JP2000511408A - 新規治療 - Google Patents
新規治療Info
- Publication number
- JP2000511408A JP2000511408A JP09538552A JP53855297A JP2000511408A JP 2000511408 A JP2000511408 A JP 2000511408A JP 09538552 A JP09538552 A JP 09538552A JP 53855297 A JP53855297 A JP 53855297A JP 2000511408 A JP2000511408 A JP 2000511408A
- Authority
- JP
- Japan
- Prior art keywords
- kda
- cleavage
- polypeptide
- compound
- species
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
- G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4711—Alzheimer's disease; Amyloid plaque core protein
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
- G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
- G01N2333/4701—Details
- G01N2333/4709—Amyloid plaque core protein
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/28—Neurological disorders
- G01N2800/2814—Dementia; Cognitive disorders
- G01N2800/2821—Alzheimer
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Neurology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Neurosurgery (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- Biochemistry (AREA)
- Hematology (AREA)
- Immunology (AREA)
- Urology & Nephrology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Cell Biology (AREA)
- Analytical Chemistry (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Biotechnology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Microbiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Psychiatry (AREA)
- Food Science & Technology (AREA)
- Physics & Mathematics (AREA)
- Public Health (AREA)
- Hospice & Palliative Care (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB9608657.4 | 1996-04-26 | ||
| GBGB9608657.4A GB9608657D0 (en) | 1996-04-26 | 1996-04-26 | Novel treatment |
| PCT/EP1997/002050 WO1997041443A2 (en) | 1996-04-26 | 1997-04-22 | Method for screening compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JP2000511408A true JP2000511408A (ja) | 2000-09-05 |
Family
ID=10792689
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP09538552A Pending JP2000511408A (ja) | 1996-04-26 | 1997-04-22 | 新規治療 |
Country Status (4)
| Country | Link |
|---|---|
| EP (1) | EP0900384A2 (de) |
| JP (1) | JP2000511408A (de) |
| GB (1) | GB9608657D0 (de) |
| WO (1) | WO1997041443A2 (de) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR020107A1 (es) * | 1998-07-09 | 2002-04-10 | Boehringer Ingelheim Pharma | Metodo para identificar una sustancia capaz de reducir o eliminar la actividad de la presenilinasa, las sustancias identificables con dicho metodo, el usode estas ultimas en la elaboracion de un medicamento para el tratamiento de enfermedades neurodegenerativas y las composiciones farmaceuticas que |
| DE19941039A1 (de) * | 1999-08-28 | 2001-03-01 | Boehringer Ingelheim Pharma | gamma-Sekretase in vitro Testsystem |
| GB0005894D0 (en) * | 2000-03-10 | 2000-05-03 | Glaxo Group Ltd | Assay |
| ATE339496T1 (de) * | 2000-05-11 | 2006-10-15 | Scios Inc | Modulation von gamma-secretase aktivität |
| DE10032709A1 (de) * | 2000-07-07 | 2002-01-24 | Boehringer Ingelheim Pharma | Aspartyl-Protease |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1339014C (en) * | 1987-10-08 | 1997-03-25 | Ronald E. Majocha | Antibodies to a4 amyloid peptide |
| US5292652A (en) * | 1990-10-05 | 1994-03-08 | Athena Neurosciences, Inc. | Amyloidin protease and uses thereof |
| AU679675B2 (en) * | 1992-05-11 | 1997-07-10 | Bayer Corporation | Methods for detecting beta amyloid precursor protein processing enzymes |
-
1996
- 1996-04-26 GB GBGB9608657.4A patent/GB9608657D0/en active Pending
-
1997
- 1997-04-22 WO PCT/EP1997/002050 patent/WO1997041443A2/en not_active Ceased
- 1997-04-22 JP JP09538552A patent/JP2000511408A/ja active Pending
- 1997-04-22 EP EP97920740A patent/EP0900384A2/de not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| EP0900384A2 (de) | 1999-03-10 |
| GB9608657D0 (en) | 1996-07-03 |
| WO1997041443A3 (en) | 1997-12-11 |
| WO1997041443A2 (en) | 1997-11-06 |
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