JP2012130341A5 - - Google Patents

Download PDF

Info

Publication number
JP2012130341A5
JP2012130341A5 JP2012004470A JP2012004470A JP2012130341A5 JP 2012130341 A5 JP2012130341 A5 JP 2012130341A5 JP 2012004470 A JP2012004470 A JP 2012004470A JP 2012004470 A JP2012004470 A JP 2012004470A JP 2012130341 A5 JP2012130341 A5 JP 2012130341A5
Authority
JP
Japan
Prior art keywords
view
field
container
cell
image
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2012004470A
Other languages
English (en)
Japanese (ja)
Other versions
JP2012130341A (ja
Filing date
Publication date
Priority claimed from US09/451,659 external-priority patent/US6534308B1/en
Priority claimed from US09/728,281 external-priority patent/US6514722B2/en
Application filed filed Critical
Publication of JP2012130341A publication Critical patent/JP2012130341A/ja
Publication of JP2012130341A5 publication Critical patent/JP2012130341A5/ja
Pending legal-status Critical Current

Links

JP2012004470A 1999-11-30 2012-01-12 細胞群内の特定細胞に選択的に照準付けする方法及び装置 Pending JP2012130341A (ja)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US09/451,659 US6534308B1 (en) 1997-03-27 1999-11-30 Method and apparatus for selectively targeting specific cells within a mixed cell population
US09/451,659 1999-11-30
US09/728,281 2000-11-30
US09/728,281 US6514722B2 (en) 1997-03-27 2000-11-30 Method and apparatus for selectively targeting specific cells within a cell population

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
JP2001542522A Division JP5087192B2 (ja) 1999-11-30 2000-11-30 細胞群内の特定細胞に選択的に照準付けする方法及び装置

Publications (2)

Publication Number Publication Date
JP2012130341A JP2012130341A (ja) 2012-07-12
JP2012130341A5 true JP2012130341A5 (2) 2013-04-18

Family

ID=27036464

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2001542522A Expired - Fee Related JP5087192B2 (ja) 1999-11-30 2000-11-30 細胞群内の特定細胞に選択的に照準付けする方法及び装置
JP2012004470A Pending JP2012130341A (ja) 1999-11-30 2012-01-12 細胞群内の特定細胞に選択的に照準付けする方法及び装置

Family Applications Before (1)

Application Number Title Priority Date Filing Date
JP2001542522A Expired - Fee Related JP5087192B2 (ja) 1999-11-30 2000-11-30 細胞群内の特定細胞に選択的に照準付けする方法及び装置

Country Status (6)

Country Link
US (5) US6514722B2 (2)
EP (2) EP1234026B1 (2)
JP (2) JP5087192B2 (2)
AU (1) AU785290B2 (2)
CA (1) CA2392534A1 (2)
WO (1) WO2001040454A1 (2)

Families Citing this family (97)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2264427B1 (en) 1997-01-31 2017-05-03 Xy, Llc Optical apparatus with focussing reflector for converging radiation onto a flow of particles, and related method of analysis
US5874266A (en) * 1997-03-27 1999-02-23 Palsson; Bernhard O. Targeted system for removing tumor cells from cell populations
US6753161B2 (en) * 1997-03-27 2004-06-22 Oncosis Llc Optoinjection methods
US6149867A (en) 1997-12-31 2000-11-21 Xy, Inc. Sheath fluids and collection systems for sex-specific cytometer sorting of sperm
US6071689A (en) * 1997-12-31 2000-06-06 Xy, Inc. System for improving yield of sexed embryos in mammals
US7208265B1 (en) * 1999-11-24 2007-04-24 Xy, Inc. Method of cryopreserving selected sperm cells
CA2392534A1 (en) 1999-11-30 2001-06-07 Oncosis Method and apparatus for selectively targeting specific cells within a cell population
CA2391317A1 (en) * 2000-07-26 2002-01-31 The Regent Of The University Of California Manipulation of live cells and inorganic objects with optical micro beam arrays
US20040031071A1 (en) * 2000-10-05 2004-02-12 Xy, Inc. System of hysteroscopic insemination of mares
EP2363828A1 (en) 2000-10-24 2011-09-07 Cyntellect, Inc. Device for selectively targeting cells within a three-dimensional specimen
US6744038B2 (en) 2000-11-13 2004-06-01 Genoptix, Inc. Methods of separating particles using an optical gradient
US6833542B2 (en) 2000-11-13 2004-12-21 Genoptix, Inc. Method for sorting particles
US20020123112A1 (en) * 2000-11-13 2002-09-05 Genoptix Methods for increasing detection sensitivity in optical dielectric sorting systems
US20030007894A1 (en) * 2001-04-27 2003-01-09 Genoptix Methods and apparatus for use of optical forces for identification, characterization and/or sorting of particles
US6784420B2 (en) 2000-11-13 2004-08-31 Genoptix, Inc. Method of separating particles using an optical gradient
US6936811B2 (en) * 2000-11-13 2005-08-30 Genoptix, Inc. Method for separating micro-particles
US20020160470A1 (en) * 2000-11-13 2002-10-31 Genoptix Methods and apparatus for generating and utilizing linear moving optical gradients
US6778724B2 (en) 2000-11-28 2004-08-17 The Regents Of The University Of California Optical switching and sorting of biological samples and microparticles transported in a micro-fluidic device, including integrated bio-chip devices
WO2002043486A1 (en) 2000-11-29 2002-06-06 Xy, Inc. System for in-vitro fertilization with spermatozoa separated into x-chromosome and y-chromosome bearing populations
US7713687B2 (en) * 2000-11-29 2010-05-11 Xy, Inc. System to separate frozen-thawed spermatozoa into x-chromosome bearing and y-chromosome bearing populations
US20030194755A1 (en) * 2001-04-27 2003-10-16 Genoptix, Inc. Early detection of apoptotic events and apoptosis using optophoretic analysis
US20040009540A1 (en) * 2001-04-27 2004-01-15 Genoptix, Inc Detection and evaluation of cancer cells using optophoretic analysis
US20030025918A1 (en) * 2001-07-16 2003-02-06 August Technology Corp. Confocal 3D inspection system and process
US8715955B2 (en) 2004-09-09 2014-05-06 Life Technologies Corporation Laser microdissection apparatus and method
US10156501B2 (en) * 2001-11-05 2018-12-18 Life Technologies Corporation Automated microdissection instrument for determining a location of a laser beam projection on a worksurface area
US8722357B2 (en) * 2001-11-05 2014-05-13 Life Technologies Corporation Automated microdissection instrument
WO2003089901A2 (en) * 2002-04-19 2003-10-30 Palsson Bernhard O Methods for preparing libraries of unique tags and related screening methods
US20040033539A1 (en) * 2002-05-01 2004-02-19 Genoptix, Inc Method of using optical interrogation to determine a biological property of a cell or population of cells
US20030211461A1 (en) * 2002-05-01 2003-11-13 Genoptix, Inc Optophoretic detection of durgs exhibiting inhibitory effect on Bcr-Abl positive tumor cells
CA2531176C (en) * 2002-07-22 2018-04-24 Xy, Inc. Sperm cell process system
JP4595067B2 (ja) * 2002-08-01 2010-12-08 エックスワイ,エルエルシー 低圧精子細胞分離システム
US8486618B2 (en) 2002-08-01 2013-07-16 Xy, Llc Heterogeneous inseminate system
CA2534394C (en) * 2002-08-15 2013-01-08 Xy, Inc. High resolution flow cytometer
US20040156743A1 (en) * 2002-08-28 2004-08-12 Eric Bornstein Near infrared microbial elimination laser system
US7713294B2 (en) 2002-08-28 2010-05-11 Nomir Medical Technologies, Inc. Near infrared microbial elimination laser systems (NIMEL)
US20040126272A1 (en) * 2002-08-28 2004-07-01 Eric Bornstein Near infrared microbial elimination laser system
US20040053209A1 (en) * 2002-09-12 2004-03-18 Genoptix, Inc Detection and evaluation of topoisomerase inhibitors using optophoretic analysis
US7169548B2 (en) 2002-09-13 2007-01-30 Xy, Inc. Sperm cell processing and preservation systems
AU2003270687B2 (en) 2002-09-13 2008-05-08 Life Technologies Corporation Interactive and automated tissue image analysis with global training database and variable-abstraction processing in cytological specimen classification and laser capture microdissection applications
US20040067167A1 (en) * 2002-10-08 2004-04-08 Genoptix, Inc. Methods and apparatus for optophoretic diagnosis of cells and particles
US8076318B2 (en) * 2002-10-24 2011-12-13 Albert Einstein College Of Medicine Of Yeshiva University Caged ligands and uses thereof
US20040121307A1 (en) * 2002-12-19 2004-06-24 Genoptix, Inc Early detection of cellular differentiation using optophoresis
US20040121474A1 (en) * 2002-12-19 2004-06-24 Genoptix, Inc Detection and evaluation of chemically-mediated and ligand-mediated t-cell activation using optophoretic analysis
US7695752B2 (en) 2003-01-24 2010-04-13 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Target activated microtransfer
US7709047B2 (en) 2003-01-24 2010-05-04 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Target activated microtransfer
JP2004259144A (ja) * 2003-02-27 2004-09-16 Renesas Technology Corp 半導体記憶装置
BRPI0408857B1 (pt) 2003-03-28 2018-09-11 Inguran Llc aparelho, métodos e processos para separar partículas e para prover esperma de animal separado por sexo
US20040202357A1 (en) 2003-04-11 2004-10-14 Perz Cynthia B. Silhouette image acquisition
AU2004239716A1 (en) * 2003-05-07 2004-11-25 Novasite Pharmaceuticals, Inc. Multiplexed multitarget screening method
EP1625404A1 (en) * 2003-05-07 2006-02-15 Novasite Pharmaceuticals, Inc. Gain of function sorting for drug discovery and development
ES2541121T3 (es) * 2003-05-15 2015-07-16 Xy, Llc Clasificación eficiente de células haploides por sistemas de citometría de flujo
EP1668355A4 (en) * 2003-08-28 2011-11-09 Celula Inc METHODS AND APPARATUS FOR SORTING CELLS USING AN OPTICAL SWITCH IN A MICROFLUIDIC CHANNEL NETWORK
US20050095578A1 (en) * 2003-10-31 2005-05-05 Koller Manfred R. Method and apparatus for cell permeabilization
US7425426B2 (en) * 2004-03-15 2008-09-16 Cyntellect, Inc. Methods for purification of cells based on product secretion
DK2801363T3 (en) 2004-03-29 2018-05-28 Inguran Llc PROCEDURE FOR STORING SORTED SPERMATOZOES
JP4034288B2 (ja) * 2004-03-31 2008-01-16 富士フイルム株式会社 撮影制御装置およびプログラム
US20050249642A1 (en) * 2004-05-07 2005-11-10 Novasite Pharmaceuticals, Inc. Sample analysis system employing direct sample mixing and injection
US7858040B2 (en) * 2004-05-07 2010-12-28 Saryna Biotechnologies Llc Direct mixing and injection for high throughput fluidic systems
JP2005333889A (ja) * 2004-05-27 2005-12-08 Cybox Co Ltd 細胞壊死方法及び細胞壊死装置
CA2574499C (en) 2004-07-22 2016-11-29 Monsanto Technology Llc Process for enriching a population of sperm cells
US8088293B2 (en) 2004-07-29 2012-01-03 Micron Technology, Inc. Methods of forming reticles configured for imprint lithography
JPWO2006088154A1 (ja) * 2005-02-18 2008-07-03 株式会社ABsize 細胞分離方法及び装置
JP4911915B2 (ja) * 2005-05-09 2012-04-04 トヨタ自動車株式会社 標的物の分解方法及び分解装置
US20070031043A1 (en) * 2005-08-02 2007-02-08 Perz Cynthia B System for and method of intelligently directed segmentation analysis for automated microscope systems
US7957466B2 (en) * 2005-09-16 2011-06-07 Sony Corporation Adaptive area of influence filter for moving object boundaries
WO2007056560A2 (en) * 2005-11-09 2007-05-18 Chemimage Corporation System and method for cytological analysis by raman spectroscopic imaging
GB0603923D0 (en) * 2006-02-28 2006-04-05 Perkinelmer Ltd Apparatus and methods for imaging and modification of biological samples
US9493817B2 (en) 2007-03-05 2016-11-15 Genesis Research Institute, Inc. Decomposition method and decomposition apparatus for nucleic acid polymer
DE102007045897A1 (de) * 2007-09-26 2009-04-09 Carl Zeiss Microimaging Gmbh Verfahren zur mikroskopischen dreidimensionalen Abbildung einer Probe
JP2012514477A (ja) * 2009-01-09 2012-06-28 イントレクソン コーポレイション 細胞の遺伝学的解析
KR20110108390A (ko) 2009-01-12 2011-10-05 신텔렉트 인코포레이티드 레이저로 매개된 박막 절개 및 세포 군체의 이동
JP2010207133A (ja) * 2009-03-10 2010-09-24 Sony Corp 細胞分離方法
US20100241058A1 (en) * 2009-03-19 2010-09-23 Ahmed Syed Yosuf Oct guided tissue ablation
US8612065B2 (en) * 2010-03-05 2013-12-17 Gsi Group Corporation Position encoder with programmable trigger output signal
US9134301B2 (en) 2010-11-22 2015-09-15 Bio-Rad Laboratories, Inc. Sorting of adherent cells by selective transformation of labels
US9176032B2 (en) 2011-12-23 2015-11-03 General Electric Company Methods of analyzing an H and E stained biological sample
US8568991B2 (en) 2011-12-23 2013-10-29 General Electric Company Photoactivated chemical bleaching of dyes
DE102012207240A1 (de) * 2012-05-02 2013-11-07 Leica Microsystems Cms Gmbh Laser-Mikrodissektionsgerät und -verfahren
CN109924024B (zh) * 2013-03-05 2021-11-23 现特技术有限公司 光子调制管理系统
JP2016513794A (ja) 2013-03-06 2016-05-16 ゼネラル・エレクトリック・カンパニイ H&e染色された生体試料を分析する方法
US9725711B2 (en) 2014-03-10 2017-08-08 Celleraser, Llc Method and device for selective hyperthermic damage of target cells
WO2015172025A1 (en) 2014-05-08 2015-11-12 The Cleveland Clinic Foundation Systems and methods for detection, analysis, isolation and/or harvesting of biological objects
US10202598B2 (en) 2014-05-30 2019-02-12 Todd Frank Ovokaitys Methods and systems for generation, use, and delivery of activated stem cells
JP2016067318A (ja) * 2014-09-30 2016-05-09 株式会社東芝 核酸検査システム
JP6470008B2 (ja) * 2014-10-17 2019-02-13 オリンパス株式会社 培養観察装置および培養観察システム
EP3277846B1 (en) 2015-04-02 2024-07-10 University of Washington Optical painting and fluorescence-activated sorting of adherent cells
JP6680492B2 (ja) * 2015-09-11 2020-04-15 シスメックス株式会社 細胞分析装置および細胞分析方法
US10324080B2 (en) * 2015-11-17 2019-06-18 Purdue Research Foundation Systems and methods for automated image-guided patch-clamp electrophysiology in vitro
WO2017192579A1 (en) * 2016-05-02 2017-11-09 The George Washington University Automated system for high-throughput all-optical dynamic electrophysiology
JP6033980B1 (ja) * 2016-06-01 2016-11-30 株式会社片岡製作所 細胞処理システム
CN110736695A (zh) * 2016-09-30 2020-01-31 多伦多大学管理委员会 用于鉴定和靶向异质群体中的个体细胞以选择性提取细胞内容物的系统
JP6532063B2 (ja) * 2017-02-13 2019-06-19 株式会社片岡製作所 細胞処理装置
JP6541160B2 (ja) 2017-02-13 2019-07-10 株式会社片岡製作所 細胞処理装置および対象物の処理方法
US11058889B1 (en) 2017-04-03 2021-07-13 Xiant Technologies, Inc. Method of using photon modulation for regulation of hormones in mammals
US11943537B2 (en) * 2017-11-30 2024-03-26 Leica Biosystems Imaging, Inc. Impulse rescan system
JP6574028B1 (ja) 2018-06-29 2019-09-11 株式会社片岡製作所 細胞処理装置および細胞のレーザ処理方法
US12246037B2 (en) 2020-12-08 2025-03-11 Todd Frank Ovokaitys Methods and systems for increased production of stem cells

Family Cites Families (114)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3674926A (en) 1968-10-15 1972-07-04 Reynolds Metals Co Feature counter with improved masking and grey level detection
US3864571A (en) 1971-02-10 1975-02-04 Wheeler International Inc Method and Apparatus for Automatically, Identifying and Counting Various Cells in Body Fluids
US4000417A (en) * 1975-08-25 1976-12-28 Honeywell Inc. Scanning microscope system with automatic cell find and autofocus
JPS5391754A (en) * 1977-01-21 1978-08-11 Canon Inc Scannint type photo detector
JPS53135660A (en) 1977-04-30 1978-11-27 Olympus Optical Co Ltd Fluorescent photometric microscope using laser light
US4264897A (en) * 1979-06-13 1981-04-28 General Electric Company Meter register encoder including electronics providing remote reading capability
US4803992A (en) 1980-10-28 1989-02-14 Lemelson Jerome H Electro-optical instruments and methods for producing same
US4395397A (en) 1981-09-17 1983-07-26 Sidney Farber Cancer Institute, Inc. Apparatus and method for killing unwanted cells
US5272081A (en) 1982-05-10 1993-12-21 Bar-Ilan University System and methods for cell selection
US4624915A (en) * 1982-07-29 1986-11-25 Board Of Trustees Of Michigan State University Positive selection sorting of cells
US4629687A (en) * 1982-07-29 1986-12-16 Board Of Trustees Of Michigan State University Positive selection sorting of cells
US4532402A (en) 1983-09-02 1985-07-30 Xrl, Inc. Method and apparatus for positioning a focused beam on an integrated circuit
JPS6083584A (ja) * 1983-10-13 1985-05-11 Rikagaku Kenkyusho 生細胞内への物質移入法
US5103660A (en) 1984-04-23 1992-04-14 Johnson Virgil T Removable steering wheel device, and methods of constructing and utilizing same
US4998284A (en) * 1987-11-17 1991-03-05 Cell Analysis Systems, Inc. Dual color camera microscope and methodology for cell staining and analysis
DE3708511A1 (de) 1987-03-16 1988-09-29 Kratzer Michael Einrichtung zur selektiven zerstoerung von zellen
US5188633A (en) * 1987-03-16 1993-02-23 Michael Kratzer Device for selective destruction of cells
JPH07122902B2 (ja) 1987-04-17 1995-12-25 株式会社日立製作所 細胞位置検出装置
US4950592A (en) 1987-05-12 1990-08-21 Eastman Kodak Company Blend of monoclonal antibodies
HU204856B (en) 1987-08-12 1992-02-28 Orszagos Mueszaki Fejlesztesi Process for releasing cell mixtures and tissues from undesired populations and for producing monoclonal antibody - hematoporphyrin conjugates
US5121436A (en) 1987-08-14 1992-06-09 International Remote Imaging Systems, Inc. Method and apparatus for generating a plurality of parameters of an object in a field of view
US4965725B1 (en) 1988-04-08 1996-05-07 Neuromedical Systems Inc Neural network based automated cytological specimen classification system and method
US5109276A (en) 1988-05-27 1992-04-28 The University Of Connecticut Multi-dimensional multi-spectral imaging system
DE3836716A1 (de) * 1988-10-28 1990-05-03 Zeiss Carl Fa Verfahren zur auswertung von zellbildern
US5089384A (en) 1988-11-04 1992-02-18 Amoco Corporation Method and apparatus for selective cell destruction using amplified immunofluorescence
JPH02168160A (ja) 1988-12-22 1990-06-28 Omron Tateisi Electron Co 細胞選別装置
US6099522A (en) 1989-02-06 2000-08-08 Visx Inc. Automated laser workstation for high precision surgical and industrial interventions
US5143854A (en) 1989-06-07 1992-09-01 Affymax Technologies N.V. Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof
US5072382A (en) 1989-10-02 1991-12-10 Kamentsky Louis A Methods and apparatus for measuring multiple optical properties of biological specimens
EP0433824B1 (de) 1989-12-22 1994-03-02 Asea Brown Boveri Ag Faseroptischer Sensor
US5093866A (en) * 1990-02-09 1992-03-03 Hamilton Equine Associates Limited Fluorescence and motility characterization system for cells, bacteria, and particles in fluids
US5202230A (en) 1990-09-07 1993-04-13 Kamentsky Louis A Methods of detecting cut cells in a tissue section
US5235522A (en) 1990-10-10 1993-08-10 Cell Analysis Systems, Inc. Method and apparatus for automated analysis of biological specimens
US5257182B1 (en) * 1991-01-29 1996-05-07 Neuromedical Systems Inc Morphological classification system and method
US5784162A (en) 1993-08-18 1998-07-21 Applied Spectral Imaging Ltd. Spectral bio-imaging methods for biological research, medical diagnostics and therapy
EP0501688A1 (en) 1991-02-27 1992-09-02 Hitachi, Ltd. Apparatus and method for applying a laser beam through a microscope
JPH05210052A (ja) * 1991-02-27 1993-08-20 Hitachi Ltd 顕微鏡を通してレーザ光を照射する装置及び方法
US5790710A (en) 1991-07-12 1998-08-04 Jeffrey H. Price Autofocus system for scanning microscopy
US5548661A (en) * 1991-07-12 1996-08-20 Price; Jeffrey H. Operator independent image cytometer
US5428690A (en) 1991-09-23 1995-06-27 Becton Dickinson And Company Method and apparatus for automated assay of biological specimens
CA2077781A1 (en) 1991-09-23 1993-03-24 James W. Bacus Method and apparatus for automated assay of biological specimens
US5298963A (en) 1992-02-26 1994-03-29 Mitsui Mining & Smelting Co., Ltd. Apparatus for inspecting the surface of materials
US6007814A (en) 1992-06-15 1999-12-28 Sloan-Kettering Institute For Cancer Research Therapeutic uses of the hypervariable region of monoclonal antibody M195 and constructs thereof
JP3099049B2 (ja) 1992-07-29 2000-10-16 農林水産省果樹試験場長 電気的細胞融合及び電気的核酸導入のための大量処理用電極
RU2054486C1 (ru) 1992-09-01 1996-02-20 Валерий Георгиевич Петухов Способ идентификации микроорганизмов
US5674698A (en) 1992-09-14 1997-10-07 Sri International Up-converting reporters for biological and other assays using laser excitation techniques
US5450463A (en) 1992-12-25 1995-09-12 Olympus Optical Co., Ltd. X-ray microscope
CA2102884A1 (en) 1993-03-04 1994-09-05 James J. Wynne Dental procedures and apparatus using ultraviolet radiation
US5422720A (en) 1993-07-21 1995-06-06 Becton Dickinson And Company Blood culture sensor station utilizing two distinct light sources
US5995645A (en) 1993-08-18 1999-11-30 Applied Spectral Imaging Ltd. Method of cancer cell detection
US5878746A (en) 1993-08-25 1999-03-09 Lemelson; Jerome H. Computerized medical diagnostic system
US5381224A (en) 1993-08-30 1995-01-10 A. E. Dixon Scanning laser imaging system
US5598842A (en) * 1993-09-03 1997-02-04 Toa Medical Electronics Co., Ltd. Non-invasive blood analyzer and method using the same
US6056738A (en) 1997-01-31 2000-05-02 Transmedica International, Inc. Interstitial fluid monitoring
EP0662512A3 (en) 1993-12-20 1997-01-15 Becton Dickinson Co Human hematopoietic stem cells.
EP0741798A4 (en) * 1994-01-21 1998-07-29 Coulter Corp ANALYSIS OF FIXED TUMORS WITH MULTIPARAMETRIC FLOW CYTOMETRY
US7378236B1 (en) 1994-06-17 2008-05-27 The Board Of Trustees Of The Leland Stanford Junior University Method for analyzing gene expression patterns
US5932872A (en) 1994-07-01 1999-08-03 Jeffrey H. Price Autofocus system for scanning microscopy having a volume image formation
US5795755A (en) 1994-07-05 1998-08-18 Lemelson; Jerome H. Method of implanting living cells by laser poration at selected sites
US5523543A (en) * 1994-09-09 1996-06-04 Litel Instruments Laser ablation control system and method
WO1996009600A1 (en) 1994-09-20 1996-03-28 Neopath, Inc. Apparatus for identification and integration of multiple cell patterns
US5552605A (en) 1994-11-18 1996-09-03 Picker International, Inc. Motion correction based on reprojection data
DE69530072T2 (de) * 1994-12-08 2004-03-04 Molecular Dynamics, Sunnyvale System zur fluoreszenzabbildung unter verwendung eines objektivs mit makroabtastung
JP3077539B2 (ja) 1994-12-22 2000-08-14 松下電器産業株式会社 レーザ加工方法
US5713364A (en) 1995-08-01 1998-02-03 Medispectra, Inc. Spectral volume microprobe analysis of materials
DE19529371C3 (de) 1995-08-10 2003-05-28 Nmi Univ Tuebingen Mikroelektroden-Anordnung
US6148096A (en) 1995-09-15 2000-11-14 Accumed International, Inc. Specimen preview and inspection system
US5732150A (en) 1995-09-19 1998-03-24 Ihc Health Services, Inc. Method and system for multiple wavelength microscopy image analysis
US6040139A (en) * 1995-09-19 2000-03-21 Bova; G. Steven Laser cell purification system
WO1997011355A1 (en) 1995-09-19 1997-03-27 Cornell Research Foundation, Inc. Multi-photon laser microscopy
DE69627183T2 (de) * 1995-11-30 2004-01-29 Chromavision Med Sys Inc Verfahren zur automatischen bildanalyse biologischer proben
US5646411A (en) 1996-02-01 1997-07-08 Molecular Dynamics, Inc. Fluorescence imaging system compatible with macro and micro scanning objectives
US5847400A (en) * 1996-02-01 1998-12-08 Molecular Dynamics, Inc. Fluorescence imaging system having reduced background fluorescence
BR9708825A (pt) 1996-04-25 1999-08-03 Gleason Works Parte da cabeça cortadora de uma ferramenta de corte para produzir artigos dentados cabeça cortadora anel dispositivo e bloco de sujeição ferramenta de corte para produzir peças de trabalho dentadas matriz de l mina de corte e lâmina de corte
US5750356A (en) 1996-05-31 1998-05-12 Anergen, Inc. Method for monitoring T cell reactivity
US5952651A (en) * 1996-06-10 1999-09-14 Moritex Corporation Laser manipulation apparatus and cell plate used therefor
US6122396A (en) * 1996-12-16 2000-09-19 Bio-Tech Imaging, Inc. Method of and apparatus for automating detection of microorganisms
US6759206B1 (en) 1997-02-27 2004-07-06 Cellomics, Inc. System for cell-based screening
US6534308B1 (en) 1997-03-27 2003-03-18 Oncosis, Llc Method and apparatus for selectively targeting specific cells within a mixed cell population
US5874266A (en) 1997-03-27 1999-02-23 Palsson; Bernhard O. Targeted system for removing tumor cells from cell populations
US6753161B2 (en) 1997-03-27 2004-06-22 Oncosis Llc Optoinjection methods
CA2287947A1 (en) * 1997-05-09 1998-11-19 Ryan S. Raz Multi-spectral imaging system and method for cytology
US5981268A (en) 1997-05-30 1999-11-09 Board Of Trustees, Leland Stanford, Jr. University Hybrid biosensors
US6326489B1 (en) 1997-08-05 2001-12-04 Howard Hughes Medical Institute Surface-bound, bimolecular, double-stranded DNA arrays
JP3735190B2 (ja) * 1997-10-28 2006-01-18 オリンパス株式会社 走査型サイトメータ
US6005256A (en) 1998-02-12 1999-12-21 Raytheon Company Method and apparatus for performing cell analysis based on simultaneous multiple marker emissions from neoplasia (CASMMEN)
US6156576A (en) 1998-03-06 2000-12-05 The Regents Of The University Of California Fast controllable laser lysis of cells for analysis
US6642018B1 (en) 1998-03-27 2003-11-04 Oncosis Llc Method for inducing a response in one or more targeted cells
US6298264B1 (en) 1998-08-31 2001-10-02 Duke University Apparatus and method for macromolecule delivery into living cells
WO2000034434A1 (en) 1998-12-07 2000-06-15 Acacia Biosciences, Inc. Multi-channel electrode arrays
JP2000275541A (ja) 1999-03-24 2000-10-06 Olympus Optical Co Ltd レーザ顕微鏡
US6424863B1 (en) 1999-03-26 2002-07-23 Stephen T. Flock Delivery of pharmaceutical compounds and collection of biomolecules using electromagnetic energy and uses thereof
US6381224B1 (en) 1999-03-31 2002-04-30 Motorola, Inc. Method and apparatus for controlling a full-duplex communication system
US6221596B1 (en) 1999-05-17 2001-04-24 Motobit Ltd. System and method for identifying and isolating rare cells from a mixed population of cells
CA2392534A1 (en) 1999-11-30 2001-06-07 Oncosis Method and apparatus for selectively targeting specific cells within a cell population
EP2363828A1 (en) 2000-10-24 2011-09-07 Cyntellect, Inc. Device for selectively targeting cells within a three-dimensional specimen
US6509166B1 (en) 2000-11-28 2003-01-21 Robert A. Levine Detection and quantification of one or more target analytes in a sample using spatially localized analyte reproduction
JP2002325572A (ja) 2000-12-25 2002-11-12 Univ Osaka 外来物質の導入方法
CA2495021A1 (en) 2001-08-06 2003-07-03 Vanderbilt University System and methods for measuring at least one metabolic rate of a plurality of cells
JP2003076569A (ja) 2001-08-31 2003-03-14 Nippon Signal Co Ltd:The バス同期2重系コンピュータ
US20030148335A1 (en) 2001-10-10 2003-08-07 Li Shen Detecting targets by unique identifier nucleotide tags
JP2003259076A (ja) 2002-03-04 2003-09-12 Ricoh Co Ltd 通信端末装置
US7312085B2 (en) 2002-04-01 2007-12-25 Fluidigm Corporation Microfluidic particle-analysis systems
US7113624B2 (en) 2002-10-15 2006-09-26 Palo Alto Research Center Incorporated Imaging apparatus and method employing a large linear aperture
US9128090B2 (en) 2003-08-29 2015-09-08 Janssen Biotech, Inc. Rapid way to obtain high expression clones of mammalian cells using a methylcellulose and immunoprecipitation screening method
US20050095578A1 (en) 2003-10-31 2005-05-05 Koller Manfred R. Method and apparatus for cell permeabilization
US7425426B2 (en) 2004-03-15 2008-09-16 Cyntellect, Inc. Methods for purification of cells based on product secretion
TWI270362B (en) 2004-12-28 2007-01-11 Ind Tech Res Inst Cell subcloning device
US7999161B2 (en) 2005-01-22 2011-08-16 Alexander Oraevsky Laser-activated nanothermolysis of cells
KR101157175B1 (ko) 2005-12-14 2012-07-03 삼성전자주식회사 세포 또는 바이러스의 농축 및 용해용 미세유동장치 및방법
US8785193B2 (en) 2006-09-14 2014-07-22 The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services Dissection tool and methods of use
US8338166B2 (en) 2007-01-04 2012-12-25 Lawrence Livermore National Security, Llc Sorting, amplification, detection, and identification of nucleic acid subsequences in a complex mixture
JP2012514477A (ja) 2009-01-09 2012-06-28 イントレクソン コーポレイション 細胞の遺伝学的解析
KR20110108390A (ko) 2009-01-12 2011-10-05 신텔렉트 인코포레이티드 레이저로 매개된 박막 절개 및 세포 군체의 이동

Similar Documents

Publication Publication Date Title
JP2012130341A5 (2)
US20230005281A1 (en) Adaptive sensing based on depth
US10578851B2 (en) Automated hardware and software for mobile microscopy
JP6470008B2 (ja) 培養観察装置および培養観察システム
EP4235254A3 (en) Real-time focusing in line scan imaging
JP5316161B2 (ja) 観察装置
JP2011008245A5 (2)
EP3333613A3 (en) Image capturing apparatus and image capturing method
ATE504856T1 (de) Bilderfassungsvorrichtung, bilderfassungsverfahren und bilderfassungsprogramm
US11828927B2 (en) Accelerating digital microscopy scans using empty/dirty area detection
US10409049B2 (en) Low resolution slide imaging and slide label imaging and high resolution slide imaging using dual optical paths and a single imaging sensor
EP1903304A3 (en) Position measuring system, position measuring method and position measuring program
EP2579100A3 (en) Inspection apparatus, lithographic apparatus, and device manufacturing method
WO2015017046A1 (en) Fluorescent imaging using a flatbed scanner
JP6692660B2 (ja) 撮像装置
JP2013506163A5 (2)
JP2012174896A5 (2)
RU2013124820A (ru) Микроскоп, устройство получения изображения и система получения изображения
CN102520507B (zh) 一种共聚焦显微成像的获取方法和装置
JP6869435B2 (ja) スライドラックカルーセル
CN111527438A (zh) 冲击重新扫描系统
JP2013109077A5 (2)
RU2009116927A (ru) Устройство и способ для наблюдения поверхности образца
US10721368B2 (en) Slide rack determination system
CN105308492B (zh) 光观察装置、用于其的摄像装置以及光观察方法