JP2000513355A - 有機賦型剤を使用する、ポリマーの生体接着特性を増強するための方法および組成物 - Google Patents

有機賦型剤を使用する、ポリマーの生体接着特性を増強するための方法および組成物

Info

Publication number
JP2000513355A
JP2000513355A JP10503153A JP50315398A JP2000513355A JP 2000513355 A JP2000513355 A JP 2000513355A JP 10503153 A JP10503153 A JP 10503153A JP 50315398 A JP50315398 A JP 50315398A JP 2000513355 A JP2000513355 A JP 2000513355A
Authority
JP
Japan
Prior art keywords
polymer
microspheres
acid
anhydride
oligomer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
JP10503153A
Other languages
English (en)
Japanese (ja)
Inventor
エイ． サントス，カミーラ
エス． ジェイコブ，ジュリス
エイ． ハーツオグ，ベンジャミン
ピー． カリノ，ジェラルド
マシオウィッツ，エディス
Original Assignee
ブラウン ユニバーシティ リサーチ ファウンデーション
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ブラウン ユニバーシティ リサーチ ファウンデーション filed Critical ブラウン ユニバーシティ リサーチ ファウンデーション
Publication of JP2000513355A publication Critical patent/JP2000513355A/ja
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5138—Organic macromolecular compounds; Dendrimers obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5146—Organic macromolecular compounds; Dendrimers obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyamines, polyanhydrides
    • A61K9/5153—Polyesters, e.g. poly(lactide-co-glycolide)

Landscapes

  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Biomedical Technology (AREA)
  • Nanotechnology (AREA)
  • Medicinal Preparation (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
JP10503153A 1996-06-25 1997-06-12 有機賦型剤を使用する、ポリマーの生体接着特性を増強するための方法および組成物 Ceased JP2000513355A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/670,326 US5955096A (en) 1996-06-25 1996-06-25 Methods and compositions for enhancing the bioadhesive properties of polymers using organic excipients
US670,326 1996-06-25
PCT/US1997/010256 WO1997049385A1 (en) 1996-06-25 1997-06-12 Methods and compositions for enhancing the bioadhesive properties of polymers using organic excipients

Publications (1)

Publication Number Publication Date
JP2000513355A true JP2000513355A (ja) 2000-10-10

Family

ID=24689975

Family Applications (1)

Application Number Title Priority Date Filing Date
JP10503153A Ceased JP2000513355A (ja) 1996-06-25 1997-06-12 有機賦型剤を使用する、ポリマーの生体接着特性を増強するための方法および組成物

Country Status (6)

Country Link
US (3) US5955096A (de)
EP (1) EP0912166B1 (de)
JP (1) JP2000513355A (de)
AT (1) ATE230978T1 (de)
DE (1) DE69718470T2 (de)
WO (1) WO1997049385A1 (de)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005533022A (ja) * 2002-05-15 2005-11-04 ブラウン ユニバーシティ リサーチ ファウンデーション 粘膜に対するポリマーの生体接着性を増強するための短鎖ポリマー

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JP2005533022A (ja) * 2002-05-15 2005-11-04 ブラウン ユニバーシティ リサーチ ファウンデーション 粘膜に対するポリマーの生体接着性を増強するための短鎖ポリマー

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EP0912166A1 (de) 1999-05-06
US20010000142A1 (en) 2001-04-05
DE69718470T2 (de) 2003-11-06
EP0912166B1 (de) 2003-01-15
US5955096A (en) 1999-09-21
WO1997049385A1 (en) 1997-12-31
DE69718470D1 (de) 2003-02-20
US6156348A (en) 2000-12-05

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