ATE198358T1 - Detektion von gensequenzen in biologischen flüssigkeiten - Google Patents

Detektion von gensequenzen in biologischen flüssigkeiten

Info

Publication number
ATE198358T1
ATE198358T1 AT93909581T AT93909581T ATE198358T1 AT E198358 T1 ATE198358 T1 AT E198358T1 AT 93909581 T AT93909581 T AT 93909581T AT 93909581 T AT93909581 T AT 93909581T AT E198358 T1 ATE198358 T1 AT E198358T1
Authority
AT
Austria
Prior art keywords
gene sequences
detection
biological liquids
dna
sample
Prior art date
Application number
AT93909581T
Other languages
English (en)
Inventor
George D Sorenson
Original Assignee
Dartmouth College
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dartmouth College filed Critical Dartmouth College
Application granted granted Critical
Publication of ATE198358T1 publication Critical patent/ATE198358T1/de

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Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6806Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/156Polymorphic or mutational markers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pathology (AREA)
  • Hospice & Palliative Care (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
AT93909581T 1992-04-27 1993-04-14 Detektion von gensequenzen in biologischen flüssigkeiten ATE198358T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US87484592A 1992-04-27 1992-04-27
PCT/US1993/003561 WO1993022456A1 (en) 1992-04-27 1993-04-14 Detection of gene sequences in biological fluids

Publications (1)

Publication Number Publication Date
ATE198358T1 true ATE198358T1 (de) 2001-01-15

Family

ID=25364694

Family Applications (1)

Application Number Title Priority Date Filing Date
AT93909581T ATE198358T1 (de) 1992-04-27 1993-04-14 Detektion von gensequenzen in biologischen flüssigkeiten

Country Status (7)

Country Link
US (1) US5496699A (de)
EP (1) EP0655090B1 (de)
JP (1) JP2001507921A (de)
AT (1) ATE198358T1 (de)
CA (1) CA2134552A1 (de)
DE (1) DE69329800D1 (de)
WO (1) WO1993022456A1 (de)

Families Citing this family (160)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5744101A (en) 1989-06-07 1998-04-28 Affymax Technologies N.V. Photolabile nucleoside protecting groups
US6955915B2 (en) 1989-06-07 2005-10-18 Affymetrix, Inc. Apparatus comprising polymers
US6919211B1 (en) 1989-06-07 2005-07-19 Affymetrix, Inc. Polypeptide arrays
US6020124A (en) * 1992-04-27 2000-02-01 Trustees Of Dartmouth College Detection of soluble gene sequences in biological fluids
EP0672187A4 (de) * 1992-10-08 1999-11-17 Univ California Pcr-testverfahren zur bestimmung der anwesenheit und konzentration einer zielsubstanz.
WO1995006137A1 (en) * 1993-08-27 1995-03-02 Australian Red Cross Society Detection of genes
US5561041A (en) * 1993-11-12 1996-10-01 The Johns Hopkins University School Of Medicine Nucleic acid mutation detection by analysis of sputum
US6235470B1 (en) 1993-11-12 2001-05-22 The Johns Hopkins University School Of Medicine Detection of neoplasia by analysis of saliva
CH686982A5 (fr) * 1993-12-16 1996-08-15 Maurice Stroun Méthode pour le diagnostic de cancers.
US5643723A (en) * 1994-05-26 1997-07-01 Roche Molecular Systems, Inc. Detection of a genetic locus encoding resistance to rifampin in mycobacterial cultures and in clinical specimens
DE4421901A1 (de) * 1994-06-23 1996-01-04 Bayer Ag Ein DNA-Schnelltest zum Nachweis von chinolonresistenten Staphylococcus aureus Erregern in klinischem Probenmaterial
US5763175A (en) * 1995-11-17 1998-06-09 Lynx Therapeutics, Inc. Simultaneous sequencing of tagged polynucleotides
US5962228A (en) * 1995-11-17 1999-10-05 Lynx Therapeutics, Inc. DNA extension and analysis with rolling primers
NO954667D0 (no) * 1995-11-17 1995-11-17 Dagfinn Oegreid Fremgangsmåte til deteksjon av Ki-ras mutasjoner
US5780231A (en) * 1995-11-17 1998-07-14 Lynx Therapeutics, Inc. DNA extension and analysis with rolling primers
US7070962B1 (en) * 1996-02-01 2006-07-04 Aventis Pharmaceuticals Inc. Positive controls in polynucleotide amplification
US6630301B1 (en) 1997-03-14 2003-10-07 The Penn State Research Foundation Detection of extracellular tumor-associated nucleic acid in blood plasma or serum
US6511805B1 (en) 1996-03-15 2003-01-28 The Penn State Research Foundation Methods for detecting papillomavirus DNA in blood plasma and serum
EP0929694A4 (de) * 1996-03-15 2002-05-02 Penn State Res Found Nachweis von extrazellulärer tumor-assoziierter nukleinsäuren im blutplasma oder -serum mittels eines nukleinsäure-amplifizierungsverfahren
US8048629B2 (en) 1996-03-15 2011-11-01 The Penn State Research Foundation Detection of extracellular tumor-associated nucleic acid in blood plasma or serum
US5948615A (en) * 1996-04-16 1999-09-07 Hitachi, Ltd. Method for analysis of nucleic acid and DNA primer sets for use therein
US6312892B1 (en) 1996-07-19 2001-11-06 Cornell Research Foundation, Inc. High fidelity detection of nucleic acid differences by ligase detection reaction
CA2268069A1 (en) * 1996-10-04 1998-04-09 Chronix Biomedical Diagnostic detection of nucleic acids
AU746892B2 (en) * 1997-04-04 2002-05-02 Caliper Life Sciences, Inc. Closed-loop biochemical analyzers
US6235471B1 (en) 1997-04-04 2001-05-22 Caliper Technologies Corp. Closed-loop biochemical analyzers
US6391622B1 (en) 1997-04-04 2002-05-21 Caliper Technologies Corp. Closed-loop biochemical analyzers
WO1998054364A1 (en) 1997-05-30 1998-12-03 Lxr Biotechnology Inc. Methods for detection of nucleic acid sequences in urine
GB9715034D0 (en) * 1997-07-18 1997-09-24 Zeneca Ltd Assay
US6826296B2 (en) 1997-07-25 2004-11-30 Affymetrix, Inc. Method and system for providing a probe array chip design database
WO1999005591A2 (en) 1997-07-25 1999-02-04 Affymetrix, Inc. Method and apparatus for providing a bioinformatics database
US7068830B2 (en) 1997-07-25 2006-06-27 Affymetrix, Inc. Method and system for providing a probe array chip design database
US6420108B2 (en) 1998-02-09 2002-07-16 Affymetrix, Inc. Computer-aided display for comparative gene expression
US6376329B1 (en) * 1997-08-04 2002-04-23 Nikon Corporation Semiconductor wafer alignment using backside illumination
DE19736691A1 (de) * 1997-08-22 1999-02-25 Michael Prof Dr Med Giesing Verfahren zur Charakterisierung und Identifizierung disseminierter und metastasierter Krebszellen
US5888740A (en) * 1997-09-19 1999-03-30 Genaco Biomedical Products, Inc. Detection of aneuploidy and gene deletion by PCR-based gene- dose co-amplification of chromosome specific sequences with synthetic sequences with synthetic internal controls
WO1999029901A1 (en) * 1997-12-11 1999-06-17 The General Hospital Corporation Broad range pcr amplification techniques
US6794133B1 (en) 1997-12-11 2004-09-21 The General Hospital Corporation Broad range PCR amplification techniques
US6185561B1 (en) 1998-09-17 2001-02-06 Affymetrix, Inc. Method and apparatus for providing and expression data mining database
US6489096B1 (en) 1998-10-15 2002-12-03 Princeton University Quantitative analysis of hybridization patterns and intensities in oligonucleotide arrays
US6949370B1 (en) 1998-10-30 2005-09-27 Cornell Research Foundation, Inc. High fidelity thermostable ligase and uses thereof
US6670464B1 (en) 1998-11-17 2003-12-30 Curagen Corporation Nucleic acids containing single nucleotide polymorphisms and methods of use thereof
US7014994B1 (en) 1999-03-19 2006-03-21 Cornell Research Foundation,Inc. Coupled polymerase chain reaction-restriction-endonuclease digestion-ligase detection reaction process
ES2170620B1 (es) * 1999-11-25 2003-12-16 Univ Alcala Henares Procedimiento de cuantificacion de acidos nucleicos mediante amplificacion por reaccion en cadena de polimerasa hemi-competitiva.
US6833240B2 (en) 2000-03-08 2004-12-21 Mcgill University Very low density lipoprotein receptor polymorphisms and uses therefor
CA2405412A1 (en) 2000-04-14 2001-10-25 Cornell Research Foundation, Inc. Method of designing addressable array for detection of nucleic acid sequence differences using ligase detection reaction
EP1307590A4 (de) * 2000-07-25 2005-01-12 Dz Genes Llc POLYMORPHISMEN FüR DIE DIAGNOSTIK DES TGF-BETA1 PROMOTERS
JP2002372533A (ja) * 2001-06-13 2002-12-26 Kiwamu Akagi 血液の検査方法、検査用チップ、並びに検査装置
US20070264641A1 (en) * 2001-10-15 2007-11-15 Li Alice X Multiplexed analysis of polymorphic loci by concurrent interrogation and enzyme-mediated detection
KR20040068122A (ko) 2001-10-15 2004-07-30 바이오어레이 솔루션스 리미티드 공동 검색과 효소-매개된 탐지에 의한 다형성 좌위의 다중분석
PT1458888E (pt) 2001-12-10 2011-06-01 Novartis Ag Métodos para tratar a psicose e a esquizofrenia baseados em polimorfismos no gene do cntf
FR2835058B1 (fr) * 2002-01-21 2004-03-12 Centre Nat Rech Scient Procede de detection d'au moins un parametre caracteristique de molecules sondes fixees sur au moins une zone active d'un capteur
WO2003071252A2 (en) 2002-02-15 2003-08-28 Exact Sciences Corporation Methods for analysis of molecular events
DK1342794T3 (da) * 2002-03-05 2006-04-24 Epigenomics Ag Fremgangsmåde og anordning til at bestemme vævsspecificitet af fritflydende DNA i legemsvæsker
US20050266405A1 (en) * 2002-03-08 2005-12-01 Kopreski Michael S Analysis of apoptotic bodies in bodily fluids
ATE544867T1 (de) * 2002-12-11 2012-02-15 Centre Nat Rech Scient Methode zur elektronischen detektion wenigstens einer spezifischen interaktion zwischen einem proben- und einem zielmolekül
EP2500440B1 (de) 2002-12-20 2015-12-16 Celera Corporation Mit Myokardinfarkt assoziierte genetische Polymorphismen, Nachweisverfahren und deren Verwendungen
EP2186913B1 (de) 2003-11-26 2016-02-10 Celera Corporation Mit kardiovaskulären Erkrankungen und dem Ansprechen auf Medikation in Zusammenhang stehende Genpolymorphismen, Methoden zu deren Nachweis und deren Verwendung
US7252946B2 (en) 2004-01-27 2007-08-07 Zoragen, Inc. Nucleic acid detection
US8304192B2 (en) * 2004-03-05 2012-11-06 University Of Toledo Methods and compositions for assessing nucleic acids and alleles
US8338578B1 (en) * 2004-03-05 2012-12-25 Quest Diagnostics Investments Incorporated Cystic fibrosis gene mutations
WO2005106036A2 (en) * 2004-04-12 2005-11-10 Medical College Of Ohio Methods and compositions for assaying analytes
EP2423326B1 (de) 2004-05-07 2014-01-08 Celera Corporation Genetischer Polymorphismus und Leberfibrose, Verfahren zur Erkennung und Verwendung davon
WO2005111244A2 (en) * 2004-05-10 2005-11-24 Exact Sciences Corporation Methods for detecting a mutant nucleic acid
US7858763B2 (en) 2004-06-04 2010-12-28 Council Of Scientific And Industrial Research Transforming growth factor beta 1 (TGFβ1) haplotypes and prediction of susceptibility for immunological disorders
US7981607B2 (en) * 2004-08-27 2011-07-19 Esoterix Genetic Laboratories LLC Method for detecting recombinant event
EP1802775B1 (de) 2004-09-14 2010-05-26 The Regents of the University of Colorado Auf genetischem targeting basierendes verfahren zur behandlung mit bucindolol
WO2006047787A2 (en) 2004-10-27 2006-05-04 Exact Sciences Corporation Method for monitoring disease progression or recurrence
EP2194144B1 (de) 2004-11-16 2015-01-07 Trustees of Boston University Anti-Dual Endothelin-1/Angiotensin II-Rezeptor (DEAR) Antikörper zur Hemmung von Krankheit-assozierter oder pathologischer Angiogenese.
US20060172324A1 (en) * 2005-01-28 2006-08-03 Roche Molecular Systems, Inc. Methods of genotyping using differences in melting temperature
CA2597411C (en) 2005-02-14 2014-08-12 University Of Iowa Research Foundation Use of complement factor h polymorphisms in treatment and diagnosis of age-related macular degeneration
CA2598281C (en) * 2005-02-22 2016-08-09 Regents Of The University Of Minnesota Sptbn2 gene associated with spinocerebellar ataxia type 5 and methods of use
EP1856296A2 (de) 2005-03-11 2007-11-21 Applera Corporation Genetische polymorphismen in zusammenhang mit koronarer herzerkrankung, detektionsverfahren und verwendungen
ATE406463T1 (de) 2005-04-06 2008-09-15 Maurice Stroun Methode zur krebsdiagnose mittels nachweis von dna und rna im kreislauf
WO2007044071A2 (en) * 2005-04-21 2007-04-19 Exact Sciences Corporation Analysis of heterogeneous nucleic acid samples
WO2006123369A1 (en) 2005-05-18 2006-11-23 Decode Genetics Ehf. Variants at chr8q24.21 confer risk of cancer
US20090280479A1 (en) * 2005-05-27 2009-11-12 John Wayne Cancer Institute Use of free circulating dna for diagnosis, prognosis, and treatment of cancer funding
US20080280843A1 (en) * 2006-05-24 2008-11-13 Van Bilsen Paul Methods and kits for linking polymorphic sequences to expanded repeat mutations
US7799530B2 (en) 2005-09-23 2010-09-21 Celera Corporation Genetic polymorphisms associated with cardiovascular disorders and drug response, methods of detection and uses thereof
US7695911B2 (en) 2005-10-26 2010-04-13 Celera Corporation Genetic polymorphisms associated with Alzheimer's Disease, methods of detection and uses thereof
US20070238106A1 (en) * 2006-04-07 2007-10-11 Agilent Technologies, Inc. Systems and methods of determining alleles and/or copy numbers
CN103424541B (zh) 2006-05-18 2018-01-30 分子压型学会股份有限公司 确定针对病状的个性化医疗介入的系统和方法
US8768629B2 (en) 2009-02-11 2014-07-01 Caris Mpi, Inc. Molecular profiling of tumors
US9273356B2 (en) * 2006-05-24 2016-03-01 Medtronic, Inc. Methods and kits for linking polymorphic sequences to expanded repeat mutations
US7642049B2 (en) 2006-06-30 2010-01-05 Bristol-Myers Squibb Company Method for identifying HIV-1 protease inhibitors with reduced metabolic affects through detection of human resistin polymorphisms
JP5431151B2 (ja) 2006-07-13 2014-03-05 ユニバーシティー オブ アイオワ リサーチ ファンデーション 血管障害および加齢黄斑変性症の治療および診断のための方法および試薬
EP2431483B1 (de) 2006-10-20 2015-04-01 Celera Corporation Mit venöser Thrombose assoziierte genetische Polymorphismen, Nachweisverfahren und deren Verwendungen
US20080131954A1 (en) * 2006-11-30 2008-06-05 Canon U.S. Life Sciences, Inc. Method of Separating Target DNA from Mixed DNA
EP2121979B1 (de) 2006-12-05 2017-07-12 Decode Genetics EHF Genetische marker für das risikomanagement bei herzrhythmusstörungen
EA018444B1 (ru) 2007-05-25 2013-08-30 Декоуд Дженетикс Ехф. ГЕНЕТИЧЕСКИЕ ВАРИАНТЫ В Chr 5p12 И 10q26 В КАЧЕСТВЕ МАРКЕРОВ ДЛЯ ПРИМЕНЕНИЯ ПРИ ОЦЕНКЕ РИСКА, ДИАГНОСТИРОВАНИИ, ПРОГНОЗИРОВАНИИ И ЛЕЧЕНИИ РАКА ГРУДИ
AU2008260029B2 (en) 2007-05-31 2015-02-12 Yale University A genetic lesion associated with cancer
EP2952588A1 (de) 2007-08-06 2015-12-09 Orion Genomics, LLC Einzelnukleotid-polymorphismen zur bestimmung der allelspezifischen expression des igf2-gens
CA2639416C (en) 2007-09-11 2019-12-31 F. Hoffmann-La Roche Ag Diagnostic test for susceptibility to b-raf kinase inhibitors
US8039212B2 (en) 2007-11-05 2011-10-18 Celera Corporation Genetic polymorphisms associated with liver fibrosis, methods of detection and uses thereof
US8697360B2 (en) 2007-11-30 2014-04-15 Decode Genetics Ehf. Genetic variants on CHR 11Q and 6Q as markers for prostate and colorectal cancer predisposition
CA2714521A1 (en) 2008-02-14 2009-08-20 Decode Genetics Ehf Susceptibility variants for lung cancer
US20090221620A1 (en) 2008-02-20 2009-09-03 Celera Corporation Gentic polymorphisms associated with stroke, methods of detection and uses thereof
EP2274450A2 (de) 2008-04-01 2011-01-19 Decode Genetics EHF Suszeptibilitätsvarianten bei peripherer arterienkrankheit und bauchschlagader-aneurysma
DK2644707T3 (en) 2008-04-30 2015-06-29 Integrated Dna Tech Inc RNase-H-based assays using modified RNA monomers.
US8911948B2 (en) * 2008-04-30 2014-12-16 Integrated Dna Technologies, Inc. RNase H-based assays utilizing modified RNA monomers
US9434988B2 (en) 2008-04-30 2016-09-06 Integrated Dna Technologies, Inc. RNase H-based assays utilizing modified RNA monomers
US20110152340A1 (en) 2008-05-16 2011-06-23 Bristol-Myers Squibb Company Methods for Identifying Subjects With an Increased Likelihood of Responding to DPP-IV Inhibitors
EP3093351B1 (de) 2008-07-09 2018-04-18 Celera Corporation Mit kardiovaskulären krankheiten assoziierte, genetische polymorphismen, verfahren zum nachweis und verwendungen davon
US8583380B2 (en) 2008-09-05 2013-11-12 Aueon, Inc. Methods for stratifying and annotating cancer drug treatment options
CN107254538A (zh) 2008-11-12 2017-10-17 卡里斯生命科学瑞士控股有限责任公司 使用外来体来确定表现型的方法和系统
US8367333B2 (en) 2008-12-12 2013-02-05 Decode Genetics Ehf. Genetic variants as markers for use in diagnosis, prognosis and treatment of eosinophilia, asthma, and myocardial infarction
CA2743704A1 (en) 2008-12-15 2010-07-08 Wisconsin Alumni Research Foundation Methods and compositions for testing and breeding cattle for improved fertility and embryonic survival
AU2010221721A1 (en) 2009-02-06 2011-08-18 Yale University A SNP marker of breast and ovarian cancer risk
EP2955234A1 (de) 2009-02-11 2015-12-16 Orion Genomics, LLC Kombinationen aus polymorphismen zur bestimmung von allelspezifischer expression von igf2
JP5457222B2 (ja) 2009-02-25 2014-04-02 エフ.ホフマン−ラ ロシュ アーゲー 小型化ハイスループット核酸分析
US9347092B2 (en) * 2009-02-25 2016-05-24 Roche Molecular System, Inc. Solid support for high-throughput nucleic acid analysis
WO2010151841A2 (en) 2009-06-25 2010-12-29 Yale University Single nucleotide polymorphisms in brca1 and cancer risk
US9512481B2 (en) 2009-09-11 2016-12-06 The Regents Of The University Of Colorado, A Body Corporate Polymorphisms in the PDE3A gene
US20110104154A1 (en) 2009-10-30 2011-05-05 Alcon Research, Ltd. Single nucleotide polymorphisms and genes associated with age-related macular degeneration
US20110117559A1 (en) * 2009-11-13 2011-05-19 Integrated Dna Technologies, Inc. Small rna detection assays
WO2011094731A2 (en) 2010-02-01 2011-08-04 The Board Of Trustees Of The Leland Stanford Junior University Methods for diagnosis and treatment of non-insulin dependent diabetes mellitus
KR20130056855A (ko) 2010-03-01 2013-05-30 카리스 라이프 사이언스 룩셈부르크 홀딩스 치료진단용 생물학적 지표들
KR20130043104A (ko) 2010-04-06 2013-04-29 카리스 라이프 사이언스 룩셈부르크 홀딩스 질병용 순환 생물학적 지표들
WO2011128096A1 (en) 2010-04-16 2011-10-20 Roche Diagnostics Gmbh Polymorphism markers for predicting response to interleukin-6 receptor-inhibiting monoclonal antibody drug treatment
US20110269735A1 (en) 2010-04-19 2011-11-03 Celera Corporation Genetic polymorphisms associated with statin response and cardiovascular diseases, methods of detection and uses thereof
KR101287431B1 (ko) * 2010-05-07 2013-07-19 (주)진매트릭스 표적 유전자의 다양한 변이가 존재하는 유전자 영역을 증폭하기 위한 프라이머 조성물, 이를 이용한 표적 유전자 증폭 방법 및 이를 포함하는 pcr 증폭 키트 그리고 이를 이용한 표적 유전자의 유전자형 분석방법
CN103228798B (zh) 2010-09-24 2015-12-09 斯坦福大学托管董事会 使用固定的引物直接捕获、扩增及测序靶标dna
US20140004510A1 (en) 2010-09-24 2014-01-02 Massachusetts Eye And Ear Infirmary Methods and compositions for prognosing and/or detecting age-related macular degeneration
US20120108651A1 (en) 2010-11-02 2012-05-03 Leiden University Medical Center (LUMC) Acting on Behalf of Academic Hospital Leiden (AZL) Genetic polymorphisms associated with venous thrombosis and statin response, methods of detection and uses thereof
GB201020982D0 (en) 2010-12-10 2011-01-26 Stiftung Offentlichen Rechts Polymorphism
US9856510B2 (en) 2010-12-14 2018-01-02 Stichting Katholieke Universiteit Chemiluminescence-based haemostasis assay
EP2675914A1 (de) 2011-02-18 2013-12-25 Yale University, Inc. Kras-variante und endometriose
US20140065615A1 (en) 2011-03-21 2014-03-06 Yale University The KRAS Variant and Tumor Biology
CA2845386A1 (en) 2011-08-31 2013-03-07 F. Hoffmann-La Roche Ag Method for predicting risk of hypertension associated with anti-angiogenesis therapy
AU2012300985A1 (en) 2011-08-31 2014-02-13 F. Hoffmann-La Roche Ag Responsiveness to angiogenesis inhibitors
US20130078252A1 (en) 2011-09-19 2013-03-28 Genentech, Inc. Combination treatments comprising c-met antagonists and b-raf antagonists
WO2013045505A1 (en) 2011-09-28 2013-04-04 Novartis Ag Biomarkers for raas combination therapy
MX2014006186A (es) 2011-11-23 2014-07-14 Hoffmann La Roche Capacidad de respuesta a los inhibidores de la angiogenesis.
US10633707B2 (en) 2012-04-10 2020-04-28 Vib Vzw Markers for detecting microsatellite instability in cancer and determining synthetic lethality with inhibition of the DNA base excision repair pathway
US10294529B2 (en) 2012-04-10 2019-05-21 Life Sciences Research Partners Vzw Microsatellite instability markers in detection of cancer
AU2013246815A1 (en) 2012-04-12 2014-10-30 Aalborg Universitet Mutations in calmodulin genes
US10077474B2 (en) 2012-05-29 2018-09-18 Abbott Molecular, Inc. Method of designing primers, method of detecting single nucleotide polymorphisms (SNPs), method of distinguishing SNPs, and related primers, detectable oligonucleotides, and kits
WO2014074942A1 (en) 2012-11-08 2014-05-15 Illumina, Inc. Risk variants of alzheimer's disease
WO2014149356A1 (en) 2013-03-15 2014-09-25 Abbott Molecular Inc. Detection of bisulfite converted nucleotide sequences
CN105229175A (zh) 2013-03-15 2016-01-06 雅培分子公司 用于扩增和测定rna融合基因变体的方法、区分它们的方法以及有关的引物、探针和试剂盒
WO2015042708A1 (en) 2013-09-25 2015-04-02 Bio-Id Diagnostic Inc. Methods for detecting nucleic acid fragments
WO2016001411A1 (en) 2014-07-03 2016-01-07 Multiplicom N.V. Methods for non-invasive detection of transplant health or rejection
GB201417499D0 (en) 2014-10-03 2014-11-19 Convergence Pharmaceuticals Novel use
GB201417497D0 (en) 2014-10-03 2014-11-19 Convergence Pharmaceuticals Novel use
GB201417500D0 (en) 2014-10-03 2014-11-19 Convergence Pharmaceuticals Novel use
EP3218515B1 (de) 2014-11-10 2023-04-26 F. Hoffmann-La Roche AG Therapeutische und diagnostische verfahren für il-33-vermittelte erkrankungen
MX2018000947A (es) 2015-07-23 2018-06-07 Merck Sharp & Dohme Marcadores geneticos asociados con la respuesta a los antagonistas del receptor crth2.
EP3402900A1 (de) 2016-01-12 2018-11-21 Interleukin Genetics, Inc. Verfahren zur vorhersage der reaktion auf eine therapie
JP2019515035A (ja) 2016-04-27 2019-06-06 ミラ ディーエックス, インコーポレイテッド Krasバリアントがん患者の免疫ベースの処置
RU2761249C2 (ru) 2016-12-14 2021-12-06 Мерк Шарп энд Доум Корп. Человеческие генетические маркеры, ассоциированные с ответом на средства для лечения, которые целенаправленно воздействуют на токсин b clostridium difficile
US10329620B2 (en) 2017-01-12 2019-06-25 Cardioforecast Ltd. Methods and kits for treating cardiovascular disease
CA3069580C (en) 2017-07-12 2023-06-13 Genecast Co., Ltd. Dna polymerase with increased gene mutation specificity and pcr buffer composition for increasing activity thereof
EP3749362A1 (de) 2018-02-09 2020-12-16 F. Hoffmann-La Roche AG Therapeutische und diagnostische verfahren für mastzellvermittelte entzündliche erkrankungen
JP7018544B2 (ja) 2018-05-25 2022-02-10 アルカ バイオファーマ, インコーポレイテッド 心房細動の処置のためのブシンドロールを伴う方法および組成物
EP3810182A4 (de) 2018-06-19 2022-08-24 BioNTech US Inc. Neoantigene und ihre verwendungen
WO2020245402A1 (en) 2019-06-06 2020-12-10 Cardioforecast Ltd Compositions and methods for treating lung, colorectal and breast cancer
WO2021028469A1 (en) 2019-08-12 2021-02-18 Sitokine Limited Compositions and methods for treating cytokine release syndrome and neurotoxicity
CN115315527A (zh) 2020-03-13 2022-11-08 免疫医疗有限公司 用于治疗il33中存在风险等位基因的受试者的治疗方法
WO2021205013A1 (en) 2020-04-09 2021-10-14 Sitokine Limited Compositions and methods for treating covid-19
WO2022020359A1 (en) 2020-07-24 2022-01-27 The Regents Of The University Of Michigan Compositions and methods for detecting and treating high grade subtypes of uterine cancer
WO2024231499A1 (en) 2023-05-10 2024-11-14 Vib Vzw Combinations of short genetic variants in the diagnosis of alzheimer disease

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2588383B1 (fr) * 1985-10-04 1988-01-08 Inst Nat Sante Rech Med Nouveau procede de recuperation et de dosage de microquantites d'acide desoxyribonucleique dans un liquide biologique acellulaire
DE3721400A1 (de) * 1987-06-29 1989-01-12 Viktor Dr Dr Med Balazs Verfahren zur untersuchung einer azellularen biologischen fluessigkeit auf zellulare onkogen-dna bzw. deren fragmente
US4988617A (en) * 1988-03-25 1991-01-29 California Institute Of Technology Method of detecting a nucleotide change in nucleic acids
US5068175A (en) * 1989-05-26 1991-11-26 Board Of Regents, The University Of Texas Sysem Method of detecting ras oncogene related malignancies
US5137806A (en) * 1989-12-11 1992-08-11 Board Of Regents, The University Of Texas System Methods and compositions for the detection of sequences in selected DNA molecules
IL97222A (en) * 1990-02-16 1995-08-31 Orion Yhtymae Oy Method and reagent for determining specific nucleotide variations

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