description 1
239000004094 surface-active agent Substances 0.000 description 1
230000002194 synthesizing effect Effects 0.000 description 1
229940124597 therapeutic agent Drugs 0.000 description 1
238000012546 transfer Methods 0.000 description 1
238000001665 trituration Methods 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
- C07C215/74—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
- C07C215/90—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton with quaternised amino groups bound to the carbon skeleton
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C211/00—Compounds containing amino groups bound to a carbon skeleton
- C07C211/62—Quaternary ammonium compounds
- C07C211/63—Quaternary ammonium compounds having quaternised nitrogen atoms bound to acyclic carbon atoms

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Ophthalmology & Optometry (AREA)
Medicinal Preparation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Compositions Of Macromolecular Compounds (AREA)

JP09529296A 1996-02-14 1996-02-14 ポリマー第４級アンモニウム化合物と、眼科用抗微生物剤としてのその使用 Abandoned JP2000505486A (ja)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
PCT/US1996/001975 WO1997029741A1 (fr)	1996-02-14	1996-02-14	Composes polymeriques d'ammonium quaternaire et leur utilisation comme antimicrobiens ophtalmiques

Publications (1)

Publication Number	Publication Date
JP2000505486A true JP2000505486A (ja)	2000-05-09

Family

ID=22254716

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
JP09529296A Abandoned JP2000505486A (ja)	1996-02-14	1996-02-14	ポリマー第４級アンモニウム化合物と、眼科用抗微生物剤としてのその使用

Country Status (4)

Country	Link
EP (1)	EP0880351A4 (fr)
JP (1)	JP2000505486A (fr)
AU (1)	AU712908B2 (fr)
WO (1)	WO1997029741A1 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CN106561631B (zh) *	2016-10-13	2020-12-11	刘鹏飞	一种唾液保存液及其制备方法和应用

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3874870A (en) *	1973-12-18	1975-04-01	Mill Master Onyx Corp	Microbiocidal polymeric quarternary ammonium compounds
US4025653A (en) *	1975-04-07	1977-05-24	Millmaster Onyx Corporation	Microbiocidal polymeric quaternary ammonium compounds
US4089977A (en) *	1976-11-24	1978-05-16	Kewanee Industries	Polymeric anti-microbial agent
US4444750A (en) *	1980-11-17	1984-04-24	Millmaster Onyx Group, Inc.	Method of conditioning hair
US4407791A (en) *	1981-09-28	1983-10-04	Alcon Laboratories, Inc.	Ophthalmic solutions
US4525346A (en) *	1981-09-28	1985-06-25	Alcon Laboratories, Inc.	Aqueous antimicrobial ophthalmic solutions
CA2009118C (fr) *	1989-02-21	1996-02-27	Mary F. Mowrey-Mckee	Methode et compose pour nettoyer et desinfecter les verres de contact
CA2041871C (fr) *	1990-05-09	2000-07-11	Ruth A. Rosenthal	Nettoyage et desinfection des lentilles corneennes a l'aide d'une association d'enzymes et de composes polymeriques d'ammonium quaternaire
CA2125060C (fr) *	1993-07-02	1999-03-30	Henry P. Dabrowski	Solution ophtalmique pour larmes artificielles
US5603929A (en) *	1994-11-16	1997-02-18	Alcon Laboratories, Inc.	Preserved ophthalmic drug compositions containing polymeric quaternary ammonium compounds

1996
- 1996-02-14 JP JP09529296A patent/JP2000505486A/ja not_active Abandoned
- 1996-02-14 AU AU49808/96A patent/AU712908B2/en not_active Ceased
- 1996-02-14 EP EP96906426A patent/EP0880351A4/fr not_active Withdrawn
- 1996-02-14 WO PCT/US1996/001975 patent/WO1997029741A1/fr not_active Ceased

Also Published As

Publication number	Publication date
AU4980896A (en)	1997-09-02
WO1997029741A1 (fr)	1997-08-21
EP0880351A1 (fr)	1998-12-02
EP0880351A4 (fr)	2003-01-08
AU712908B2 (en)	1999-11-18

Legal Events

Date

Code

Title

Description

2004-03-04

A762

Written abandonment of application

Free format text: JAPANESE INTERMEDIATE CODE: A762

Effective date: 20040209

Publication	Publication Date	Title
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JP3353423B2 (ja)	2002-12-03	新規の重合体抗菌剤類及び薬剤組成物へのそれらの使用
FI66589C (fi)	1984-11-12	Linjaerae kvaternaera ammoniumpolymerer
US4482680A (en)	1984-11-13	Quaternary ammonium group-containing polymers having antimicrobial activity
US5512597A (en)	1996-04-30	Polymeric quaternary ammonium compounds and their use as ophthalmic antimicrobials
US5683709A (en)	1997-11-04	Poly(benzalkonium salt) as an anti-microbial agent for aqueous drug compositions
EP0731714B1 (fr)	2003-07-16	Utilisation de composes d'ammonium quaternaire polymeres contenant de l'oxyde de polyethylene dans des compositions pharmaceutiques
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