JP2005036009A5 - - Google Patents

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Publication number: JP2005036009A5
Authority: JP; Japan
Prior art keywords: pharmaceutically acceptable; aminomethyl; acetic acid; acceptable salt; compound according
Prior art date: 2004-09-14
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Granted

Application number

JP2004266488A

Other languages

English (en)

Japanese (ja)

Other versions

JP3744928B2 (ja

JP2005036009A (ja

Filing date

2004-09-14

Publication date

2005-09-08

2004-09-14 Application filed filed Critical

2005-02-10 Publication of JP2005036009A publication Critical patent/JP2005036009A/ja

2005-09-08 Publication of JP2005036009A5 publication Critical patent/JP2005036009A5/ja

2006-02-15 Application granted granted Critical

2006-02-15 Publication of JP3744928B2 publication Critical patent/JP3744928B2/ja

2020-10-17 Anticipated expiration legal-status Critical

Status Expired - Fee Related legal-status Critical Current

Links

150000001875 compounds Chemical class 0.000 claims 17
150000003839 salts Chemical class 0.000 claims 15
239000003814 drug Substances 0.000 claims 9
238000004519 manufacturing process Methods 0.000 claims 9
ONKWZNBXHSMMDK-UHFFFAOYSA-N 2-[2-(aminomethyl)-1,3,3a,4,5,6,7,7a-octahydroinden-2-yl]acetic acid Chemical compound C1CCCC2CC(CN)(CC(O)=O)CC21 ONKWZNBXHSMMDK-UHFFFAOYSA-N 0.000 claims 4
GSBZRDSCOPXLJJ-UHFFFAOYSA-N 2-[2-(aminomethyl)-3,3a,4,5,6,6a-hexahydro-1h-pentalen-2-yl]acetic acid Chemical compound C1CCC2CC(CN)(CC(O)=O)CC21 GSBZRDSCOPXLJJ-UHFFFAOYSA-N 0.000 claims 4
NDDZVQRQVFTNSN-UHFFFAOYSA-N 2-[3-(aminomethyl)-3-bicyclo[3.2.0]heptanyl]acetic acid Chemical compound C1C(CN)(CC(O)=O)CC2CCC21 NDDZVQRQVFTNSN-UHFFFAOYSA-N 0.000 claims 4
HZROAXDCVPLQAB-UHFFFAOYSA-N 2-[3-(aminomethyl)-3-bicyclo[3.1.0]hexanyl]acetic acid Chemical compound C1C(CN)(CC(O)=O)CC2CC21 HZROAXDCVPLQAB-UHFFFAOYSA-N 0.000 claims 3
208000002193 Pain Diseases 0.000 claims 2
208000019901 Anxiety disease Diseases 0.000 claims 1
208000020401 Depressive disease Diseases 0.000 claims 1
206010036618 Premenstrual syndrome Diseases 0.000 claims 1
230000036506 anxiety Effects 0.000 claims 1
201000010099 disease Diseases 0.000 claims 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
239000003937 drug carrier Substances 0.000 claims 1
206010015037 epilepsy Diseases 0.000 claims 1
208000021245 head disease Diseases 0.000 claims 1
230000003483 hypokinetic effect Effects 0.000 claims 1
208000004296 neuralgia Diseases 0.000 claims 1
230000004770 neurodegeneration Effects 0.000 claims 1
208000015122 neurodegenerative disease Diseases 0.000 claims 1
230000002981 neuropathic effect Effects 0.000 claims 1
208000021722 neuropathic pain Diseases 0.000 claims 1
239000008194 pharmaceutical composition Substances 0.000 claims 1
206010042772 syncope Diseases 0.000 claims 1

JP2004266488A 1999-10-20 2004-09-14 医薬製剤としての２環式アミノ酸 Expired - Fee Related JP3744928B2 (ja)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US16072599P	1999-10-20	1999-10-20

Related Parent Applications (1)

Application Number	Title	Priority Date	Filing Date
JP2001531783A Division JP3632191B2 (ja)	1999-10-20	2000-10-17	医薬製剤としての２環式アミノ酸

Publications (3)

Publication Number	Publication Date
JP2005036009A JP2005036009A (ja)	2005-02-10
JP2005036009A5 true JP2005036009A5 (2)	2005-09-08
JP3744928B2 JP3744928B2 (ja)	2006-02-15

Family

ID=22578159

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
JP2001531783A Expired - Fee Related JP3632191B2 (ja)	1999-10-20	2000-10-17	医薬製剤としての２環式アミノ酸
JP2004266488A Expired - Fee Related JP3744928B2 (ja)	1999-10-20	2004-09-14	医薬製剤としての２環式アミノ酸

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
JP2001531783A Expired - Fee Related JP3632191B2 (ja)	1999-10-20	2000-10-17	医薬製剤としての２環式アミノ酸

Country Status (50)

Country	Link
US (2)	US6689906B1 (2)
EP (2)	EP1506955B1 (2)
JP (2)	JP3632191B2 (2)
KR (2)	KR100593349B1 (2)
CN (1)	CN1165518C (2)
AP (2)	AP2004003186A0 (2)
AR (2)	AR026087A1 (2)
AT (2)	ATE358116T1 (2)
AU (2)	AU778871B2 (2)
BG (2)	BG108860A (2)
BR (1)	BR0014972B1 (2)
CA (1)	CA2386297C (2)
CO (1)	CO5280060A1 (2)
CR (1)	CR6620A (2)
CU (1)	CU23112A3 (2)
CZ (1)	CZ295960B6 (2)
DE (2)	DE60034157T2 (2)
DO (1)	DOP2000000083A (2)
DZ (1)	DZ3197A1 (2)
EA (1)	EA005206B1 (2)
EC (1)	ECSP045393A (2)
EE (1)	EE200200211A (2)
ES (2)	ES2237464T3 (2)
GE (1)	GEP20043297B (2)
GT (2)	GT200000183AA (2)
HK (1)	HK1049826B (2)
HN (1)	HN2000000224A (2)
HR (2)	HRP20040709A2 (2)
HU (1)	HUP0203325A3 (2)
IL (3)	IL149143A0 (2)
IS (2)	IS6348A (2)
MA (1)	MA26842A1 (2)
MX (1)	MXPA02003229A (2)
MY (1)	MY127678A (2)
NO (2)	NO20021780D0 (2)
NZ (1)	NZ517961A (2)
OA (1)	OA12070A (2)
PA (1)	PA8505201A1 (2)
PE (1)	PE20010740A1 (2)
PL (1)	PL354607A1 (2)
PT (1)	PT1226110E (2)
SI (1)	SI1226110T1 (2)
SK (1)	SK5232002A3 (2)
SV (1)	SV2001000188A (2)
TR (2)	TR200201094T2 (2)
TW (2)	TWI225855B (2)
UA (1)	UA72931C2 (2)
WO (1)	WO2001028978A1 (2)
YU (2)	YU73004A (2)
ZA (1)	ZA200202543B (2)

Families Citing this family (38)

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US7164034B2 (en)	1999-06-10	2007-01-16	Pfizer Inc.	Alpha2delta ligands for fibromyalgia and other disorders
PL359872A1 (en) *	2000-06-26	2004-09-06	Warner-Lambert Company	Gabapentin analogues for sleep disorders
US6620829B2 (en)	2000-10-17	2003-09-16	Warner-Lambert Company	Method of treating noninflammatory cartilage damage
EP1226820A1 (en)	2001-01-26	2002-07-31	Warner-Lambert Company	Use of bicyclic amino acids for preventing and treating visceral pain and gastrointestinal disorders
BR0208922A (pt) *	2001-04-19	2004-04-20	Warner Lambert Co	Aminoácidos bicìclicos ou tricìclicos fundidos
GB2375108A (en) *	2001-05-04	2002-11-06	Warner Lambert Co	Production of a bicycloheptanone
GB2375109A (en) *	2001-05-04	2002-11-06	Warner Lambert Co	Process for preparing bicyclic amino acid
CA2449729C (en) *	2001-06-11	2009-11-03	Xenoport, Inc.	Prodrugs of gaba analogs, compositions and uses thereof
US6818787B2 (en)	2001-06-11	2004-11-16	Xenoport, Inc.	Prodrugs of GABA analogs, compositions and uses thereof
US7232924B2 (en)	2001-06-11	2007-06-19	Xenoport, Inc.	Methods for synthesis of acyloxyalkyl derivatives of GABA analogs
US7186855B2 (en)	2001-06-11	2007-03-06	Xenoport, Inc.	Prodrugs of GABA analogs, compositions and uses thereof
US8048917B2 (en)	2005-04-06	2011-11-01	Xenoport, Inc.	Prodrugs of GABA analogs, compositions and uses thereof
CN1625393A (zh)	2002-01-31	2005-06-08	沃纳-兰伯特公司	治疗耳鸣的α2δ配体
PL372210A1 (en) *	2002-02-22	2005-07-11	Warner-Lambert Company Llc	Combinations of an alpha-2-delta ligand with a selective inhibitor of cyclooxygenase-2
WO2004002462A2 (en) *	2002-06-27	2004-01-08	Warner-Lambert Company Llc	Use of an alpha2delta ligand such as gabapentin or pregabalin for treating ttention deficit hyperactivity disorder
GB0219024D0 (en) *	2002-08-15	2002-09-25	Pfizer Ltd	Synergistic combinations
US7419981B2 (en)	2002-08-15	2008-09-02	Pfizer Inc.	Synergistic combinations of an alpha-2-delta ligand and a cGMP phosphodieterse 5 inhibitor
JP2005539092A (ja) *	2002-08-15	2005-12-22	ファイザー・インク	縮合二環式または三環式アミノ酸の治療における使用
GB0223072D0 (en)	2002-10-04	2002-11-13	Pfizer Ltd	Cyclic nitromethyl acetic acid derivatives
US7018818B2 (en)	2002-10-04	2006-03-28	Pfizer Inc.	Intermediates in the preparation of therapeutic fused bicyclic amino acids
US7060727B2 (en)	2002-12-11	2006-06-13	Xenoport, Inc.	Prodrugs of fused GABA analogs, pharmaceutical compositions and uses thereof
CA2451267A1 (en)	2002-12-13	2004-06-13	Warner-Lambert Company Llc	Pharmaceutical uses for alpha2delta ligands
AU2003303041B2 (en)	2002-12-13	2008-07-24	Warner-Lambert Company Llc	Alpha-2-delta ligand to treat lower urinary tract symptoms
NZ540591A (en)	2002-12-13	2008-03-28	Warner Lambert Co	Pregabalin derivatives for the treatment of fibromyalgia and other disorders
AU2004271800A1 (en)	2003-09-12	2005-03-24	Pfizer Inc.	Combinations comprising alpha-2-delta ligands and serotonin / noradrenaline re-uptake inhibitors
WO2006092692A1 (en) *	2005-03-01	2006-09-08	Pfizer Limited	Use of combinations of pde7 inhibitors and alpha-2-delty ligands for the treatment of neuropathic pain
AR061728A1 (es) *	2006-06-30	2008-09-17	Pfizer Prod Inc	Composicion para tratamiento usando compuestos selectivos alfa-2-delta-1
CA2673545A1 (en)	2006-12-22	2008-07-03	Recordati Ireland Limited	Combination therapy of lower urinary tract disorders with .alpha.2.delta. ligands and nsaids
EP2657219B1 (en)	2007-09-28	2014-12-10	Daiichi Sankyo Company, Limited	Intermediate for producing bicyclic y-amino acid derivative
JP5557292B2 (ja)	2009-03-26	2014-07-23	第一三共株式会社	二環性γ−アミノ酸誘導体の製造方法
EP2719676B1 (en)	2011-06-08	2017-12-13	Daiichi Sankyo Company, Limited	Method for producing bicyclic compound via iminium salt
WO2012169475A1 (ja)	2011-06-08	2012-12-13	第一三共株式会社	クライゼン転位反応による二環性化合物の製造方法
IN2014MN01046A (2)	2011-12-15	2015-05-01	Daiichi Sankyo Companyltd
EP2837689B1 (en)	2012-04-10	2017-02-15	Daiichi Sankyo Company, Limited	Optical resolution method for bicyclic compound using enzyme
US9066853B2 (en)	2013-01-15	2015-06-30	Warsaw Orthopedic, Inc.	Clonidine compounds in a biodegradable fiber
TWI635071B (zh)	2013-07-08	2018-09-11	第一三共股份有限公司	光學活性二環γ－胺基酸衍生物及其製造方法
WO2018166855A1 (en)	2017-03-16	2018-09-20	Basf Se	Heterobicyclic substituted dihydroisoxazoles
CN113045410A (zh) *	2021-03-29	2021-06-29	华东理工大学	一种双环降二萜类化合物及其合成基因及制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3641129A (en)	1969-06-17	1972-02-08	Merck & Co Inc	Antifibrinolytic compounds
DE2460891C2 (de)	1974-12-21	1982-09-23	Gödecke AG, 1000 Berlin	1-Aminomethyl-1-cycloalkanessigsäuren und deren Ester, Verfahren zu deren Herstellung und diese Verbindungen enthaltende Arzneimittel
US4087544A (en) *	1974-12-21	1978-05-02	Warner-Lambert Company	Treatment of cranial dysfunctions using novel cyclic amino acids
HUP0004310A3 (en)	1997-10-27	2001-11-28	Warner Lambert Co	Cyclic amino acids, and derivatives thereof and pharmaceutical compositions comprising the said compounds as active agents

2000
- 2000-10-05 HN HN2000000224A patent/HN2000000224A/es unknown
- 2000-10-06 SV SV2000000188A patent/SV2001000188A/es not_active Application Discontinuation
- 2000-10-17 GE GE4783A patent/GEP20043297B/en unknown
- 2000-10-17 DZ DZ003197A patent/DZ3197A1/xx active
- 2000-10-17 TR TR2002/01094T patent/TR200201094T2/xx unknown
- 2000-10-17 SI SI200030670T patent/SI1226110T1/xx unknown
- 2000-10-17 HR HRP20040709 patent/HRP20040709A2/xx not_active Application Discontinuation
- 2000-10-17 JP JP2001531783A patent/JP3632191B2/ja not_active Expired - Fee Related
- 2000-10-17 EA EA200200293A patent/EA005206B1/ru unknown
- 2000-10-17 AP AP2004003186A patent/AP2004003186A0/xx unknown
- 2000-10-17 AU AU10920/01A patent/AU778871B2/en not_active Ceased
- 2000-10-17 CZ CZ20021310A patent/CZ295960B6/cs not_active IP Right Cessation
- 2000-10-17 HU HU0203325A patent/HUP0203325A3/hu unknown
- 2000-10-17 KR KR1020027005036A patent/KR100593349B1/ko not_active Expired - Fee Related
- 2000-10-17 NZ NZ517961A patent/NZ517961A/xx unknown
- 2000-10-17 UA UA2002032434A patent/UA72931C2/uk unknown
- 2000-10-17 KR KR1020067002249A patent/KR100566462B1/ko not_active Expired - Fee Related
- 2000-10-17 CA CA2386297A patent/CA2386297C/en not_active Expired - Fee Related
- 2000-10-17 SK SK523-2002A patent/SK5232002A3/sk unknown
- 2000-10-17 EE EEP200200211A patent/EE200200211A/xx unknown
- 2000-10-17 HK HK03101868.4A patent/HK1049826B/zh not_active IP Right Cessation
- 2000-10-17 WO PCT/US2000/028687 patent/WO2001028978A1/en not_active Ceased
- 2000-10-17 IL IL14914300A patent/IL149143A0/xx not_active IP Right Cessation
- 2000-10-17 AT AT04027485T patent/ATE358116T1/de not_active IP Right Cessation
- 2000-10-17 US US10/130,023 patent/US6689906B1/en not_active Expired - Fee Related
- 2000-10-17 TR TR2005/00221T patent/TR200500221T2/xx unknown
- 2000-10-17 CN CNB008145644A patent/CN1165518C/zh not_active Expired - Fee Related
- 2000-10-17 YU YU73004A patent/YU73004A/sh unknown
- 2000-10-17 DE DE60034157T patent/DE60034157T2/de not_active Expired - Lifetime
- 2000-10-17 MX MXPA02003229A patent/MXPA02003229A/es active IP Right Grant
- 2000-10-17 EP EP04027485A patent/EP1506955B1/en not_active Expired - Lifetime
- 2000-10-17 PL PL00354607A patent/PL354607A1/xx not_active Application Discontinuation
- 2000-10-17 ES ES00972226T patent/ES2237464T3/es not_active Expired - Lifetime
- 2000-10-17 BR BRPI0014972-1A patent/BR0014972B1/pt not_active IP Right Cessation
- 2000-10-17 AT AT00972226T patent/ATE293590T1/de not_active IP Right Cessation
- 2000-10-17 YU YU29302A patent/YU29302A/sh unknown
- 2000-10-17 AP APAP/P/2002/002517A patent/AP2002002517A0/en unknown
- 2000-10-17 DE DE60019628T patent/DE60019628T2/de not_active Expired - Lifetime
- 2000-10-17 OA OA1200200117A patent/OA12070A/en unknown
- 2000-10-17 EP EP00972226A patent/EP1226110B1/en not_active Expired - Lifetime
- 2000-10-17 HR HR20020428A patent/HRP20020428B1/xx not_active IP Right Cessation
- 2000-10-17 PT PT00972226T patent/PT1226110E/pt unknown
- 2000-10-17 ES ES04027485T patent/ES2282785T3/es not_active Expired - Lifetime
- 2000-10-17 IL IL16406000A patent/IL164060A0/xx unknown
- 2000-10-18 MY MYPI20004896A patent/MY127678A/en unknown
- 2000-10-18 PA PA20008505201A patent/PA8505201A1/es unknown
- 2000-10-19 GT GT200000183AK patent/GT200000183AA/es unknown
- 2000-10-19 CO CO00079741A patent/CO5280060A1/es not_active Application Discontinuation
- 2000-10-19 DO DO2000000083A patent/DOP2000000083A/es unknown
- 2000-10-19 PE PE2000001116A patent/PE20010740A1/es not_active Application Discontinuation
- 2000-10-19 AR ARP000105497A patent/AR026087A1/es unknown
- 2000-10-19 GT GT200000183A patent/GT200000183A/es unknown
- 2000-10-20 TW TW089122115A patent/TWI225855B/zh not_active IP Right Cessation
- 2000-10-20 TW TW093125953A patent/TW200505824A/zh unknown
2002
- 2002-03-28 ZA ZA200202543A patent/ZA200202543B/xx unknown
- 2002-04-15 IL IL149143A patent/IL149143A/en unknown
- 2002-04-16 CU CU78A patent/CU23112A3/es unknown
- 2002-04-16 NO NO20021780A patent/NO20021780D0/no not_active Application Discontinuation
- 2002-04-17 IS IS6348A patent/IS6348A/is unknown
- 2002-04-18 CR CR6620A patent/CR6620A/es not_active Application Discontinuation
- 2002-05-10 MA MA26634A patent/MA26842A1/fr unknown
- 2002-05-20 BG BG108860A patent/BG108860A/en unknown
- 2002-05-20 BG BG106719A patent/BG106719A/bg unknown
2004
- 2004-01-21 US US10/762,026 patent/US6835751B2/en not_active Expired - Fee Related
- 2004-07-28 EC EC2004005393A patent/ECSP045393A/es unknown
- 2004-08-17 AR ARP040102937A patent/AR045456A2/es unknown
- 2004-09-01 NO NO20043663A patent/NO20043663L/no not_active Application Discontinuation
- 2004-09-14 JP JP2004266488A patent/JP3744928B2/ja not_active Expired - Fee Related
- 2004-10-08 IS IS7497A patent/IS7497A/is unknown
2005
- 2005-03-23 AU AU2005201268A patent/AU2005201268A1/en not_active Abandoned

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