JP2000507204A - C1―インヒビターの補体及び血液凝固阻害特性の強化 - Google Patents

C1―インヒビターの補体及び血液凝固阻害特性の強化

Info

Publication number
JP2000507204A
JP2000507204A JP9522672A JP52267297A JP2000507204A JP 2000507204 A JP2000507204 A JP 2000507204A JP 9522672 A JP9522672 A JP 9522672A JP 52267297 A JP52267297 A JP 52267297A JP 2000507204 A JP2000507204 A JP 2000507204A
Authority
JP
Japan
Prior art keywords
inhibition
inhibitors
inhibitor
esterase
pharmaceutical composition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP9522672A
Other languages
English (en)
Japanese (ja)
Inventor
ハク,コルネリス・エリク
ウイレミン,ワルター
Original Assignee
ステイヒテイング・サンキン・ブロードボールジーニング
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ステイヒテイング・サンキン・ブロードボールジーニング filed Critical ステイヒテイング・サンキン・ブロードボールジーニング
Publication of JP2000507204A publication Critical patent/JP2000507204A/ja
Pending legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/737Sulfated polysaccharides, e.g. chondroitin sulfate, dermatan sulfate
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55Protease inhibitors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Dermatology (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Rheumatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
JP9522672A 1995-12-18 1996-12-18 C1―インヒビターの補体及び血液凝固阻害特性の強化 Pending JP2000507204A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP95203537 1995-12-18
EP95203537.6 1995-12-18
PCT/NL1996/000488 WO1997022347A1 (en) 1995-12-18 1996-12-18 Potentiation of complement and coagulation inhibitory properties of c1-inhibitor.

Publications (1)

Publication Number Publication Date
JP2000507204A true JP2000507204A (ja) 2000-06-13

Family

ID=8220969

Family Applications (1)

Application Number Title Priority Date Filing Date
JP9522672A Pending JP2000507204A (ja) 1995-12-18 1996-12-18 C1―インヒビターの補体及び血液凝固阻害特性の強化

Country Status (4)

Country Link
EP (1) EP0868191A1 (de)
JP (1) JP2000507204A (de)
AU (1) AU1042597A (de)
WO (1) WO1997022347A1 (de)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2023521919A (ja) * 2020-04-15 2023-05-25 ティーエックス メディック エービー 敗血症および高サイトカイン血症の治療薬

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2502539A1 (en) * 2002-10-17 2004-04-29 Pharming Intellectual Property B.V. Protein modification
SMT201900141T1 (it) 2013-03-15 2019-05-10 Shire Viropharma Inc Composizioni di c1-inh e metodi per la prevenzione e il trattamento di disturbi associati a deficit di inibitore di c1 esterasi
US20150104445A1 (en) * 2013-10-10 2015-04-16 Viropharma Holdings Limited Methods of inhibiting the alternative pathway of complement immune system activation and compositions used therein
SE539575C2 (en) 2015-07-30 2017-10-17 Tx Medic Ab Dextran sulfate for use in treating, inhibiting or preventing cardiac fibrosis

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3634392A1 (de) * 1986-10-09 1988-04-14 Knoll Ag Verwendung polysulfatierter niedermolekularer dextransulfate
IL85145A (en) * 1987-01-23 1994-08-26 Univ Australian Anti-metastatic pharmacological or veterinary preparations containing modified herpin with reduced anticoagulant activity
EP0293826A3 (de) * 1987-06-02 1989-05-10 Stichting REGA V.Z.W. Therapeutische und prophylaktische Gabe von sulfatierten Polysacchariden gegen AIDS
AU6879091A (en) * 1989-10-16 1991-05-16 Invitron Corporation Protease nexin i/dextran sulfate anticoagulant
ATE135585T1 (de) * 1990-08-27 1996-04-15 Monsanto Co Anticoagulatorische zusammensetzung aus laci und sulfatierten polysacchariden
WO1992022320A1 (en) * 1991-06-14 1992-12-23 Genentech, Inc. C1 inhibitor variants and treating inflammatory response with c1 inhibitor
DE4244735A1 (de) * 1992-08-24 1994-03-31 Behringwerke Ag Verwendung von C1-Inaktivator zur Bekämpfung von Komplikationen bei der Anwendung von Zytokinen, endogenen Mediatoren, gentechnisch produzierten Mediator-Hybriden oder Wachstumsfaktoren im Rahmen der therapeutischen Anwendung dieser Substanzen

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2023521919A (ja) * 2020-04-15 2023-05-25 ティーエックス メディック エービー 敗血症および高サイトカイン血症の治療薬
JP7758356B2 (ja) 2020-04-15 2025-10-22 ティーエックス メディック エービー 敗血症および高サイトカイン血症の治療薬

Also Published As

Publication number Publication date
WO1997022347A1 (en) 1997-06-26
AU1042597A (en) 1997-07-14
EP0868191A1 (de) 1998-10-07

Similar Documents

Publication Publication Date Title
Wuillemin et al. Potentiation of C1 inhibitor by glycosaminoglycans: dextran sulfate species are effective inhibitors of in vitro complement activation in plasma
Olson et al. Regulation of thrombin activity by antithrombin and heparin
EP0497756B1 (de) Antithrombotische zusammensetzung
Day et al. Recombinant lipoprotein-associated coagulation inhibitor inhibits tissue thromboplastin-induced intravascular coagulation in the rabbit
Luchtman-Jones et al. The current status of coagulation
JPS6218401A (ja) 結合組織病理において有効な医薬の製造に使用する多糖およびオリゴ糖
Castelino et al. Natural anticoagulants and the liver
US5777081A (en) Process for producing an inter-alpha-trypsin inhibitor concentrate for therapeutic use and concentrate thus obtained
EP0473564B1 (de) Anticoagulatorische Zusammensetzung aus LACI und sulfatierten Polysacchariden
Abbink et al. Quantification of functional and inactivated α2-macroglobulin in sepsis
Vinazzer Hereditary and acquired antithrombin deficiency
Abildgaard Antithrombin–early prophecies and present challenges
JP2000507204A (ja) C1―インヒビターの補体及び血液凝固阻害特性の強化
US7008933B2 (en) Process for prophylaxis and therapy of thrombotic processes employing heparin having particular average molecular weights
JPH08511764A (ja) 好中球エラスターゼ及びカテプシンgの阻害方法及び阻害薬
Wuillemin et al. Clearance of human factor XIa–inhibitor complexes in rats
Bridey et al. Recombinant hirudin (HBW 023): Biological data of ten patients with severe venous thrombo‐embolism
CA2239787A1 (en) Potentiation of complement and coagulation inhibitory properties of c1-inhibitor
Kaiser et al. Recombinant TFPI and variants: potential implications in the treatment of cardiovascular disorders
Mattsson et al. Antithrombotic properties in rabbits of heparin and heparin fragments covalently coupled to human antithrombin III.
US20050014701A1 (en) Combination product comprising melagatran and dexamethasone
US6291427B1 (en) Anticoagulant combination of LACI and sulfated polysaccharides
US20010055591A1 (en) Antithrombin H-helix mutants
AU2002363023A1 (en) A combination product comprising melagatran and dexamethasone
Jeske Pharmacologic studies on synthetic analogues of heparin with selective affinity to endogenous serine protease inhibitors