|
US3536809A
(en)
|
1969-02-17 |
1970-10-27 |
Alza Corp |
Medication method
|
|
US3598123A
(en)
|
1969-04-01 |
1971-08-10 |
Alza Corp |
Bandage for administering drugs
|
|
US3845770A
(en)
|
1972-06-05 |
1974-11-05 |
Alza Corp |
Osmatic dispensing device for releasing beneficial agent
|
|
US3916899A
(en)
|
1973-04-25 |
1975-11-04 |
Alza Corp |
Osmotic dispensing device with maximum and minimum sizes for the passageway
|
|
US4008719A
(en)
|
1976-02-02 |
1977-02-22 |
Alza Corporation |
Osmotic system having laminar arrangement for programming delivery of active agent
|
|
US4328245A
(en)
|
1981-02-13 |
1982-05-04 |
Syntex (U.S.A.) Inc. |
Carbonate diester solutions of PGE-type compounds
|
|
US4410545A
(en)
|
1981-02-13 |
1983-10-18 |
Syntex (U.S.A.) Inc. |
Carbonate diester solutions of PGE-type compounds
|
|
US4409239A
(en)
|
1982-01-21 |
1983-10-11 |
Syntex (U.S.A.) Inc. |
Propylene glycol diester solutions of PGE-type compounds
|
|
HU196714B
(en)
|
1984-10-04 |
1989-01-30 |
Monsanto Co |
Process for producing non-aqueous composition comprising somatotropin
|
|
IE58110B1
(en)
|
1984-10-30 |
1993-07-14 |
Elan Corp Plc |
Controlled release powder and process for its preparation
|
|
US5052558A
(en)
|
1987-12-23 |
1991-10-01 |
Entravision, Inc. |
Packaged pharmaceutical product
|
|
US5033252A
(en)
|
1987-12-23 |
1991-07-23 |
Entravision, Inc. |
Method of packaging and sterilizing a pharmaceutical product
|
|
US5073543A
(en)
|
1988-07-21 |
1991-12-17 |
G. D. Searle & Co. |
Controlled release formulations of trophic factors in ganglioside-lipsome vehicle
|
|
US5612059A
(en)
|
1988-08-30 |
1997-03-18 |
Pfizer Inc. |
Use of asymmetric membranes in delivery devices
|
|
IT1229203B
(it)
|
1989-03-22 |
1991-07-25 |
Bioresearch Spa |
Impiego di acido 5 metiltetraidrofolico, di acido 5 formiltetraidrofolico e dei loro sali farmaceuticamente accettabili per la preparazione di composizioni farmaceutiche in forma a rilascio controllato attive nella terapia dei disturbi mentali organici e composizioni farmaceutiche relative.
|
|
PH30995A
(en)
|
1989-07-07 |
1997-12-23 |
Novartis Inc |
Sustained release formulations of water soluble peptides.
|
|
US5120548A
(en)
|
1989-11-07 |
1992-06-09 |
Merck & Co., Inc. |
Swelling modulated polymeric drug delivery device
|
|
US5585112A
(en)
|
1989-12-22 |
1996-12-17 |
Imarx Pharmaceutical Corp. |
Method of preparing gas and gaseous precursor-filled microspheres
|
|
IT1246382B
(it)
|
1990-04-17 |
1994-11-18 |
Eurand Int |
Metodo per la cessione mirata e controllata di farmaci nell'intestino e particolarmente nel colon
|
|
US5733566A
(en)
|
1990-05-15 |
1998-03-31 |
Alkermes Controlled Therapeutics Inc. Ii |
Controlled release of antiparasitic agents in animals
|
|
US5543390A
(en)
|
1990-11-01 |
1996-08-06 |
State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University |
Covalent microparticle-drug conjugates for biological targeting
|
|
US5580578A
(en)
|
1992-01-27 |
1996-12-03 |
Euro-Celtique, S.A. |
Controlled release formulations coated with aqueous dispersions of acrylic polymers
|
|
US5323907A
(en)
|
1992-06-23 |
1994-06-28 |
Multi-Comp, Inc. |
Child resistant package assembly for dispensing pharmaceutical medications
|
|
TW333456B
(en)
|
1992-12-07 |
1998-06-11 |
Takeda Pharm Ind Co Ltd |
A pharmaceutical composition of sustained-release preparation the invention relates to a pharmaceutical composition of sustained-release preparation which comprises a physiologically active peptide.
|
|
US5591767A
(en)
|
1993-01-25 |
1997-01-07 |
Pharmetrix Corporation |
Liquid reservoir transdermal patch for the administration of ketorolac
|
|
US6274552B1
(en)
|
1993-03-18 |
2001-08-14 |
Cytimmune Sciences, Inc. |
Composition and method for delivery of biologically-active factors
|
|
US5523092A
(en)
|
1993-04-14 |
1996-06-04 |
Emory University |
Device for local drug delivery and methods for using the same
|
|
US5985307A
(en)
|
1993-04-14 |
1999-11-16 |
Emory University |
Device and method for non-occlusive localized drug delivery
|
|
US6087324A
(en)
|
1993-06-24 |
2000-07-11 |
Takeda Chemical Industries, Ltd. |
Sustained-release preparation
|
|
US6004534A
(en)
|
1993-07-23 |
1999-12-21 |
Massachusetts Institute Of Technology |
Targeted polymerized liposomes for improved drug delivery
|
|
IT1270594B
(it)
|
1994-07-07 |
1997-05-07 |
Recordati Chem Pharm |
Composizione farmaceutica a rilascio controllato di moguisteina in sospensione liquida
|
|
US5759542A
(en)
|
1994-08-05 |
1998-06-02 |
New England Deaconess Hospital Corporation |
Compositions and methods for the delivery of drugs by platelets for the treatment of cardiovascular and other diseases
|
|
EP0711804A3
(de)
|
1994-11-14 |
1999-09-22 |
Ciba SC Holding AG |
Kryptolichtschutzmittel
|
|
US5660854A
(en)
|
1994-11-28 |
1997-08-26 |
Haynes; Duncan H |
Drug releasing surgical implant or dressing material
|
|
US6316652B1
(en)
|
1995-06-06 |
2001-11-13 |
Kosta Steliou |
Drug mitochondrial targeting agents
|
|
US5798119A
(en)
|
1995-06-13 |
1998-08-25 |
S. C. Johnson & Son, Inc. |
Osmotic-delivery devices having vapor-permeable coatings
|
|
AU6242096A
(en)
|
1995-06-27 |
1997-01-30 |
Takeda Chemical Industries Ltd. |
Method of producing sustained-release preparation
|
|
JP3512911B2
(ja)
|
1995-07-11 |
2004-03-31 |
富士写真フイルム株式会社 |
紫外線吸収剤前駆体化合物、それを含有する感光性樹脂組成物及び画像形成方法
|
|
TW448055B
(en)
|
1995-09-04 |
2001-08-01 |
Takeda Chemical Industries Ltd |
Method of production of sustained-release preparation
|
|
JP2909418B2
(ja)
|
1995-09-18 |
1999-06-23 |
株式会社資生堂 |
薬物の遅延放出型マイクロスフイア
|
|
US6039975A
(en)
|
1995-10-17 |
2000-03-21 |
Hoffman-La Roche Inc. |
Colon targeted delivery system
|
|
US5980945A
(en)
|
1996-01-16 |
1999-11-09 |
Societe De Conseils De Recherches Et D'applications Scientifique S.A. |
Sustained release drug formulations
|
|
TW345603B
(en)
|
1996-05-29 |
1998-11-21 |
Gmundner Fertigteile Gmbh |
A noise control device for tracks
|
|
US6264970B1
(en)
|
1996-06-26 |
2001-07-24 |
Takeda Chemical Industries, Ltd. |
Sustained-release preparation
|
|
US6419961B1
(en)
|
1996-08-29 |
2002-07-16 |
Takeda Chemical Industries, Ltd. |
Sustained release microcapsules of a bioactive substance and a biodegradable polymer
|
|
HUP0000116A3
(en)
|
1996-10-01 |
2000-08-28 |
Stanford Res Inst Int |
Taste-masked microcapsule compositions and methods of manufacture
|
|
CA2217134A1
(en)
|
1996-10-09 |
1998-04-09 |
Sumitomo Pharmaceuticals Co., Ltd. |
Sustained release formulation
|
|
DE69730093T2
(de)
|
1996-10-31 |
2006-07-20 |
Takeda Pharmaceutical Co. Ltd. |
Zubereitung mit verzögerter Freisetzung
|
|
US6131570A
(en)
|
1998-06-30 |
2000-10-17 |
Aradigm Corporation |
Temperature controlling device for aerosol drug delivery
|
|
WO1998027980A2
(en)
|
1996-12-20 |
1998-07-02 |
Takeda Chemical Industries, Ltd. |
Method of producing a sustained-release preparation
|
|
US5891474A
(en)
|
1997-01-29 |
1999-04-06 |
Poli Industria Chimica, S.P.A. |
Time-specific controlled release dosage formulations and method of preparing same
|
|
US6120751A
(en)
|
1997-03-21 |
2000-09-19 |
Imarx Pharmaceutical Corp. |
Charged lipids and uses for the same
|
|
US6060082A
(en)
|
1997-04-18 |
2000-05-09 |
Massachusetts Institute Of Technology |
Polymerized liposomes targeted to M cells and useful for oral or mucosal drug delivery
|
|
KR100563514B1
(ko)
|
1997-07-24 |
2006-03-27 |
젠야쿠코교가부시키가이샤 |
헤테로고리 화합물 및 이를 유효성분으로 하는 항종양제
|
|
JPH11174638A
(ja)
|
1997-12-08 |
1999-07-02 |
Konica Corp |
ハロゲン化銀カラー写真感光材料
|
|
US6350458B1
(en)
|
1998-02-10 |
2002-02-26 |
Generex Pharmaceuticals Incorporated |
Mixed micellar drug deliver system and method of preparation
|
|
US6613358B2
(en)
|
1998-03-18 |
2003-09-02 |
Theodore W. Randolph |
Sustained-release composition including amorphous polymer
|
|
US6048736A
(en)
|
1998-04-29 |
2000-04-11 |
Kosak; Kenneth M. |
Cyclodextrin polymers for carrying and releasing drugs
|
|
KR19990085365A
(ko)
|
1998-05-16 |
1999-12-06 |
허영섭 |
지속적으로 약물 조절방출이 가능한 생분해성 고분자 미립구 및그 제조방법
|
|
US6248363B1
(en)
|
1999-11-23 |
2001-06-19 |
Lipocine, Inc. |
Solid carriers for improved delivery of active ingredients in pharmaceutical compositions
|
|
US6271359B1
(en)
|
1999-04-14 |
2001-08-07 |
Musc Foundation For Research Development |
Tissue-specific and pathogen-specific toxic agents and ribozymes
|
|
AU5636900A
(en)
*
|
1999-06-30 |
2001-01-31 |
Merck & Co., Inc. |
Src kinase inhibitor compounds
|
|
CA2394727A1
(en)
*
|
1999-12-28 |
2001-07-05 |
Pharmacopeia, Inc. |
Pyrimidine and triazine kinase inhibitors
|
|
ES2788383T3
(es)
|
2000-04-25 |
2020-10-21 |
Icos Corp |
Inhibidores de delta fosfatidilo-inositol 3-quinasa humana
|
|
US6777439B2
(en)
|
2000-05-30 |
2004-08-17 |
Advanced Research & Technology Institute, Inc. |
Compositions and methods for identifying agents which modulate PTEN function and PI-3 kinase pathways
|
|
AP2001002264A0
(en)
|
2000-08-30 |
2001-09-30 |
Pfizer Prod Inc |
Sustained release formulations for growth hormone secretagogues.
|
|
EP1389617B1
(en)
|
2001-04-27 |
2007-01-03 |
Zenyaku Kogyo Kabushiki Kaisha |
Heterocyclic compound and antitumor agent containing the same as active ingredient
|
|
DE10207037A1
(de)
|
2002-02-20 |
2003-08-28 |
Bayer Cropscience Gmbh |
2-Amino-4-bicyclyamino-6H-1,3.5-triazine, Verfahren zu deren Herstellung und deren Verwendung als Herbizide und Pflanzenwachstumsregulatoren
|
|
WO2003078423A1
(en)
|
2002-03-15 |
2003-09-25 |
Vertex Pharmaceuticals, Inc. |
Compositions useful as inhibitors of protein kinases
|
|
DE60327999D1
(de)
|
2002-03-15 |
2009-07-30 |
Vertex Pharma |
Azolylaminoazine als inhibitoren von proteinkinasen
|
|
EP1485100B1
(en)
|
2002-03-15 |
2010-05-05 |
Vertex Pharmaceuticals Incorporated |
Azinylaminoazoles as inhibitors of protein kinases
|
|
AU2003218215A1
(en)
|
2002-03-15 |
2003-09-29 |
Vertex Pharmaceuticals, Inc. |
Azolylaminoazines as inhibitors of protein kinases
|
|
CN1668759A
(zh)
|
2002-05-17 |
2005-09-14 |
协和发酵工业株式会社 |
具有抗糖尿病作用的物质的探索方法
|
|
KR101046015B1
(ko)
|
2002-10-25 |
2011-07-01 |
젠야쿠코교가부시키가이샤 |
헤테로고리 화합물 및 이것을 유효성분으로 하는 항종양제
|
|
US7423148B2
(en)
|
2002-11-21 |
2008-09-09 |
Chiron Corporation |
Small molecule PI 3-kinase inhibitors and methods of their use
|
|
WO2005028467A1
(en)
|
2003-09-15 |
2005-03-31 |
Anadys Pharmaceuticals, Inc. |
Antibacterial 3,5-diaminopiperidine-substitute aromatic and heteroaromatic compounds
|
|
NZ546058A
(en)
|
2004-01-12 |
2010-09-30 |
Ym Biosciences Australia Pty |
Benzimidazole and other fused ring derivatives as selective janus kinase inhibitors
|
|
CA2561406C
(en)
|
2004-03-31 |
2012-07-03 |
Zenyaku Kogyo Kabushiki Kaisha |
Heterocyclic compound and anti-malignant-tumor agent comprising the same as effective component
|
|
ME01309B
(me)
|
2004-08-26 |
2013-12-20 |
Pfizer |
Pirazolom supstituirani heteroarilni spojevi kao inhibitori proteinskih kinaza
|
|
WO2006053109A1
(en)
|
2004-11-10 |
2006-05-18 |
Synta Pharmaceuticals Corp. |
Heteroaryl compounds
|
|
EP1819341A4
(en)
|
2004-11-10 |
2011-06-29 |
Synta Pharmaceuticals Corp |
IL-12 MODULATORY CONNECTIONS
|
|
TWI381841B
(zh)
|
2005-03-11 |
2013-01-11 |
Zenyaku Kogyo Kk |
An immunosuppressive agent and an antitumor agent containing a heterocyclic compound as an active ingredient
|
|
GB0510390D0
(en)
|
2005-05-20 |
2005-06-29 |
Novartis Ag |
Organic compounds
|
|
GB0525080D0
(en)
|
2005-12-09 |
2006-01-18 |
Astrazeneca Ab |
Pyrimidine derivatives
|
|
GB0525081D0
(en)
|
2005-12-09 |
2006-01-18 |
Astrazeneca Ab |
Pyrimidine derivatives
|
|
JO2660B1
(en)
|
2006-01-20 |
2012-06-17 |
نوفارتيس ايه جي |
Pi-3 inhibitors and methods of use
|
|
US20070244110A1
(en)
|
2006-04-14 |
2007-10-18 |
Zenyaku Kogyo Kabushiki Kaisha |
Treatment of prostate cancer, melanoma or hepatic cancer
|
|
TWI498332B
(zh)
|
2006-04-26 |
2015-09-01 |
Hoffmann La Roche |
作為pi3k抑制劑之嘧啶衍生物及相關製備方法、醫藥組合物、用途、套組及產物
|
|
CN101511840A
(zh)
|
2006-04-26 |
2009-08-19 |
吉宁特有限公司 |
磷酸肌醇3-激酶抑制剂化合物及其使用方法
|
|
DK2050749T3
(en)
|
2006-08-08 |
2018-01-08 |
Chugai Pharmaceutical Co Ltd |
PYRIMIDINE DERIVATIVES AS PI3K INHIBITOR AND USE THEREOF
|
|
WO2008032077A1
(en)
|
2006-09-14 |
2008-03-20 |
Astrazeneca Ab |
Pyrimidine derivatives
|
|
CN101595103A
(zh)
|
2006-09-14 |
2009-12-02 |
阿斯利康(瑞典)有限公司 |
嘧啶衍生物
|
|
JP2010503651A
(ja)
|
2006-09-14 |
2010-02-04 |
アストラゼネカ アクチボラグ |
増殖性障害の治療用のPI3K及びmTOR阻害剤としての2−ベンゾイミダゾリル−6−モルホリノ−フェニルピリミジン誘導体
|
|
WO2008032091A1
(en)
|
2006-09-14 |
2008-03-20 |
Astrazeneca Ab |
4-benzimidaz0lyl-6-m0rph0lin0-2-piperidin-4-ylpyrimidine derivatives as pi3k and mtor inhibitors for the treatment of proliferative disorders
|
|
EP2069330A1
(en)
|
2006-09-14 |
2009-06-17 |
AstraZeneca AB |
2 -benzimidazolyl- 6 -morpholino-4- (azetidine, pyrrolidine, piperidine or azepine) pyrimidine derivatives as pi3k and mtor inhibitors for the treatment of proliferative disorders
|
|
WO2008032072A1
(en)
|
2006-09-14 |
2008-03-20 |
Astrazeneca Ab |
2-benzimidaz0lyl-6-m0rph0lin0-4-piperidin-4-ylpyrimidine derivatives as pi3k and mtor inhibitors for the treatment of proliferative disorders
|
|
WO2008032036A1
(en)
|
2006-09-14 |
2008-03-20 |
Astrazeneca Ab |
6-benzimidaz0lyl-2-m0rph0lin0-4- (azetidine, pyrrolidine, piperidine or azepine) pyrimidine derivatives as pi3k and mtor inhibitors for the treatment of proliferative disorders
|
|
WO2008032041A1
(en)
|
2006-09-14 |
2008-03-20 |
Astrazeneca Ab |
Pyrimidine derivatives having inhibitory activity against pi3k enzymes
|
|
WO2008032033A1
(en)
|
2006-09-14 |
2008-03-20 |
Astrazeneca Ab |
4-benzimidazolyl-2-morpholino-6-piperazinylpyrimidine derivatives as pi3k and mtor inhibitors for the treatment of proliferative disorders
|
|
WO2008032027A1
(en)
|
2006-09-14 |
2008-03-20 |
Astrazeneca Ab |
Pyrimidine derivatives
|
|
WO2008032060A1
(en)
|
2006-09-14 |
2008-03-20 |
Astrazeneca Ab |
4-benzimidaz0lyl-6-m0rph0lin0-2-piperazinylpyrimidine derivatives as p13k and mtor inhibitors for the treatment of proliferative disorders
|
|
WO2008032089A1
(en)
|
2006-09-14 |
2008-03-20 |
Astrazeneca Ab |
4-benzimidaz0lyl-2-m0rph0lin0-6-piperidin-4-ylpyrimidine derivatives as pi3k and mtor inhibitors for the treatment of proliferative disorders
|
|
WO2008098058A1
(en)
|
2007-02-06 |
2008-08-14 |
Novartis Ag |
Pi 3-kinase inhibitors and methods of their use
|
|
WO2008110891A2
(en)
|
2007-03-09 |
2008-09-18 |
Orchid Research Laboratories Limited, |
New heterocyclic compounds
|
|
US20080234262A1
(en)
|
2007-03-21 |
2008-09-25 |
Wyeth |
Pyrazolopyrimidine analogs and their use as mtor kinase and pi3 kinase inhibitors
|
|
US20080233127A1
(en)
|
2007-03-21 |
2008-09-25 |
Wyeth |
Imidazolopyrimidine analogs and their use as pi3 kinase and mtor inhibitors
|
|
EP2125819B1
(en)
*
|
2007-03-21 |
2014-10-22 |
Bristol-Myers Squibb Company |
Fused heterocyclic compounds useful for the treatment of proliferative, allergic, autoimmune or inflammatory diseases
|
|
AU2008262291A1
(en)
|
2007-06-11 |
2008-12-18 |
Miikana Therapeutics, Inc. |
Substituted pyrazole compounds
|
|
WO2009007751A2
(en)
|
2007-07-09 |
2009-01-15 |
Astrazeneca Ab |
Trisubstituted pyrimidine derivatives for the treatment of proliferative diseases
|
|
EP2209785A1
(en)
|
2007-10-05 |
2010-07-28 |
S*BIO Pte Ltd |
2-morpholinylpurines as inhibitors of pi3k
|
|
BRPI0817503B8
(pt)
|
2007-10-05 |
2021-05-25 |
Sstarbio Pte Ltd |
derivados de purina substituídos por pirimidina, composição farmacêutica compreendendo ditos compostos e uso dos mesmos para a prevenção ou tratamento de uma condição proliferativa
|
|
TWI482768B
(zh)
|
2007-11-22 |
2015-05-01 |
Zenyaku Kogyo Kk |
雜環化合物之非晶質體、含有其之固體分散體、藥劑及其製法
|
|
US8193182B2
(en)
|
2008-01-04 |
2012-06-05 |
Intellikine, Inc. |
Substituted isoquinolin-1(2H)-ones, and methods of use thereof
|
|
WO2009091788A1
(en)
|
2008-01-15 |
2009-07-23 |
Wyeth |
3h-[1,2,3]triazolo[4,5-d]pyrimidine compounds, their use as mtor kinase and pi3 kinase inhibitors, and their syntheses
|
|
WO2009093981A1
(en)
|
2008-01-23 |
2009-07-30 |
S Bio Pte Ltd |
Triazine compounds as kinase inhibitors
|
|
US20090192176A1
(en)
|
2008-01-30 |
2009-07-30 |
Wyeth |
1H-PYRAZOLO[3,4-D]PYRIMIDINE, PURINE, 7H-PURIN-8(9H)-ONE, 3H-[1,2,3]TRIAZOLO[4,5-D]PYRIMIDINE, AND THIENO[3,2-D]PYRIMIDINE COMPOUNDS, THEIR USE AS mTOR KINASE AND PI3 KINASE INHIBITORS, AND THEIR SYNTHESES
|
|
TW200938201A
(en)
|
2008-02-07 |
2009-09-16 |
Chugai Pharmaceutical Co Ltd |
Pyrrolopyrimidine derivative as PI3K inhibitor and use thereof
|
|
EP2276750A2
(en)
|
2008-03-27 |
2011-01-26 |
Auckland Uniservices Limited |
Substituted pyrimidines and triazines and their use in cancer therapy
|
|
AP2775A
(en)
|
2008-05-23 |
2013-09-30 |
Wyeth Llc |
Triazine compounds as P13 kinase and MTOR inhibitors
|
|
EP2310391A1
(en)
|
2008-06-27 |
2011-04-20 |
S*BIO Pte Ltd |
Pyrazine substituted purines
|
|
JP2011527342A
(ja)
|
2008-07-07 |
2011-10-27 |
エックスカバリー ホールディング カンパニー エルエルシー |
Pi3kアイソフォーム選択的阻害剤
|
|
WO2010048149A2
(en)
|
2008-10-20 |
2010-04-29 |
Kalypsys, Inc. |
Heterocyclic modulators of gpr119 for treatment of disease
|
|
GB2465405A
(en)
|
2008-11-10 |
2010-05-19 |
Univ Basel |
Triazine, pyrimidine and pyridine analogues and their use in therapy
|
|
CN102271683B
(zh)
|
2008-11-13 |
2014-07-09 |
吉里德卡利斯托加公司 |
恶性血液病的治疗
|
|
US20120165309A1
(en)
|
2009-02-12 |
2012-06-28 |
Astellas Pharma Inc. |
Hetero ring derivative
|
|
WO2010110686A1
(en)
|
2009-03-27 |
2010-09-30 |
Pathway Therapeutics Limited |
Pyrimidinyl and 1,3,5 triazinyl benzimidazoles and their use in cancer therapy
|
|
SG174527A1
(en)
*
|
2009-03-27 |
2011-11-28 |
Pathway Therapeutics Inc |
Pyrimidinyl and 1,3,5-triazinyl benzimidazole sulfonamides and their use in cancer therapy
|
|
CA2772371A1
(en)
|
2009-05-27 |
2010-12-02 |
F. Hoffmann-La Roche Ag |
Bicyclic indole-pyrimidine pi3k inhibitor compounds selective for p110 delta, and methods of use
|
|
CN102459272B
(zh)
|
2009-05-27 |
2014-08-06 |
健泰科生物技术公司 |
对P110δ具有选择性的为PI3K抑制剂的二环嘧啶化合物和使用方法
|
|
EA201270013A1
(ru)
|
2009-06-25 |
2012-06-29 |
Амген Инк. |
Гетероциклические соединения и их применение
|
|
CN102625799A
(zh)
|
2009-06-25 |
2012-08-01 |
安姆根有限公司 |
杂环化合物及其用途
|
|
WO2010151735A2
(en)
|
2009-06-25 |
2010-12-29 |
Amgen Inc. |
Heterocyclic compounds and their uses
|
|
EP2445902A2
(en)
|
2009-06-25 |
2012-05-02 |
Amgen, Inc |
Heterocyclic compounds and their uses as inhibitors of pi3k activity
|
|
US8486939B2
(en)
*
|
2009-07-07 |
2013-07-16 |
Pathway Therapeutics Inc. |
Pyrimidinyl and 1,3,5-triazinyl benzimidazoles and their use in cancer therapy
|
|
KR101759762B1
(ko)
*
|
2010-08-10 |
2017-07-19 |
아스텔라스세이야쿠 가부시키가이샤 |
헤테로환 화합물
|
|
EP2648676A4
(en)
|
2010-12-06 |
2016-05-04 |
Follica Inc |
METHODS FOR TREATING CALVITIA AND PROMOTING HAIR GROWTH
|
|
WO2012129562A2
(en)
|
2011-03-24 |
2012-09-27 |
The Scripps Research Institute |
Compounds and methods for inducing chondrogenesis
|
|
JP2014509648A
(ja)
*
|
2011-03-28 |
2014-04-21 |
メイ プハルマ,インコーポレーテッド |
(α−置換シクロアルキルアミノ及びヘテロシクリルアミノ)ピリミジニル及び1,3,5−トリアジニルベンズイミダゾール、その医薬組成物、並びに増殖性疾患の治療におけるそれらの使用
|
|
ES2608967T3
(es)
*
|
2011-03-28 |
2017-04-17 |
Mei Pharma, Inc. |
(Aralquilamino sustituido en alfa y heteroarilalquilamino)pirimidinil y 1,3,5-triazinil benzimidazoles, composiciones farmacéuticas que los contienen, y estos compuestos para usar en el tratamiento de enfermedades proliferativas
|
|
WO2012135166A1
(en)
|
2011-03-28 |
2012-10-04 |
Pathway Therapeutics Inc. |
(fused ring arylamino and heterocyclylamino) pyrimidynyl and 1,3,5-triazinyl benzimidazoles, pharmaceutical compositions thereof, and their use in treating proliferative diseases
|
|
EP2723745A1
(en)
|
2011-06-22 |
2014-04-30 |
Vertex Pharmaceuticals Inc. |
Compounds useful as inhibitors of atr kinase
|
|
WO2012178124A1
(en)
|
2011-06-22 |
2012-12-27 |
Vertex Pharmaceuticals Incorporated |
Compounds useful as inhibitors of atr kinase
|
|
WO2012178125A1
(en)
|
2011-06-22 |
2012-12-27 |
Vertex Pharmaceuticals Incorporated |
Compounds useful as inhibitors of atr kinase
|
|
WO2013006408A1
(en)
|
2011-07-01 |
2013-01-10 |
Tempero Pharmaceuticals, Inc. |
Compounds and methods
|
|
EP2776386B1
(de)
|
2011-11-11 |
2019-11-20 |
Merck Patent GmbH |
Verfahren zur herstellung von arylaminen
|
|
BR112015002285B1
(pt)
|
2012-08-09 |
2022-05-10 |
Celgene Corporation |
Uso do composto 3-(4-((4-(morfolinometil)benzil)oxi)-1-oxoisoindolin-2-il)piperidina-2,6-diona para tratar ou gerenciar câncer
|
|
WO2014055647A1
(en)
|
2012-10-03 |
2014-04-10 |
Mei Pharma, Inc. |
(sulfinyl and sulfonyl benzimidazolyl) pyrimidines and triazines, pharmaceutical compositions thereof, and their use for treating proliferative diseases
|
|
US9963452B2
(en)
|
2013-03-14 |
2018-05-08 |
Augusta Pharmaceuticals Inc. |
Methods, compounds, and compositions for inhibition of ROS
|
|
EP2832358A1
(en)
|
2013-08-02 |
2015-02-04 |
Bionsil S.r.l. |
Pharmaceutical kit for use in the treatment of colon and colorectal cancer
|
|
EA201691169A1
(ru)
|
2013-12-05 |
2016-09-30 |
Асерта Фарма Б.В. |
Терапевтическая комбинация ингибитора pi3k и ингибитора btk
|
|
AU2015220427B2
(en)
|
2014-02-19 |
2017-09-21 |
Piramal Enterprises Limited |
Compounds for use as GPR120 agonists
|
|
US9949971B2
(en)
|
2014-06-17 |
2018-04-24 |
Acerta Pharma B.V. |
Therapeutic combinations of a BTK inhibitor, a PI3K inhibitor and/or a JAK-2 inhibitor
|
|
US10869926B2
(en)
|
2014-07-15 |
2020-12-22 |
The Johns Hopkins University |
Suppression of myeloid derived suppressor cells and immune checkpoint blockade
|
|
US20170239351A1
(en)
|
2014-08-11 |
2017-08-24 |
Acerta Pharma B.V. |
Therapeutic Combinations of a BTK Inhibitor, a PI3K Inhibitor, a JAK-2 Inhibitor, a PD-1 Inhibitor, and/or a PD-L1 Inhibitor
|
|
WO2016024227A1
(en)
|
2014-08-11 |
2016-02-18 |
Acerta Pharma B.V. |
Btk inhibitors to treat solid tumors through modulation of the tumor microenvironment
|
|
PT3262071T
(pt)
|
2014-09-23 |
2020-06-16 |
H Hoffnabb La Roche Ag |
Métodos de utilização de imunoconjugados anti-cd79b
|
|
AU2015367977B9
(en)
|
2014-12-24 |
2020-02-06 |
Lg Chem, Ltd |
Biaryl derivative as GPR120 agonist
|
|
AR105392A1
(es)
|
2015-07-20 |
2017-09-27 |
Genzyme Corp |
Inhibidores del receptor del factor estimulador de colonias 1 (csf-1r)
|
|
WO2017035234A1
(en)
|
2015-08-24 |
2017-03-02 |
Epizyme, Inc. |
Method for treating cancer
|
|
EP3355875B1
(en)
|
2015-10-01 |
2021-09-29 |
Gilead Sciences, Inc. |
Combination of a btk inhibitor and a checkpoint inhibitor for treating cancers
|
|
WO2017066705A1
(en)
|
2015-10-14 |
2017-04-20 |
Aquinnah Pharmaceuticals, Inc. |
Compounds, compositions and methods of use against stress granules
|
|
EP3487878A4
(en)
|
2016-07-20 |
2020-03-25 |
University of Utah Research Foundation |
CD229-CAR-T CELLS AND METHOD FOR USE THEREOF
|
|
WO2018060833A1
(en)
|
2016-09-27 |
2018-04-05 |
Novartis Ag |
Dosage regimen for alpha-isoform selective phosphatidylinositol 3-kinase inhibitor alpelisib
|
|
US11304953B2
(en)
|
2017-05-23 |
2022-04-19 |
Mei Pharma, Inc. |
Combination therapy
|
|
KR20200041358A
(ko)
|
2017-08-14 |
2020-04-21 |
메이 파마, 아이엔씨. |
병용 요법
|
|
EP3768258A4
(en)
|
2018-03-21 |
2022-01-12 |
MEI Pharma, Inc. |
COMBINATION THERAPY
|
|
AU2019321526A1
(en)
|
2018-08-14 |
2021-03-25 |
Mei Pharma, Inc. |
Treatment of relapsed follicular lymphoma
|
|
MX2021001606A
(es)
|
2018-08-14 |
2021-04-19 |
Mei Pharma Inc |
Tratamiento de la malignidades de las celulas b.
|
|
WO2020132563A1
(en)
|
2018-12-21 |
2020-06-25 |
Mei Pharma, Inc. |
Combination therapy
|