JP2017522273A5 - - Google Patents
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- Publication number
- JP2017522273A5 JP2017522273A5 JP2016570242A JP2016570242A JP2017522273A5 JP 2017522273 A5 JP2017522273 A5 JP 2017522273A5 JP 2016570242 A JP2016570242 A JP 2016570242A JP 2016570242 A JP2016570242 A JP 2016570242A JP 2017522273 A5 JP2017522273 A5 JP 2017522273A5
- Authority
- JP
- Japan
- Prior art keywords
- substituted
- unsubstituted
- alkyl
- heteroaryl
- aryl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462007702P | 2014-06-04 | 2014-06-04 | |
| US62/007,702 | 2014-06-04 | ||
| PCT/US2015/034281 WO2015187998A2 (en) | 2014-06-04 | 2015-06-04 | Use of inhibitor of apoptosis protein (iap) antagonists in hiv therapy |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020066803A Division JP2020125302A (ja) | 2014-06-04 | 2020-04-02 | Hiv治療におけるアポトーシスタンパク質阻害剤(iap)のアンタゴニストの使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017522273A JP2017522273A (ja) | 2017-08-10 |
| JP2017522273A5 true JP2017522273A5 (2) | 2018-07-12 |
| JP6768522B2 JP6768522B2 (ja) | 2020-10-14 |
Family
ID=54767596
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016570242A Active JP6768522B2 (ja) | 2014-06-04 | 2015-06-04 | Hiv治療におけるアポトーシスタンパク質阻害剤(iap)のアンタゴニストの使用 |
| JP2020066803A Pending JP2020125302A (ja) | 2014-06-04 | 2020-04-02 | Hiv治療におけるアポトーシスタンパク質阻害剤(iap)のアンタゴニストの使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020066803A Pending JP2020125302A (ja) | 2014-06-04 | 2020-04-02 | Hiv治療におけるアポトーシスタンパク質阻害剤(iap)のアンタゴニストの使用 |
Country Status (5)
| Country | Link |
|---|---|
| US (2) | US10300074B2 (2) |
| EP (1) | EP3151920B1 (2) |
| JP (2) | JP6768522B2 (2) |
| CA (1) | CA2950911C (2) |
| WO (1) | WO2015187998A2 (2) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9546174B2 (en) | 2012-11-30 | 2017-01-17 | Sanford-Burnham Medical Research Institute | Inhibitor of apoptosis protein (IAP) antagonists |
| KR20160030099A (ko) * | 2013-06-25 | 2016-03-16 | 더 월터 앤드 엘리자 홀 인스티튜트 오브 메디컬 리서치 | 세포내 감염의 치료 방법 |
| WO2015109391A1 (en) | 2014-01-24 | 2015-07-30 | Children's Hospital Of Eastern Ontario Research Institute Inc. | Smc combination therapy for the treatment of cancer |
| JP6768522B2 (ja) | 2014-06-04 | 2020-10-14 | サンフォード−バーンハム メディカル リサーチ インスティテュート | Hiv治療におけるアポトーシスタンパク質阻害剤(iap)のアンタゴニストの使用 |
| CN118436801A (zh) | 2016-05-20 | 2024-08-06 | 豪夫迈·罗氏有限公司 | Protac抗体缀合物及其使用方法 |
| CN113453678A (zh) * | 2018-11-26 | 2021-09-28 | 德彪药业国际股份公司 | Hiv感染的联合治疗 |
| WO2020110056A1 (en) * | 2018-11-30 | 2020-06-04 | Glaxosmithkline Intellectual Property Development Limited | Compounds useful in hiv therapy |
| US10870663B2 (en) | 2018-11-30 | 2020-12-22 | Glaxosmithkline Intellectual Property Development Limited | Compounds useful in HIV therapy |
| CN110028508B (zh) * | 2019-05-16 | 2021-05-28 | 南京华威医药科技集团有限公司 | 一种抗肿瘤的重氮双环类细胞凋亡蛋白抑制剂 |
| WO2021026349A1 (en) | 2019-08-08 | 2021-02-11 | Institute For Cancer Research D/B/A The Research Institute Of Fox Chase Cancer Center | Combination therapy for treatment of cancer |
| EP4036570B1 (en) * | 2019-09-26 | 2025-03-05 | FUJIFILM Corporation | Reagent for measuring skin sensitization, method for measuring skin sensitization, and compound |
| CA3160666A1 (en) * | 2019-11-08 | 2021-05-14 | Sanford Burnham Prebys Medical Discovery Institute | Inhibitor of apoptosis (iap) protein antagonists |
| AU2021265826B2 (en) * | 2020-04-30 | 2026-03-19 | Sanford Burnham Prebys Medical Discovery Institute | Inhibitor of apoptosis (IAP) protein antagonists |
| WO2023056069A1 (en) | 2021-09-30 | 2023-04-06 | Angiex, Inc. | Degrader-antibody conjugates and methods of using same |
| AR131299A1 (es) | 2022-12-09 | 2025-03-05 | Debiopharm Int Sa | Nuevos inhibidores de iap, métodos para fabricarlos y usos de los mismos |
| EP4712960A2 (en) * | 2023-05-15 | 2026-03-25 | Recludix Pharma, Inc. | Stat degraders and uses thereof |
Family Cites Families (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4107288A (en) | 1974-09-18 | 1978-08-15 | Pharmaceutical Society Of Victoria | Injectable compositions, nanoparticles useful therein, and process of manufacturing same |
| US5145684A (en) | 1991-01-25 | 1992-09-08 | Sterling Drug Inc. | Surface modified drug nanoparticles |
| US5455242A (en) | 1991-09-27 | 1995-10-03 | Merrell Dow Pharmaceuticals Inc. | Carboxyalkyl tricyclic derivatives useful as inhibitors of enkephalinase and ace |
| US5457196A (en) | 1991-09-27 | 1995-10-10 | Merrell Dow Pharmaceuticals Inc. | 2-substituted indane-2-carboxyalkyl derivatives useful as inhibitors of enkephalinase and ACE |
| DE69329701T2 (de) | 1992-10-30 | 2001-05-10 | Merrell Pharmaceuticals Inc., Cincinnati | Mercaptoacetylamid substituiertes bizyclisches laktam zur verwendung als enkephalinase und ace-hemmer |
| US5508272A (en) | 1993-06-15 | 1996-04-16 | Bristol-Myers Squibb Company | Compounds containing a fused bicycle ring and processes therefor |
| WO2004007529A2 (en) | 2002-07-15 | 2004-01-22 | The Trustees Of Princeton University | Iap binding compounds |
| BRPI0506883A (pt) | 2004-01-16 | 2007-05-29 | Univ Michigan | miméticos de smac conformacionalmente comprimidos e seus usos |
| WO2005084317A2 (en) | 2004-03-01 | 2005-09-15 | Board Of Regents, The University Of Texas System | Dimeric small molecule potentiators of apoptosis |
| AU2005228950B2 (en) | 2004-03-23 | 2012-02-02 | Genentech, Inc. | Azabicyclo-octane inhibitors of IAP |
| DK2253614T3 (da) | 2004-04-07 | 2013-01-07 | Novartis Ag | IAP-inhibitorer |
| KR100984459B1 (ko) | 2004-07-02 | 2010-09-29 | 제넨테크, 인크. | Iap의 억제제 |
| WO2006010118A2 (en) | 2004-07-09 | 2006-01-26 | The Regents Of The University Of Michigan | Conformationally constrained smac mimetics and the uses thereof |
| CA2573644A1 (en) | 2004-07-12 | 2006-02-16 | Idun Pharmaceuticals, Inc. | Tetrapeptide analogs |
| ES2475207T3 (es) | 2004-07-15 | 2014-07-10 | Tetralogic Pharmaceuticals Corporation | Compuestos de unión a IAP |
| DK1836201T4 (da) | 2004-12-20 | 2013-11-11 | Genentech Inc | Pyrrolidininhibitorer af IAP. |
| MX2007010371A (es) | 2005-02-25 | 2008-01-11 | Tetralogic Pharmaceuticals | Inhibidores dimericos iap. |
| US7989441B2 (en) | 2005-06-08 | 2011-08-02 | Novartis Ag | Organic compounds |
| WO2007041775A1 (en) | 2005-10-10 | 2007-04-19 | The University Of Queensland | Cysteine protease inhibitors incorporating azide groups |
| WO2007048224A1 (en) | 2005-10-25 | 2007-05-03 | Aegera Therapeutics Inc. | Iap bir domain binding compounds |
| WO2007101347A1 (en) | 2006-03-07 | 2007-09-13 | Aegera Therapeutics Inc. | Bir domain binding compounds |
| NZ572531A (en) | 2006-05-05 | 2011-09-30 | Univ Michigan | Bivalent smac mimetics and the uses thereof |
| KR20090086244A (ko) | 2006-12-07 | 2009-08-11 | 노파르티스 아게 | 증식성 질환의 치료에서의 6-옥소-1,6-디히드로피리미딘-2-일 |
| US20090010941A1 (en) | 2007-04-09 | 2009-01-08 | University Of Massachusetts | Methods for treating HIV |
| JP5454943B2 (ja) | 2007-04-12 | 2014-03-26 | ジョイアント ファーマスーティカルズ、インク. | 抗癌剤として有用なsmac模倣二量体及び三量体 |
| WO2008128171A2 (en) | 2007-04-13 | 2008-10-23 | The Regents Of The University Of Michigan | Diazo bicyclic smac mimetics and the uses thereof |
| WO2008134679A1 (en) | 2007-04-30 | 2008-11-06 | Genentech, Inc. | Inhibitors of iap |
| EP2058312A1 (en) | 2007-11-09 | 2009-05-13 | Universita' degli Studi di Milano | SMAC mimetic compounds as apoptosis inducers |
| US8445473B2 (en) | 2008-04-11 | 2013-05-21 | The Regents Of The University Of Michigan | Heteroaryl-substituted bicyclic Smac mimetics and the uses thereof |
| JP2013516422A (ja) * | 2009-12-30 | 2013-05-13 | アビラ セラピューティクス, インコーポレイテッド | タンパク質のリガンド−指向性共有的修飾 |
| LT3494972T (lt) | 2010-01-27 | 2024-03-12 | Viiv Healthcare Company | Dolutegraviro ir lamivudino kompozicija živ infekcijai gydyti |
| US9346852B2 (en) | 2011-03-14 | 2016-05-24 | Bristol-Myers Scuibb Company | Substituted adipic acid amides and uses thereof |
| AU2013273481B2 (en) * | 2012-06-06 | 2018-04-05 | Bionor Immuno As | HIV vaccine |
| US9546174B2 (en) | 2012-11-30 | 2017-01-17 | Sanford-Burnham Medical Research Institute | Inhibitor of apoptosis protein (IAP) antagonists |
| JP6768522B2 (ja) | 2014-06-04 | 2020-10-14 | サンフォード−バーンハム メディカル リサーチ インスティテュート | Hiv治療におけるアポトーシスタンパク質阻害剤(iap)のアンタゴニストの使用 |
-
2015
- 2015-06-04 JP JP2016570242A patent/JP6768522B2/ja active Active
- 2015-06-04 CA CA2950911A patent/CA2950911C/en active Active
- 2015-06-04 WO PCT/US2015/034281 patent/WO2015187998A2/en not_active Ceased
- 2015-06-04 US US15/313,286 patent/US10300074B2/en active Active
- 2015-06-04 EP EP15803740.8A patent/EP3151920B1/en active Active
-
2019
- 2019-05-24 US US16/421,966 patent/US10864217B2/en active Active
-
2020
- 2020-04-02 JP JP2020066803A patent/JP2020125302A/ja active Pending
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