JP2004159661A5 - - Google Patents
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- Publication number
- JP2004159661A5 JP2004159661A5 JP2004000679A JP2004000679A JP2004159661A5 JP 2004159661 A5 JP2004159661 A5 JP 2004159661A5 JP 2004000679 A JP2004000679 A JP 2004000679A JP 2004000679 A JP2004000679 A JP 2004000679A JP 2004159661 A5 JP2004159661 A5 JP 2004159661A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- nucleic acid
- kit
- target
- neoplasm
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000000034 method Methods 0.000 claims 15
- 108020004707 nucleic acids Proteins 0.000 claims 12
- 150000007523 nucleic acids Chemical class 0.000 claims 12
- 102000039446 nucleic acids Human genes 0.000 claims 12
- 206010028980 Neoplasm Diseases 0.000 claims 8
- 108091034117 Oligonucleotide Proteins 0.000 claims 8
- 239000013615 primer Substances 0.000 claims 7
- 108091092878 Microsatellite Proteins 0.000 claims 6
- 230000035772 mutation Effects 0.000 claims 6
- 239000000523 sample Substances 0.000 claims 6
- 230000003321 amplification Effects 0.000 claims 5
- 208000035269 cancer or benign tumor Diseases 0.000 claims 5
- 238000003199 nucleic acid amplification method Methods 0.000 claims 5
- 210000003296 saliva Anatomy 0.000 claims 4
- 201000011510 cancer Diseases 0.000 claims 3
- 230000037430 deletion Effects 0.000 claims 2
- 238000012217 deletion Methods 0.000 claims 2
- 238000001514 detection method Methods 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 239000012634 fragment Substances 0.000 claims 2
- 230000003211 malignant effect Effects 0.000 claims 2
- 230000001613 neoplastic effect Effects 0.000 claims 2
- 238000007899 nucleic acid hybridization Methods 0.000 claims 2
- 238000006467 substitution reaction Methods 0.000 claims 2
- 239000003155 DNA primer Substances 0.000 claims 1
- JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 claims 1
- 239000005547 deoxyribonucleotide Substances 0.000 claims 1
- 125000002637 deoxyribonucleotide group Chemical group 0.000 claims 1
- 238000009396 hybridization Methods 0.000 claims 1
- 210000004072 lung Anatomy 0.000 claims 1
- 239000002773 nucleotide Substances 0.000 claims 1
- 125000003729 nucleotide group Chemical group 0.000 claims 1
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/038,637 US6235470B1 (en) | 1993-11-12 | 1998-03-10 | Detection of neoplasia by analysis of saliva |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000535774A Division JP2002505888A (ja) | 1998-03-10 | 1999-03-10 | 唾液分析による新生物の検出 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2004159661A JP2004159661A (ja) | 2004-06-10 |
| JP2004159661A5 true JP2004159661A5 (2) | 2006-06-15 |
Family
ID=21901047
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000535774A Pending JP2002505888A (ja) | 1998-03-10 | 1999-03-10 | 唾液分析による新生物の検出 |
| JP2004000679A Pending JP2004159661A (ja) | 1998-03-10 | 2004-01-05 | 唾液分析による新生物の検出 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000535774A Pending JP2002505888A (ja) | 1998-03-10 | 1999-03-10 | 唾液分析による新生物の検出 |
Country Status (9)
| Country | Link |
|---|---|
| US (4) | US6235470B1 (2) |
| EP (1) | EP1062366B1 (2) |
| JP (2) | JP2002505888A (2) |
| AT (1) | ATE433498T1 (2) |
| AU (1) | AU769035B2 (2) |
| CA (1) | CA2323060A1 (2) |
| DE (1) | DE69940969D1 (2) |
| NO (1) | NO20004504L (2) |
| WO (1) | WO1999046408A1 (2) |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6235470B1 (en) * | 1993-11-12 | 2001-05-22 | The Johns Hopkins University School Of Medicine | Detection of neoplasia by analysis of saliva |
| AU726045B2 (en) * | 1996-08-28 | 2000-10-26 | Johns Hopkins University School Of Medicine, The | Method for detecting cell proliferative disorders |
| US7888324B2 (en) * | 2001-08-01 | 2011-02-15 | Genzyme Corporation | Antisense modulation of apolipoprotein B expression |
| US7407943B2 (en) * | 2001-08-01 | 2008-08-05 | Isis Pharmaceuticals, Inc. | Antisense modulation of apolipoprotein B expression |
| MXPA04002659A (es) * | 2001-12-14 | 2004-06-18 | Zila Inc | Analisis molecular dirigido por tincion para pronostico y diagnostico de cancer. |
| US7511131B2 (en) * | 2002-11-13 | 2009-03-31 | Genzyme Corporation | Antisense modulation of apolipoprotein B expression |
| US20060009410A1 (en) * | 2002-11-13 | 2006-01-12 | Crooke Rosanne M | Effects of apolipoprotein B inhibition on gene expression profiles in animals |
| EP3351919A1 (en) | 2003-01-24 | 2018-07-25 | University of Utah | Methods of predicting mortality risk by determining telomere length |
| EP1730160A4 (en) * | 2004-03-17 | 2008-04-09 | Univ Johns Hopkins | Neoplasia diagnostic compositions and methods of use |
| US20050287558A1 (en) * | 2004-05-05 | 2005-12-29 | Crooke Rosanne M | SNPs of apolipoprotein B and modulation of their expression |
| ES2401114T3 (es) * | 2004-08-10 | 2013-04-17 | Genzyme Corporation | Modulación antisentido de la expresión de apolipoproteína B |
| JP2009536222A (ja) | 2006-05-05 | 2009-10-08 | アイシス ファーマシューティカルズ， インコーポレーテッド | Ｐｃｓｋ９の発現を調節するための化合物および方法 |
| WO2007133725A1 (en) * | 2006-05-12 | 2007-11-22 | University Of Miami | Biomarkers for detection and diagnosis of head and neck squamous cell carcinoma |
| CA2682082A1 (en) * | 2007-03-24 | 2008-10-02 | Genzyme Corporation | Administering antisense oligonucleotides complementary to human apolipoprotein b |
| US20090023138A1 (en) * | 2007-07-17 | 2009-01-22 | Zila Biotechnology, Inc. | Oral cancer markers and their detection |
| WO2009015294A1 (en) | 2007-07-24 | 2009-01-29 | Wisconsin Alumni Research Foundation | Biomarkers for human papillomavirus-associated cancers |
| CN102439171B (zh) | 2008-12-22 | 2017-07-14 | 犹他大学研究基金会 | 单色多重定量pcr |
| EP2408796B1 (en) | 2009-03-16 | 2020-04-22 | Ionis Pharmaceuticals, Inc. | Targeting Apolipoprotein B for the reduction of Apolipoprotein C-III |
| ITBO20090554A1 (it) * | 2009-08-27 | 2011-02-28 | Maria Gabriella Fornaro | Metodo per individuare la predisposizione al carcinoma della prostata. |
| EP2553463B1 (en) * | 2010-03-26 | 2017-05-03 | Hongzhi Zou | Methods and materials for detecting colorectal neoplasm |
| AU2012340441A1 (en) | 2011-11-15 | 2014-05-29 | University Of Miami | Methods for detecting human papillomavirus and providing prognosis for head and neck squamous cell carcinoma |
| EP2798091A4 (en) * | 2011-12-31 | 2015-08-12 | Telome Health Inc | MEASUREMENTS OF LARGE TELOMERS FROM STORAGE AND SAMPLE DETECTION DEVICE |
| CA2902916C (en) | 2013-03-14 | 2018-08-28 | Mayo Foundation For Medical Education And Research | Detecting neoplasm |
| CA2912216A1 (en) | 2013-05-22 | 2014-11-27 | Telomere Diagnostics, Inc. | Measures of short telomere abundance |
| CN120700143A (zh) | 2014-03-31 | 2025-09-26 | 梅奥医学教育和研究基金会 | 检测结直肠赘生物 |
| US10184154B2 (en) | 2014-09-26 | 2019-01-22 | Mayo Foundation For Medical Education And Research | Detecting cholangiocarcinoma |
| WO2016108954A1 (en) | 2014-12-30 | 2016-07-07 | Telomere Diagnostics, Inc. | Multiplex quantitative pcr |
| US10030272B2 (en) | 2015-02-27 | 2018-07-24 | Mayo Foundation For Medical Education And Research | Detecting gastrointestinal neoplasms |
| US10435755B2 (en) | 2015-03-27 | 2019-10-08 | Exact Sciences Development Company, Llc | Detecting esophageal disorders |
| CN114574585A (zh) | 2015-08-31 | 2022-06-03 | 梅约医药教育及研究基金会 | 检测胃肿瘤 |
| US10370726B2 (en) | 2016-04-14 | 2019-08-06 | Mayo Foundation For Medical Education And Research | Detecting colorectal neoplasia |
| JP7481804B2 (ja) | 2016-04-14 | 2024-05-13 | マヨ ファウンデーション フォア メディカル エデュケーション アンド リサーチ | 高度膵異形成の検出 |
| JP7356349B2 (ja) | 2017-02-28 | 2023-10-04 | マヨ ファウンデーション フォア メディカル エデュケーション アンド リサーチ | 前立腺癌検出 |
| JP7277460B2 (ja) | 2017-11-30 | 2023-05-19 | マヨ ファウンデーション フォア メディカル エデュケーション アンド リサーチ | 乳癌の検出 |
| MX2020014243A (es) | 2018-06-19 | 2021-05-12 | Biontech Us Inc | Neoantigenos y usos de los mismos. |
| CN114885938A (zh) * | 2022-02-25 | 2022-08-12 | 厦门迈威生物科技有限公司 | 一种浆膜腔积液脱落细胞保存液及其生产方法 |
| USD1034632S1 (en) * | 2022-05-03 | 2024-07-09 | SimpliSafe, Inc. | Display screen with graphical user interface |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4683195A (en) | 1986-01-30 | 1987-07-28 | Cetus Corporation | Process for amplifying, detecting, and/or-cloning nucleic acid sequences |
| US4683202A (en) | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
| EP0390323B2 (en) | 1989-03-29 | 2012-08-08 | Johns Hopkins University | Detection of loss of the wild-type p53 gene |
| US5527676A (en) | 1989-03-29 | 1996-06-18 | The Johns Hopkins University | Detection of loss of the wild-type P53 gene and kits therefor |
| DK0489149T3 (da) | 1990-06-27 | 2001-12-27 | Univ Princeton | Prober til påvisning af mutant P53 |
| AU662906B2 (en) | 1991-06-26 | 1995-09-21 | F. Hoffmann-La Roche Ag | Methods for detection of carcinoma metastases by nucleic acid amplification |
| JP3633932B2 (ja) | 1992-04-01 | 2005-03-30 | ザ ジョーンズ ホプキンズ ユニバーシティー スクール オブ メディシン | 糞便試料から単離した哺乳類の核酸を検出する方法、およびその検出用試薬 |
| ATE198358T1 (de) | 1992-04-27 | 2001-01-15 | Dartmouth College | Detektion von gensequenzen in biologischen flüssigkeiten |
| US5561041A (en) | 1993-11-12 | 1996-10-01 | The Johns Hopkins University School Of Medicine | Nucleic acid mutation detection by analysis of sputum |
| US6235470B1 (en) * | 1993-11-12 | 2001-05-22 | The Johns Hopkins University School Of Medicine | Detection of neoplasia by analysis of saliva |
| CH686982A5 (fr) * | 1993-12-16 | 1996-08-15 | Maurice Stroun | Méthode pour le diagnostic de cancers. |
| US5589579A (en) | 1994-07-19 | 1996-12-31 | Cytoclonal Pharmaceutics, Inc. | Gene sequence and probe for a marker of non-small cell lung carinoma |
| MXPA00009654A (es) * | 1994-08-31 | 2005-09-08 | Univ Johns Hopkins Med | Deteccion de secuencias de acidos nucleicos hipermutables en tejidos. |
| AU726045B2 (en) * | 1996-08-28 | 2000-10-26 | Johns Hopkins University School Of Medicine, The | Method for detecting cell proliferative disorders |
| DE19712332A1 (de) * | 1997-03-25 | 1998-10-01 | Boehringer Mannheim Gmbh | Verfahren zum Nachweis von Mikrosatelliten-Instabilität zur Tumordiagnostik |
| CA2285384C (en) * | 1997-03-28 | 2012-10-16 | Epitope, Inc. | Simultaneous collection of dna and non-nucleic analytes from oral fluids |
-
1998
- 1998-03-10 US US09/038,637 patent/US6235470B1/en not_active Expired - Lifetime
-
1999
- 1999-03-10 EP EP99911289A patent/EP1062366B1/en not_active Expired - Lifetime
- 1999-03-10 CA CA002323060A patent/CA2323060A1/en not_active Abandoned
- 1999-03-10 AT AT99911289T patent/ATE433498T1/de not_active IP Right Cessation
- 1999-03-10 DE DE69940969T patent/DE69940969D1/de not_active Expired - Lifetime
- 1999-03-10 AU AU29969/99A patent/AU769035B2/en not_active Expired
- 1999-03-10 JP JP2000535774A patent/JP2002505888A/ja active Pending
- 1999-03-10 WO PCT/US1999/005220 patent/WO1999046408A1/en not_active Ceased
-
2000
- 2000-09-08 NO NO20004504A patent/NO20004504L/no unknown
-
2001
- 2001-05-22 US US09/863,806 patent/US20020197608A1/en not_active Abandoned
-
2004
- 2004-01-05 JP JP2004000679A patent/JP2004159661A/ja active Pending
- 2004-01-09 US US10/754,478 patent/US7279312B2/en not_active Expired - Fee Related
-
2007
- 2007-10-08 US US11/868,683 patent/US7601521B2/en not_active Expired - Fee Related
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