MX370179B - Resina de cromatografía estéril y uso de la misma en procesos de fabricación. - Google Patents

Resina de cromatografía estéril y uso de la misma en procesos de fabricación.

Info

Publication number
MX370179B
MX370179B MX2016009296A MX2016009296A MX370179B MX 370179 B MX370179 B MX 370179B MX 2016009296 A MX2016009296 A MX 2016009296A MX 2016009296 A MX2016009296 A MX 2016009296A MX 370179 B MX370179 B MX 370179B
Authority
MX
Mexico
Prior art keywords
chromatography resin
chromatography
bioburden
chelator
reduced bioburden
Prior art date
Application number
MX2016009296A
Other languages
English (en)
Other versions
MX2016009296A (es
Inventor
Warikoo Veena
Godawat Rahul
PATIL Rohan
Konstantinov Konstantin
Kishore RYAKALA Venkat
Original Assignee
Genzyme Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genzyme Corp filed Critical Genzyme Corp
Publication of MX2016009296A publication Critical patent/MX2016009296A/es
Publication of MX370179B publication Critical patent/MX370179B/es

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/34—Regenerating or reactivating
    • B01J20/3441—Regeneration or reactivation by electric current, ultrasound or irradiation, e.g. electromagnetic radiation such as X-rays, UV, light, microwaves
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Disinfection or sterilisation of materials or objects, in general; Accessories therefor
    • A61L2/02—Disinfection or sterilisation of materials or objects, in general; Accessories therefor using physical processes
    • A61L2/08—Radiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Disinfection or sterilisation of materials or objects, in general; Accessories therefor
    • A61L2/02—Disinfection or sterilisation of materials or objects, in general; Accessories therefor using physical processes
    • A61L2/08—Radiation
    • A61L2/081—Gamma radiation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
    • B01D15/18—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
    • B01D15/18—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns
    • B01D15/1864—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns using two or more columns
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
    • B01D15/20—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the conditioning of the sorbent material
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/32—Bonded phase chromatography
    • B01D15/325—Reversed phase
    • B01D15/327—Reversed phase with hydrophobic interaction
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/34—Size-selective separation, e.g. size-exclusion chromatography; Gel filtration; Permeation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/36—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction, e.g. ion-exchange, ion-pair, ion-suppression or ion-exclusion
    • B01D15/361—Ion-exchange
    • B01D15/362—Cation-exchange
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/36—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction, e.g. ion-exchange, ion-pair, ion-suppression or ion-exclusion
    • B01D15/361—Ion-exchange
    • B01D15/363—Anion-exchange
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/38—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 and B01D15/30 - B01D15/36, e.g. affinity, ligand exchange or chiral chromatography
    • B01D15/3804—Affinity chromatography
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/22—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising organic material
    • B01J20/26—Synthetic macromolecular compounds
    • B01J20/265—Synthetic macromolecular compounds modified or post-treated polymers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/281—Sorbents specially adapted for preparative, analytical or investigative chromatography
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J39/00—Cation exchange; Use of material as cation exchangers; Treatment of material for improving the cation exchange properties
    • B01J39/26—Cation exchangers for chromatographic processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J41/00—Anion exchange; Use of material as anion exchangers; Treatment of material for improving the anion exchange properties
    • B01J41/08—Use of material as anion exchangers; Treatment of material for improving the anion exchange properties
    • B01J41/12—Macromolecular compounds
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J41/00—Anion exchange; Use of material as anion exchangers; Treatment of material for improving the anion exchange properties
    • B01J41/20—Anion exchangers for chromatographic processes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/18—Ion-exchange chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/22—Affinity chromatography or related techniques based upon selective absorption processes
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T29/00—Metal working
    • Y10T29/49—Method of mechanical manufacture
    • Y10T29/49826—Assembling or joining

Landscapes

  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Physics & Mathematics (AREA)
  • Electromagnetism (AREA)
  • Toxicology (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Food Preservation Except Freezing, Refrigeration, And Drying (AREA)
  • Apparatus For Disinfection Or Sterilisation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

En la presente memoria se proporcionan métodos para reducir la carga biológica (por ejemplo, esterilización) de una resina de cromatografía, que incluyen exponer un recipiente que incluye una composición que incluye una resina de cromatografía y al menos un agente antioxidante y/o un quelante, a una dosis de irradiación gamma suficiente para reducir la carga biológica del recipiente y de la resina de cromatografía, en donde al menos un agente antioxidante y/o quelante están presentes en una cantidad suficiente para mejorar la pérdida de capacidad de unión de la resina de cromatografía después/tras la exposición a la dosis irradiación gamma. También se proporcionan columnas de cromatografía con carga biológica reducida que incluyen la resina de cromatografía con carga biológica reducida, composiciones que incluyen una resina de cromatografía y al menos un quelante y/o agente antioxidante, métodos para realizar cromatografía en columna con carga biológica reducida usando al menos una de estas columnas de cromatografía con carga biológica reducida, y procesos integrados, cerrados y continuos para la fabricación de una proteína recombinante purificada con carga biológica reducida.
MX2016009296A 2014-01-17 2015-01-16 Resina de cromatografía estéril y uso de la misma en procesos de fabricación. MX370179B (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201461928929P 2014-01-17 2014-01-17
US201462001498P 2014-05-21 2014-05-21
PCT/US2015/011705 WO2015109151A1 (en) 2014-01-17 2015-01-16 Sterile chromatography resin and use thereof in manufacturing processes

Publications (2)

Publication Number Publication Date
MX2016009296A MX2016009296A (es) 2016-11-11
MX370179B true MX370179B (es) 2019-12-04

Family

ID=52440888

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2019014428A MX381357B (es) 2014-01-17 2015-01-16 Resina de cromatografia esteril y uso de la misma en procesos de fabricacion.
MX2016009296A MX370179B (es) 2014-01-17 2015-01-16 Resina de cromatografía estéril y uso de la misma en procesos de fabricación.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
MX2019014428A MX381357B (es) 2014-01-17 2015-01-16 Resina de cromatografia esteril y uso de la misma en procesos de fabricacion.

Country Status (18)

Country Link
US (4) US10071364B2 (es)
EP (1) EP3094392B1 (es)
JP (2) JP6560236B2 (es)
KR (1) KR102306419B1 (es)
CN (2) CN106068150B (es)
AU (2) AU2015206341B2 (es)
BR (1) BR112016016332B1 (es)
CA (1) CA2936969C (es)
DK (1) DK3094392T3 (es)
ES (1) ES2982088T3 (es)
HU (1) HUE067110T2 (es)
IL (2) IL246775B (es)
MX (2) MX381357B (es)
PL (1) PL3094392T3 (es)
RU (1) RU2679134C2 (es)
SG (2) SG10201804483PA (es)
TW (1) TWI709569B (es)
WO (1) WO2015109151A1 (es)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2958988A2 (en) 2013-02-22 2015-12-30 Genzyme Corporation Microcarrier perfusion culturing methods and uses thereof
CN105143443A (zh) 2013-02-22 2015-12-09 建新公司 微载体灌注培养方法及其用途
SG10201709131UA (en) 2013-03-08 2017-12-28 Genzyme Corp Continuous purification of therapeutic proteins
TWI709569B (zh) 2014-01-17 2020-11-11 美商健臻公司 無菌層析樹脂及其用於製造方法的用途
TWI671312B (zh) 2014-01-17 2019-09-11 美商健臻公司 無菌層析法及製法
TW202204596A (zh) 2014-06-06 2022-02-01 美商健臻公司 灌注培養方法及其用途
TWI776235B (zh) 2014-06-09 2022-09-01 美商健臻公司 種子罐培養法(seed train processes)及其用途
KR20250025516A (ko) 2014-12-22 2025-02-21 젠자임 코포레이션 포유류 세포의 배양 방법
JP7811061B2 (ja) * 2017-11-30 2026-02-04 コーニング インコーポレイテッド バッチクロマトグラフィー用のパッケージ
CN108776190B (zh) * 2018-04-19 2020-08-07 中国林业科学研究院林业研究所 沙棘中酚类物质定量检测方法
HK40046210A (en) * 2018-08-31 2021-10-29 Genzyme Corporation Sterile chromatography resin and use thereof in manufacturing processes
TW202534309A (zh) 2019-10-22 2025-09-01 美商健臻公司 整合式連續生物製造中的線上產物監測
WO2022261050A1 (en) * 2021-06-07 2022-12-15 The University Of Massachusetts Apparatus and method for continuous production of rna
CA3247416A1 (en) * 2022-04-08 2023-10-12 Csl Behring Ag Methods of sanitizing and/or regenerating a chromatography medium
GB2626063A (en) * 2023-01-06 2024-07-10 Micronclean Ltd Disinfectant formulation
WO2024155768A1 (en) * 2023-01-18 2024-07-25 President And Fellows Of Harvard College Devices, chromatography columns, methods for automated chromatography in parallel and methods for purification of extracellular vesicles
WO2025059162A1 (en) 2023-09-11 2025-03-20 Dana-Farber Cancer Institute, Inc. Car-engager containing il-2 variants to enhance the functionality of car t cells

Family Cites Families (130)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US533575A (en) 1895-02-05 wilkens
US4401108A (en) 1980-02-13 1983-08-30 Thomas Jefferson University Radioactive material loading, calibration and injection systems
SU1033181A1 (ru) 1982-02-02 1983-08-07 Томское Отделение Охтинского Ордена Ленина И Ордена Трудового Красного Знамени Научно-Производственного Объединения "Пластполимер" Способ обработки полимерного сорбента дл хроматографии
JPS6075530A (ja) 1983-09-30 1985-04-27 Asahi Chem Ind Co Ltd 金属元素の新しい分離精製方法
US4559175A (en) 1984-04-19 1985-12-17 The United States Of America As Represented By The Secretary Of The Air Force Halo-substituted diphospha-s-triazines and their derivatives
US4885250A (en) 1987-03-02 1989-12-05 E. I. Du Pont De Nemours And Company Enzyme immobilization and bioaffinity separations with perfluorocarbon polymer-based supports
US5612016A (en) 1988-04-01 1997-03-18 Immunomedics, Inc. Conjugates of antibodies and bifunctional ligands
US5169936A (en) 1989-04-14 1992-12-08 Biogen, Inc. Protein purification on immobilized metal affinity resins effected by elution using a weak ligand
US5226895A (en) 1989-06-05 1993-07-13 Eli Lilly And Company Multiple dose injection pen
AU6355790A (en) 1989-08-04 1991-03-11 Peter Grandics An integrated cell culture-protein purification system for the automated production and purification of cell culture products
US5244816A (en) 1989-10-11 1993-09-14 Akzo N.V. Method for purifying chelator conjugated compounds
GB9007113D0 (en) 1990-03-29 1990-05-30 Sams Bernard Dispensing device
WO1992017403A1 (en) 1991-04-05 1992-10-15 Brigham Young University Support bonded polyalkylene-polyamine-poly(carboxylic acid) and extraction of metal ions therewith
DK0525525T3 (da) 1991-07-24 1995-10-02 Medico Dev Investment Co Injektor
DK175491D0 (da) 1991-10-18 1991-10-18 Novo Nordisk As Apparat
US5279585A (en) 1992-02-04 1994-01-18 Becton, Dickinson And Company Medication delivery pen having improved dose delivery features
RU2034853C1 (ru) * 1992-07-14 1995-05-10 Научно-исследовательский институт строительных материалов при Томской государственной инженерно-строительной академии Способ получения полимерного сорбента для хроматографии
US5320609A (en) 1992-12-07 1994-06-14 Habley Medical Technology Corporation Automatic pharmaceutical dispensing syringe
US5383865A (en) 1993-03-15 1995-01-24 Eli Lilly And Company Medication dispensing device
ZA941881B (en) 1993-04-02 1995-09-18 Lilly Co Eli Manifold medication injection apparatus and method
JP2871435B2 (ja) 1993-04-22 1999-03-17 イー・アイ・デュポン・ドウ・ヌムール・アンド・カンパニー 親水性ポリマー被覆パーフルオロカーボンポリマーベースのマトリックスの製造方法
JPH07110229A (ja) 1993-10-12 1995-04-25 Nkk Corp 金属ストリップループの最下点位置検出装置
US5478924A (en) 1994-02-16 1995-12-26 Cramer; Steven M. Displacement chromatography of proteins using low molecular weight displacers
US5429746A (en) * 1994-02-22 1995-07-04 Smith Kline Beecham Corporation Antibody purification
US5856179A (en) 1994-03-10 1999-01-05 Genentech, Inc. Polypeptide production in animal cell culture
US5423982A (en) 1994-05-31 1995-06-13 Biosepra Inc. Liquid chromatography column adapted for in situ chemical sterilization
US5610285A (en) 1994-08-24 1997-03-11 Bayer Corporation Purification of α-1 proteinase inhibitor using novel chromatographic separation conditions
US5582598A (en) 1994-09-19 1996-12-10 Becton Dickinson And Company Medication delivery pen with variable increment dose scale
JP3568959B2 (ja) 1995-03-07 2004-09-22 イーライ・リリー・アンド・カンパニー 再利用可能な投薬装置
US6359114B1 (en) 1995-06-07 2002-03-19 Aphton Corp. System for method for the modification and purification of proteins
US5688251A (en) 1995-09-19 1997-11-18 Becton Dickinson And Company Cartridge loading and priming mechanism for a pen injector
US5674204A (en) 1995-09-19 1997-10-07 Becton Dickinson And Company Medication delivery pen cap actuated dose delivery clutch
US5691152A (en) * 1995-11-09 1997-11-25 E. R. Squibb & Sons, Inc. Stable avidin composition
AR005035A1 (es) 1995-12-11 1999-04-07 Merck Patent Ges Mit Beschränkter Haftung Procedimiento para preparar proteinas recombinantes en e. coli, mediante fermentacion con gran concentracion de celulas.
EP0950067B1 (en) 1996-11-27 2007-08-29 Genentech, Inc. Affinity purification of polypeptide on protein a matrix
US6955917B2 (en) 1997-06-20 2005-10-18 Bayer Healthcare Llc Chromatographic method for high yield purification and viral inactivation of antibodies
US5886154A (en) 1997-06-20 1999-03-23 Lebing; Wytold R. Chromatographic method for high yield purification and viral inactivation of antibodies
DE19730999C1 (de) 1997-07-18 1998-12-10 Disetronic Licensing Ag Dosierknopfsicherung an einer Vorrichtung zur dosierten Verabreichung eines injizierbaren Produkts
US5921966A (en) 1997-08-11 1999-07-13 Becton Dickinson And Company Medication delivery pen having an improved clutch assembly
US6265542B1 (en) 1997-10-24 2001-07-24 Genentech, Inc. Purification of molecules
US7611831B2 (en) 1998-01-06 2009-11-03 Cerus Corporation Adsorbing pathogen-inactivating compounds with porous particles immobilized in a matrix
DE69900026T2 (de) 1998-01-30 2001-05-10 Novo Nordisk As Eine injektionsspritze
US5961495A (en) 1998-02-20 1999-10-05 Becton, Dickinson And Company Medication delivery pen having a priming mechanism
US6221053B1 (en) 1998-02-20 2001-04-24 Becton, Dickinson And Company Multi-featured medication delivery pen
US6248095B1 (en) 1998-02-23 2001-06-19 Becton, Dickinson And Company Low-cost medication delivery pen
PT1308456E (pt) 1998-05-06 2007-12-03 Genentech Inc Purificação de anticorpos por cromatografia de permuta iónica
DE19858892A1 (de) 1998-12-19 2000-06-21 Merck Patent Gmbh Kontinuierliches Verfahren zur Trennung von Stoffen nach Molekülgröße
GB9902000D0 (en) * 1999-01-30 1999-03-17 Delta Biotechnology Ltd Process
CA2378325C (en) 1999-08-05 2008-09-30 Becton, Dickinson And Company Medication delivery pen
GB0007071D0 (en) 2000-03-24 2000-05-17 Sams Bernard One-way clutch mechanisms and injector devices
US6663602B2 (en) 2000-06-16 2003-12-16 Novo Nordisk A/S Injection device
GB0028879D0 (en) 2000-11-27 2001-01-10 Prometic Biosciences Ltd Adsorbents and their use
US6899699B2 (en) 2001-01-05 2005-05-31 Novo Nordisk A/S Automatic injection device with reset feature
JP2005505494A (ja) 2001-02-23 2005-02-24 イミュネックス・コーポレーション 活性タンパク質の回収増加
DK2258424T3 (da) 2001-05-16 2013-02-18 Lilly Co Eli Indretning til injektion af lægemidler
ITBO20010426A1 (it) 2001-07-06 2003-01-06 Alfa Wassermann Spa Processo per la purificazione di proteine farmacologicamente attive mediante cromatografia in scambio cationico
US7252799B2 (en) 2001-08-31 2007-08-07 Clearant, Inc. Methods for sterilizing preparations containing albumin
US20030095890A1 (en) 2001-09-24 2003-05-22 Shirley Miekka Methods for sterilizing biological materials containing non-aqueous solvents
AU2002343100A1 (en) * 2001-11-27 2003-06-10 Prometic Biosciences Ltd. The use of metal-chelating adsorbents
US6660172B2 (en) 2002-01-31 2003-12-09 Koslow Technologies Corporation Precoat filtration media and methods of making and using
AU2003210802B2 (en) 2002-02-05 2009-09-10 Genentech Inc. Protein purification
CA2478925C (en) 2002-04-26 2016-06-07 Robert Lee Fahrner Non-affinity purification of proteins
US6902909B2 (en) 2002-07-09 2005-06-07 Synthecon, Inc. Methods for efficient production of mammalian recombinant proteins
SI1543038T2 (sl) 2002-09-11 2020-12-31 Genentech, Inc. Čiščenje proteinov
DK1545574T3 (da) 2002-09-13 2014-09-08 Biogen Idec Inc Fremgangsmåde til rensning af polypeptider ved simuleret moving-bed-chromatografi
GB0304823D0 (en) 2003-03-03 2003-04-09 Dca Internat Ltd Improvements in and relating to a pen-type injector
GB0304822D0 (en) 2003-03-03 2003-04-09 Dca Internat Ltd Improvements in and relating to a pen-type injector
US7157276B2 (en) 2003-06-20 2007-01-02 Biogen Idec Inc. Use of depth filtration in series with continuous centrifugation to clarify mammalian cell cultures
AU2005216847B2 (en) 2004-02-27 2010-04-01 Cytiva Bioprocess R&D Ab A process for the purification of antibodies
CN1922207B (zh) 2004-02-27 2012-06-06 奥克特珐玛股份有限公司 提供纯化的、病毒安全的抗体制剂的方法
MXPA06014099A (es) 2004-06-04 2007-05-09 Xcellerex Inc Sistemas biorreactores desechables y metodos.
US20060004621A1 (en) 2004-06-30 2006-01-05 Malek Kamal M Real-time selection of survey candidates
WO2006026248A1 (en) 2004-08-25 2006-03-09 Sigma-Aldrich Co. Compositions and methods employing zwitterionic detergent combinations
US20060153861A1 (en) 2004-09-30 2006-07-13 Scheinberg David A BCR-ABL imatinib resistance-associated peptides and methods of use thereof
WO2006039588A2 (en) 2004-09-30 2006-04-13 Bayer Healthcare Llc Devices and methods for integrated continuous manufacturing of biological molecules
KR101243601B1 (ko) 2004-10-21 2013-03-20 지이 헬스케어 바이오-사이언시스 에이비 크로마토그래피 리간드
JP5553963B2 (ja) 2004-10-22 2014-07-23 アムジエン・インコーポレーテツド 組換え抗体をリフォールディングする方法
GB2438760A (en) 2004-12-22 2007-12-05 Ambrx Inc Methods for expression and purification of recombinant human growth hormone
DE102004063648A1 (de) 2004-12-31 2006-07-20 Tecpharma Licensing Ag Injektions- oder Infusionsgerät mit Lebensdauer-Ermittlungseinrichtung
CA2599650A1 (en) 2005-03-07 2006-09-14 Ge Healthcare Bio-Sciences Ab Method of sterilization
CN1923290A (zh) 2005-04-29 2007-03-07 成都夸常医学工业有限公司 一种病毒灭活方法、其中所用的处理系统以及装置
WO2007055789A2 (en) 2005-10-31 2007-05-18 Neose Technologies, Inc. Expression of soluble therapeutic proteins
WO2007075283A2 (en) 2005-12-06 2007-07-05 Amgen Inc. Polishing steps used in multi-step protein purification processes
CN101484464A (zh) 2006-02-17 2009-07-15 诺华有限公司 纯化细菌抗原
US7673757B2 (en) 2006-02-17 2010-03-09 Millipore Corporation Adsorbent filter media for removal of biological contaminants in process liquids
CN101529240A (zh) 2006-04-21 2009-09-09 拜尔保健股份有限公司 用于原位测量的系统和方法
WO2008036899A2 (en) 2006-09-22 2008-03-27 Amgen Inc. Methods for removing viral contaminants during protein purification
WO2008073620A2 (en) 2006-11-02 2008-06-19 Neose Technologies, Inc. Manufacturing process for the production of polypeptides expressed in insect cell-lines
CA2677213C (en) 2007-02-01 2015-02-03 Mallinckrodt Baker, Inc. Chromatographic media and chromatographic equipment storage solutions and use thereof
US9597610B2 (en) 2007-03-09 2017-03-21 Ge Healthcare Bioprocess R&D Ab Packing system and method for chromatography columns
GB0704603D0 (en) 2007-03-09 2007-04-18 Ge Healthcare Bio Sciences Ab Packing system and method for chromatography columns
JP5140721B2 (ja) 2007-04-17 2013-02-13 イクスエンド、ホールディング、ベスローテン、フェンノートシャップ 連続メンブレン吸着方法および装置
US7901581B2 (en) 2007-06-15 2011-03-08 Ge Healthcare Bio-Sciences Ab Chromatography method
US7809258B2 (en) 2007-07-06 2010-10-05 Flir Systems Ab Camera and method for use with camera
US9109193B2 (en) 2007-07-30 2015-08-18 Ge Healthcare Bio-Sciences Corp. Continuous perfusion bioreactor system
CN101889025B (zh) 2007-10-30 2013-11-13 健泰科生物技术公司 通过阳离子交换层析进行的抗体纯化
KR20130133893A (ko) 2007-12-27 2013-12-09 오츠카 세이야쿠 가부시키가이샤 에쿠올 합성에 관여하는 효소
US8647309B2 (en) 2008-05-02 2014-02-11 Sanofi-Aventis Deutschland Gmbh Medication delivery device
KR20160104740A (ko) 2008-06-24 2016-09-05 옥타파마 아게 응고 인자 ｖｉｉｉ을 정제하는 방법
AU2009347206C1 (en) 2008-10-20 2016-12-08 Abbvie Inc. Isolation and purification of antibodies using Protein A affinity chromatography
JP5756407B2 (ja) 2008-12-08 2015-07-29 ノヴォ ノルディスク アー／エス ポリペプチドの向流精製
US8728479B2 (en) 2009-03-31 2014-05-20 The Trustees Of The University Of Pennsylvania Antigen-binding proteins comprising recombinant protein scaffolds
EP2236617A1 (en) * 2009-03-31 2010-10-06 Leukocare Ag Methods of terminal sterilization of biofunctional compositions
US20120104380A1 (en) 2009-06-22 2012-05-03 Merck Patent Gmbh Conducting formulation
US8580554B2 (en) 2009-07-31 2013-11-12 Baxter International Inc. Method of producing a polypeptide or virus of interest in a continuous cell culture
US8986609B2 (en) 2009-10-29 2015-03-24 Ascendis Pharma A/S Sterilization of biodegradable hydrogels
GB0922426D0 (en) 2009-12-22 2010-02-03 Ge Healthcare Bio Sciences Ab Containers for chromatography media
WO2011078772A1 (en) 2009-12-22 2011-06-30 Ge Healthcare Bio-Sciences Ab Method for dry packing chromatography columns
WO2011147762A2 (en) * 2010-05-25 2011-12-01 Bayer Pharma Aktiengesellschaft Stabilized radiopharmaceutical composition
EP2577289B1 (en) * 2010-06-03 2021-03-17 Cytiva BioProcess R&D AB A parallel assembly of chromatography column modules
CA2801332C (en) 2010-10-15 2016-08-23 Straumann Holding Ag New emd formulation comprising pga
WO2012071135A2 (en) * 2010-11-23 2012-05-31 Biovec Transfusion, Llc Methods for removing pathogens from a platelet preparation
JP5132838B2 (ja) 2010-11-29 2013-01-30 三菱電機株式会社 レーザ加工機の光路構造
US20130248451A1 (en) 2010-12-03 2013-09-26 Ge Healthcare Bio-Sciences Ab System and process for biopolymer chromatography
KR102027596B1 (ko) * 2010-12-06 2019-10-01 타폰 바이오시스템즈, 인코포레이티드 생물학적 산물을 위한 연속 처리 방법
CN102321316B (zh) 2011-08-25 2013-04-24 上海恒方大高分子材料科技有限公司 一种适用于γ射线辐照消毒的医用PVC材料及其制备方法
EP2760902B1 (de) 2011-09-30 2018-08-08 Covestro Deutschland AG Homogene extrudierte artikel aus thermoplastisch verarbeitbaren polyurethanen auf basis von polyesterdiolen aus bernsteinsäure und 1,3 -propandiol
EP2656892A1 (en) 2012-04-23 2013-10-30 Merck Patent GmbH Chromatography method
US20140154270A1 (en) 2012-05-21 2014-06-05 Chen Wang Purification of non-human antibodies using kosmotropic salt enhanced protein a affinity chromatography
CN104411820B (zh) 2012-06-29 2017-05-03 Emd密理博公司 在蛋白纯化过程中灭活病毒的方法
EP2682168A1 (en) 2012-07-02 2014-01-08 Millipore Corporation Purification of biological molecules
US20150275195A1 (en) 2012-10-24 2015-10-01 Genzyme Corporation Elution of biomolecules from multi-modal resins using mes and mops as mobile phase modifiers
SG10201709131UA (en) 2013-03-08 2017-12-28 Genzyme Corp Continuous purification of therapeutic proteins
CN103223333B (zh) * 2013-04-15 2015-01-14 河海大学 一种含双偕胺肟基的改性硅胶吸附剂及其制备方法
TWI709569B (zh) 2014-01-17 2020-11-11 美商健臻公司 無菌層析樹脂及其用於製造方法的用途
US10610807B2 (en) 2014-01-17 2020-04-07 Repligen Corporation Sterilizing chromatography columns
TWI671312B (zh) 2014-01-17 2019-09-11 美商健臻公司 無菌層析法及製法
US20240100450A9 (en) 2014-01-17 2024-03-28 Repligen Corporation Sterilizing chromatography columns
EP4403193A3 (en) 2017-01-30 2025-01-22 Regeneron Pharmaceuticals, Inc. Method for reducing bioburden in chromatography
HK40046210A (en) 2018-08-31 2021-10-29 Genzyme Corporation Sterile chromatography resin and use thereof in manufacturing processes

Also Published As

Publication number Publication date
IL246775B (en) 2020-06-30
WO2015109151A1 (en) 2015-07-23
CN108114508A (zh) 2018-06-05
AU2015206341A1 (en) 2016-08-18
MX2019014428A (es) 2020-01-30
US20150203531A1 (en) 2015-07-23
HUE067110T2 (hu) 2024-09-28
ES2982088T3 (es) 2024-10-14
TW201538521A (zh) 2015-10-16
US20180369786A1 (en) 2018-12-27
RU2016133484A3 (es) 2018-08-23
CN106068150A (zh) 2016-11-02
US10071364B2 (en) 2018-09-11
IL275181B (en) 2021-02-28
EP3094392A1 (en) 2016-11-23
JP6880117B2 (ja) 2021-06-02
CA2936969C (en) 2022-12-13
US9630165B2 (en) 2017-04-25
DK3094392T3 (da) 2024-07-15
JP2017508135A (ja) 2017-03-23
BR112016016332A8 (pt) 2020-06-16
KR102306419B1 (ko) 2021-09-30
CA2936969A1 (en) 2015-07-23
RU2679134C2 (ru) 2019-02-06
EP3094392B1 (en) 2024-04-24
CN108114508B (zh) 2020-10-27
TWI709569B (zh) 2020-11-11
US10919021B2 (en) 2021-02-16
IL246775A0 (en) 2016-08-31
BR112016016332B1 (pt) 2022-10-25
JP2019215352A (ja) 2019-12-19
RU2019102196A (ru) 2019-02-22
RU2016133484A (ru) 2018-02-22
AU2019268188B2 (en) 2022-03-17
MX2016009296A (es) 2016-11-11
MX381357B (es) 2025-03-12
US20210268477A1 (en) 2021-09-02
BR112016016332A2 (es) 2017-08-08
JP6560236B2 (ja) 2019-08-14
HK1228329A1 (en) 2017-11-03
AU2015206341B2 (en) 2019-08-22
AU2019268188A1 (en) 2019-12-12
PL3094392T3 (pl) 2024-09-16
US11839861B2 (en) 2023-12-12
US20150202595A1 (en) 2015-07-23
SG10201804483PA (en) 2018-07-30
SG11201605625XA (en) 2016-08-30
CN106068150B (zh) 2018-02-27
IL275181A (en) 2020-07-30
KR20160111427A (ko) 2016-09-26

Similar Documents

Publication Publication Date Title
AU2019268188A1 (en) Sterile chromatography resin and use thereof in manufacturing processes
PH12018500810A1 (en) Antibody agents specific for human cd19 and uses thereof
JOP20200055A1 (ar) مركبات بيرازولو بيريميدينون واستخداماتها
BR112017012342A2 (pt) compostos inibitórios de bcl-xl e conjugados de anticorpo-fármaco incluindo os mesmos
IL256085B (en) A converted derivative of huanic acid, a pharmaceutical preparation containing it and the converted derivative for use in treatment
IL255509B (en) Compounds as modulators of ccr2, pharmaceutical preparations containing them and their use in the treatment of diseases
MX2025014490A (es) Resina de cromatografia esteril y uso de la misma en procedimientos de produccion
NZ631701A (en) Apoptosis-including agents for the treatment of cancer and immune and autoimmune diseases
IL256684B (en) Medicinal compounds and preparations for the treatment of social disorders and substance use disorders
EP3342858A4 (en) ROR1-POSITIVE MESENCHYMAL STEM CELLS AND PREPARATION METHOD THEREOF, PHARMACEUTICAL COMPOSITION CONTAINING SAME, AND PREPARATION METHOD THEREOF, AND METHOD FOR PREVENTING OR TREATING DISEASES USING SAID ROR1 POSITIVE MESENCHYMAL STEM CELLS
IL258246B (en) Isolidine compound, pharmaceutical compositions comprising same, their combinations with therapeutic agents for use in the treatment of cancer
PH12017501625A1 (en) Fixed dose combinations and formulations comprising etc1002 and ezetimibe and methods of treating or reducing the risk of cardiovascular disease
MX357284B (es) Compuestos de quinona para tratar enfermedades mediadas por ape1.
IL262847A (en) Analytical method for quanitification of viable bacteria contained in microbiota restoration therapy (mrt) compositions
PL3223611T3 (pl) Dwuskładnikowa kompozycja dezynfekująca zawierająca kwas nadoctowy i środek chelatujący
SG10201805646WA (en) Angiopoietin-like 4 antibodies and methods of use
IL280921A (en) Preparations containing cyclobenzaprine or amitriptyline for use in the treatment of stress disorders
PH12016500775A1 (en) Herbal composition, process for its preparation and use thereof
PL3324985T3 (pl) Sposób i kompozycja do inseminacji małymi dawkami
MX371343B (es) Moduladores del receptor x hepatico (lxr).
IL280389A (en) Bile acid receptor modulators conjugated to G.1 protein and methods of using them
IL249440B (en) Pharmaceutical compounds and preparations containing them for the treatment of neurodegenerative diseases
EP3235808A4 (en) Modified taurine, and pharmaceutical composition for preventing or treating metabolic diseases containing same
GB201513543D0 (en) Compositions for use in the treatment of diabetes
FI20155045A7 (fi) Havupuun pihka steriilin tulehduksen hoitamiseksi ja ennaltaehkäisemiseksi

Legal Events

Date Code Title Description
FG Grant or registration