JP2007504193A - 血管性頭痛の予防のためのテルミサルタンの使用 - Google Patents

血管性頭痛の予防のためのテルミサルタンの使用 Download PDF

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Publication number: JP2007504193A
Authority: JP; Japan
Prior art keywords: telmisartan; physiologically acceptable; acceptable salt; migraine; prevention
Prior art date: 2003-09-05
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Pending

Application number

JP2006525094A

Other languages

English (en)

Japanese (ja)

Inventor

エムディージョーラディヴィデイ

Original Assignee

ベーリンガーインゲルハイムインターナショナルゲゼルシャフトミットベシュレンクテルハフツング

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-09-05

Filing date

2004-09-01

Publication date

2007-03-01

2004-09-01 Application filed by ベーリンガーインゲルハイムインターナショナルゲゼルシャフトミットベシュレンクテルハフツング filed Critical ベーリンガーインゲルハイムインターナショナルゲゼルシャフトミットベシュレンクテルハフツング

2007-03-01 Publication of JP2007504193A publication Critical patent/JP2007504193A/ja

Status Pending legal-status Critical Current

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RMMXLENWKUUMAY-UHFFFAOYSA-N telmisartan Chemical compound CCCC1=NC2=C(C)C=C(C=3N(C4=CC=CC=C4N=3)C)C=C2N1CC(C=C1)=CC=C1C1=CC=CC=C1C(O)=O RMMXLENWKUUMAY-UHFFFAOYSA-N 0.000 title claims abstract description 118
239000005537 C09CA07 - Telmisartan Substances 0.000 title claims abstract description 61
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238000000034 method Methods 0.000 claims abstract description 21
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ITIXDWVDFFXNEG-JHOUSYSJSA-N olcegepant Chemical group C([C@H](C(=O)N[C@@H](CCCCN)C(=O)N1CCN(CC1)C=1C=CN=CC=1)NC(=O)N1CCC(CC1)N1C(NC2=CC=CC=C2C1)=O)C1=CC(Br)=C(O)C(Br)=C1 ITIXDWVDFFXNEG-JHOUSYSJSA-N 0.000 claims description 15
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
- A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/225—Calcitonin gene related peptide
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents

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Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
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Animal Behavior & Ethology (AREA)
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Veterinary Medicine (AREA)
Epidemiology (AREA)
Bioinformatics & Cheminformatics (AREA)
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Chemical Kinetics & Catalysis (AREA)
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Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

JP2006525094A 2003-09-05 2004-09-01 血管性頭痛の予防のためのテルミサルタンの使用 Pending JP2007504193A (ja)

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US50081703P	2003-09-05	2003-09-05
PCT/EP2004/009709 WO2005023250A1 (fr)	2003-09-05	2004-09-01	Utilisation de telmisartan pour la prevention de la cephalee vasculaire

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US (2)	US20050065094A1 (fr)
EP (1)	EP1663208A1 (fr)
JP (1)	JP2007504193A (fr)
CA (1)	CA2537748C (fr)
WO (1)	WO2005023250A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2011068208A1 (fr) *	2009-12-05	2011-06-09	国立大学法人名古屋大学	Agent thérapeutique pour l'atrophie musculaire spinale et bulbaire

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7220862B2 (en)	2002-06-05	2007-05-22	Bristol-Myers Squibb Company	Calcitonin gene related peptide receptor antagonists
US7842808B2 (en) *	2002-06-05	2010-11-30	Bristol-Myers Squibb Company	Anti-migraine spirocycles
RS52552B (sr) *	2002-06-05	2013-04-30	Bristol-Myers Squibb Company	Antagonisti, peptidnog receptora koji je u vezi sa kalcitoninskim genom
TW200524601A (en)	2003-12-05	2005-08-01	Bristol Myers Squibb Co	Heterocyclic anti-migraine agents
TW200533398A (en) *	2004-03-29	2005-10-16	Bristol Myers Squibb Co	Novel therapeutic agents for the treatment of migraine
US7384931B2 (en) *	2004-11-03	2008-06-10	Bristol-Myers Squibb Company	Constrained compounds as CGRP-receptor antagonists
US7384930B2 (en) *	2004-11-03	2008-06-10	Bristol-Myers Squibb Company	Constrained compounds as CGRP-receptor antagonists
US7449586B2 (en) *	2004-12-03	2008-11-11	Bristol-Myers Squibb Company	Processes for the preparation of CGRP-receptor antagonists and intermediates thereof
US7834007B2 (en) *	2005-08-25	2010-11-16	Bristol-Myers Squibb Company	CGRP antagonists
KR101333697B1 (ko)	2008-10-14	2013-11-27	제일모직주식회사	벤즈이미다졸계 화합물 및 이를 포함하는 유기 광전 소자
US8707060B2 (en) *	2008-10-31	2014-04-22	Intel Corporation	Deterministic management of dynamic thermal response of processors
TWI754772B (zh) *	2017-09-06	2022-02-11	美商美國禮來大藥廠	用於治療偏頭痛之拉米迪坦(lasmiditan)與cgrp拮抗劑之組合療法
AU2021255701B2 (en) *	2020-04-17	2025-12-04	Honeybrains, Llc	Compositions and methods for treating neuropsychiatric disorders

Citations (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP2000505100A (ja)	1996-09-10	2000-04-25	ドクトルカルルトーマエゲゼルシャフトミットベシュレンクテルハフツング	修飾アミノ酸、これらの化合物を含む薬物及びそれらの調製方法
WO2001097807A1 (fr) *	2000-06-22	2001-12-27	Astrazeneca Ab	Nouvelle utilisation d'antagonistes d'angiotensine ii
WO2002036071A2 (fr)	2000-11-03	2002-05-10	Pharmacia & Upjohn Company	Procede de traitement et prevention de la migraine
WO2003015787A1 (fr)	2001-08-17	2003-02-27	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Utilisation de bibn4096 en combinaison avec d'autres medicaments contre la migraine pour le traitement de la migraine
JP2003508438A (ja)	1999-08-30	2003-03-04	フィアトリスゲゼルシャフトミットベシュレンクテルハフツングウントコンパニーコマンディトゲゼルシャフト	αリポ酸又はその誘導体の投与による片頭痛の治療

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5977145A (en) *	1998-02-12	1999-11-02	Taylor Pharmaceuticals	Method of treating migraine
TR200100062T2 (tr) *	1998-07-10	2001-06-21	Novartis Ag	Valsartan ve kalsiyum kanalı bloklayıcısının anti-hipertensif kombinasyonu
WO2002060439A1 (fr) *	2001-01-29	2002-08-08	Takeda Chemical Industries, Ltd.	Medicaments analgesiques et anti-inflammatoires

2004
- 2004-08-24 US US10/925,788 patent/US20050065094A1/en not_active Abandoned
- 2004-09-01 WO PCT/EP2004/009709 patent/WO2005023250A1/fr not_active Ceased
- 2004-09-01 JP JP2006525094A patent/JP2007504193A/ja active Pending
- 2004-09-01 CA CA2537748A patent/CA2537748C/fr not_active Expired - Fee Related
- 2004-09-01 EP EP04764674A patent/EP1663208A1/fr not_active Ceased
2006
- 2006-06-16 US US11/454,720 patent/US8618148B2/en not_active Expired - Fee Related

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP2000505100A (ja)	1996-09-10	2000-04-25	ドクトルカルルトーマエゲゼルシャフトミットベシュレンクテルハフツング	修飾アミノ酸、これらの化合物を含む薬物及びそれらの調製方法
JP2003508438A (ja)	1999-08-30	2003-03-04	フィアトリスゲゼルシャフトミットベシュレンクテルハフツングウントコンパニーコマンディトゲゼルシャフト	αリポ酸又はその誘導体の投与による片頭痛の治療
WO2001097807A1 (fr) *	2000-06-22	2001-12-27	Astrazeneca Ab	Nouvelle utilisation d'antagonistes d'angiotensine ii
WO2002036071A2 (fr)	2000-11-03	2002-05-10	Pharmacia & Upjohn Company	Procede de traitement et prevention de la migraine
WO2003015787A1 (fr)	2001-08-17	2003-02-27	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Utilisation de bibn4096 en combinaison avec d'autres medicaments contre la migraine pour le traitement de la migraine

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
JPN5006012758; ＥＴＭＩＮＡＮ　ＭＡＨＹＡＲ: ＴＨＥ　ＡＭＥＲＩＣＡＮ　ＪＯＵＲＮＡＬ　ＯＦ　ＭＥＤＩＣＩＮＥＶ１１２　Ｎ８, 20020601, Ｐ６４２-６４６
JPN6009041511; ＪＡＭＡｖｏｌ．　２８９，　ｎｏ．　１, 20030101, ｐ．ｐ．　６５-６９ *
JPN6009041513; Ｔｈｅ　Ａｍｅｒｉｃａｎ　Ｊｏｕｒｎａｌ　ｏｆ　Ｍｅｄｉｃｉｎｅｖｏｌ．　１１２, 20020601, ｐ．ｐ．　６４２-６４６ *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2011068208A1 (fr) *	2009-12-05	2011-06-09	国立大学法人名古屋大学	Agent thérapeutique pour l'atrophie musculaire spinale et bulbaire
JP5765839B2 (ja) *	2009-12-05	2015-08-19	国立大学法人名古屋大学	球脊髄性筋萎縮症治療薬

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US20050065094A1 (en)	2005-03-24
WO2005023250A1 (fr)	2005-03-17
CA2537748C (fr)	2012-12-04
US20060234946A1 (en)	2006-10-19
US8618148B2 (en)	2013-12-31
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