JP2011006480A5 - - Google Patents

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Publication number: JP2011006480A5
Authority: JP; Japan
Prior art keywords: group; compound; cancer; lower alkyl; substituted
Prior art date: 2010-10-08
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Granted

Application number

JP2010228356A

Other languages

English (en)

Japanese (ja)

Other versions

JP5679757B2 (ja

JP2011006480A (ja

Filing date

2010-10-08

Publication date

2011-11-17

2010-10-08 Application filed filed Critical

2011-01-13 Publication of JP2011006480A publication Critical patent/JP2011006480A/ja

2011-11-17 Publication of JP2011006480A5 publication Critical patent/JP2011006480A5/ja

2015-03-04 Application granted granted Critical

2015-03-04 Publication of JP5679757B2 publication Critical patent/JP5679757B2/ja

2023-11-07 Anticipated expiration legal-status Critical

Status Expired - Fee Related legal-status Critical Current

Links

150000001875 compounds Chemical class 0.000 claims 9
125000000217 alkyl group Chemical group 0.000 claims 6
201000010099 disease Diseases 0.000 claims 4
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 4
230000003463 hyperproliferative effect Effects 0.000 claims 4
125000001475 halogen functional group Chemical group 0.000 claims 3
125000004765 (C1-C4) haloalkyl group Chemical group 0.000 claims 2
241001465754 Metazoa Species 0.000 claims 2
206010028980 Neoplasm Diseases 0.000 claims 2
201000011510 cancer Diseases 0.000 claims 2
239000003814 drug Substances 0.000 claims 2
125000002887 hydroxy group Chemical group [H]O* 0.000 claims 2
125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 2
150000003839 salts Chemical class 0.000 claims 2
125000004105 2-pyridyl group Chemical group N1=C([*])C([H])=C([H])C([H])=C1[H] 0.000 claims 1
201000001320 Atherosclerosis Diseases 0.000 claims 1
206010006187 Breast cancer Diseases 0.000 claims 1
208000026310 Breast neoplasm Diseases 0.000 claims 1
206010009944 Colon cancer Diseases 0.000 claims 1
208000001333 Colorectal Neoplasms Diseases 0.000 claims 1
201000004681 Psoriasis Diseases 0.000 claims 1
239000013543 active substance Substances 0.000 claims 1
125000004945 acylaminoalkyl group Chemical group 0.000 claims 1
125000003342 alkenyl group Chemical group 0.000 claims 1
125000003545 alkoxy group Chemical group 0.000 claims 1
125000003282 alkyl amino group Chemical group 0.000 claims 1
125000005277 alkyl imino group Chemical group 0.000 claims 1
125000000304 alkynyl group Chemical group 0.000 claims 1
125000000852 azido group Chemical group *N=[N+]=[N-] 0.000 claims 1
ICCBZGUDUOMNOF-UHFFFAOYSA-N azidoamine Chemical compound NN=[N+]=[N-] ICCBZGUDUOMNOF-UHFFFAOYSA-N 0.000 claims 1
230000001413 cellular effect Effects 0.000 claims 1
125000004093 cyano group Chemical group *C#N 0.000 claims 1
125000000753 cycloalkyl group Chemical group 0.000 claims 1
125000004663 dialkyl amino group Chemical group 0.000 claims 1
239000003937 drug carrier Substances 0.000 claims 1
-1 hydroxy, hydroxy Chemical group 0.000 claims 1
238000004519 manufacturing process Methods 0.000 claims 1
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
201000006417 multiple sclerosis Diseases 0.000 claims 1
208000002154 non-small cell lung carcinoma Diseases 0.000 claims 1
125000004043 oxo group Chemical group O=* 0.000 claims 1
208000037803 restenosis Diseases 0.000 claims 1
206010039073 rheumatoid arthritis Diseases 0.000 claims 1
125000005309 thioalkoxy group Chemical group 0.000 claims 1
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 1
208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 claims 1

JP2010228356A 2002-11-07 2010-10-08 トランス−９，１０−デヒドロエポチロンｃおよびｄ、それらのアナログ、ならびにそれらを作製する方法 Expired - Fee Related JP5679757B2 (ja)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date
US42535202P	2002-11-07	2002-11-07
US60/425,352		2002-11-07
US47374303P	2003-05-27	2003-05-27
US60/473,743		2003-05-27

Related Parent Applications (1)

Application Number	Title	Priority Date	Filing Date
JP2005507102A Division JP4641941B2 (ja)	2002-11-07	2003-11-07	トランス−９，１０−デヒドロエポチロンｃおよびｄ、それらのアナログ、ならびにそれらを作製する方法

Related Child Applications (1)

Application Number	Title	Priority Date	Filing Date
JP2013147528A Division JP2013213054A (ja)	2002-11-07	2013-07-16	トランス−９，１０−デヒドロエポチロンｃおよびｄ、それらのアナログ、ならびにそれらを作製する方法

Publications (3)

Publication Number	Publication Date
JP2011006480A JP2011006480A (ja)	2011-01-13
JP2011006480A5 true JP2011006480A5 (2)	2011-11-17
JP5679757B2 JP5679757B2 (ja)	2015-03-04

Family

ID=32314587

Family Applications (3)

Application Number	Title	Priority Date	Filing Date
JP2005507102A Expired - Fee Related JP4641941B2 (ja)	2002-11-07	2003-11-07	トランス−９，１０−デヒドロエポチロンｃおよびｄ、それらのアナログ、ならびにそれらを作製する方法
JP2010228356A Expired - Fee Related JP5679757B2 (ja)	2002-11-07	2010-10-08	トランス−９，１０−デヒドロエポチロンｃおよびｄ、それらのアナログ、ならびにそれらを作製する方法
JP2013147528A Pending JP2013213054A (ja)	2002-11-07	2013-07-16	トランス−９，１０−デヒドロエポチロンｃおよびｄ、それらのアナログ、ならびにそれらを作製する方法

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
JP2005507102A Expired - Fee Related JP4641941B2 (ja)	2002-11-07	2003-11-07	トランス−９，１０−デヒドロエポチロンｃおよびｄ、それらのアナログ、ならびにそれらを作製する方法

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
JP2013147528A Pending JP2013213054A (ja)	2002-11-07	2013-07-16	トランス−９，１０−デヒドロエポチロンｃおよびｄ、それらのアナログ、ならびにそれらを作製する方法

Country Status (14)

Country	Link
US (2)	US20040152708A1 (2)
EP (3)	EP2135867B1 (2)
JP (3)	JP4641941B2 (2)
KR (2)	KR100966667B1 (2)
AT (1)	ATE452888T1 (2)
AU (1)	AU2003291337B2 (2)
CA (1)	CA2505368C (2)
CY (1)	CY1110295T1 (2)
DE (1)	DE60330703D1 (2)
DK (1)	DK1562941T3 (2)
ES (2)	ES2336911T3 (2)
PT (1)	PT1562941E (2)
SI (1)	SI1562941T1 (2)
WO (1)	WO2004043954A2 (2)

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US7649006B2 (en)	2002-08-23	2010-01-19	Sloan-Kettering Institute For Cancer Research	Synthesis of epothilones, intermediates thereto and analogues thereof
DE60330407D1 (de)	2002-08-23	2010-01-14	Sloan Kettering Inst Cancer	Synthese von Epothilonen, Zwischenprodukte davon, Analoga und ihre Verwendung
US6921769B2 (en)	2002-08-23	2005-07-26	Sloan-Kettering Institute For Cancer Research	Synthesis of epothilones, intermediates thereto and analogues thereof
CN101088998A (zh) *	2002-11-07	2007-12-19	科桑生物科学公司	反式－9,10－脱氢埃坡霉素c和d,其类似物以及制备这些化合物的方法
ES2336911T3 (es) *	2002-11-07	2010-04-19	Kosan Biosciences, Inc.	Trans-9,10-dehidroepotilonas c y d, sus analogos y procedimientos de preparacion.
BRPI0408891A (pt) *	2003-03-28	2006-04-11	Kosan Biosciences Inc	dispositivos, métodos, e composições para prevenir restenose
EP1670487A4 (en) *	2003-10-09	2008-05-21	Kosan Biosciences Inc	THERAPEUTIC FORMULATIONS
US20050215604A1 (en) *	2004-03-26	2005-09-29	Kosan Biosciences, Inc.	Combination therapies with epothilones and carboplatin
CN105061577A (zh) *	2006-12-14	2015-11-18	爱勒让治疗公司	双巯基大环化系统
US7981998B2 (en) *	2006-12-14	2011-07-19	Aileron Therapeutics, Inc.	Bis-sulfhydryl macrocyclization systems
EP2952522B1 (en)	2007-01-31	2019-10-30	Dana-Farber Cancer Institute, Inc.	Stabilized p53 peptides and uses thereof
ES2398310T3 (es)	2007-02-23	2013-03-15	Aileron Therapeutics, Inc.	Péptidos macrocíclicos unidos a triazol
AU2008232709C1 (en)	2007-03-28	2015-01-15	President And Fellows Of Harvard College	Stitched polypeptides
US8030503B2 (en)	2007-05-11	2011-10-04	Kosan Biosciences Incorporated	Process for the preparation of epothilones
WO2008141234A2 (en) *	2007-05-11	2008-11-20	Kosan Biosciences Incorporated	Methods of making epothilones
WO2010083347A2 (en)	2009-01-14	2010-07-22	Aileron Therapeutics, Inc.	Peptidomimetic macrocycles
US20130072439A1 (en)	2009-09-22	2013-03-21	Huw M. Nash	Peptidomimetic macrocycles
KR20170058446A (ko)	2010-08-13	2017-05-26	에일러론 테라퓨틱스 인코포레이티드	펩티도미메틱 거대고리
AR088392A1 (es)	2011-10-18	2014-05-28	Aileron Therapeutics Inc	Macrociclos peptidomimeticos
CA2862038C (en)	2012-02-15	2021-05-25	Aileron Therapeutics, Inc.	Peptidomimetic macrocycles
HK1205454A1 (en)	2012-02-15	2015-12-18	Aileron Therapeutics, Inc.	Triazole-crosslinked and thioether-crosslinked peptidomimetic macrocycles
CA2776178A1 (en) *	2012-04-05	2013-10-05	Hydro-Quebec	Ionic compounds
BR112015009470A2 (pt)	2012-11-01	2019-12-17	Aileron Therapeutics Inc	aminoácidos dissubstituídos e seus métodos de preparação e uso
SG11201702175YA (en)	2014-09-24	2017-04-27	Aileron Therapeutics Inc	Peptidomimetic macrocycles and formulations thereof
WO2016049359A1 (en)	2014-09-24	2016-03-31	Aileron Therapeutics, Inc.	Peptidomimetic macrocycles and uses thereof
US10253067B2 (en)	2015-03-20	2019-04-09	Aileron Therapeutics, Inc.	Peptidomimetic macrocycles and uses thereof
US10059741B2 (en)	2015-07-01	2018-08-28	Aileron Therapeutics, Inc.	Peptidomimetic macrocycles
JP2018528217A (ja)	2015-09-10	2018-09-27	エルロン・セラピューティクス・インコーポレイテッドＡｉｌｅｒｏｎＴｈｅｒａｐｅｕｔｉｃｓ，Ｉｎｃ．	Ｍｃｌ−１のモジュレーターとしてのペプチド模倣大環状分子

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EP0706373B1 (en)	1992-03-23	2000-07-19	Georgetown University	Liposome encapsulated taxol and a method of using the same
AU6833994A (en)	1993-05-17	1994-12-12	Liposome Company, Inc., The	Incorporation of taxol into liposomes and gels
US5415869A (en)	1993-11-12	1995-05-16	The Research Foundation Of State University Of New York	Taxol formulation
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US5534270A (en)	1995-02-09	1996-07-09	Nanosystems Llc	Method of preparing stable drug nanoparticles
US5510118A (en)	1995-02-14	1996-04-23	Nanosystems Llc	Process for preparing therapeutic compositions containing nanoparticles
DE69735057T2 (de)	1996-03-12	2006-08-31	PG-TXL Co., L.P., Houston	Wasserlösliche paclitaxel-prodrogen
US6458373B1 (en)	1997-01-07	2002-10-01	Sonus Pharmaceuticals, Inc.	Emulsion vehicle for poorly soluble drugs
SK287775B6 (sk)	1998-02-05	2011-09-05	Novartis Ag	Farmaceutická formulácia obsahujúca epothilon, infúzny roztok a použitie farmaceutickej formulácie
US6596875B2 (en) *	2000-02-07	2003-07-22	James David White	Method for synthesizing epothilones and epothilone analogs
DE19954229A1 (de) *	1999-11-04	2001-05-10	Schering Ag	Epothilon-Derivate, Verfahren zu deren Herstellung und ihre pharmazeutische Verwendung
DE19907480A1 (de) *	1999-02-11	2000-08-17	Schering Ag	Epothilon-Derivate, Verfahren zu deren Herstellung und ihre pharmazeutische Verwendung
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EP1652926B1 (en)	2000-04-28	2009-09-30	Kosan Biosciences, Inc.	Crystalline epothilone d
AU2001266583A1 (en) *	2000-05-26	2001-12-11	Kosan Biosciences, Inc.	Epothilone derivatives and methods for making and using the same
US6906188B2 (en) *	2001-04-30	2005-06-14	State Of Oregon Acting By And Through The State Board Of Higher Education On Behalf Of Oregon State University	Method for synthesizing epothilones and epothilone analogs
WO2003022844A2 (en) *	2001-09-06	2003-03-20	Sloan-Kettering Institute For Cancer Research	Synthesis of epothilones intermediates thereto and analogues thereof
US6921769B2 (en) *	2002-08-23	2005-07-26	Sloan-Kettering Institute For Cancer Research	Synthesis of epothilones, intermediates thereto and analogues thereof
US7649006B2 (en) *	2002-08-23	2010-01-19	Sloan-Kettering Institute For Cancer Research	Synthesis of epothilones, intermediates thereto and analogues thereof
DE60330407D1 (de) *	2002-08-23	2010-01-14	Sloan Kettering Inst Cancer	Synthese von Epothilonen, Zwischenprodukte davon, Analoga und ihre Verwendung
ES2336911T3 (es) *	2002-11-07	2010-04-19	Kosan Biosciences, Inc.	Trans-9,10-dehidroepotilonas c y d, sus analogos y procedimientos de preparacion.

2003
- 2003-11-07 ES ES03768730T patent/ES2336911T3/es not_active Expired - Lifetime
- 2003-11-07 US US10/703,404 patent/US20040152708A1/en not_active Abandoned
- 2003-11-07 WO PCT/US2003/035411 patent/WO2004043954A2/en not_active Ceased
- 2003-11-07 SI SI200331732T patent/SI1562941T1/sl unknown
- 2003-11-07 PT PT03768730T patent/PT1562941E/pt unknown
- 2003-11-07 EP EP09012671.5A patent/EP2135867B1/en not_active Expired - Lifetime
- 2003-11-07 JP JP2005507102A patent/JP4641941B2/ja not_active Expired - Fee Related
- 2003-11-07 DE DE60330703T patent/DE60330703D1/de not_active Expired - Lifetime
- 2003-11-07 CA CA2505368A patent/CA2505368C/en not_active Expired - Fee Related
- 2003-11-07 EP EP03768730A patent/EP1562941B1/en not_active Expired - Lifetime
- 2003-11-07 DK DK03768730.8T patent/DK1562941T3/da active
- 2003-11-07 KR KR1020057008039A patent/KR100966667B1/ko not_active Expired - Fee Related
- 2003-11-07 AU AU2003291337A patent/AU2003291337B2/en not_active Ceased
- 2003-11-07 KR KR1020107000780A patent/KR100996996B1/ko not_active Expired - Fee Related
- 2003-11-07 AT AT03768730T patent/ATE452888T1/de active
- 2003-11-07 ES ES09012671T patent/ES2436296T3/es not_active Expired - Lifetime
- 2003-11-07 EP EP09012860A patent/EP2135868A1/en not_active Withdrawn
2008
- 2008-07-11 US US12/172,174 patent/US20090186927A1/en not_active Abandoned
2010
- 2010-03-19 CY CY20101100250T patent/CY1110295T1/el unknown
- 2010-10-08 JP JP2010228356A patent/JP5679757B2/ja not_active Expired - Fee Related
2013
- 2013-07-16 JP JP2013147528A patent/JP2013213054A/ja active Pending

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