|
US5504074A
(en)
*
|
1993-08-06 |
1996-04-02 |
Children's Medical Center Corporation |
Estrogenic compounds as anti-angiogenic agents
|
|
US20040214807A1
(en)
*
|
1993-08-06 |
2004-10-28 |
D'amato Robert J. |
Estrogenic compounds as anti-mitotic agents
|
|
US6908910B2
(en)
|
1993-08-06 |
2005-06-21 |
The Children's Medical Center Corporation |
Estrogenic compounds as anti-mitotic agents
|
|
US6346510B1
(en)
*
|
1995-10-23 |
2002-02-12 |
The Children's Medical Center Corporation |
Therapeutic antiangiogenic endostatin compositions
|
|
EP0888310B1
(en)
*
|
1996-03-15 |
2005-09-07 |
AstraZeneca AB |
Cinnoline derivatives and use as medicine
|
|
GB9707800D0
(en)
|
1996-05-06 |
1997-06-04 |
Zeneca Ltd |
Chemical compounds
|
|
GB9718972D0
(en)
|
1996-09-25 |
1997-11-12 |
Zeneca Ltd |
Chemical compounds
|
|
KR100567649B1
(ko)
|
1996-09-25 |
2006-04-05 |
아스트라제네카 유케이 리미티드 |
혈관 내피 성장 인자와 같은 성장 인자의 효과를 억제하는 퀴놀린 유도체
|
|
WO1999010349A1
(en)
|
1997-08-22 |
1999-03-04 |
Zeneca Limited |
Oxindolylquinazoline derivatives as angiogenesis inhibitors
|
|
US20020002294A1
(en)
*
|
1997-09-24 |
2002-01-03 |
D' Amato Robert J. |
Estrogenic compounds as antiangiogenic agents
|
|
ATE459616T1
(de)
*
|
1998-08-11 |
2010-03-15 |
Novartis Ag |
Isochinoline derivate mit angiogenesis-hemmender wirkung
|
|
WO2000009098A2
(en)
*
|
1998-08-13 |
2000-02-24 |
Novartis Ag |
Method for treating ocular neovascular diseases
|
|
UA71971C2
(en)
|
1999-06-04 |
2005-01-17 |
Agoron Pharmaceuticals Inc |
Diaminothiazoles, composition based thereon, a method for modulation of protein kinases activity, a method for the treatment of diseases mediated by protein kinases
|
|
PE20010306A1
(es)
*
|
1999-07-02 |
2001-03-29 |
Agouron Pharma |
Compuestos de indazol y composiciones farmaceuticas que los contienen utiles para la inhibicion de proteina kinasa
|
|
US7141581B2
(en)
|
1999-07-02 |
2006-11-28 |
Agouron Pharmaceuticals, Inc. |
Indazole compounds and pharmaceutical compositions for inhibiting protein kinases, and methods for their use
|
|
TWI262914B
(en)
|
1999-07-02 |
2006-10-01 |
Agouron Pharma |
Compounds and pharmaceutical compositions for inhibiting protein kinases
|
|
US6271233B1
(en)
|
1999-08-10 |
2001-08-07 |
Ciba Vision Corporation |
Method for treating ocular neovascular diseases
|
|
US7087592B1
(en)
*
|
1999-08-23 |
2006-08-08 |
Entre Med, Inc. |
Compositions comprising purified 2-methoxyestradiol and methods of producing same
|
|
US6921763B2
(en)
|
1999-09-17 |
2005-07-26 |
Abbott Laboratories |
Pyrazolopyrimidines as therapeutic agents
|
|
CZ301689B6
(cs)
|
1999-11-05 |
2010-05-26 |
Astrazeneca Ab |
Derivát chinazolinu a farmaceutický prostredek, který ho obsahuje
|
|
YU54202A
(sh)
|
2000-01-18 |
2006-01-16 |
Agouron Pharmaceuticals Inc. |
Jedinjenja indazola, farmaceutske smeše i postupci za stimulisanje i inhibiranje ćelijske proliferacije
|
|
HN2001000008A
(es)
|
2000-01-21 |
2003-12-11 |
Inc Agouron Pharmaceuticals |
Compuesto de amida y composiciones farmaceuticas para inhibir proteinquinasas, y su modo de empleo
|
|
JP2003521543A
(ja)
|
2000-02-07 |
2003-07-15 |
アボット ゲーエムベーハー ウント カンパニー カーゲー |
２−ベンゾチアゾリル尿素誘導体およびそのプロテインキナーゼ阻害剤としての使用
|
|
PT1254138E
(pt)
*
|
2000-02-09 |
2005-09-30 |
Novartis Ag |
Derivados de piridina que inibem a angiogenese e/ou o receptor de tirosina cinase do vegf
|
|
AU2001235804A1
(en)
*
|
2000-03-06 |
2001-09-17 |
Astrazeneca Ab |
Therapy
|
|
GB0008269D0
(en)
*
|
2000-04-05 |
2000-05-24 |
Astrazeneca Ab |
Combination chemotherapy
|
|
ES2267748T3
(es)
|
2000-04-07 |
2007-03-16 |
Astrazeneca Ab |
Compuestos de quinazolina.
|
|
JP2004501083A
(ja)
|
2000-04-18 |
2004-01-15 |
アゴーロン・ファーマシューティカルズ・インコーポレイテッド |
プロテインキナーゼを阻害するためのピラゾール
|
|
US6995278B2
(en)
*
|
2000-08-18 |
2006-02-07 |
Entre Med, Inc. |
Antiangiogenic agents
|
|
US7135581B2
(en)
*
|
2000-08-18 |
2006-11-14 |
Entremed, Inc. |
Antiangiogenic agents
|
|
US20050192258A1
(en)
*
|
2000-08-18 |
2005-09-01 |
Agoston Gregory E. |
Antiangiogenic agents
|
|
ATE295354T1
(de)
|
2000-08-18 |
2005-05-15 |
Agouron Pharma |
Heterozyklische-hydroximino-fluorene und ihre verwendung zur inhibierung von proteinkinasen
|
|
EP1313734B1
(en)
|
2000-09-01 |
2009-11-11 |
Novartis Vaccines and Diagnostics, Inc. |
Aza heterocyclic derivatives and their therapeutic use
|
|
CZ304344B6
(cs)
*
|
2000-09-11 |
2014-03-19 |
Novartis Vaccines & Diagnostics, Inc. |
Chinolinonový derivát a jeho použití a farmaceutický prostředek s obsahem tohoto derivátu
|
|
MXPA03008560A
(es)
|
2001-03-22 |
2004-06-30 |
Abbot Gmbh & Co Kg |
Pirazolopirimidinas como agentes terapeuticos.
|
|
HN2002000156A
(es)
|
2001-07-06 |
2003-11-27 |
Inc Agouron Pharmaceuticals |
Derivados de benzamida tiazol y composiciones farmaceuticas para inhibir la proliferacion de celulas y metodos para su utilización.
|
|
WO2003063791A2
(en)
*
|
2002-01-30 |
2003-08-07 |
Entremed, Inc. |
Non-steroidal analogs of 2-methoxyestradiol
|
|
JP4608215B2
(ja)
*
|
2002-02-01 |
2011-01-12 |
アストラゼネカ アクチボラグ |
キナゾリン化合物
|
|
UA77303C2
(en)
|
2002-06-14 |
2006-11-15 |
Pfizer |
Derivatives of thienopyridines substituted by benzocondensed heteroarylamide useful as therapeutic agents, pharmaceutical compositions and methods for their use
|
|
EP2280003B1
(en)
|
2002-07-15 |
2014-04-02 |
Symphony Evolution, Inc. |
Process for preparing receptor-type kinase modulators
|
|
US7825132B2
(en)
|
2002-08-23 |
2010-11-02 |
Novartis Vaccines And Diagnostics, Inc. |
Inhibition of FGFR3 and treatment of multiple myeloma
|
|
CA2496164C
(en)
|
2002-08-23 |
2010-11-09 |
Chiron Corporation |
Benzimidazole quinolinones and uses thereof
|
|
RU2350618C2
(ru)
*
|
2002-11-04 |
2009-03-27 |
Астразенека Аб |
ПРОИЗВОДНЫЕ ХИНАЗОЛИНА В КАЧЕСТВЕ ИНГИБИТОРОВ Src ТИРОЗИНКИНАЗЫ
|
|
US7268137B2
(en)
*
|
2002-11-07 |
2007-09-11 |
Campochiaro Peter A |
Ocular therapy
|
|
AU2003290699B2
(en)
|
2002-11-13 |
2009-08-27 |
Novartis Vaccines And Diagnostics, Inc. |
Methods of treating cancer and related methods
|
|
WO2004056806A1
(en)
|
2002-12-19 |
2004-07-08 |
Pfizer Inc. |
2-(1h-indazol-6-ylamino)-benzamide compounds as protein kinases inhibitors useful for the treatment of ophtalmic diseases
|
|
JP2006526025A
(ja)
*
|
2003-05-28 |
2006-11-16 |
エントレメッド インコーポレイテッド |
抗血管新生剤
|
|
NZ592039A
(en)
|
2003-08-27 |
2013-03-28 |
Ophthotech Corp |
Combination therapy for the treatment of ocular neovascular disorders
|
|
EP1660504B1
(en)
|
2003-08-29 |
2008-10-29 |
Pfizer Inc. |
Thienopyridine-phenylacet amides and their derivatives useful as new anti-angiogenic agents
|
|
PT2213661E
(pt)
|
2003-09-26 |
2011-12-15 |
Exelixis Inc |
Moduladores de c-met e métodos de uso
|
|
KR100872204B1
(ko)
*
|
2003-10-15 |
2008-12-09 |
오에스아이 파마슈티컬스, 인코포레이티드 |
이미다조피라진 티로신 키나제 억제제
|
|
CN102225926A
(zh)
|
2003-11-07 |
2011-10-26 |
诺华疫苗和诊断公司 |
具有改进药物特性的喹啉酮类化合物的药学上可接受的盐
|
|
AU2004293443A1
(en)
|
2003-11-19 |
2005-06-09 |
Signal Pharmaceuticals, Llc. |
Indazole Compounds and methods of use thereof as protein kinase inhibitors
|
|
US7875624B2
(en)
|
2004-02-20 |
2011-01-25 |
Novartis Vaccines And Diagnostics, Inc. |
Modulating and measuring cellular adhesion
|
|
US20070004689A1
(en)
*
|
2004-03-12 |
2007-01-04 |
Agoston Gregory E |
Antiangiogenic agents
|
|
US7498322B2
(en)
*
|
2004-03-12 |
2009-03-03 |
Entremed, Inc. |
Antiangiogenic agents
|
|
TWI378934B
(en)
*
|
2004-04-02 |
2012-12-11 |
Osi Pharm Inc |
6,6-bicyclic ring substituted heterobicyclic protein kinase inhibitors
|
|
TW200613306A
(en)
|
2004-07-20 |
2006-05-01 |
Osi Pharm Inc |
Imidazotriazines as protein kinase inhibitors
|
|
AU2005282721A1
(en)
*
|
2004-09-03 |
2006-03-16 |
Memory Pharmaceuticals Corporation |
4-substituted 4, 6-dialkoxy-cinnoline derivatives as phospodiesterase 10 inhibitors for the treatment of psychiatric or neurological syndroms
|
|
PL1805175T3
(pl)
|
2004-10-14 |
2008-08-29 |
Hoffmann La Roche |
Nowe azaindolotiazolinony jako środki przeciwrakowe
|
|
WO2006058298A2
(en)
*
|
2004-11-29 |
2006-06-01 |
Entremed, Inc. |
A method of administering anti-angiogenic agents and a method of treating disease using same
|
|
CA2593005A1
(en)
*
|
2005-01-03 |
2006-07-13 |
Myriad Genetics Inc. |
Pharmaceutical compounds as activators of caspases and inducers of apoptosis and the use thereof
|
|
DOP2006000051A
(es)
|
2005-02-24 |
2006-08-31 |
Lilly Co Eli |
Inhibidores de vegf-r2 y métodos
|
|
US7304074B2
(en)
|
2005-04-05 |
2007-12-04 |
Hoffmann-La Roche Inc. |
Substituted 1,5-naphthyridine azolinones
|
|
US20060264439A1
(en)
*
|
2005-05-17 |
2006-11-23 |
Supergen, Inc. |
Inhibitors of polo-like kinase-1
|
|
JP5545925B2
(ja)
|
2005-05-17 |
2014-07-09 |
ノバルティス アーゲー |
ヘテロ環化合物の合成方法
|
|
MX2007014782A
(es)
|
2005-05-23 |
2008-02-19 |
Novartis Ag |
Formas cristalinas y otras formas de las sales de acido lactico de 4-amino-5-fluoro-3-[6-(4-metilpiperazin-1-il)-1h-bencimidazol-2 -il]-1h quinolin-2-ona.
|
|
US7566721B2
(en)
*
|
2005-08-08 |
2009-07-28 |
Osi Pharmaceuticals, Inc. |
Substituted thienol[2,3-d]pyrimidines as kinase inhibitors
|
|
US20070185069A1
(en)
*
|
2005-11-14 |
2007-08-09 |
Plum Stacy M |
Anti-angiogenic activity of 2-methoxyestradiol in combination with anti-cancer agents
|
|
RU2433826C2
(ru)
|
2005-11-29 |
2011-11-20 |
Новартис Аг |
Композиции хинолинонов
|
|
AR057960A1
(es)
|
2005-12-02 |
2007-12-26 |
Osi Pharm Inc |
Inhibidores de proteina quinasa biciclicos
|
|
US8575164B2
(en)
*
|
2005-12-19 |
2013-11-05 |
OSI Pharmaceuticals, LLC |
Combination cancer therapy
|
|
US20070176403A1
(en)
*
|
2006-02-01 |
2007-08-02 |
Dennis Calderone |
Air adjustable seat
|
|
WO2007109312A2
(en)
*
|
2006-03-20 |
2007-09-27 |
Entremed, Inc. |
Disease modifying anti-arthritic activity of 2-methoxyestradiol
|
|
US20070258976A1
(en)
*
|
2006-05-04 |
2007-11-08 |
Ward Keith W |
Combination Therapy for Diseases Involving Angiogenesis
|
|
US20080234243A1
(en)
*
|
2007-01-31 |
2008-09-25 |
Lavallee Theresa M |
Method of treating amyloidosis mediated diseases
|
|
US20080190689A1
(en)
*
|
2007-02-12 |
2008-08-14 |
Ballard Ebbin C |
Inserts for engine exhaust systems
|
|
JP2011510018A
(ja)
*
|
2008-01-18 |
2011-03-31 |
オーエスアイ・フアーマスーテイカルズ・インコーポレーテツド |
癌治療のためのイミダゾピラジノール誘導体
|
|
EP2283020B8
(en)
*
|
2008-05-19 |
2012-12-12 |
OSI Pharmaceuticals, LLC |
Substituted imidazopyr-and imidazotri-azines
|
|
SG173014A1
(en)
|
2009-01-16 |
2011-08-29 |
Exelixis Inc |
Malate salt of n- (4- { [ 6, 7-bis (methyloxy) quin0lin-4-yl] oxy}phenyl)-n' - (4 -fluorophenyl) cyclopropane-1,1-dicarboxamide, and crystalline forms therof for the treatment of cancer
|
|
WO2010123792A1
(en)
|
2009-04-20 |
2010-10-28 |
Osi Pharmaceuticals, Inc. |
Preparation of c-pyrazine-methylamines
|
|
EP2427192A1
(en)
*
|
2009-05-07 |
2012-03-14 |
OSI Pharmaceuticals, LLC |
Use of osi-906 for treating adrenocortical carcinoma
|
|
UA108618C2
(uk)
|
2009-08-07 |
2015-05-25 |
|
Застосування c-met-модуляторів в комбінації з темозоломідом та/або променевою терапією для лікування раку
|
|
US20110189174A1
(en)
*
|
2010-02-01 |
2011-08-04 |
Afshin Shafiee |
Compositions and methods for treating, reducing, ameliorating, alleviating, or inhibiting progression of, pathogenic ocular neovascularization
|
|
US10968290B2
(en)
|
2017-03-28 |
2021-04-06 |
Exxonmobil Chemical Patents Inc. |
Metallocene-catalyzed polyalpha-olefins
|
|
WO2019157169A1
(en)
|
2018-02-12 |
2019-08-15 |
Exxonmobil Chemical Patents Inc. |
Catalyst systems and processes for poly alpha-olefin having high vinylidene content
|
|
US11078308B2
(en)
|
2018-02-12 |
2021-08-03 |
Exxonmobil Chemical Patents Inc. |
Processes to produce poly alpha-olefin trimers
|
|
US11021553B2
(en)
|
2018-02-12 |
2021-06-01 |
Exxonmobil Chemical Patents Inc. |
Metallocene dimer selective catalysts and processes to produce poly alpha-olefin dimers
|
|
WO2019210026A1
(en)
|
2018-04-26 |
2019-10-31 |
Exxonmobil Chemical Patents Inc. |
Non-coordinating anion type activators containing cation having large alkyl groups
|
|
US11059791B2
(en)
|
2019-04-25 |
2021-07-13 |
Exxonmobil Chemical Patents Inc. |
Non-coordinating anion type benzimidazolium activators
|
|
US12344696B2
(en)
|
2019-08-09 |
2025-07-01 |
Exxonmobil Chemical Patents Inc. |
Process to produce low viscosity polyalphaolefins using non-aromatic-hydrocarbon soluble activators
|
|
CN112694474B
(zh)
*
|
2019-10-23 |
2022-03-18 |
四川大学 |
吲唑类衍生物及其制备方法和用途
|
|
EP4051656A1
(en)
|
2019-10-28 |
2022-09-07 |
ExxonMobil Chemical Patents Inc. |
Dimer selective metallocene catalysts, non-aromatic hydrocarbon soluble activators, and processes to produce poly alpha-olefin oligmers therewith
|
|
US11572423B2
(en)
|
2019-12-11 |
2023-02-07 |
Exxonmobil Chemicals Patents Inc. |
Processes for introduction of liquid activators in olefin polymerization reactions
|
|
US11584707B2
(en)
|
2019-12-16 |
2023-02-21 |
Exxonmobil Chemical Patents Inc. |
Non-coordinating anion type activators containing cation having aryldiamine groups and uses thereof
|
|
WO2021173361A1
(en)
|
2020-02-24 |
2021-09-02 |
Exxonmobil Chemical Patents Inc. |
Ansa-bis(inden-2-yl) catalysts for producing vinylidene-terminated polyalphaolefins
|
|
US11746163B2
(en)
|
2021-01-05 |
2023-09-05 |
Exxonmobil Chemical Patents Inc. |
Isohexane-soluble unsaturated alkyl anilinium tetrakis(perfluoroaryl)borate activators
|
|
CN119638634B
(zh)
*
|
2023-09-18 |
2026-01-30 |
上海赛默罗生物科技有限公司 |
噌啉-2-氧化物类化合物及其制备方法和用途
|