JP2000515866A5 - - Google Patents

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Publication number: JP2000515866A5
Authority: JP; Japan
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Granted

Application number

JP1998508318A

Other languages

English (en)

Japanese (ja)

Other versions

JP2000515866A (ja

JP4033494B2 (ja

Filing date

1997-07-25

Publication date

2004-08-19

1997-07-25 Application filed filed Critical

1997-07-25 Priority claimed from PCT/US1997/013244 external-priority patent/WO1998004569A1/en

2000-11-28 Publication of JP2000515866A publication Critical patent/JP2000515866A/ja

2004-08-19 Publication of JP2000515866A5 publication Critical patent/JP2000515866A5/ja

2008-01-16 Application granted granted Critical

2008-01-16 Publication of JP4033494B2 publication Critical patent/JP4033494B2/ja

2017-07-25 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Links

JP50831898A 1996-07-26 1997-07-25 ヌクレオチドアナログ Expired - Lifetime JP4033494B2 (ja)

Applications Claiming Priority (5)

Application Number	Priority Date	Filing Date	Title
US2270896P	1996-07-26	1996-07-26
US68683896A	1996-07-26	1996-07-26
US08/686,838		1996-07-26
US60/022,708		1996-07-26
PCT/US1997/013244 WO1998004569A1 (en)	1996-07-26	1997-07-25	Nucleotide analogs

Related Child Applications (1)

Application Number	Title	Priority Date	Filing Date
JP2007180398A Division JP2007297406A (ja)	1996-07-26	2007-07-09	ヌクレオチドアナログ

Publications (3)

Publication Number	Publication Date
JP2000515866A JP2000515866A (ja)	2000-11-28
JP2000515866A5 true JP2000515866A5 (2)	2004-08-19
JP4033494B2 JP4033494B2 (ja)	2008-01-16

Family

ID=26696272

Family Applications (6)

Application Number	Title	Priority Date	Filing Date
JP50831898A Expired - Lifetime JP4033494B2 (ja)	1996-07-26	1997-07-25	ヌクレオチドアナログ
JP2007180398A Withdrawn JP2007297406A (ja)	1996-07-26	2007-07-09	ヌクレオチドアナログ
JP2010233086A Withdrawn JP2011016847A (ja)	1996-07-26	2010-10-15	ヌクレオチドアナログ
JP2014083387A Withdrawn JP2014159450A (ja)	1996-07-26	2014-04-15	ヌクレオチドアナログ
JP2015091141A Withdrawn JP2015164934A (ja)	1996-07-26	2015-04-28	ヌクレオチドアナログ
JP2016212748A Withdrawn JP2017031212A (ja)	1996-07-26	2016-10-31	ヌクレオチドアナログ

Family Applications After (5)

Application Number	Title	Priority Date	Filing Date
JP2007180398A Withdrawn JP2007297406A (ja)	1996-07-26	2007-07-09	ヌクレオチドアナログ
JP2010233086A Withdrawn JP2011016847A (ja)	1996-07-26	2010-10-15	ヌクレオチドアナログ
JP2014083387A Withdrawn JP2014159450A (ja)	1996-07-26	2014-04-15	ヌクレオチドアナログ
JP2015091141A Withdrawn JP2015164934A (ja)	1996-07-26	2015-04-28	ヌクレオチドアナログ
JP2016212748A Withdrawn JP2017031212A (ja)	1996-07-26	2016-10-31	ヌクレオチドアナログ

Country Status (4)

Country	Link
JP (6)	JP4033494B2 (2)
CA (1)	CA2261619C (2)
TW (2)	TW470748B (2)
WO (1)	WO1998004569A1 (2)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA2261619C (en) *	1996-07-26	2006-05-23	Gilead Sciences, Inc.	Nucleotide analogs
ES2249511T3 (es) *	1997-07-25	2006-04-01	Gilead Sciences, Inc.	Composiciones de analogos de nucleotido y procedimiento de sintesis.
EP1243590B1 (en) *	1997-07-25	2005-02-09	Gilead Sciences, Inc.	Nucleotide analog composition and synthesis method
PT1256584E (pt) *	1997-07-25	2004-12-31	Gilead Sciences Inc	Processo para a preparacao de adefovir-dipivoxil
MXPA00012842A (es) *	1998-06-24	2004-06-22	Univ Emory	Uso de 3'-azido-2',3'-didesoxiuridina en combinacion de drogas adicionales contra el vih para la manufactura de un medicamento para el tratamiento del vih.
CZ304734B6 (cs) *	2000-07-21	2014-09-10	Gilead Sciences, Inc.	Způsob přípravy 9-[2-(fosfonomethoxy)propyl]adeninu a 9-[2-(fosfonomethoxy)ethyl]adeninu
AU2003231765B9 (en)	2002-04-26	2010-01-28	Gilead Sciences, Inc.	Cellular accumulation of phosphonate analogs of HIV protease inhibitor compounds and the compounds as such
MXPA05007016A (es)	2003-01-14	2005-09-12	Gilead Sciences Inc	Composiciones y metodos para terapia antiviral de combinacion.
WO2005002626A2 (en)	2003-04-25	2005-01-13	Gilead Sciences, Inc.	Therapeutic phosphonate compounds
EP2359833A1 (en)	2003-04-25	2011-08-24	Gilead Sciences, Inc.	Antiviral phosphonate analogs
US7273716B2 (en)	2003-04-25	2007-09-25	Gilead Sciences, Inc.	Methods and compositions for identifying therapeutic compounds with GS-7340 ester hydrolase
US7407965B2 (en)	2003-04-25	2008-08-05	Gilead Sciences, Inc.	Phosphonate analogs for treating metabolic diseases
US7470724B2 (en)	2003-04-25	2008-12-30	Gilead Sciences, Inc.	Phosphonate compounds having immuno-modulatory activity
MXPA05011296A (es)	2003-04-25	2006-01-24	Gilead Sciences Inc	Conjugados de fosfonato inhibidores de la cinasa.
US7452901B2 (en)	2003-04-25	2008-11-18	Gilead Sciences, Inc.	Anti-cancer phosphonate analogs
US7432261B2 (en)	2003-04-25	2008-10-07	Gilead Sciences, Inc.	Anti-inflammatory phosphonate compounds
US7300924B2 (en)	2003-04-25	2007-11-27	Gilead Sciences, Inc.	Anti-infective phosphonate analogs
WO2004096287A2 (en)	2003-04-25	2004-11-11	Gilead Sciences, Inc.	Inosine monophosphate dehydrogenase inhibitory phosphonate compounds
CN101410120A (zh) *	2003-04-25	2009-04-15	吉里德科学公司	抗炎的膦酸酯化合物
DE602004031115D1 (de)	2003-06-16	2011-03-03	Acad Of Science Czech Republic	Pyrimidinverbindungen mit phosphonatgruppen als antivirale nucleotidanaloga
WO2005044308A1 (en)	2003-10-24	2005-05-19	Gilead Sciences, Inc.	Phosphonate analogs of antimetabolites
US7427624B2 (en)	2003-10-24	2008-09-23	Gilead Sciences, Inc.	Purine nucleoside phosphorylase inhibitory phosphonate compounds
WO2005063751A1 (en)	2003-12-22	2005-07-14	Gilead Sciences, Inc.	4’-substituted carbovir-and abacavir-derivatives as well as related compounds with hiv and hcv antiviral activity
CA2548951A1 (en) *	2003-12-22	2005-07-14	Gilead Sciences, Inc.	Kinase inhibitor phosphonate conjugates
ME03423B (me)	2004-07-27	2020-01-20	Gilead Sciences Inc	Fosfonatni analozi jedinjenja hiv inhibitora
TWI375560B (en)	2005-06-13	2012-11-01	Gilead Sciences Inc	Composition comprising dry granulated emtricitabine and tenofovir df and method for making the same
TWI471145B (zh)	2005-06-13	2015-02-01	Bristol Myers Squibb & Gilead Sciences Llc	單一式藥學劑量型
WO2006133632A1 (fr) *	2005-06-13	2006-12-21	Brightgene Bio-Medical Technology Co., Ltd.	Promedicament analogue nucleotidique et sa preparation
EP2420238A3 (en)	2007-04-13	2012-03-07	Southern Research Institute	Anti-angiogenic agents
JP2010527996A (ja) *	2007-05-22	2010-08-19	ウルティモルフィクス・テクノロジーズ・ベー・フェー	テノホビルジソプロキシル−ヘミフマル酸共結晶
WO2009064174A1 (en) *	2007-11-14	2009-05-22	Ultimorphix Technologies B.V.	Polymorphic form of tenofovir disoproxil fumarate, method for its preparation and use
NZ588796A (en) *	2008-04-25	2012-07-27	Cipla Ltd	Crystalline form of tenofovir disoproxil and a process for its preparation
UA103329C2 (ru)	2008-07-08	2013-10-10	Гилиад Сайенсиз, Инк.	Соли соединений-ингибиторов вич
CN102093422B (zh)	2009-12-10	2015-02-25	中国人民解放军军事医学科学院毒物药物研究所	无环核苷膦酸酯衍生物及其医药用途
US20140073607A1 (en) *	2011-05-10	2014-03-13	Okapi Sciences Nv	Compounds for use in the treatment of feline retroviral infections
HRP20161696T4 (hr)	2011-08-16	2023-10-13	Gilead Sciences, Inc.	Tenofovir alafenamid hemifumarat
CN103626802A (zh) *	2012-08-23	2014-03-12	重庆药友制药有限责任公司	一种制备替诺福韦的新方法
CN103665043B (zh)	2012-08-30	2017-11-10	江苏豪森药业集团有限公司	一种替诺福韦前药及其在医药上的应用
CA2889903C (en)	2012-10-29	2021-03-09	Manjinder Singh Phull	Antiviral phosphonate analogues and process for preparation thereof
PT2860184T (pt)	2013-10-09	2018-11-20	Zentiva Ks	Sal de di-hidrogenofosfato de tenofovir disoproxil
EP2860185A1 (en)	2013-10-09	2015-04-15	Zentiva, k.s.	An improved process for the preparation of Tenofovir disoproxil and pharmaceutically acceptable salts thereof
TWI660965B (zh) *	2014-01-15	2019-06-01	美商基利科學股份有限公司	泰諾福韋之固體形式
SI3661937T1 (sl)	2017-08-01	2021-11-30	Gilead Sciences, Inc.	Kristalinične oblike etil((S)-((((2R,5R)-5-(6-amino-9H-purin-9-IL)-4- fluoro-2,5-dihidrofuran-2-IL)oksi)metil)(fenoksi)fosforil)-L-alaninata (GS-9131) za zdravljenje virusnih okužb
CN107805202A (zh) *	2017-12-01	2018-03-16	内蒙古圣氏化学股份有限公司	一种氯甲基异丙基碳酸酯连续化反应装置及方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IL84477A (en) *	1986-11-18	1995-12-08	Bristol Myers Squibb Co	History of Phosphonomethoxyalkylene Purinopyrimidine and Pharmaceutical Preparations Containing Them
EP0481214B1 (en) *	1990-09-14	1998-06-24	Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic	Prodrugs of phosphonates
GB9026164D0 (en) *	1990-12-01	1991-01-16	Beecham Group Plc	Pharmaceuticals
AU691527B2 (en) *	1993-09-17	1998-05-21	Gilead Sciences, Inc.	Nucleotide analogs
CA2261619C (en) *	1996-07-26	2006-05-23	Gilead Sciences, Inc.	Nucleotide analogs

1997
- 1997-07-25 CA CA002261619A patent/CA2261619C/en not_active Expired - Lifetime
- 1997-07-25 WO PCT/US1997/013244 patent/WO1998004569A1/en not_active Ceased
- 1997-07-25 JP JP50831898A patent/JP4033494B2/ja not_active Expired - Lifetime
- 1997-08-21 TW TW089123708A patent/TW470748B/zh not_active IP Right Cessation
- 1997-08-21 TW TW086110757A patent/TW444020B/zh not_active IP Right Cessation
2007
- 2007-07-09 JP JP2007180398A patent/JP2007297406A/ja not_active Withdrawn
2010
- 2010-10-15 JP JP2010233086A patent/JP2011016847A/ja not_active Withdrawn
2014
- 2014-04-15 JP JP2014083387A patent/JP2014159450A/ja not_active Withdrawn
2015
- 2015-04-28 JP JP2015091141A patent/JP2015164934A/ja not_active Withdrawn
2016
- 2016-10-31 JP JP2016212748A patent/JP2017031212A/ja not_active Withdrawn

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