JP2000512631A5 - - Google Patents
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- Publication number
- JP2000512631A5 JP2000512631A5 JP1998500502A JP50050298A JP2000512631A5 JP 2000512631 A5 JP2000512631 A5 JP 2000512631A5 JP 1998500502 A JP1998500502 A JP 1998500502A JP 50050298 A JP50050298 A JP 50050298A JP 2000512631 A5 JP2000512631 A5 JP 2000512631A5
- Authority
- JP
- Japan
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE9602263-7 | 1996-06-07 | ||
| SE9602263A SE9602263D0 (sv) | 1996-06-07 | 1996-06-07 | New amino acid derivatives |
| PCT/SE1997/000989 WO1997046577A1 (en) | 1996-06-07 | 1997-06-05 | New amino acid derivatives and their use as thrombin inhibitors |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2000512631A JP2000512631A (ja) | 2000-09-26 |
| JP2000512631A5 true JP2000512631A5 (2) | 2005-01-13 |
| JP4237824B2 JP4237824B2 (ja) | 2009-03-11 |
Family
ID=20402928
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP50050298A Expired - Fee Related JP4237824B2 (ja) | 1996-06-07 | 1997-06-05 | 新規なアミノ酸誘導体およびトロンビン阻害剤としてのその使用 |
Country Status (26)
| Country | Link |
|---|---|
| US (2) | US6255301B1 (2) |
| EP (1) | EP0910573B1 (2) |
| JP (1) | JP4237824B2 (2) |
| CN (1) | CN1129604C (2) |
| AR (1) | AR008046A1 (2) |
| AT (1) | ATE231883T1 (2) |
| AU (1) | AU723420B2 (2) |
| BR (1) | BR9709560A (2) |
| CA (1) | CA2255625A1 (2) |
| CZ (1) | CZ398698A3 (2) |
| DE (1) | DE69718791T2 (2) |
| DK (1) | DK0910573T3 (2) |
| EE (1) | EE9800425A (2) |
| ES (1) | ES2191840T3 (2) |
| HU (1) | HUP0002404A3 (2) |
| ID (1) | ID17016A (2) |
| IL (2) | IL127325A0 (2) |
| IS (1) | IS4906A (2) |
| NO (1) | NO317135B1 (2) |
| NZ (1) | NZ332964A (2) |
| PL (1) | PL330482A1 (2) |
| SE (1) | SE9602263D0 (2) |
| SK (1) | SK165398A3 (2) |
| TR (1) | TR199802536T2 (2) |
| WO (1) | WO1997046577A1 (2) |
| ZA (1) | ZA974542B (2) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SA96170106A (ar) * | 1995-07-06 | 2005-12-03 | أسترا أكتيبولاج | مشتقات حامض أميني جديدة |
| AR013084A1 (es) | 1997-06-19 | 2000-12-13 | Astrazeneca Ab | Derivados de amidino utiles como inhibidores de la trombina, composicion farmaceutica, utilizacion de dichos compuestos para la preparacion demedicamentos y proceso para la preparacion de los compuestos mencionados |
| SE9704543D0 (sv) * | 1997-12-05 | 1997-12-05 | Astra Ab | New compounds |
| WO1999055355A1 (en) | 1998-04-24 | 1999-11-04 | 3-Dimensional Pharmaceuticals, Inc. | Amino acid amidinohydrazones, alkoxyguanidines and aminoguanidines as protease inhibitors |
| SE9804313D0 (sv) | 1998-12-14 | 1998-12-14 | Astra Ab | New compounds |
| EP1150996B1 (en) * | 1999-01-13 | 2007-11-21 | AstraZeneca AB | New amidinobenzylamine derivatives and their use as thrombin inhibitors |
| AR023510A1 (es) | 1999-04-21 | 2002-09-04 | Astrazeneca Ab | Un equipo de partes, formulacion farmaceutica y uso de un inhibidor de trombina. |
| SE9902270D0 (sv) * | 1999-06-16 | 1999-06-16 | Astra Ab | Pharmaceutically active compounds |
| SE0001803D0 (sv) * | 2000-05-16 | 2000-05-16 | Astrazeneca Ab | New compounds i |
| US6433186B1 (en) * | 2000-08-16 | 2002-08-13 | Astrazeneca Ab | Amidino derivatives and their use as thormbin inhibitors |
| EP1311480B1 (en) * | 2000-08-16 | 2008-09-03 | AstraZeneca AB | New amidino derivatives and their use as thrombin inhibitors |
| AR035216A1 (es) | 2000-12-01 | 2004-05-05 | Astrazeneca Ab | Derivados de acido mandelico ,derivados farmaceuticamente aceptables, uso de estos derivados para la fabricacion de medicamentos, metodos de tratamiento ,procesos para la preparacion de estos derivados, y compuestos intermediarios |
| RU2300521C2 (ru) * | 2000-12-01 | 2007-06-10 | Астразенека Аб | Новые производные миндальной кислоты и их применение в качестве ингибиторов тромбина |
| US7129233B2 (en) | 2000-12-01 | 2006-10-31 | Astrazeneca Ab | Mandelic acid derivatives and their use as thrombin inhibitors |
| AR034517A1 (es) | 2001-06-21 | 2004-02-25 | Astrazeneca Ab | Formulacion farmaceutica |
| SE0201661D0 (sv) | 2002-05-31 | 2002-05-31 | Astrazeneca Ab | New salts |
| SE0201659D0 (sv) | 2002-05-31 | 2002-05-31 | Astrazeneca Ab | Modified release pharmaceutical formulation |
| US7781424B2 (en) * | 2003-05-27 | 2010-08-24 | Astrazeneca Ab | Modified release pharmaceutical formulation |
| TW200827336A (en) * | 2006-12-06 | 2008-07-01 | Astrazeneca Ab | New crystalline forms |
| US20090061000A1 (en) * | 2007-08-31 | 2009-03-05 | Astrazeneca Ab | Pharmaceutical formulation use 030 |
| HRP20120968T1 (hr) | 2008-02-06 | 2013-01-31 | Astrazeneca Ab | Spojevi |
| GB0913342D0 (en) | 2009-07-31 | 2009-09-16 | Astrazeneca Ab | Compounds - 801 |
| KR101181918B1 (ko) * | 2010-11-09 | 2012-09-11 | 주식회사 세라젬 | 온열치료기용 상하운동 조절장치 |
| WO2015044951A1 (en) | 2013-09-30 | 2015-04-02 | Council Of Scientific & Industrial Research | 3,7-diazabicyclo[3.3.1 ]nonane carboxamides as antithrombotic agents |
| RU2733405C2 (ru) * | 2014-02-07 | 2020-10-01 | Экзитера Фармасьютикалз Инк. | Терапевтические соединения и композиции |
| CN108530297B (zh) * | 2017-03-03 | 2021-09-24 | 联化科技股份有限公司 | 2-氯-3-甲基苯甲酸及其中间体的制备方法 |
Family Cites Families (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HU178398B (en) | 1979-06-12 | 1982-04-28 | Gyogyszerkutato Intezet | Process for producing new agmatine derivatives of activity against haemagglutination |
| HU192646B (en) | 1984-12-21 | 1987-06-29 | Gyogyszerkutato Intezet | Process for preparing new n-alkyl-peptide aldehydes |
| ZA86746B (en) | 1985-02-04 | 1986-09-24 | Merrell Dow Pharma | Novel peptidase inhibitors |
| US5187157A (en) | 1987-06-05 | 1993-02-16 | Du Pont Merck Pharmaceutical Company | Peptide boronic acid inhibitors of trypsin-like proteases |
| EP0362002B1 (en) | 1988-09-01 | 1995-07-26 | Merrell Dow Pharmaceuticals Inc. | HIV protease inhibitors |
| ZA897515B (en) | 1988-10-07 | 1990-06-27 | Merrell Dow Pharma | Novel peptidase inhibitors |
| TW201303B (2) | 1990-07-05 | 1993-03-01 | Hoffmann La Roche | |
| CA2075154A1 (en) | 1991-08-06 | 1993-02-07 | Neelakantan Balasubramanian | Peptide aldehydes as antithrombotic agents |
| SE9102462D0 (sv) | 1991-08-28 | 1991-08-28 | Astra Ab | New isosteric peptides |
| NZ245039A (en) | 1991-11-12 | 1994-12-22 | Lilly Co Eli | N-phenylalanyl and n-phenylglycyl derivatives of the dipeptide of l-azetidine-2-carboxylic acid and l-arginine aldehyde; anti-blood clotting compositions |
| SE9103612D0 (sv) | 1991-12-04 | 1991-12-04 | Astra Ab | New peptide derivatives |
| DE69314478T2 (de) | 1992-03-04 | 1999-02-11 | Gyogyszerkutato Intezet Kft., Budapest | Neuartige antikoagulierende peptidderivate und arzneimittel die solche enthalten so wie entsprechendes herstellungsverfahren |
| TW223629B (2) | 1992-03-06 | 1994-05-11 | Hoffmann La Roche | |
| US5583146A (en) | 1992-12-02 | 1996-12-10 | Bristol-Myers Squibb Company | Heterocyclic thrombin inhibitors |
| AU675981B2 (en) | 1992-12-02 | 1997-02-27 | Bristol-Myers Squibb Company | Guanidinyl-substituted heterocyclic thrombin inhibitors |
| JPH06340619A (ja) | 1993-05-03 | 1994-12-13 | Bristol Myers Squibb Co | グアニジニルまたはアミジニル置換メチルアミノ複素環トロンビン抑制剤 |
| US5783563A (en) | 1993-06-03 | 1998-07-21 | Astra Aktiebolag | Method for treatment or prophylaxis of venous thrombosis |
| SE9301916D0 (sv) | 1993-06-03 | 1993-06-03 | Ab Astra | New peptides derivatives |
| EP0648780A1 (en) | 1993-08-26 | 1995-04-19 | Bristol-Myers Squibb Company | Heterocyclic thrombin inhibitors |
| TW394760B (en) | 1993-09-07 | 2000-06-21 | Hoffmann La Roche | Novel Carboxamides, process for their preparation and pharmaceutical composition containing the same |
| AU1025795A (en) | 1994-01-27 | 1995-08-03 | Mitsubishi Chemical Corporation | Prolineamide derivatives |
| US5726159A (en) | 1994-03-04 | 1998-03-10 | Eli Lilly And Company | Antithrombotic agents |
| US5705487A (en) | 1994-03-04 | 1998-01-06 | Eli Lilly And Company | Antithrombotic agents |
| ZA951617B (en) * | 1994-03-04 | 1997-02-27 | Lilly Co Eli | Antithrombotic agents. |
| US5707966A (en) | 1994-03-04 | 1998-01-13 | Eli Lilly And Company | Antithrombotic agents |
| US5561146A (en) | 1994-06-10 | 1996-10-01 | Bristol-Myers Squibb Company | Modified guanidino and amidino thrombin inhibitors |
| DE4421052A1 (de) * | 1994-06-17 | 1995-12-21 | Basf Ag | Neue Thrombininhibitoren, ihre Herstellung und Verwendung |
| US5510369A (en) | 1994-07-22 | 1996-04-23 | Merck & Co., Inc. | Pyrrolidine thrombin inhibitors |
| DE4443390A1 (de) | 1994-12-06 | 1996-06-13 | Basf Ag | Neue dipeptidische p-Amidinobenzylamide mit N-terminalen Sulfonyl- bzw. Aminosulfonylresten |
| MX9705970A (es) | 1995-02-10 | 1997-11-29 | Basf Ag | Inhibidores de trombina. |
| CZ245797A3 (cs) | 1995-02-17 | 1998-06-17 | Basf Aktiengesellschaft | Derivát amidinu dipeptidu jako inhibitor thrombinu |
| US5914319A (en) | 1995-02-27 | 1999-06-22 | Eli Lilly And Company | Antithrombotic agents |
| US5710130A (en) | 1995-02-27 | 1998-01-20 | Eli Lilly And Company | Antithrombotic agents |
| AU698911B2 (en) | 1995-04-04 | 1998-11-12 | Merck & Co., Inc. | Thrombin inhibitors |
| US5629324A (en) | 1995-04-10 | 1997-05-13 | Merck & Co., Inc. | Thrombin inhibitors |
| SA96170106A (ar) | 1995-07-06 | 2005-12-03 | أسترا أكتيبولاج | مشتقات حامض أميني جديدة |
| TWI238827B (en) | 1995-12-21 | 2005-09-01 | Astrazeneca Ab | Prodrugs of thrombin inhibitors |
| JPH1095898A (ja) | 1996-09-25 | 1998-04-14 | Sumitomo Bakelite Co Ltd | 難燃性樹脂組成物およびこれを用いた積層板 |
| DE19632773A1 (de) | 1996-08-14 | 1998-02-19 | Basf Ag | Neue Thrombininhibitoren |
| DE19632772A1 (de) | 1996-08-14 | 1998-02-19 | Basf Ag | Neue Benzamidine |
| SE9704543D0 (sv) * | 1997-12-05 | 1997-12-05 | Astra Ab | New compounds |
-
1996
- 1996-06-07 SE SE9602263A patent/SE9602263D0/xx unknown
-
1997
- 1997-05-23 ZA ZA9704542A patent/ZA974542B/xx unknown
- 1997-06-03 ID IDP971884A patent/ID17016A/id unknown
- 1997-06-05 TR TR1998/02536T patent/TR199802536T2/xx unknown
- 1997-06-05 HU HU0002404A patent/HUP0002404A3/hu unknown
- 1997-06-05 CN CN97196864A patent/CN1129604C/zh not_active Expired - Fee Related
- 1997-06-05 JP JP50050298A patent/JP4237824B2/ja not_active Expired - Fee Related
- 1997-06-05 EE EE9800425A patent/EE9800425A/xx unknown
- 1997-06-05 WO PCT/SE1997/000989 patent/WO1997046577A1/en not_active Ceased
- 1997-06-05 DK DK97926356T patent/DK0910573T3/da active
- 1997-06-05 AT AT97926356T patent/ATE231883T1/de not_active IP Right Cessation
- 1997-06-05 SK SK1653-98A patent/SK165398A3/sk unknown
- 1997-06-05 CZ CZ983986A patent/CZ398698A3/cs unknown
- 1997-06-05 DE DE69718791T patent/DE69718791T2/de not_active Expired - Fee Related
- 1997-06-05 CA CA002255625A patent/CA2255625A1/en not_active Abandoned
- 1997-06-05 ES ES97926356T patent/ES2191840T3/es not_active Expired - Lifetime
- 1997-06-05 AU AU31140/97A patent/AU723420B2/en not_active Ceased
- 1997-06-05 NZ NZ332964A patent/NZ332964A/xx not_active IP Right Cessation
- 1997-06-05 EP EP97926356A patent/EP0910573B1/en not_active Expired - Lifetime
- 1997-06-05 IL IL12732597A patent/IL127325A0/xx active IP Right Grant
- 1997-06-05 BR BR9709560A patent/BR9709560A/pt active Search and Examination
- 1997-06-05 PL PL97330482A patent/PL330482A1/xx unknown
- 1997-06-05 US US08/860,871 patent/US6255301B1/en not_active Expired - Fee Related
- 1997-06-06 AR ARP970102484A patent/AR008046A1/es not_active Application Discontinuation
-
1998
- 1998-11-25 IS IS4906A patent/IS4906A/is unknown
- 1998-11-30 IL IL127325A patent/IL127325A/en not_active IP Right Cessation
- 1998-12-04 NO NO19985700A patent/NO317135B1/no not_active IP Right Cessation
-
2001
- 2001-04-30 US US09/844,427 patent/US6838478B2/en not_active Expired - Fee Related