JP2017508135A5 - - Google Patents

Download PDF

Info

Publication number
JP2017508135A5
JP2017508135A5 JP2016546935A JP2016546935A JP2017508135A5 JP 2017508135 A5 JP2017508135 A5 JP 2017508135A5 JP 2016546935 A JP2016546935 A JP 2016546935A JP 2016546935 A JP2016546935 A JP 2016546935A JP 2017508135 A5 JP2017508135 A5 JP 2017508135A5
Authority
JP
Japan
Prior art keywords
proteins
recombinant therapeutic
recombinant
alpha
protein
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2016546935A
Other languages
English (en)
Japanese (ja)
Other versions
JP6560236B2 (ja
JP2017508135A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2015/011705 external-priority patent/WO2015109151A1/en
Publication of JP2017508135A publication Critical patent/JP2017508135A/ja
Publication of JP2017508135A5 publication Critical patent/JP2017508135A5/ja
Application granted granted Critical
Publication of JP6560236B2 publication Critical patent/JP6560236B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2016546935A 2014-01-17 2015-01-16 無菌クロマトグラフィー樹脂および製造方法におけるその使用 Active JP6560236B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201461928929P 2014-01-17 2014-01-17
US61/928,929 2014-01-17
US201462001498P 2014-05-21 2014-05-21
US62/001,498 2014-05-21
PCT/US2015/011705 WO2015109151A1 (en) 2014-01-17 2015-01-16 Sterile chromatography resin and use thereof in manufacturing processes

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2019131561A Division JP6880117B2 (ja) 2014-01-17 2019-07-17 無菌クロマトグラフィー樹脂および製造方法におけるその使用

Publications (3)

Publication Number Publication Date
JP2017508135A JP2017508135A (ja) 2017-03-23
JP2017508135A5 true JP2017508135A5 (2) 2018-02-08
JP6560236B2 JP6560236B2 (ja) 2019-08-14

Family

ID=52440888

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2016546935A Active JP6560236B2 (ja) 2014-01-17 2015-01-16 無菌クロマトグラフィー樹脂および製造方法におけるその使用
JP2019131561A Active JP6880117B2 (ja) 2014-01-17 2019-07-17 無菌クロマトグラフィー樹脂および製造方法におけるその使用

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2019131561A Active JP6880117B2 (ja) 2014-01-17 2019-07-17 無菌クロマトグラフィー樹脂および製造方法におけるその使用

Country Status (18)

Country Link
US (4) US10071364B2 (2)
EP (1) EP3094392B1 (2)
JP (2) JP6560236B2 (2)
KR (1) KR102306419B1 (2)
CN (2) CN108114508B (2)
AU (2) AU2015206341B2 (2)
BR (1) BR112016016332B1 (2)
CA (1) CA2936969C (2)
DK (1) DK3094392T3 (2)
ES (1) ES2982088T3 (2)
HU (1) HUE067110T2 (2)
IL (2) IL246775B (2)
MX (2) MX381357B (2)
PL (1) PL3094392T3 (2)
RU (1) RU2679134C2 (2)
SG (2) SG10201804483PA (2)
TW (1) TWI709569B (2)
WO (1) WO2015109151A1 (2)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG10201806083RA (en) 2013-02-22 2018-08-30 Genzyme Corp Microcarrier perfusion culturing methods and uses thereof
HUE042094T2 (hu) 2013-02-22 2019-06-28 Genzyme Corp Mikrokarrier-perfúziós tenyésztési eljárások és alkalmazásuk
AU2014226126B2 (en) 2013-03-08 2019-02-14 Genzyme Corporation Continuous purification of therapeutic proteins
TWI709569B (zh) 2014-01-17 2020-11-11 美商健臻公司 無菌層析樹脂及其用於製造方法的用途
TWI709570B (zh) 2014-01-17 2020-11-11 美商健臻公司 無菌層析法及製法
TWI743024B (zh) 2014-06-06 2021-10-21 美商健臻公司 灌注培養方法及其用途
TWI707949B (zh) 2014-06-09 2020-10-21 美商健臻公司 種子罐培養法(seed train processes)及其用途
SG10202001034PA (en) 2014-12-22 2020-04-29 Genzyme Corp Methods of culturing a mammalian cell
EP3717624A1 (en) * 2017-11-30 2020-10-07 Corning Incorporated Package for batch chromatography
CN108776190B (zh) * 2018-04-19 2020-08-07 中国林业科学研究院林业研究所 沙棘中酚类物质定量检测方法
AU2019332764B2 (en) * 2018-08-31 2025-05-29 Genzyme Corporation Sterile chromatography resin and use thereof in manufacturing processes
TW202134631A (zh) 2019-10-22 2021-09-16 美商健臻公司 整合式連續生物製造中的線上產品監測
US20240368654A1 (en) * 2021-06-07 2024-11-07 University Of Massachusetts Apparatus and method for continuous production of rna
CA3247416A1 (en) * 2022-04-08 2023-10-12 Csl Behring Ag Methods of sanitizing and/or regenerating a chromatography medium
GB2626063A (en) * 2023-01-06 2024-07-10 Micronclean Ltd Disinfectant formulation
WO2024155768A1 (en) * 2023-01-18 2024-07-25 President And Fellows Of Harvard College Devices, chromatography columns, methods for automated chromatography in parallel and methods for purification of extracellular vesicles
WO2025059162A1 (en) 2023-09-11 2025-03-20 Dana-Farber Cancer Institute, Inc. Car-engager containing il-2 variants to enhance the functionality of car t cells

Family Cites Families (130)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US533575A (en) 1895-02-05 wilkens
US4401108A (en) 1980-02-13 1983-08-30 Thomas Jefferson University Radioactive material loading, calibration and injection systems
SU1033181A1 (ru) 1982-02-02 1983-08-07 Томское Отделение Охтинского Ордена Ленина И Ордена Трудового Красного Знамени Научно-Производственного Объединения "Пластполимер" Способ обработки полимерного сорбента дл хроматографии
JPS6075530A (ja) 1983-09-30 1985-04-27 Asahi Chem Ind Co Ltd 金属元素の新しい分離精製方法
US4559175A (en) 1984-04-19 1985-12-17 The United States Of America As Represented By The Secretary Of The Air Force Halo-substituted diphospha-s-triazines and their derivatives
US4885250A (en) 1987-03-02 1989-12-05 E. I. Du Pont De Nemours And Company Enzyme immobilization and bioaffinity separations with perfluorocarbon polymer-based supports
US5612016A (en) 1988-04-01 1997-03-18 Immunomedics, Inc. Conjugates of antibodies and bifunctional ligands
US5169936A (en) 1989-04-14 1992-12-08 Biogen, Inc. Protein purification on immobilized metal affinity resins effected by elution using a weak ligand
US5226895A (en) 1989-06-05 1993-07-13 Eli Lilly And Company Multiple dose injection pen
AU6355790A (en) 1989-08-04 1991-03-11 Peter Grandics An integrated cell culture-protein purification system for the automated production and purification of cell culture products
US5244816A (en) 1989-10-11 1993-09-14 Akzo N.V. Method for purifying chelator conjugated compounds
GB9007113D0 (en) 1990-03-29 1990-05-30 Sams Bernard Dispensing device
AU1742092A (en) 1991-04-05 1992-11-02 Brigham Young University Support bonded polyalkylene-polyamine-poly(carboxylic acid) and extraction of metal ions therewith
EP0525525B1 (de) 1991-07-24 1995-05-03 Medico Development Investment Company Injektor
DK175491D0 (da) 1991-10-18 1991-10-18 Novo Nordisk As Apparat
US5279585A (en) 1992-02-04 1994-01-18 Becton, Dickinson And Company Medication delivery pen having improved dose delivery features
RU2034853C1 (ru) * 1992-07-14 1995-05-10 Научно-исследовательский институт строительных материалов при Томской государственной инженерно-строительной академии Способ получения полимерного сорбента для хроматографии
US5320609A (en) 1992-12-07 1994-06-14 Habley Medical Technology Corporation Automatic pharmaceutical dispensing syringe
US5383865A (en) 1993-03-15 1995-01-24 Eli Lilly And Company Medication dispensing device
ZA941881B (en) 1993-04-02 1995-09-18 Lilly Co Eli Manifold medication injection apparatus and method
JP2871435B2 (ja) 1993-04-22 1999-03-17 イー・アイ・デュポン・ドウ・ヌムール・アンド・カンパニー 親水性ポリマー被覆パーフルオロカーボンポリマーベースのマトリックスの製造方法
JPH07110229A (ja) 1993-10-12 1995-04-25 Nkk Corp 金属ストリップループの最下点位置検出装置
US5478924A (en) 1994-02-16 1995-12-26 Cramer; Steven M. Displacement chromatography of proteins using low molecular weight displacers
US5429746A (en) * 1994-02-22 1995-07-04 Smith Kline Beecham Corporation Antibody purification
US5856179A (en) 1994-03-10 1999-01-05 Genentech, Inc. Polypeptide production in animal cell culture
US5423982A (en) 1994-05-31 1995-06-13 Biosepra Inc. Liquid chromatography column adapted for in situ chemical sterilization
US5610285A (en) 1994-08-24 1997-03-11 Bayer Corporation Purification of α-1 proteinase inhibitor using novel chromatographic separation conditions
US5582598A (en) 1994-09-19 1996-12-10 Becton Dickinson And Company Medication delivery pen with variable increment dose scale
WO1996027400A1 (en) 1995-03-07 1996-09-12 Eli Lilly And Company Recyclable medication dispensing device
US6359114B1 (en) 1995-06-07 2002-03-19 Aphton Corp. System for method for the modification and purification of proteins
US5688251A (en) 1995-09-19 1997-11-18 Becton Dickinson And Company Cartridge loading and priming mechanism for a pen injector
US5674204A (en) 1995-09-19 1997-10-07 Becton Dickinson And Company Medication delivery pen cap actuated dose delivery clutch
US5691152A (en) * 1995-11-09 1997-11-25 E. R. Squibb & Sons, Inc. Stable avidin composition
AR005035A1 (es) 1995-12-11 1999-04-07 Merck Patent Ges Mit Beschränkter Haftung Procedimiento para preparar proteinas recombinantes en e. coli, mediante fermentacion con gran concentracion de celulas.
DE69738075T2 (de) 1996-11-27 2008-05-21 Genentech, Inc., South San Francisco Affinitätsreinigung von polypeptiden an einer protein a-matrix
US6955917B2 (en) 1997-06-20 2005-10-18 Bayer Healthcare Llc Chromatographic method for high yield purification and viral inactivation of antibodies
US5886154A (en) 1997-06-20 1999-03-23 Lebing; Wytold R. Chromatographic method for high yield purification and viral inactivation of antibodies
DE19730999C1 (de) 1997-07-18 1998-12-10 Disetronic Licensing Ag Dosierknopfsicherung an einer Vorrichtung zur dosierten Verabreichung eines injizierbaren Produkts
US5921966A (en) 1997-08-11 1999-07-13 Becton Dickinson And Company Medication delivery pen having an improved clutch assembly
US6265542B1 (en) 1997-10-24 2001-07-24 Genentech, Inc. Purification of molecules
US7611831B2 (en) 1998-01-06 2009-11-03 Cerus Corporation Adsorbing pathogen-inactivating compounds with porous particles immobilized in a matrix
ATE197408T1 (de) 1998-01-30 2000-11-11 Novo Nordisk As Eine injektionsspritze
US6221053B1 (en) 1998-02-20 2001-04-24 Becton, Dickinson And Company Multi-featured medication delivery pen
US6096010A (en) 1998-02-20 2000-08-01 Becton, Dickinson And Company Repeat-dose medication delivery pen
US6248095B1 (en) 1998-02-23 2001-06-19 Becton, Dickinson And Company Low-cost medication delivery pen
NZ507557A (en) 1998-05-06 2003-10-31 Genentech Inc Protein purification by ion exchange chromatography
DE19858892A1 (de) 1998-12-19 2000-06-21 Merck Patent Gmbh Kontinuierliches Verfahren zur Trennung von Stoffen nach Molekülgröße
GB9902000D0 (en) * 1999-01-30 1999-03-17 Delta Biotechnology Ltd Process
ES2258469T3 (es) 1999-08-05 2006-09-01 Becton Dickinson And Company Lapiz de administracion de medicacion.
GB0007071D0 (en) 2000-03-24 2000-05-17 Sams Bernard One-way clutch mechanisms and injector devices
US6663602B2 (en) 2000-06-16 2003-12-16 Novo Nordisk A/S Injection device
GB0028879D0 (en) 2000-11-27 2001-01-10 Prometic Biosciences Ltd Adsorbents and their use
US6899699B2 (en) 2001-01-05 2005-05-31 Novo Nordisk A/S Automatic injection device with reset feature
IL157446A0 (en) 2001-02-23 2004-03-28 Immunex Corp Immunex Corp Increased recovery of active proteins
PT2258424E (pt) 2001-05-16 2013-03-28 Lilly Co Eli Aparelho injector de medicamento
ITBO20010426A1 (it) 2001-07-06 2003-01-06 Alfa Wassermann Spa Processo per la purificazione di proteine farmacologicamente attive mediante cromatografia in scambio cationico
US7252799B2 (en) 2001-08-31 2007-08-07 Clearant, Inc. Methods for sterilizing preparations containing albumin
US20030095890A1 (en) 2001-09-24 2003-05-22 Shirley Miekka Methods for sterilizing biological materials containing non-aqueous solvents
WO2003045546A1 (en) * 2001-11-27 2003-06-05 Prometic Biosciences Ltd. The use of metal-chelating adsorbents
US6660172B2 (en) 2002-01-31 2003-12-09 Koslow Technologies Corporation Precoat filtration media and methods of making and using
CA2473144C (en) 2002-02-05 2013-05-28 Genentech, Inc. Protein purification
WO2003102132A2 (en) 2002-04-26 2003-12-11 Genetech, Inc. Non-affinity purification of proteins
US6902909B2 (en) 2002-07-09 2005-06-07 Synthecon, Inc. Methods for efficient production of mammalian recombinant proteins
HUE033623T2 (en) 2002-09-11 2017-12-28 Genentech Inc protein purification
JP2006507249A (ja) 2002-09-13 2006-03-02 バイオジェン アイデック インコーポレイテッド 疑似移動床式クロマトグラフィーによる、ポリペプチドを精製する方法
GB0304822D0 (en) 2003-03-03 2003-04-09 Dca Internat Ltd Improvements in and relating to a pen-type injector
GB0304823D0 (en) 2003-03-03 2003-04-09 Dca Internat Ltd Improvements in and relating to a pen-type injector
US7157276B2 (en) 2003-06-20 2007-01-02 Biogen Idec Inc. Use of depth filtration in series with continuous centrifugation to clarify mammalian cell cultures
KR101150050B1 (ko) 2004-02-27 2012-07-05 지이 헬스케어 바이오-사이언시스 에이비 항체 정제 방법
CA2557229C (en) 2004-02-27 2012-07-10 Octapharma Ag A method of providing a purified, virus safe antibody preparation
DK1773976T4 (da) 2004-06-04 2020-02-10 Global Life Sciences Solutions Usa Llc Engangsbioreaktorsystemer og -fremgangsmåder
US20060004621A1 (en) 2004-06-30 2006-01-05 Malek Kamal M Real-time selection of survey candidates
WO2006026248A1 (en) 2004-08-25 2006-03-09 Sigma-Aldrich Co. Compositions and methods employing zwitterionic detergent combinations
PL1807101T3 (pl) 2004-09-30 2016-11-30 Urządzenia i sposoby do zintegrowanego wytwarzania cząsteczek biologicznych w sposób ciągły
WO2006039533A2 (en) 2004-09-30 2006-04-13 Sloan Kettering Institure For Cancer Research Bcr-abl imatinib resistance-associated peptides and methods of use thereof
CA2583578C (en) 2004-10-21 2014-04-01 Ge Healthcare Bio-Sciences Ab Chromatography ligand
AU2005299716B2 (en) 2004-10-22 2012-09-06 Amgen Inc. Methods for refolding of recombinant antibodies
EP1836316A4 (en) 2004-12-22 2009-07-22 Ambrx Inc PROCESS FOR EXPRESSION AND CLEANING OF RECOMBINANT HUMAN GROWTH HORMONE
DE102004063647A1 (de) 2004-12-31 2006-07-20 Tecpharma Licensing Ag Vorrichtung zur dosierten Verabreichung eines fluiden Produkts mit Kupplung
JP5021610B2 (ja) 2005-03-07 2012-09-12 ジーイー・ヘルスケア・バイオサイエンス・アクチボラグ 滅菌法
CN1923290A (zh) 2005-04-29 2007-03-07 成都夸常医学工业有限公司 一种病毒灭活方法、其中所用的处理系统以及装置
WO2007055789A2 (en) 2005-10-31 2007-05-18 Neose Technologies, Inc. Expression of soluble therapeutic proteins
WO2007075283A2 (en) 2005-12-06 2007-07-05 Amgen Inc. Polishing steps used in multi-step protein purification processes
WO2007116322A2 (en) 2006-02-17 2007-10-18 Novartis Ag Purification of bacterial antigens
US7673757B2 (en) 2006-02-17 2010-03-09 Millipore Corporation Adsorbent filter media for removal of biological contaminants in process liquids
JP2010507068A (ja) 2006-04-21 2010-03-04 バイエル・コーポレーシヨン 原位置測定のための装置、システム、方法
US20080132688A1 (en) 2006-09-22 2008-06-05 Amgen Inc. Methods for Removing Viral Contaminants During Protein Purification
US20080207487A1 (en) 2006-11-02 2008-08-28 Neose Technologies, Inc. Manufacturing process for the production of polypeptides expressed in insect cell-lines
MX2009008002A (es) 2007-02-01 2009-08-07 Mallinckrodt Baker Inc Soluciones de almacenamiento para medios cromatograficos y equipo cromatografico y uso de las mismas.
GB0704603D0 (en) 2007-03-09 2007-04-18 Ge Healthcare Bio Sciences Ab Packing system and method for chromatography columns
US9597610B2 (en) 2007-03-09 2017-03-21 Ge Healthcare Bioprocess R&D Ab Packing system and method for chromatography columns
JP5140721B2 (ja) 2007-04-17 2013-02-13 イクスエンド、ホールディング、ベスローテン、フェンノートシャップ 連続メンブレン吸着方法および装置
WO2008153472A1 (en) 2007-06-15 2008-12-18 Ge Healthcare Bio-Sciences Ab Chromatography method
US7809258B2 (en) 2007-07-06 2010-10-05 Flir Systems Ab Camera and method for use with camera
US9109193B2 (en) 2007-07-30 2015-08-18 Ge Healthcare Bio-Sciences Corp. Continuous perfusion bioreactor system
ES2533266T5 (es) 2007-10-30 2018-04-18 Genentech, Inc. Purificación de anticuerpos mediante cromatografía de intercambio catiónico
SI2404994T1 (sl) 2007-12-27 2013-10-30 Otsuka Pharmaceutical Co., Ltd. Encim, povezan s sintezo ekvola
US8647309B2 (en) 2008-05-02 2014-02-11 Sanofi-Aventis Deutschland Gmbh Medication delivery device
EP2300497B1 (en) 2008-06-24 2012-08-08 Octapharma AG A process of purifying coagulation factor viii
NZ592095A (en) 2008-10-20 2013-01-25 Abbott Lab Isolation and purification of il-12 and tnf-alpha antibodies using protein a affinity chromatography
EP2373391A1 (en) 2008-12-08 2011-10-12 Novo Nordisk A/S Counter current purification of polypeptides
WO2010120514A2 (en) 2009-03-31 2010-10-21 The Trustees Of The University Of Pennsylvania Antigen-binding proteins comprising recombinant protein scaffolds
EP2236617A1 (en) 2009-03-31 2010-10-06 Leukocare Ag Methods of terminal sterilization of biofunctional compositions
US8877060B2 (en) * 2010-11-23 2014-11-04 Biovec Transfusion, Llc Methods for removing pathogens from a platelet preparation
CN102421858A (zh) 2009-06-22 2012-04-18 默克专利有限公司 导电制剂
US8580554B2 (en) 2009-07-31 2013-11-12 Baxter International Inc. Method of producing a polypeptide or virus of interest in a continuous cell culture
JP5893566B2 (ja) 2009-10-29 2016-03-23 アセンディス ファーマ エー/エス 生分解性ヒドロゲルの滅菌
EP2517000B1 (en) 2009-12-22 2015-12-16 GE Healthcare Bio-Sciences AB Method for dry packing chromatography columns
GB0922426D0 (en) * 2009-12-22 2010-02-03 Ge Healthcare Bio Sciences Ab Containers for chromatography media
WO2011147762A2 (en) * 2010-05-25 2011-12-01 Bayer Pharma Aktiengesellschaft Stabilized radiopharmaceutical composition
WO2011152788A1 (en) 2010-06-03 2011-12-08 Ge Healthcare Bio-Sciences Ab A parallel assembly of chromatography column modules
JP5671618B2 (ja) 2010-10-15 2015-02-18 ストラウマン ホールディング アーゲー Pgaを含んでなる新しいemd製剤
CN102844145A (zh) 2010-11-29 2012-12-26 三菱电机株式会社 激光加工机的光路构造
US20130248451A1 (en) 2010-12-03 2013-09-26 Ge Healthcare Bio-Sciences Ab System and process for biopolymer chromatography
JP2013544524A (ja) * 2010-12-06 2013-12-19 ターポン バイオシステムズ,インコーポレイテッド 生物学的生成物の連続プロセス法
CN102321316B (zh) 2011-08-25 2013-04-24 上海恒方大高分子材料科技有限公司 一种适用于γ射线辐照消毒的医用PVC材料及其制备方法
IN2014DN01802A (2) 2011-09-30 2015-05-15 Bayer Ip Gmbh
EP2656892A1 (en) 2012-04-23 2013-10-30 Merck Patent GmbH Chromatography method
US20140154270A1 (en) 2012-05-21 2014-06-05 Chen Wang Purification of non-human antibodies using kosmotropic salt enhanced protein a affinity chromatography
EP2682168A1 (en) 2012-07-02 2014-01-08 Millipore Corporation Purification of biological molecules
WO2014004103A1 (en) 2012-06-29 2014-01-03 Emd Millipore Corporation Methods for inactivating viruses during a protein purification process
WO2014066471A1 (en) 2012-10-24 2014-05-01 Genzyme Corporation Elution of biomolecules from multi-modal resins using mes and mops as mobile phase modifiers
AU2014226126B2 (en) 2013-03-08 2019-02-14 Genzyme Corporation Continuous purification of therapeutic proteins
CN103223333B (zh) * 2013-04-15 2015-01-14 河海大学 一种含双偕胺肟基的改性硅胶吸附剂及其制备方法
TWI709569B (zh) 2014-01-17 2020-11-11 美商健臻公司 無菌層析樹脂及其用於製造方法的用途
EP3094391B1 (en) 2014-01-17 2024-11-20 Repligen Corporation Sterilizing chromatography columns
US20240100450A9 (en) 2014-01-17 2024-03-28 Repligen Corporation Sterilizing chromatography columns
TWI709570B (zh) 2014-01-17 2020-11-11 美商健臻公司 無菌層析法及製法
AU2018212974B2 (en) 2017-01-30 2023-08-24 Regeneron Pharmaceuticals, Inc. Compositions and methods for reducing bioburden in chromatography
AU2019332764B2 (en) 2018-08-31 2025-05-29 Genzyme Corporation Sterile chromatography resin and use thereof in manufacturing processes

Similar Documents

Publication Publication Date Title
JP2017508135A5 (2)
JP2017506218A5 (2)
US10246494B2 (en) Polypeptides and antibodies for treating HBV infection and related diseases
AU2025287335A1 (en) Continuous manufacturing process for bispecific antibody products
Brady Antibody-mediated immunomodulation: a strategy to improve host responses against microbial antigens
RU2014121832A (ru) РАЗРАБОТКА СТАБИЛЬНОГО ГЕТЕРОДИМЕРНОГО АНТИТЕЛА С МУТАЦИЯМИ В ДОМЕНЕ Fc
EP2121763B1 (en) Anti-idiotype monoclonal antibodies as mimotopes of the hiv gp120 antigen
RU2019121086A (ru) Иммунотерапия с применением антител, связывающих лиганд 1 белка программируемой смерти клеток (PD-L1)
AU2026200142A1 (en) Automated biomass-based perfusion control in the manufacturing of biologics
US12000839B2 (en) Methods for characterizing disulfide bonds
JP7146926B2 (ja) Cd4ヘルパーt細胞エピトープの融合ペプチドおよびそのワクチン
Castro et al. Identification and characterization of B-cell epitopes of 3FTx and PLA2 toxins from Micrurus corallinus snake venom
HRP20210830T1 (hr) Kontinuirani proces smanjenja heterogenosti terapijskog proteina
US20140234316A1 (en) Vaccibodies targeted to cross-presenting dendritic cells
US20200255499A1 (en) Antibody to Epstein Barr Virus and Uses Thereof
CN103333244B (zh) 利用GST 表达体系制备的hZimp10-N 端高效价抗体及应用
CN115093477A (zh) 一种抗新型冠状病毒核蛋白n端区的单克隆抗体及其应用
JP6199054B2 (ja) 抗イヌIgEモノクローナル抗体並びに抗イヌIgEモノクローナル抗体の重鎖可変領域及び軽鎖可変領域
JP2017527279A (ja) 抗c型肝炎抗体及びその抗原結合断片
CN105602915A (zh) 一种多价ezh2肿瘤相关抗原肽及其制备
CN118406159A (zh) RSV pre-F截短体及其生产方法和应用
RU2014143032A (ru) Эпитопы поверхностного антигена рецептора эпидермального фактора роста и их применение
CA3107524C (en) Humanized Monocolonial Antibody Against CTLA4: Preparation Method and Application
US20220372114A1 (en) Sars-cov-2 spike protein antibodies
CN103524625B (zh) 一种新型诱导抗体产生的方法