JP2008523031A - 部分的ドーパミン−ｄ２受容体作動性とセロトニン再摂取阻害の組み合わせを示すフェニルピペラジン誘導体 - Google Patents

部分的ドーパミン−ｄ２受容体作動性とセロトニン再摂取阻害の組み合わせを示すフェニルピペラジン誘導体 Download PDF

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Publication number: JP2008523031A
Authority: JP; Japan
Prior art keywords: mmol; alkyl; compound; disease; scheme
Prior art date: 2004-12-08
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Withdrawn

Application number

JP2007544897A

Other languages

English (en)

Japanese (ja)

Inventor

フエーンストラ，ローロフ・ダブリユー

ストイト，アクセル

テルプストラ，ヤン−ウイレム

プラス−ラベス，マリア・エル

マクリーリー，アンドリユー・シー

バン・ブリート，ベルナルド・ジエイ

ヘセリンク，マイケ・ビー

クルゼ，コルネリス・ジー

バン・シヤレンブルク，グスターフ・ジエイ・エム

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Abbott Healthcare Products BV

Original Assignee

Abbott Healthcare Products BV

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2004-12-08

Filing date

2005-12-06

Publication date

2008-07-03

2005-12-06 Application filed by Abbott Healthcare Products BV filed Critical Abbott Healthcare Products BV

2008-07-03 Publication of JP2008523031A publication Critical patent/JP2008523031A/ja

Status Withdrawn legal-status Critical Current

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Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
- C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
- C07D263/58—Benzoxazoles; Hydrogenated benzoxazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
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- A61P25/00—Drugs for disorders of the nervous system
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- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

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JP2007544897A 2004-12-08 2005-12-06 部分的ドーパミン−ｄ２受容体作動性とセロトニン再摂取阻害の組み合わせを示すフェニルピペラジン誘導体 Withdrawn JP2008523031A (ja)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US63407404P	2004-12-08	2004-12-08
EP04106394		2004-12-08
PCT/EP2005/056507 WO2006061378A1 (fr)	2004-12-08	2005-12-06	Derives de phenylpiperazine avec combinaison d'agonisme partiel de recepteurs de dopamine-d2 et inhibition de reabsorption de serotonine

Publications (1)

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JP2008523031A true JP2008523031A (ja)	2008-07-03

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Application Number	Title	Priority Date	Filing Date
JP2007544897A Withdrawn JP2008523031A (ja)	2004-12-08	2005-12-06	部分的ドーパミン−ｄ２受容体作動性とセロトニン再摂取阻害の組み合わせを示すフェニルピペラジン誘導体
JP2007544898A Withdrawn JP2008537725A (ja)	2004-12-08	2005-12-06	部分的ドーパミン−ｄ２受容体作動性とセロトニン再摂取阻害の組み合わせを示すフェニルピペラジン誘導体
JP2007544895A Withdrawn JP2008523029A (ja)	2004-12-08	2005-12-06	部分的ドーパミン−ｄ２受容体作動性とセロトニン再摂取阻害の組み合わせを示すアリールオキシエチルアミン誘導体
JP2007544896A Withdrawn JP2008523030A (ja)	2004-12-08	2005-12-06	部分的ドーパミン−ｄ２受容体作動性とセロトニン再摂取阻害の組み合わせを示すフェニルピペラジン誘導体

Family Applications After (3)

Application Number	Title	Priority Date	Filing Date
JP2007544898A Withdrawn JP2008537725A (ja)	2004-12-08	2005-12-06	部分的ドーパミン−ｄ２受容体作動性とセロトニン再摂取阻害の組み合わせを示すフェニルピペラジン誘導体
JP2007544895A Withdrawn JP2008523029A (ja)	2004-12-08	2005-12-06	部分的ドーパミン−ｄ２受容体作動性とセロトニン再摂取阻害の組み合わせを示すアリールオキシエチルアミン誘導体
JP2007544896A Withdrawn JP2008523030A (ja)	2004-12-08	2005-12-06	部分的ドーパミン−ｄ２受容体作動性とセロトニン再摂取阻害の組み合わせを示すフェニルピペラジン誘導体

Country Status (18)

Country	Link
EP (4)	EP1827427B1 (fr)
JP (4)	JP2008523031A (fr)
KR (4)	KR20070085959A (fr)
AT (2)	ATE413173T1 (fr)
AU (4)	AU2005313312A1 (fr)
BR (1)	BRPI0518613A2 (fr)
CA (4)	CA2587381A1 (fr)
DE (2)	DE602005008471D1 (fr)
DK (2)	DK1827427T3 (fr)
ES (2)	ES2317335T3 (fr)
HR (2)	HRP20090015T3 (fr)
IL (4)	IL183062A0 (fr)
NO (4)	NO20072969L (fr)
PL (2)	PL1827427T3 (fr)
PT (2)	PT1824479E (fr)
RU (4)	RU2007125658A (fr)
SI (2)	SI1824479T1 (fr)
WO (4)	WO2006061379A1 (fr)

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BRPI0706778A2 (pt) *	2006-01-30	2011-04-05	Speedel Experimenta Ag	processos para a preparação estéreo-seletiva de álcoois a partir de compostos alfa, beta-insaturados
US8063062B2 (en)	2006-12-20	2011-11-22	Solvay Pharmaceuticals B.V.	Compounds with a combination of cannabinoid-CB1 antagonism and acetylcholinesterase inhibition
US8138174B2 (en)	2007-01-10	2012-03-20	Solvay Pharmaceuticals B.V.	Compounds with a combination of cannabinoid CB1 antagonism and serotonin reuptake inhibition
EA200970672A1 (ru) *	2007-01-10	2010-02-26	Солвей Фармасьютикалс Б.В.	Соединения с комбинацией каннабиноид-свантагонизма и ингибирования обратного захвата серотонина
WO2008128996A1 (fr) *	2007-04-23	2008-10-30	Janssen Pharmaceutica N.V.	Thia(dia)zoles en tant qu'antagonistes du récepteur de la dopamine à dissociation rapide
KR20100016498A (ko) *	2007-04-23	2010-02-12	얀센 파마슈티카 엔.브이.	속해리성 도파민 2 수용체 길항제로서의 피리딘 유도체
JP5431305B2 (ja) *	2007-04-23	2014-03-05	ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ	高速解離性ドパミン２受容体アンタゴニストとしての４−アルコキシピリダジン誘導体
CN103360342B (zh) *	2012-04-09	2015-12-16	江苏恩华药业股份有限公司	3-氰基苯胺烷基芳基哌嗪衍生物及在制备药物中的应用
CN103570698B (zh) *	2012-08-01	2016-08-03	江苏恩华药业股份有限公司	用于制备维拉佐酮的化合物及其中间体和应用
ITMI20130392A1 (it) *	2013-03-15	2014-09-16	Dipharma Francis Srl	Sintesi di un inibitore della ricaptazione della serotonina
US9725463B2 (en)	2013-06-21	2017-08-08	Lupin Limited	Substituted heterocyclic compounds as CRAC modulators
US9790231B2 (en)	2013-06-24	2017-10-17	Lupin Limited	Chromane and chromene derivatives and their use as CRAC modulators
EP3027607B1 (fr)	2013-07-29	2020-08-26	Sunshine Lake Pharma Co., Ltd.	Composés hétéroaryliques substitués et procédés d'utilisation

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FR2692264B1 (fr) *	1992-06-12	1994-08-05	Adir	Nouvelles piperazines 1,4-disubstituees, leur procede de preparation et les compositions pharmaceutiques les contenant.
EP0900792B1 (fr) *	1997-09-02	2003-10-29	Duphar International Research B.V	Dérivés de pipéridine et de pipérazine comme agonistes du récepteur 5-HT1
JP2002510675A (ja) *	1998-04-08	2002-04-09	アメリカン・ホーム・プロダクツ・コーポレイション	うつ病治療用のｎ−アリールオキシエチル−インドリル−アルキルアミン（５−ｈｔ１ａ受容体活性薬）
JP2003521443A (ja) *	1998-06-19	2003-07-15	ハー・ルンドベック・アクチエゼルスカベット	４，５，６及び７−インドール及びインドリン誘導体、その製造方法及びその使用方法
AR022303A1 (es) *	1999-01-22	2002-09-04	Lundbeck & Co As H	Derivados de piperidina, tetrahidropiridina y piperazina, su preparacion y utilizacion
IL148218A0 (en) *	1999-08-23	2002-09-12	Solvay Pharm Bv	New phenylpiperazines
BR0317126A (pt) *	2002-12-10	2005-10-25	Merck Patent Gmbh	Derivados de indol e o uso dos mesmos como ligantes de 5-ht

2005
- 2005-12-06 HR HR20090015T patent/HRP20090015T3/xx unknown
- 2005-12-06 EP EP05850037A patent/EP1827427B1/fr not_active Expired - Lifetime
- 2005-12-06 JP JP2007544897A patent/JP2008523031A/ja not_active Withdrawn
- 2005-12-06 KR KR1020077013015A patent/KR20070085959A/ko not_active Withdrawn
- 2005-12-06 KR KR1020077013063A patent/KR20070085988A/ko not_active Withdrawn
- 2005-12-06 AT AT05816322T patent/ATE413173T1/de not_active IP Right Cessation
- 2005-12-06 RU RU2007125658/04A patent/RU2007125658A/ru not_active Application Discontinuation
- 2005-12-06 JP JP2007544898A patent/JP2008537725A/ja not_active Withdrawn
- 2005-12-06 DE DE602005008471T patent/DE602005008471D1/de not_active Expired - Fee Related
- 2005-12-06 KR KR1020077013041A patent/KR20070085975A/ko not_active Withdrawn
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- 2005-12-06 CA CA002587559A patent/CA2587559A1/fr not_active Abandoned
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- 2005-12-06 RU RU2007125660/04A patent/RU2007125660A/ru not_active Application Discontinuation
- 2005-12-06 WO PCT/EP2005/056508 patent/WO2006061379A1/fr not_active Ceased
- 2005-12-06 WO PCT/EP2005/056505 patent/WO2006061376A1/fr not_active Ceased
- 2005-12-06 SI SI200530416T patent/SI1827427T1/sl unknown
- 2005-12-06 WO PCT/EP2005/056507 patent/WO2006061378A1/fr not_active Ceased
- 2005-12-06 DK DK05816322T patent/DK1824479T3/da active
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- 2005-12-06 AU AU2005313311A patent/AU2005313311A1/en not_active Abandoned
- 2005-12-06 WO PCT/EP2005/056506 patent/WO2006061377A1/fr not_active Ceased
- 2005-12-06 KR KR1020077012935A patent/KR20070085916A/ko not_active Withdrawn
- 2005-12-06 JP JP2007544895A patent/JP2008523029A/ja not_active Withdrawn
- 2005-12-06 DE DE602005010902T patent/DE602005010902D1/de not_active Expired - Fee Related
- 2005-12-06 JP JP2007544896A patent/JP2008523030A/ja not_active Withdrawn
- 2005-12-06 EP EP05816324A patent/EP1824480A1/fr not_active Withdrawn
- 2005-12-06 ES ES05816322T patent/ES2317335T3/es not_active Expired - Lifetime
- 2005-12-06 AU AU2005313391A patent/AU2005313391A1/en not_active Abandoned
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- 2005-12-06 EP EP05813645A patent/EP1827426A1/fr not_active Withdrawn
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- 2005-12-06 CA CA002587357A patent/CA2587357A1/fr not_active Abandoned
- 2005-12-06 PL PL05816322T patent/PL1824479T3/pl unknown
- 2005-12-06 AU AU2005313390A patent/AU2005313390A1/en not_active Abandoned
- 2005-12-06 CA CA002587202A patent/CA2587202A1/fr not_active Abandoned
- 2005-12-06 RU RU2007125659/04A patent/RU2007125659A/ru not_active Application Discontinuation
- 2005-12-06 EP EP05816322A patent/EP1824479B1/fr not_active Expired - Lifetime
2007
- 2007-05-08 IL IL183062A patent/IL183062A0/en unknown
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- 2007-06-11 NO NO20072969A patent/NO20072969L/no not_active Application Discontinuation
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- 2007-06-11 NO NO20072977A patent/NO20072977L/no not_active Application Discontinuation
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Also Published As

Publication number	Publication date
SI1827427T1 (sl)	2008-12-31
EP1824479A1 (fr)	2007-08-29
JP2008523030A (ja)	2008-07-03
KR20070085975A (ko)	2007-08-27
EP1824480A1 (fr)	2007-08-29
ES2317335T3 (es)	2009-04-16
AU2005313312A1 (en)	2006-06-15
EP1827427A1 (fr)	2007-09-05
AU2005313391A1 (en)	2006-06-15
ATE401883T1 (de)	2008-08-15
RU2007125659A (ru)	2009-01-20
CA2587202A1 (fr)	2006-06-15
EP1827426A1 (fr)	2007-09-05
JP2008523029A (ja)	2008-07-03
NO20072974L (no)	2007-08-23
AU2005313311A1 (en)	2006-06-15
WO2006061376A1 (fr)	2006-06-15
DE602005008471D1 (de)	2008-09-04
IL183061A0 (en)	2007-09-20
IL183062A0 (en)	2007-09-20
HRP20080538T3 (en)	2008-12-31
KR20070085988A (ko)	2007-08-27
NO20072981L (no)	2007-09-05
BRPI0518613A2 (pt)	2008-11-25
RU2007125658A (ru)	2009-01-20
WO2006061379A1 (fr)	2006-06-15
NO20072969L (no)	2007-08-31
CA2587357A1 (fr)	2006-06-15
CA2587559A1 (fr)	2006-06-15
PT1827427E (pt)	2008-11-03
IL183063A0 (en)	2007-09-20
DE602005010902D1 (de)	2008-12-18
DK1824479T3 (da)	2009-03-09
AU2005313390A1 (en)	2006-06-15
IL183064A0 (en)	2007-09-20
KR20070085916A (ko)	2007-08-27
CA2587381A1 (fr)	2006-06-15
RU2007125661A (ru)	2009-01-20
ATE413173T1 (de)	2008-11-15
JP2008537725A (ja)	2008-09-25
PL1827427T3 (pl)	2009-01-30
WO2006061378A1 (fr)	2006-06-15
NO20072977L (no)	2007-09-05
KR20070085959A (ko)	2007-08-27
PL1824479T3 (pl)	2009-04-30
SI1824479T1 (sl)	2009-04-30
ES2311245T3 (es)	2009-02-01
RU2007125660A (ru)	2009-01-20
WO2006061377A1 (fr)	2006-06-15
EP1827427B1 (fr)	2008-07-23
DK1827427T3 (da)	2008-11-24
HRP20090015T3 (en)	2009-02-28
PT1824479E (pt)	2009-01-30
EP1824479B1 (fr)	2008-11-05

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Publication	Publication Date	Title
EP1218352B1 (fr)	2004-05-12	Derives de benzimidazolone possedant une affinite mixte envers les recepteurs de serotonine et de dopamine
US8101619B2 (en)	2012-01-24	Phenylpiperazine derivatives with a combination of partial dopamine-D2 receptor agonism and serotonin reuptake inhibition
EP1824479B1 (fr)	2008-11-05	Derives de phenylpiperazine avec combinaison d'agonisme partiel de recepteurs de dopamine-d2 et inhibition de reabsorption de serotonine
ZA200704156B (en)	2008-05-28	Benzdioxane piperazine derivatives with a combination of affinity for dopamine-D2 receptors and serotonin reuptake sites
KR20070091646A (ko)	2007-09-11	도파민-ｄ2 수용체 및 세로토닌 재흡수 위치에 대한친화도를 함께 갖는 페닐피페라진
MX2007006817A (es)	2007-07-24	Derivados de fenilpiperazina con una combinacion de agonismo parcial del receptor de dopamina-d2 e inhibicion de la reabsorcion de serotonina.
US20070142397A2 (en)	2007-06-21	Phenypiperazine derivatives with a combination of partial dopamine-d2 receptor agonism and serotonin reuptake inhibition
ZA200609447B (en)	2008-06-25	Substituted cyclic urea derivatives
US7371769B2 (en)	2008-05-13	Tetrahydropyridin-4-yl indoles with a combination of affinity for dopamine-D2 receptors and serotonin reuptake sites
US20060122175A1 (en)	2006-06-08	Benzdioxane piperazine derivatives with a combination of affinity for dopamine-D2 receptors and serotonin reuptake sites
HK1113903A (en)	2008-10-17	Phenylpiperazine derivatives with a combination of partial dopamine-d2 receptor agonism and serotonin reuptake inhibition
US20060122177A1 (en)	2006-06-08	Phenylpiperazines with a combination of affinity for dopamine-D2 receptors and serotonin reuptake sites
CA2587936A1 (fr)	2006-06-15	Indoles de tetrahydropyridine-4-yle comportant une combinaison de sites a affinite avec des recepteurs de dopamine d2 et inhibant la reabsorption de la serotonine
HK1109343A (en)	2008-06-06	Phenylpiperazine derivatives with a combination of partial dopamine-d2 receptor agonism and serotonin reuptake inhibition
HK1109571A (en)	2008-06-13	Phenylpiperazine derivatives with a combination of partial dopamine-d2 receptor agonism and serotonin reuptake inhibition