JP2004123760A5 - - Google Patents
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- Publication number
- JP2004123760A5 JP2004123760A5 JP2004005518A JP2004005518A JP2004123760A5 JP 2004123760 A5 JP2004123760 A5 JP 2004123760A5 JP 2004005518 A JP2004005518 A JP 2004005518A JP 2004005518 A JP2004005518 A JP 2004005518A JP 2004123760 A5 JP2004123760 A5 JP 2004123760A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- carbohydrate
- glutamine
- composition according
- amount
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 claims 21
- 150000001720 carbohydrates Chemical class 0.000 claims 7
- 235000014633 carbohydrates Nutrition 0.000 claims 7
- ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 claims 6
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims 2
- 230000003139 buffering effect Effects 0.000 claims 2
- 239000001913 cellulose Substances 0.000 claims 2
- 235000010980 cellulose Nutrition 0.000 claims 2
- 229920002678 cellulose Polymers 0.000 claims 2
- 150000001875 compounds Chemical class 0.000 claims 2
- 239000003995 emulsifying agent Substances 0.000 claims 2
- LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 claims 2
- 239000003755 preservative agent Substances 0.000 claims 2
- 230000002335 preservative effect Effects 0.000 claims 2
- 150000005846 sugar alcohols Chemical class 0.000 claims 2
- CHHHXKFHOYLYRE-UHFFFAOYSA-M 2,4-Hexadienoic acid, potassium salt (1:1), (2E,4E)- Chemical compound [K+].CC=CC=CC([O-])=O CHHHXKFHOYLYRE-UHFFFAOYSA-M 0.000 claims 1
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims 1
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims 1
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims 1
- 229930195725 Mannitol Natural products 0.000 claims 1
- 229920000168 Microcrystalline cellulose Polymers 0.000 claims 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims 1
- 229930006000 Sucrose Natural products 0.000 claims 1
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- 239000002518 antifoaming agent Substances 0.000 claims 1
- 239000007864 aqueous solution Substances 0.000 claims 1
- 239000000679 carrageenan Substances 0.000 claims 1
- 235000010418 carrageenan Nutrition 0.000 claims 1
- 229920001525 carrageenan Polymers 0.000 claims 1
- 229940113118 carrageenan Drugs 0.000 claims 1
- 230000004700 cellular uptake Effects 0.000 claims 1
- AMTWCFIAVKBGOD-UHFFFAOYSA-N dioxosilane;methoxy-dimethyl-trimethylsilyloxysilane Chemical compound O=[Si]=O.CO[Si](C)(C)O[Si](C)(C)C AMTWCFIAVKBGOD-UHFFFAOYSA-N 0.000 claims 1
- 150000002016 disaccharides Chemical class 0.000 claims 1
- 239000000796 flavoring agent Substances 0.000 claims 1
- 235000013355 food flavoring agent Nutrition 0.000 claims 1
- 235000011187 glycerol Nutrition 0.000 claims 1
- 239000000594 mannitol Substances 0.000 claims 1
- 235000010355 mannitol Nutrition 0.000 claims 1
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 claims 1
- 235000010270 methyl p-hydroxybenzoate Nutrition 0.000 claims 1
- 239000004292 methyl p-hydroxybenzoate Substances 0.000 claims 1
- 229960002216 methylparaben Drugs 0.000 claims 1
- 235000019813 microcrystalline cellulose Nutrition 0.000 claims 1
- 239000008108 microcrystalline cellulose Substances 0.000 claims 1
- 229940016286 microcrystalline cellulose Drugs 0.000 claims 1
- 150000002772 monosaccharides Chemical class 0.000 claims 1
- 229910000403 monosodium phosphate Inorganic materials 0.000 claims 1
- 235000019799 monosodium phosphate Nutrition 0.000 claims 1
- 229920005862 polyol Polymers 0.000 claims 1
- 150000003077 polyols Chemical class 0.000 claims 1
- 239000004302 potassium sorbate Substances 0.000 claims 1
- 235000010241 potassium sorbate Nutrition 0.000 claims 1
- 229940069338 potassium sorbate Drugs 0.000 claims 1
- 229940083037 simethicone Drugs 0.000 claims 1
- AJPJDKMHJJGVTQ-UHFFFAOYSA-M sodium dihydrogen phosphate Chemical compound [Na+].OP(O)([O-])=O AJPJDKMHJJGVTQ-UHFFFAOYSA-M 0.000 claims 1
- 239000001488 sodium phosphate Substances 0.000 claims 1
- 239000008247 solid mixture Substances 0.000 claims 1
- 239000000600 sorbitol Substances 0.000 claims 1
- 235000010356 sorbitol Nutrition 0.000 claims 1
- 239000003381 stabilizer Substances 0.000 claims 1
- 239000005720 sucrose Substances 0.000 claims 1
- 239000000230 xanthan gum Substances 0.000 claims 1
- 229920001285 xanthan gum Polymers 0.000 claims 1
- 235000010493 xanthan gum Nutrition 0.000 claims 1
- 229940082509 xanthan gum Drugs 0.000 claims 1
- 239000000811 xylitol Substances 0.000 claims 1
- 235000010447 xylitol Nutrition 0.000 claims 1
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 claims 1
- 229960002675 xylitol Drugs 0.000 claims 1
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 claims 1
Claims (19)
- 炭水化物が、水溶液からのグルタミンの細胞取り込みを増加するのに有効な量で存在する、本質的に、グルタミンと約１５〜５０ｗ／ｗ％の少なくとも１種の炭水化物との乾燥混合物からなる固体組成物。
- グルタミンの量が、約５〜５８ｗ／ｗ％である請求項１に記載の組成物。
- グルタミンの量が、約５０〜５８ｗ／ｗ％である請求項１または２に記載の組成物。
- 少なくとも１種の炭水化物の量が、約３０〜５０ｗ／ｗ％である請求項１に記載の組成物。
- 少なくとも１種の炭水化物が、単糖類、二糖類またはその組み合せである請求項１に記載の組成物。
- 少なくとも１種の炭水化物が、スクロースを含む請求項５に記載の組成物。
- 少なくとも１種の炭水化物が、糖アルコールまたはポリオールを含む請求項５に記載の組成物。
- 糖アルコールが、ソルビトール、マンニトールまたはキシリトールである請求項７に記載の組成物。
- 炭水化物が、グリセリンを含む請求項５または７に記載の組成物。
- さらに、有効量の緩衝液または緩衝性化合物を含む請求項１に記載の組成物。
- 緩衝性化合物が、無水リン酸モノナトリウムである請求項１０に記載の組成物。
- さらに、有効量の修飾セルロースを含む請求項５または７に記載の組成物。
- 修飾セルロースが、微結晶セルロースである請求項１２に記載の組成物。
- さらに、安定剤、乳化剤、保存剤、消泡剤、香味剤またはその組み合わせを含む請求項１に記載の組成物。
- 乳化剤が、キサンタンガム、カラギーナンまたはその組み合わせを含む請求項１４に記載の組成物。
- 保存剤が、メチルパラベン、ソルビン酸カリウムまたはその組み合わせを含む請求項１４に記載の組成物。
- 消泡剤が、シメチコンを含む請求項１４に記載の組成物。
- グルタミンが、組成物中の唯一のアミノ酸である請求項１、４または５に記載の組成物。
- グルタミンが、組成物の約５８ｗ／ｗ％である請求項１、４または５に記載の組成物。
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13444299P | 1999-05-17 | 1999-05-17 | |
| US60/134,442 | 1999-05-17 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000617930A Division JP4698843B2 (ja) | 1999-05-17 | 2000-05-15 | 生体活性剤の改良された細胞取り込み |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2004123760A JP2004123760A (ja) | 2004-04-22 |
| JP2004123760A5 true JP2004123760A5 (ja) | 2007-06-28 |
| JP5015411B2 JP5015411B2 (ja) | 2012-08-29 |
Family
ID=22463417
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000617930A Expired - Fee Related JP4698843B2 (ja) | 1999-05-17 | 2000-05-15 | 生体活性剤の改良された細胞取り込み |
| JP2004005518A Expired - Fee Related JP5015411B2 (ja) | 1999-05-17 | 2004-01-13 | 生体活性剤の改良された細胞取り込み |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000617930A Expired - Fee Related JP4698843B2 (ja) | 1999-05-17 | 2000-05-15 | 生体活性剤の改良された細胞取り込み |
Country Status (6)
| Country | Link |
|---|---|
| US (4) | US6734170B2 (ja) |
| EP (1) | EP1206283A2 (ja) |
| JP (2) | JP4698843B2 (ja) |
| AU (1) | AU779783B2 (ja) |
| CA (1) | CA2374003C (ja) |
| WO (1) | WO2000069470A2 (ja) |
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| EP1206283A2 (en) * | 1999-05-17 | 2002-05-22 | Aesgen, Inc. | Improved cellular uptake of bioactive agents |
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| AU2003257963B2 (en) | 2002-08-01 | 2009-08-13 | Board Of Trustees Of The University Of Arkansas | Improved treatment of cancer with glutamine |
| AU2003282619A1 (en) * | 2002-10-11 | 2004-05-04 | University Of Virginia Patent Foundation | Use of stable glutamine derivatives to improve drug absorption |
| US20040265359A1 (en) * | 2003-04-17 | 2004-12-30 | Sacks Gordon S. | Oral delivery formulations of L-glutamine |
| US7186517B2 (en) * | 2003-08-01 | 2007-03-06 | Aesgen, Inc. | Compositions and methods for monitoring breast cancer treatment |
| KR20050104152A (ko) | 2004-04-28 | 2005-11-02 | 최승호 | 경구용 약물의 흡수를 증진하는 약제학적 조성물 |
| WO2005110046A2 (en) * | 2004-05-10 | 2005-11-24 | Aesgen, Inc. | Method of enhancing uptake of keratinocyte growth factor |
| JP4804728B2 (ja) * | 2004-07-23 | 2011-11-02 | 株式会社ファンケル | Ｄｆａ含有経皮吸収促進剤 |
| KR100699279B1 (ko) | 2005-04-28 | 2007-03-23 | 학교법인 포항공과대학교 | 당 또는 당 유사체를 골격으로 하는 분자 수송체 및 그의제조방법 |
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| WO2012031123A2 (en) | 2010-09-01 | 2012-03-08 | Trythisfirst, Inc. | Method of treating ear infections |
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| CN118453493A (zh) | 2015-05-29 | 2024-08-09 | 西德奈克西斯公司 | D2o稳定化的药物制剂 |
| US11154619B2 (en) | 2017-02-17 | 2021-10-26 | Creighton University | Liposomal compositions with light illumination-induced drug release |
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| US11865139B2 (en) | 2020-11-12 | 2024-01-09 | Thermolife International, Llc | Method of treating migraines and headaches |
| WO2022104157A1 (en) | 2020-11-12 | 2022-05-19 | Thermolife International, Llc | Methods of increasing blood oxygen saturation |
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| TWI810852B (zh) | 2022-03-18 | 2023-08-01 | 生展生物科技股份有限公司 | 凝結芽孢桿菌bc198或其代謝產物用於預防或輔助治療化療導致腸道受損相關病變或菌叢失衡之用途 |
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-
2000
- 2000-05-15 EP EP00930732A patent/EP1206283A2/en not_active Withdrawn
- 2000-05-15 WO PCT/US2000/013260 patent/WO2000069470A2/en not_active Ceased
- 2000-05-15 JP JP2000617930A patent/JP4698843B2/ja not_active Expired - Fee Related
- 2000-05-15 CA CA002374003A patent/CA2374003C/en not_active Expired - Fee Related
- 2000-05-15 AU AU48501/00A patent/AU779783B2/en not_active Ceased
-
2001
- 2001-11-14 US US09/993,465 patent/US6734170B2/en not_active Expired - Lifetime
-
2004
- 2004-01-13 JP JP2004005518A patent/JP5015411B2/ja not_active Expired - Fee Related
- 2004-03-09 US US10/796,261 patent/US7041651B2/en not_active Expired - Lifetime
-
2005
- 2005-10-21 US US11/255,771 patent/US20060121091A1/en not_active Abandoned
-
2007
- 2007-02-27 US US11/679,517 patent/US20080021106A1/en not_active Abandoned
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