JP2008540687A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2008540687A5 JP2008540687A5 JP2008512617A JP2008512617A JP2008540687A5 JP 2008540687 A5 JP2008540687 A5 JP 2008540687A5 JP 2008512617 A JP2008512617 A JP 2008512617A JP 2008512617 A JP2008512617 A JP 2008512617A JP 2008540687 A5 JP2008540687 A5 JP 2008540687A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- group
- aryl
- heteroaryl
- cycloalkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- CYRMSUTZVYGINF-UHFFFAOYSA-N trichlorofluoromethane Chemical compound FC(Cl)(Cl)Cl CYRMSUTZVYGINF-UHFFFAOYSA-N 0.000 claims 403
- 125000000217 alkyl group Chemical group 0.000 claims 244
- 125000003118 aryl group Chemical group 0.000 claims 195
- 125000000753 cycloalkyl group Chemical group 0.000 claims 193
- 125000001072 heteroaryl group Chemical group 0.000 claims 193
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims 163
- 125000005343 heterocyclic alkyl group Chemical group 0.000 claims 161
- 125000003710 aryl alkyl group Chemical group 0.000 claims 124
- 229910052739 hydrogen Inorganic materials 0.000 claims 116
- 239000001257 hydrogen Substances 0.000 claims 116
- 150000002431 hydrogen Chemical class 0.000 claims 106
- 125000001188 haloalkyl group Chemical group 0.000 claims 92
- 150000001875 compounds Chemical class 0.000 claims 88
- 125000004446 heteroarylalkyl group Chemical group 0.000 claims 88
- 125000000304 alkynyl group Chemical group 0.000 claims 85
- 229910052717 sulfur Inorganic materials 0.000 claims 72
- 125000001316 cycloalkyl alkyl group Chemical group 0.000 claims 70
- 229910052799 carbon Inorganic materials 0.000 claims 56
- 125000005843 halogen group Chemical group 0.000 claims 55
- 125000003342 alkenyl group Chemical group 0.000 claims 49
- 125000000623 heterocyclic group Chemical group 0.000 claims 49
- 229910052760 oxygen Inorganic materials 0.000 claims 42
- 125000003709 fluoroalkyl group Chemical group 0.000 claims 36
- 150000001602 bicycloalkyls Chemical group 0.000 claims 32
- 125000005842 heteroatom Chemical group 0.000 claims 30
- 150000001721 carbon Chemical group 0.000 claims 26
- 125000004103 aminoalkyl group Chemical group 0.000 claims 24
- 229910052757 nitrogen Inorganic materials 0.000 claims 22
- 125000003545 alkoxy group Chemical group 0.000 claims 18
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 18
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 18
- 239000000203 mixture Substances 0.000 claims 14
- 150000003839 salts Chemical class 0.000 claims 13
- 201000010099 disease Diseases 0.000 claims 12
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 12
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 10
- 230000001404 mediated effect Effects 0.000 claims 10
- 125000004356 hydroxy functional group Chemical group O* 0.000 claims 8
- 150000001204 N-oxides Chemical class 0.000 claims 7
- YUCFVHQCAFKDQG-UHFFFAOYSA-N fluoromethane Chemical compound F[CH] YUCFVHQCAFKDQG-UHFFFAOYSA-N 0.000 claims 7
- 238000009472 formulation Methods 0.000 claims 7
- 239000000651 prodrug Substances 0.000 claims 7
- 229940002612 prodrug Drugs 0.000 claims 7
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 4
- 102000005741 Metalloproteases Human genes 0.000 claims 4
- 108010006035 Metalloproteases Proteins 0.000 claims 4
- 125000002619 bicyclic group Chemical group 0.000 claims 4
- 125000004122 cyclic group Chemical group 0.000 claims 4
- 125000001153 fluoro group Chemical group F* 0.000 claims 4
- 125000004428 fluoroalkoxy group Chemical group 0.000 claims 4
- 229920006395 saturated elastomer Polymers 0.000 claims 4
- 239000003937 drug carrier Substances 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- 102100027995 Collagenase 3 Human genes 0.000 claims 2
- 108050005238 Collagenase 3 Proteins 0.000 claims 2
- 125000004432 carbon atom Chemical group C* 0.000 claims 2
- 125000006297 carbonyl amino group Chemical group [H]N([*:2])C([*:1])=O 0.000 claims 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 2
- 125000001309 chloro group Chemical group Cl* 0.000 claims 2
- VKUYLANQOAKALN-UHFFFAOYSA-N 2-[benzyl-(4-methoxyphenyl)sulfonylamino]-n-hydroxy-4-methylpentanamide Chemical compound C1=CC(OC)=CC=C1S(=O)(=O)N(C(CC(C)C)C(=O)NO)CC1=CC=CC=C1 VKUYLANQOAKALN-UHFFFAOYSA-N 0.000 claims 1
- 102100027400 A disintegrin and metalloproteinase with thrombospondin motifs 4 Human genes 0.000 claims 1
- 108091005664 ADAMTS4 Proteins 0.000 claims 1
- 201000001320 Atherosclerosis Diseases 0.000 claims 1
- 102100027998 Macrophage metalloelastase Human genes 0.000 claims 1
- 101710187853 Macrophage metalloelastase Proteins 0.000 claims 1
- 102100030411 Neutrophil collagenase Human genes 0.000 claims 1
- 101710118230 Neutrophil collagenase Proteins 0.000 claims 1
- 102100030416 Stromelysin-1 Human genes 0.000 claims 1
- 101710108790 Stromelysin-1 Proteins 0.000 claims 1
- 239000003435 antirheumatic agent Substances 0.000 claims 1
- 230000008512 biological response Effects 0.000 claims 1
- 229940111134 coxibs Drugs 0.000 claims 1
- 239000003260 cyclooxygenase 1 inhibitor Substances 0.000 claims 1
- 230000016396 cytokine production Effects 0.000 claims 1
- 229960003444 immunosuppressant agent Drugs 0.000 claims 1
- 230000001861 immunosuppressant effect Effects 0.000 claims 1
- 239000003018 immunosuppressive agent Substances 0.000 claims 1
- 208000027866 inflammatory disease Diseases 0.000 claims 1
- 230000002757 inflammatory effect Effects 0.000 claims 1
- 239000003112 inhibitor Substances 0.000 claims 1
- 239000003607 modifier Substances 0.000 claims 1
- 201000006417 multiple sclerosis Diseases 0.000 claims 1
- 239000000041 non-steroidal anti-inflammatory agent Substances 0.000 claims 1
- 229940021182 non-steroidal anti-inflammatory drug Drugs 0.000 claims 1
- 201000008482 osteoarthritis Diseases 0.000 claims 1
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 1
- 150000003384 small molecules Chemical class 0.000 claims 1
- 150000003431 steroids Chemical class 0.000 claims 1
- 125000004950 trifluoroalkyl group Chemical group 0.000 claims 1
- 0 C*N(*)C(C1=O)=C(*)C1=O Chemical compound C*N(*)C(C1=O)=C(*)C1=O 0.000 description 8
- HZXKDXQJOUWZBL-WHERFPGRSA-N CCC(C1C2=CCC2[C@H](C)C1)I Chemical compound CCC(C1C2=CCC2[C@H](C)C1)I HZXKDXQJOUWZBL-WHERFPGRSA-N 0.000 description 1
- NQVGOJWKNOFTHT-UHFFFAOYSA-N OC(C1(C2C34)C5C23C2C4(CNC(c3cc(C(NCc(cc4)cc(OC(F)F)c4F)=O)nc4ccn[n]34)=O)C5C12)=O Chemical compound OC(C1(C2C34)C5C23C2C4(CNC(c3cc(C(NCc(cc4)cc(OC(F)F)c4F)=O)nc4ccn[n]34)=O)C5C12)=O NQVGOJWKNOFTHT-UHFFFAOYSA-N 0.000 description 1
- NHFDHHSIROMKHM-UHFFFAOYSA-N OC(c1ccc(CNc2n[nH]c3c2ncnc3C(NCc(cc2)cc(Cl)c2F)=O)cc1)=O Chemical compound OC(c1ccc(CNc2n[nH]c3c2ncnc3C(NCc(cc2)cc(Cl)c2F)=O)cc1)=O NHFDHHSIROMKHM-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US68347005P | 2005-05-20 | 2005-05-20 | |
| US60/683,470 | 2005-05-20 | ||
| US70646505P | 2005-08-08 | 2005-08-08 | |
| US60/706,465 | 2005-08-08 | ||
| US73499105P | 2005-11-09 | 2005-11-09 | |
| US60/734,991 | 2005-11-09 | ||
| PCT/US2006/020970 WO2006128184A2 (en) | 2005-05-20 | 2006-05-22 | Pyrimidine or triazine fused bicyclic metalloprotease inhibitors |
Related Child Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013089076A Division JP5391351B2 (ja) | 2005-05-20 | 2013-04-22 | ヘテロ二環式メタロプロテアーゼ阻害薬 |
| JP2013254709A Division JP2014088396A (ja) | 2005-05-20 | 2013-12-10 | ヘテロ二環式メタロプロテアーゼ阻害薬 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008540687A JP2008540687A (ja) | 2008-11-20 |
| JP2008540687A5 true JP2008540687A5 (2) | 2009-07-30 |
| JP5463034B2 JP5463034B2 (ja) | 2014-04-09 |
Family
ID=37239216
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008512617A Expired - Fee Related JP5463034B2 (ja) | 2005-05-20 | 2006-05-22 | ピリミジン若しくはトリアジン縮合二環式メタロプロテアーゼ阻害薬 |
| JP2013089076A Expired - Fee Related JP5391351B2 (ja) | 2005-05-20 | 2013-04-22 | ヘテロ二環式メタロプロテアーゼ阻害薬 |
| JP2013254709A Withdrawn JP2014088396A (ja) | 2005-05-20 | 2013-12-10 | ヘテロ二環式メタロプロテアーゼ阻害薬 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013089076A Expired - Fee Related JP5391351B2 (ja) | 2005-05-20 | 2013-04-22 | ヘテロ二環式メタロプロテアーゼ阻害薬 |
| JP2013254709A Withdrawn JP2014088396A (ja) | 2005-05-20 | 2013-12-10 | ヘテロ二環式メタロプロテアーゼ阻害薬 |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US20060293345A1 (2) |
| EP (1) | EP1910367A2 (2) |
| JP (3) | JP5463034B2 (2) |
| KR (1) | KR20080087070A (2) |
| CN (1) | CN101238127A (2) |
| AU (1) | AU2006251989B2 (2) |
| BR (1) | BRPI0609802A2 (2) |
| CA (1) | CA2608890C (2) |
| CR (1) | CR9614A (2) |
| EA (1) | EA013525B1 (2) |
| IL (1) | IL187495A0 (2) |
| NO (1) | NO20076554L (2) |
| WO (1) | WO2006128184A2 (2) |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20070155737A1 (en) * | 2005-05-20 | 2007-07-05 | Alantos Pharmaceuticals, Inc. | Heterobicyclic metalloprotease inhibitors |
| US20070155738A1 (en) * | 2005-05-20 | 2007-07-05 | Alantos Pharmaceuticals, Inc. | Heterobicyclic metalloprotease inhibitors |
| US20090238763A1 (en) | 2006-07-09 | 2009-09-24 | Chongxi Yu | High penetration compositions and uses thereof |
| US20090221703A1 (en) | 2006-07-09 | 2009-09-03 | Chongxi Yu | High penetration composition and uses thereof |
| AU2007321922A1 (en) * | 2006-11-20 | 2008-05-29 | Alantos Pharmaceuticals Holding, Inc. | Heterobicyclic matrix metalloprotease inhibitors |
| CA2670083A1 (en) * | 2006-11-20 | 2008-05-29 | Alantos Pharmaceuticals Holding, Inc. | Heterobicyclic metalloprotease inhibitors |
| AU2008223348A1 (en) * | 2007-03-07 | 2008-09-12 | Alantos Pharmaceuticals Holding, Inc. | Metalloprotease inhibitors containing a heterocyclic moiety |
| WO2008149181A1 (en) * | 2007-06-04 | 2008-12-11 | Techfields Inc | Pro-drugs of nsaias with very high skin and membranes penetration rates and their new medicinal uses |
| WO2009075790A1 (en) * | 2007-12-07 | 2009-06-18 | Alantos Pharmaceuticals Holding, Inc. | Metalloprotease inhibitors for intra-articular application |
| LT2303270T (lt) | 2008-05-05 | 2017-09-11 | Sanofi | Acilamino-pakeistieji sulieti ciklopentankarboksirūgšties dariniai ir jų panaudojimas kaip vaistų |
| RU2630577C2 (ru) | 2008-12-04 | 2017-09-11 | Чунси ЮЙ | Композиции интенсивного проникновения и их применение |
| AR079022A1 (es) | 2009-11-02 | 2011-12-21 | Sanofi Aventis | Derivados de acido carboxilico ciclico sustituidos con acilamino, su uso como productos farmaceuticos, composicion farmaceutica y metodo de preparacion |
| CN101709034B (zh) * | 2009-12-14 | 2017-05-31 | 大连九信精细化工有限公司 | 双环[2.2.2]辛烷‑1，4‑二羧酸单甲酯的合成方法 |
| WO2011082271A2 (en) | 2009-12-30 | 2011-07-07 | Arqule, Inc. | Substituted triazolo-pyrimidine compounds |
| CA2820362C (en) | 2010-12-08 | 2020-03-24 | The United States Of America, As Represented By The Secretary, Departmt Of Health And Human Services | Substituted pyrazolopyrimidines as glucocerebrosidase activators |
| JP2014517079A (ja) | 2011-06-22 | 2014-07-17 | バーテックス ファーマシューティカルズ インコーポレイテッド | Ａｔｒキナーゼ阻害剤として有用な化合物 |
| KR101935868B1 (ko) | 2011-12-30 | 2019-04-03 | 에스케이이노베이션 주식회사 | 폴리프로필렌 카보네이트 발포체 조성물 제조방법 및 이로부터 제조된 성형품 |
| ES2969344T3 (es) | 2012-01-18 | 2024-05-17 | Techfields Pharma Co Ltd | Composiciones de profármaco de alta penetración y composición farmacéutica del mismo para el tratamiento de afecciones pulmonares |
| SMT202000713T1 (it) | 2012-12-07 | 2021-03-15 | Vertex Pharma | Pirazolo [1,5-a] pirimidine utili come inibitori dell'atr chinasi per il trattamento di malattie del cancro |
| CN114558032B (zh) | 2012-12-21 | 2025-07-29 | 安斯泰来再生医药协会 | 由多能干细胞制备血小板的方法及其组合物 |
| JP2016512815A (ja) | 2013-03-15 | 2016-05-09 | バーテックス ファーマシューティカルズ インコーポレイテッドＶｅｒｔｅｘ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃｏｒｐｏｒａｔｅｄ | Ａｔｒキナーゼの阻害剤として有用な縮合ピラゾロピリミジン誘導体 |
| WO2014143241A1 (en) | 2013-03-15 | 2014-09-18 | Vertex Pharmaceuticals Incorporated | Compounds useful as inhibitors of atr kinase |
| EP2970288A1 (en) | 2013-03-15 | 2016-01-20 | Vertex Pharmaceuticals Incorporated | Compounds useful as inhibitors of atr kinase |
| HUE046727T2 (hu) | 2013-12-06 | 2020-03-30 | Vertex Pharma | Az ATR-kináz inhibitoraként használható vegyület, 2-amino-6-fluoro-N-[5-fluoro-piridin-3-IL]-pirazolo-[1,5-A]-pirimidin-3-karboxamid, ennek elõállítása, különbözõ szilárd formái és ezek radioaktív nyomjelzett származékai |
| CN107074863B (zh) | 2014-06-05 | 2019-12-03 | 沃泰克斯药物股份有限公司 | Atr激酶抑制剂的制备方法及其不同的固体形式 |
| PL3157566T3 (pl) | 2014-06-17 | 2019-10-31 | Vertex Pharma | Metoda leczenia nowotworu przy użyciu kombinacji inhibitorów chk1 i atr |
| CN104326914A (zh) * | 2014-11-18 | 2015-02-04 | 江苏恒祥化工有限责任公司 | 一种反式-4-甲酸甲酯环己烷甲酸的制备方法 |
| WO2016103042A1 (en) | 2014-12-25 | 2016-06-30 | Guangzhou Ribobio Co., Ltd. | Compositions and methods for inhibiting expression of adamts-5 and adam17 |
| CN104560997B (zh) * | 2014-12-25 | 2018-05-04 | 中国科学院广州生物医药与健康研究院 | 抑制ADAMTS-5和ADAM17基因的siRNA组合物及其应用 |
| KR102678021B1 (ko) | 2015-09-30 | 2024-06-26 | 버텍스 파마슈티칼스 인코포레이티드 | Dna 손상제와 병용되는, atr 저해제를 포함하는 암 치료용 약제학적 조성물 |
| US10633315B2 (en) | 2016-10-19 | 2020-04-28 | Eastman Chemical Company | Synthesis of bicyclo[2.2.2]octanes |
| WO2019075004A1 (en) * | 2017-10-11 | 2019-04-18 | Eastman Chemical Company | SYNTHESIS OF BICYCLO [2.2.2] OCTANE DERIVATIVES |
| CN117964573B (zh) * | 2018-01-19 | 2026-04-14 | 赛特凯恩蒂克公司 | 作为心肌节抑制剂的二氢苯并呋喃和茚类似物 |
| CN108558672B (zh) * | 2018-06-21 | 2021-04-30 | 利尔化学股份有限公司 | 2-硝基-4-三氟甲基苯甲酸及其异构体的制备方法 |
| WO2020063636A1 (zh) * | 2018-09-27 | 2020-04-02 | 苏州锐明新药研发有限公司 | 吡唑并嘧啶化合物及制备方法与制备抗癌症药物的应用 |
| US10836899B2 (en) | 2018-12-13 | 2020-11-17 | Eastman Chemical Company | Polyesters with specified crystallization half-times |
| CN116283995B (zh) * | 2022-09-08 | 2023-12-29 | 华中科技大学同济医学院附属同济医院 | 一种脂酰辅酶a合成酶短链家族成员3的激动剂及其应用 |
| CN116969831B (zh) * | 2023-08-01 | 2025-09-23 | 菏泽皓元医药科技有限公司 | 一种莫奈太尔的中间体及其制备方法 |
Family Cites Families (79)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4497814A (en) * | 1982-08-16 | 1985-02-05 | Schering Corporation | 2-(Pyridinyl)-1,2,4-triazolo[1,5-a]pyrimidines and derivatives useful in increasing cardiac contractility |
| JPH0750322B2 (ja) * | 1986-06-25 | 1995-05-31 | 富士写真フイルム株式会社 | ハロゲン化銀カラ−写真感光材料の処理方 |
| DE3704203A1 (de) * | 1987-02-11 | 1988-08-25 | Boehringer Ingelheim Kg | Verwendung von oxochinazolinderivaten bei der behandlung der hyperurikaemie |
| FI883320L (fi) * | 1987-08-07 | 1989-02-08 | Sankei Yakuhin Kk | --laktam, dess framstaellning och mellanprodukter foer dess framstaellning. |
| US5236917A (en) * | 1989-05-04 | 1993-08-17 | Sterling Winthrop Inc. | Saccharin derivatives useful as proteolytic enzyme inhibitors and compositions and method of use thereof |
| US5716964A (en) * | 1989-12-04 | 1998-02-10 | G.D. Searle & Co. | Tetrazolyl substituted imidazo 1,2-a!pyridinylalkyl compounds for treatment of neurotoxic injury |
| KR910011852A (ko) * | 1989-12-04 | 1991-08-07 | 폴 디. 매튜카이티스 | 신경독 장해 치료용 이미다조[1,2-a]피리디닐알킬 화합물 |
| DE3942357A1 (de) * | 1989-12-21 | 1991-06-27 | Boehringer Mannheim Gmbh | 3-aminopyrazolo-heterocyclen, deren verwendung zur bestimmung von wasserstoffperoxid, wasserstoffperoxid-bildenden systemen, peroxidase, peroxidatisch wirksamen substanzen oder von elektronenreichen aromatischen verbindungen, entsprechende bestimmungsverfahren und hierfuer geeignete mittel |
| US5955470A (en) * | 1991-06-11 | 1999-09-21 | Merrell Pharmaceuticals, Inc. | Derivatives of amide analogs of certain methano bridged quinolizines |
| CA2113115A1 (en) * | 1991-07-29 | 1993-02-18 | Vlad E. Gregor | Quinazoline derivatives as acetylcholinesterase inhibitors |
| DK0662004T3 (da) * | 1991-08-09 | 1998-10-19 | Nycomed Innovation Ab | Anvendelse af stabile frie radikaler ved magnetiskresonans-billeddannnelse |
| US5302586A (en) * | 1991-12-19 | 1994-04-12 | G. D. Searle & Co. | Phosphonomethyl-imidazo[1,2-a]pyrimidine-2-carboxylic acid compounds for treatment of neurotoxic injury |
| FR2687675B1 (fr) * | 1992-01-31 | 1997-04-18 | Roussel Uclaf | Nouveaux derives bicycliques de la pyridine, leur procede de preparation, les nouveaux intermediaires obtenus, leur application a titre de medicaments et les compositions pharmaceutiques les renfermant. |
| JP2794510B2 (ja) * | 1992-03-27 | 1998-09-10 | 富士写真フイルム株式会社 | ハロゲン化銀写真感光材料 |
| US5464843A (en) * | 1992-06-23 | 1995-11-07 | G.D. Searle & Co. | Imidazo[1,2-a]pyridinyldiacid compounds for cognitive enhancement and for treatment of cognitive disorders and neutrotoxic injury |
| MX9304801A (es) * | 1992-08-06 | 1997-06-28 | Warner Lambert Co | 2-toindoles (selenoidoles) disulfuros (seleniduros) relacinados, los cuales inhiben a las proteinas tirosina cinasas y los cuales tienen propiedades anti-tumorales. |
| DE4327027A1 (de) * | 1993-02-15 | 1994-08-18 | Bayer Ag | Imidazoazine |
| DE4311460A1 (de) * | 1993-04-08 | 1994-10-13 | Boehringer Mannheim Gmbh | Verfahren zur kolorimetrischen Bestimmung eines Analyten mittels Benzylalkoholdehydrogenase und einem chromogenen Redoxindikator |
| DE4311464A1 (de) * | 1993-04-08 | 1994-10-13 | Boehringer Mannheim Gmbh | Verfahren zur kolorimetrischen Bestimmung eines Analyten mit einer PQQ-abhängigen Dehydrogenase |
| JPH11500123A (ja) * | 1995-02-15 | 1999-01-06 | ファルマシア・アンド・アップジョン・カンパニー | ＣＮＳおよび心臓病の治療のためのイミダゾ［１，２−ａ］ピリジン類 |
| HUP9801135A2 (hu) * | 1995-05-09 | 1998-08-28 | Basf Aktiengesellschaft | Pirazolo[1,5-a]pirimidinek, eljárás előállításukra és alkalmazásuk |
| US5760028A (en) * | 1995-12-22 | 1998-06-02 | The Dupont Merck Pharmaceutical Company | Integrin receptor antagonists |
| IT1286545B1 (it) * | 1996-02-09 | 1998-07-15 | Antonio Guarna | Derivati benzo(c) chinolizinici,loro preparazione ed uso come inibitori delle 5-alfa-riduttasi |
| AR015104A1 (es) * | 1996-11-13 | 2001-04-18 | Dowelanco | Compuestos de n-arilsulfilimina sustituidos, utiles como catalizadores en la preparacion de compuestos de n-arilarilsulfonamida; proceso para preparar dichos compuestos y su uso para catalizar dicha preparacion. |
| WO1998039342A1 (en) * | 1997-03-07 | 1998-09-11 | Metabasis Therapeutics, Inc. | Novel indole and azaindole inhibitors of fructose-1,6-bisphosphatase |
| US6110944A (en) * | 1997-03-12 | 2000-08-29 | G. D. Searle & Co. | LTA4, hydrolase inhibitors |
| WO1998043962A1 (en) * | 1997-03-28 | 1998-10-08 | Du Pont Pharmaceuticals Company | Heterocyclic integrin inhibitor prodrugs |
| ITFI970193A1 (it) * | 1997-08-01 | 1999-02-01 | Applied Research Systems | Uso di derivati benzo(c) chinolizinici come regolatori della crescita delle piante e composizioni ad uso agricolo che contengono tali |
| US6013654A (en) * | 1997-08-14 | 2000-01-11 | Pharmacia & Upjohn Company | Imidazo[1,2-A]pyridines for the treatment of CNS and cardiac diseases |
| JP3773227B2 (ja) * | 1997-10-16 | 2006-05-10 | 東京応化工業株式会社 | レジスト用剥離液組成物およびこれを用いたレジスト剥離方法 |
| US6187777B1 (en) * | 1998-02-06 | 2001-02-13 | Amgen Inc. | Compounds and methods which modulate feeding behavior and related diseases |
| AUPP278498A0 (en) * | 1998-04-03 | 1998-04-30 | Australian Nuclear Science & Technology Organisation | Peripheral benzodiazepine receptor binding agents |
| US6232320B1 (en) * | 1998-06-04 | 2001-05-15 | Abbott Laboratories | Cell adhesion-inhibiting antiinflammatory compounds |
| US6319660B1 (en) * | 1998-12-28 | 2001-11-20 | Eastman Kodak Company | Color photographic element containing speed improving compound |
| US6190848B1 (en) * | 1999-07-21 | 2001-02-20 | Eastman Kodak Company | Color photographic element containing ballasted triazole derivative and inhibitor releasing coupler |
| GB9919778D0 (en) * | 1999-08-21 | 1999-10-27 | Zeneca Ltd | Chemical compounds |
| FR2801308B1 (fr) * | 1999-11-19 | 2003-05-09 | Oreal | COMPOSITIONS DE TEINTURE DE FIBRES KERATINIQUES CONTENANT DE DES 3-AMINO PYRAZOLO-[1,(-a]-PYRIDINES, PROCEDE DE TEINTURE, NOUVELLES 3-AMINO PYRAZOLO-[1,5-a]-PYRIDINES |
| US6461538B2 (en) * | 1999-12-16 | 2002-10-08 | Fuji Photo Film Co., Ltd. | Production process for indolizine compounds and their use in organic light-emitting devices |
| US6770666B2 (en) * | 1999-12-27 | 2004-08-03 | Japan Tobacco Inc. | Fused-ring compounds and use thereof as drugs |
| FR2805539B1 (fr) * | 2000-02-25 | 2005-06-10 | Oreal | Compositions de teinture des fibres keratiniques contenant des derives d'indolizine et procede de teinture |
| JP2001348520A (ja) * | 2000-04-03 | 2001-12-18 | Fuji Photo Film Co Ltd | メチン化合物、固体微粒子分散物、インクジェット用記録液、およびインクジェット記録方法 |
| US6403588B1 (en) * | 2000-04-27 | 2002-06-11 | Yamanouchi Pharmaceutical Co., Ltd. | Imidazopyridine derivatives |
| CA2407677A1 (en) * | 2000-04-28 | 2002-10-28 | Baxter Healthcare Sa | 2-acyl indol derivatives and their use as anti-tumour agents |
| JP2004502691A (ja) * | 2000-06-30 | 2004-01-29 | ワイス | 抗癌薬としての置換トリアゾロピリミジン |
| US20020041880A1 (en) * | 2000-07-05 | 2002-04-11 | Defeo-Jones Deborah | Method of treating cancer |
| AUPQ969800A0 (en) * | 2000-08-28 | 2000-09-21 | Fujisawa Pharmaceutical Co., Ltd. | Pyrazolopyridine compound and pharmaceutical use thereof |
| TWI243019B (en) * | 2000-08-31 | 2005-11-11 | Basf Ag | Process for the preparation of a solid herbicidal formulation |
| JP2002205992A (ja) * | 2000-11-08 | 2002-07-23 | Takeda Chem Ind Ltd | 二環式トリアゾロン誘導体およびそれを含有する除草剤 |
| ATE301653T1 (de) * | 2000-12-15 | 2005-08-15 | Glaxo Group Ltd | Pyrazolopyridine |
| JP2004518723A (ja) * | 2001-02-14 | 2004-06-24 | ワーナー−ランバート・カンパニー、リミテッド、ライアビリティ、カンパニー | ピリミジンマトリックスメタロプロテイナーゼ阻害剤 |
| PA8539501A1 (es) * | 2001-02-14 | 2002-09-30 | Warner Lambert Co | Compuestos triazolo como inhibidores de mmp |
| BR0207096A (pt) * | 2001-02-20 | 2004-01-20 | Astrazeneca Ab | Uso de um composto, compostos, formulação farmacêutica, e, método de tratamento e/ou profilaxia de condições associadas com a inibição de glicogênio sintase quinase-3 |
| EP1372643A1 (en) * | 2001-03-30 | 2004-01-02 | Smithkline Beecham Corporation | Pyrazolopyridines, process for their preparation and use as therapeutic compounds |
| US6756498B2 (en) * | 2001-04-27 | 2004-06-29 | Smithkline Beecham Corporation | Process for the preparation of chemical compounds |
| US20030027820A1 (en) * | 2001-05-30 | 2003-02-06 | Alteon, Inc. | Method for treating fibrotic diseases or other indications V |
| AR035543A1 (es) * | 2001-06-26 | 2004-06-16 | Japan Tobacco Inc | Agente terapeutico para la hepatitis c que comprende un compuesto de anillo condensado, compuesto de anillo condensado, composicion farmaceutica que lo comprende, compuestos de benzimidazol, tiazol y bifenilo utiles como intermediarios para producir dichos compuestos, uso del compuesto de anillo con |
| US20040116462A1 (en) * | 2002-12-12 | 2004-06-17 | Mitsunori Ono | Indolizine compounds |
| IL160810A0 (en) * | 2001-09-13 | 2004-08-31 | Synta Pharmaceuticals Corp | 1-glyoxlylamide indolizines for treating cancer |
| EP1427408A4 (en) * | 2001-09-17 | 2005-10-26 | Bristol Myers Squibb Co | CYCLIC HYDROXAMINE ACIDS AS INHIBITORS OF MATRIX METALLOPROTEINASES AND / OR TNF-a-CONVERTASE (TACE TNF-a-CONVERTING ENZYM) |
| DE10160357A1 (de) * | 2001-12-08 | 2003-06-18 | Aventis Pharma Gmbh | Verwendung von Pyridin-2,4-dicarbonsäurediamiden und Pyrimidin-4,6-dicarbonsäurediamiden zur selektiven Inhibierung von Kollagenasen |
| EP1479681A4 (en) * | 2002-01-31 | 2006-05-10 | Daiichi Seiyaku Co | IMIDAZO (1,2-a) pyridine |
| US20050165232A1 (en) * | 2002-05-13 | 2005-07-28 | Richard Beresis | Phenyl substituted imidaopyridines and phenyl substituted benzimidazoles |
| EP1511751B1 (en) * | 2002-06-04 | 2008-03-19 | Neogenesis Pharmaceuticals, Inc. | Pyrazolo[1,5-a]pyrimidine compounds as antiviral agents |
| AU2003249535A1 (en) * | 2002-08-13 | 2004-02-25 | Warner-Lambert Company Llc | 1,6-fused uracil derivatives as matrix metalloproteinase inhibitors |
| AU2003253165A1 (en) * | 2002-08-13 | 2004-02-25 | Warner-Lambert Company Llc | Pyrimidine fused bicyclic metalloproteinase inhibitors |
| MXPA05004365A (es) * | 2002-11-02 | 2005-07-05 | Aventis Pharma Gmbh | Nuevas diamidas del acido pirimidin -4, 6 - dicarboxilico para la inhibicion selectiva de colagenasas. |
| RU2005118421A (ru) * | 2002-11-15 | 2006-01-20 | Айденикс (Кайман) Лимитед (Ky) | 2'-разветвленные нуклеозиды и мутация flaviviridae |
| AU2003299651A1 (en) * | 2002-12-11 | 2004-06-30 | Merck And Co., Inc. | Tyrosine kinase inhibitors |
| CA2517034A1 (en) * | 2003-03-13 | 2004-09-30 | Synta Pharmaceuticals Corp. | Fused pyrrole compounds |
| EP2258365B1 (en) * | 2003-03-28 | 2013-05-29 | Novartis Vaccines and Diagnostics, Inc. | Use of organic compounds for immunopotentiation |
| US7235569B2 (en) * | 2003-05-02 | 2007-06-26 | Wyeth | Piperidinyl indole and tetrohydropyridinyl indole derivatives and method of their use |
| US20050096256A1 (en) * | 2003-07-01 | 2005-05-05 | President And Fellows Of Harvard College | Compositions for manipulating the lifespan and stress response of cells and organisms |
| EP1653968A4 (en) * | 2003-07-23 | 2006-09-06 | Synta Pharmaceuticals Corp | METHOD FOR MODULATING CALCIUMION RELIEF ACTIVATED CALCIUMION CHANNELS |
| FR2857966A1 (fr) * | 2003-07-24 | 2005-01-28 | Aventis Pharma Sa | Produits aryl-heteroaromatiques, compositions les contenant et utilisation |
| US7144907B2 (en) * | 2003-09-03 | 2006-12-05 | Array Biopharma Inc. | Heterocyclic inhibitors of MEK and methods of use thereof |
| US20060173183A1 (en) * | 2004-12-31 | 2006-08-03 | Alantos Pharmaceuticals, Inc., | Multicyclic bis-amide MMP inhibitors |
| US20070155738A1 (en) * | 2005-05-20 | 2007-07-05 | Alantos Pharmaceuticals, Inc. | Heterobicyclic metalloprotease inhibitors |
| US20070155737A1 (en) * | 2005-05-20 | 2007-07-05 | Alantos Pharmaceuticals, Inc. | Heterobicyclic metalloprotease inhibitors |
| WO2007079199A2 (en) * | 2005-12-30 | 2007-07-12 | Alantos Pharmaceuticals, Holding, Inc. | Substituted bis-amide metalloprotease inhibitors |
-
2006
- 2006-05-22 US US11/440,087 patent/US20060293345A1/en not_active Abandoned
- 2006-05-22 AU AU2006251989A patent/AU2006251989B2/en not_active Ceased
- 2006-05-22 EA EA200702568A patent/EA013525B1/ru not_active IP Right Cessation
- 2006-05-22 KR KR1020077029688A patent/KR20080087070A/ko not_active Abandoned
- 2006-05-22 CN CNA2006800262633A patent/CN101238127A/zh active Pending
- 2006-05-22 CA CA2608890A patent/CA2608890C/en not_active Expired - Fee Related
- 2006-05-22 EP EP20060760560 patent/EP1910367A2/en not_active Withdrawn
- 2006-05-22 BR BRPI0609802A patent/BRPI0609802A2/pt not_active IP Right Cessation
- 2006-05-22 WO PCT/US2006/020970 patent/WO2006128184A2/en not_active Ceased
- 2006-05-22 JP JP2008512617A patent/JP5463034B2/ja not_active Expired - Fee Related
-
2007
- 2007-11-19 IL IL187495A patent/IL187495A0/en unknown
- 2007-12-07 US US12/001,041 patent/US20080161300A1/en not_active Abandoned
- 2007-12-19 CR CR9614A patent/CR9614A/es not_active Application Discontinuation
- 2007-12-19 NO NO20076554A patent/NO20076554L/no not_active Application Discontinuation
-
2013
- 2013-04-22 JP JP2013089076A patent/JP5391351B2/ja not_active Expired - Fee Related
- 2013-12-10 JP JP2013254709A patent/JP2014088396A/ja not_active Withdrawn
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| RU2370495C2 (ru) | Дополнительные гетероциклические соединения и их применение в качестве антагонистов метаботропного глутаматного рецептора | |
| RU2007120454A (ru) | Производные хинуклидина и их применение в качестве антагонистов мускариновых рецепторов м3 | |
| JP2006502119A5 (2) | ||
| JP2006500394A5 (2) | ||
| JP2018524339A5 (2) | ||
| JP2004530641A5 (2) | ||
| JP2002543185A5 (2) | ||
| JP2006506352A5 (2) | ||
| WO2005037216A3 (en) | Bicyclic [3.1.0] derivatives as glycine transporter inhibitors | |
| JP2007517006A5 (2) | ||
| DE60309829D1 (de) | Glucocorticoid mimetika, verfahren zu ihrer herstellung, pharmazeutische formulierungen sie enthaltend und verwendungen davon | |
| JP2010526079A5 (2) | ||
| KR960705795A (ko) | 항염증제로서의 이속사졸린 화합물(isoxazoline compounds as antinflammatiory agents) | |
| CA2652834A1 (en) | Substituted arylimidazolones and -triazolones and the use thereof | |
| JP2015501833A5 (2) | ||
| JP2003506491A5 (2) | ||
| JP2006512293A5 (2) | ||
| ATE402175T1 (de) | 4-oxo-1-(3-substituiertesphenyl)-1,4-dihydro-1, - naphthyridin-3-carbonsäureamide alsphoshodiesterase-4-inhibitoren | |
| JP2008514650A5 (2) | ||
| JP2002515427A5 (2) | ||
| JP2004529145A5 (2) | ||
| RU2007108863A (ru) | Производные пиразола для лечения состояний, опосредованных активацией рецептора аденозина а2в или а3 | |
| JP2017537911A5 (2) | ||
| JP2005529842A5 (2) | ||
| RU2006144710A (ru) | Новые производные циклопента [b] бензофурана и их применение |