JP2017530992A5 - - Google Patents
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- Publication number
- JP2017530992A5 JP2017530992A5 JP2017519320A JP2017519320A JP2017530992A5 JP 2017530992 A5 JP2017530992 A5 JP 2017530992A5 JP 2017519320 A JP2017519320 A JP 2017519320A JP 2017519320 A JP2017519320 A JP 2017519320A JP 2017530992 A5 JP2017530992 A5 JP 2017530992A5
- Authority
- JP
- Japan
- Prior art keywords
- compound according
- substituted
- atom
- unsubstituted
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 150000001875 compounds Chemical class 0.000 claims 22
- 125000000217 alkyl group Chemical group 0.000 claims 8
- 125000005843 halogen group Chemical group 0.000 claims 6
- 125000000753 cycloalkyl group Chemical group 0.000 claims 4
- 239000003814 drug Substances 0.000 claims 4
- 125000000623 heterocyclic group Chemical group 0.000 claims 4
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 4
- 125000003342 alkenyl group Chemical group 0.000 claims 3
- 125000002947 alkylene group Chemical group 0.000 claims 3
- 125000001153 fluoro group Chemical group F* 0.000 claims 3
- 229940124597 therapeutic agent Drugs 0.000 claims 3
- 125000000171 (C1-C6) haloalkyl group Chemical group 0.000 claims 2
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 2
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 claims 2
- 206010061603 Respiratory syncytial virus infection Diseases 0.000 claims 2
- 125000004432 carbon atom Chemical group C* 0.000 claims 2
- 229910052801 chlorine Inorganic materials 0.000 claims 2
- 125000001309 chloro group Chemical group Cl* 0.000 claims 2
- 239000003085 diluting agent Substances 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- 229910052731 fluorine Inorganic materials 0.000 claims 2
- 229910052739 hydrogen Inorganic materials 0.000 claims 2
- 239000001257 hydrogen Substances 0.000 claims 2
- 229940121649 protein inhibitor Drugs 0.000 claims 2
- 239000012268 protein inhibitor Substances 0.000 claims 2
- 108090000623 proteins and genes Proteins 0.000 claims 2
- 102000004169 proteins and genes Human genes 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 125000006570 (C5-C6) heteroaryl group Chemical group 0.000 claims 1
- QVISTKCFDABZAC-UHFFFAOYSA-N 1'-[[5-(aminomethyl)-1-(3-methylbutyl)benzimidazol-2-yl]methyl]spiro[cyclopropane-1,3'-pyrrolo[2,3-b]pyridine]-2'-one Chemical compound NCC1=CC2=C(N(C(=N2)CN2C(C3(C=4C2=NC=CC=4)CC3)=O)CCC(C)C)C=C1 QVISTKCFDABZAC-UHFFFAOYSA-N 0.000 claims 1
- UVULRHITNGOBAO-UHFFFAOYSA-N 1'-[[5-(aminomethyl)-1-(3-methylbutyl)benzimidazol-2-yl]methyl]spiro[cyclopropane-1,3'-pyrrolo[2,3-c]pyridine]-2'-one Chemical compound NCC1=CC2=C(N(C(=N2)CN2C(C3(C=4C2=CN=CC=4)CC3)=O)CCC(C)C)C=C1 UVULRHITNGOBAO-UHFFFAOYSA-N 0.000 claims 1
- JOPCJJSYRPUEDS-UHFFFAOYSA-N 1'-[[5-(aminomethyl)-1-(4,4,4-trifluorobutyl)benzimidazol-2-yl]methyl]-6'-fluorospiro[cyclopropane-1,3'-indole]-2'-one Chemical compound NCC1=CC2=C(N(C(=N2)CN2C(C3(C4=CC=C(C=C24)F)CC3)=O)CCCC(F)(F)F)C=C1 JOPCJJSYRPUEDS-UHFFFAOYSA-N 0.000 claims 1
- YFGJRCVEZREHGZ-UHFFFAOYSA-N 1'-[[5-(aminomethyl)-1-(4,4,4-trifluorobutyl)benzimidazol-2-yl]methyl]spiro[cyclopropane-1,3'-pyrrolo[2,3-b]pyridine]-2'-one Chemical compound NCC1=CC2=C(N(C(=N2)CN2C(C3(C=4C2=NC=CC=4)CC3)=O)CCCC(F)(F)F)C=C1 YFGJRCVEZREHGZ-UHFFFAOYSA-N 0.000 claims 1
- UGTWLLBIEDUTMG-UHFFFAOYSA-N 1'-[[5-(aminomethyl)-1-(oxan-4-yl)benzimidazol-2-yl]methyl]-6'-fluorospiro[cyclopropane-1,3'-indole]-2'-one Chemical compound NCC1=CC2=C(N(C(=N2)CN2C(C3(C4=CC=C(C=C24)F)CC3)=O)C2CCOCC2)C=C1 UGTWLLBIEDUTMG-UHFFFAOYSA-N 0.000 claims 1
- 108010068327 4-hydroxyphenylpyruvate dioxygenase Proteins 0.000 claims 1
- UZILRIRZFHDNDJ-UHFFFAOYSA-N Clc1ccc2n(C3CCOCC3)c(CN3C(=O)C4(CC4)c4ccncc34)nc2c1 Chemical compound Clc1ccc2n(C3CCOCC3)c(CN3C(=O)C4(CC4)c4ccncc34)nc2c1 UZILRIRZFHDNDJ-UHFFFAOYSA-N 0.000 claims 1
- LVZWSLJZHVFIQJ-UHFFFAOYSA-N Cyclopropane Chemical compound C1CC1 LVZWSLJZHVFIQJ-UHFFFAOYSA-N 0.000 claims 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
- 102000007982 Phosphoproteins Human genes 0.000 claims 1
- 108010089430 Phosphoproteins Proteins 0.000 claims 1
- 102000002689 Toll-like receptor Human genes 0.000 claims 1
- 108020000411 Toll-like receptor Proteins 0.000 claims 1
- 241000700605 Viruses Species 0.000 claims 1
- 125000004450 alkenylene group Chemical group 0.000 claims 1
- 125000000304 alkynyl group Chemical group 0.000 claims 1
- 125000004419 alkynylene group Chemical group 0.000 claims 1
- 125000004202 aminomethyl group Chemical group [H]N([H])C([H])([H])* 0.000 claims 1
- 230000003110 anti-inflammatory effect Effects 0.000 claims 1
- 230000002128 anti-rhinoviral effect Effects 0.000 claims 1
- 230000000840 anti-viral effect Effects 0.000 claims 1
- 125000004093 cyano group Chemical group *C#N 0.000 claims 1
- 125000001072 heteroaryl group Chemical group 0.000 claims 1
- 150000002431 hydrogen Chemical class 0.000 claims 1
- 125000003037 imidazol-2-yl group Chemical group [H]N1C([*])=NC([H])=C1[H] 0.000 claims 1
- 230000002519 immonomodulatory effect Effects 0.000 claims 1
- 206010022000 influenza Diseases 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 230000000241 respiratory effect Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1417707.5 | 2014-10-07 | ||
| GBGB1417707.5A GB201417707D0 (en) | 2014-10-07 | 2014-10-07 | Pharmaceutical compounds |
| PCT/GB2015/052920 WO2016055780A1 (en) | 2014-10-07 | 2015-10-06 | Spiro-indolines for the treatment and prophylaxis of respiratory syncytial virus infection (rsv) |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017530992A JP2017530992A (ja) | 2017-10-19 |
| JP2017530992A5 true JP2017530992A5 (2) | 2018-11-15 |
| JP6695334B2 JP6695334B2 (ja) | 2020-05-20 |
Family
ID=51946966
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017519320A Active JP6695334B2 (ja) | 2014-10-07 | 2015-10-06 | 呼吸器合胞体ウイルス感染症（ｒｓｖ）の治療又は予防のためのスピロインドリン |
Country Status (31)
| Country | Link |
|---|---|
| US (1) | US10106539B2 (2) |
| EP (1) | EP3204375B1 (2) |
| JP (1) | JP6695334B2 (2) |
| KR (2) | KR20230116097A (2) |
| CN (1) | CN107108557B (2) |
| AR (1) | AR102181A1 (2) |
| AU (1) | AU2015329778B2 (2) |
| BR (1) | BR112017007311B1 (2) |
| CA (1) | CA2963740C (2) |
| CL (1) | CL2017000839A1 (2) |
| CO (1) | CO2017004603A2 (2) |
| CY (1) | CY1121564T1 (2) |
| DK (1) | DK3204375T3 (2) |
| ES (1) | ES2718976T3 (2) |
| GB (1) | GB201417707D0 (2) |
| HR (1) | HRP20190808T1 (2) |
| HU (1) | HUE043553T2 (2) |
| LT (1) | LT3204375T (2) |
| MX (1) | MX373233B (2) |
| NZ (1) | NZ731323A (2) |
| PE (1) | PE20170949A1 (2) |
| PL (1) | PL3204375T3 (2) |
| PT (1) | PT3204375T (2) |
| RS (1) | RS58706B1 (2) |
| RU (1) | RU2734248C2 (2) |
| SG (1) | SG11201702766YA (2) |
| SI (1) | SI3204375T1 (2) |
| SM (1) | SMT201900249T1 (2) |
| TR (1) | TR201903362T4 (2) |
| TW (1) | TWI718107B (2) |
| WO (1) | WO2016055780A1 (2) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2821649T3 (es) | 2015-06-08 | 2021-04-27 | Shangdong Danhong Pharmaceutical Co Ltd | Método para preparar derivados de imidazol e intermedios de los mismos y formas cristalinas |
| ES2878058T3 (es) * | 2016-08-04 | 2021-11-18 | Reviral Ltd | Derivados de pirimidina y su uso en el tratamiento y la prevención de una infección por virus respiratorio sincitial |
| GB201711704D0 (en) * | 2017-07-20 | 2017-09-06 | Reviral Ltd | Pharmaceutical compounds |
| GB201721812D0 (en) | 2017-12-22 | 2018-02-07 | Reviral Ltd | Pharmaceutical compounds |
| CN116077494A (zh) * | 2023-01-11 | 2023-05-09 | 黑龙江中医药大学 | 一种治疗呼吸道合胞病毒的药物组合物及其制备方法 |
| WO2024174953A1 (zh) * | 2023-02-21 | 2024-08-29 | 苏州隆博泰药业有限公司 | 苯并咪唑类衍生物及其医药用途 |
| WO2024252355A1 (en) | 2023-06-08 | 2024-12-12 | Pfizer Inc. | Pediatric dosing regimens comprising a fusion inhibitor for the treatment of rsv |
| WO2025120500A1 (en) | 2023-12-06 | 2025-06-12 | Pfizer Inc. | Benzodiazepine compounds as n-protein inhibitors |
| WO2025153942A1 (en) | 2024-01-16 | 2025-07-24 | Pfizer Inc. | Benzodiazepine pyrazolo carboxamides as n-protein inhibitors |
| WO2025248535A1 (en) * | 2024-05-29 | 2025-12-04 | Zydus Lifesciences Limited | Novel spirocyclic compounds to treat viral infections |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS57102863A (en) * | 1980-12-16 | 1982-06-26 | Takeda Chem Ind Ltd | Spiroindolinone and its preparation |
| PL194216B1 (pl) * | 1998-01-23 | 2007-05-31 | Sankyo Co | Pochodne spiropiperydyny, lekarstwo oraz środek zapobiegawczy lub terapeutyczny zawierające jako składnik czynny te pochodne i zastosowanie pochodnych spiropiperydyny |
| SI1196408T1 (en) * | 1999-06-28 | 2005-02-28 | Janssen Pharmaceutica N.V. | Respiratory syncytial virus replication inhibitors |
| US6774134B2 (en) | 2000-12-20 | 2004-08-10 | Bristol-Myers Squibb Company | Heterocyclic substituted 2-methyl-benzimidazole antiviral agents |
| US6919331B2 (en) | 2001-12-10 | 2005-07-19 | Bristol-Myers Squibb Company | Substituted 2-methyl-benzimidazole respiratory syncytial virus antiviral agents |
| US7205328B2 (en) * | 2002-10-21 | 2007-04-17 | Irm Llc | Oxindoles with anti-HIV activity |
| JO2355B1 (en) | 2003-04-15 | 2006-12-12 | ميرك شارب اند دوم كوربوريشن | Hereditary calcitonin polypeptide receptor antagonists |
| US7390798B2 (en) | 2004-09-13 | 2008-06-24 | Merck & Co., Inc. | Carboxamide spirolactam CGRP receptor antagonists |
| BRPI0517418A (pt) | 2004-10-13 | 2008-10-07 | Merck & Co Inc | composto, composição farmacêutica, e, métodos para antagonismo de atividade do receptor de cgrp em um mamìfero, para tratar, controlar, melhorar ou reduzir o risco de dor de cabeça, enxaqueca ou cefalgia, e de tratamento ou prevenção de dores de cabeça de enxaqueca, cefalgias, e dores de cabeça |
| US20100278835A1 (en) | 2009-03-10 | 2010-11-04 | Astrazeneca Uk Limited | Novel compounds 660 |
| GB201119538D0 (en) * | 2011-11-10 | 2011-12-21 | Viral Ltd | Pharmaceutical compounds |
| MY172021A (en) | 2012-10-16 | 2019-11-12 | Janssen Sciences Ireland Uc | Rsv antiviral compounds |
| EP2997028A1 (en) | 2013-05-14 | 2016-03-23 | F.Hoffmann-La Roche Ag | Aza-oxo-indoles for the treatment and prophylaxis of respiratory syncytial virus infection |
| KR20160007629A (ko) * | 2013-05-14 | 2016-01-20 | 에프. 호프만-라 로슈 아게 | 호흡기 세포융합 바이러스 감염의 치료 및 예방을 위한 아자-옥소-인돌 |
| CN105392787B (zh) * | 2013-05-14 | 2017-11-24 | 豪夫迈·罗氏有限公司 | 用于治疗和预防呼吸道合胞病毒感染的氮杂‑氧代‑吲哚 |
| KR20160030271A (ko) * | 2013-08-12 | 2016-03-16 | 에프. 호프만-라 로슈 아게 | 호흡기 세포융합 바이러스 감염의 치료 및 예방을 위한 아자-옥소-인돌 |
| CN105408330A (zh) * | 2013-08-12 | 2016-03-16 | 豪夫迈·罗氏有限公司 | 新的用于治疗和预防呼吸道合胞病毒感染的氮杂-氧代-吲哚 |
| JP6211195B2 (ja) * | 2013-08-12 | 2017-10-11 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | 呼吸器合胞体ウイルス感染症の処置および予防のための新規アザ−オキソ−インドール |
| CN105431419A (zh) * | 2013-08-15 | 2016-03-23 | 豪夫迈·罗氏有限公司 | 新的用于治疗和预防呼吸道合胞病毒感染的氮杂-氧代-吲哚 |
| HK1222855A1 (zh) * | 2013-08-15 | 2017-07-14 | F. Hoffmann-La Roche Ag | 新的用於治疗和预防呼吸道合胞病毒感染的氮杂-氧代-吲哚 |
| KR20160030569A (ko) * | 2013-08-15 | 2016-03-18 | 에프. 호프만-라 로슈 아게 | 호흡기 세포융합 바이러스 감염의 치료 및 예방을 위한 신규한 아자-옥소-인돌 |
-
2014
- 2014-10-07 GB GBGB1417707.5A patent/GB201417707D0/en not_active Ceased
-
2015
- 2015-10-06 TR TR2019/03362T patent/TR201903362T4/tr unknown
- 2015-10-06 JP JP2017519320A patent/JP6695334B2/ja active Active
- 2015-10-06 CN CN201580066385.4A patent/CN107108557B/zh active Active
- 2015-10-06 KR KR1020237025697A patent/KR20230116097A/ko active Pending
- 2015-10-06 BR BR112017007311-0A patent/BR112017007311B1/pt active IP Right Grant
- 2015-10-06 PE PE2017000576A patent/PE20170949A1/es unknown
- 2015-10-06 CA CA2963740A patent/CA2963740C/en active Active
- 2015-10-06 RU RU2017113026A patent/RU2734248C2/ru active
- 2015-10-06 ES ES15782033T patent/ES2718976T3/es active Active
- 2015-10-06 DK DK15782033.3T patent/DK3204375T3/en active
- 2015-10-06 PT PT15782033T patent/PT3204375T/pt unknown
- 2015-10-06 AR ARP150103215A patent/AR102181A1/es not_active Application Discontinuation
- 2015-10-06 SI SI201530634T patent/SI3204375T1/sl unknown
- 2015-10-06 WO PCT/GB2015/052920 patent/WO2016055780A1/en not_active Ceased
- 2015-10-06 SM SM20190249T patent/SMT201900249T1/it unknown
- 2015-10-06 KR KR1020177012311A patent/KR102561796B1/ko active Active
- 2015-10-06 HU HUE15782033A patent/HUE043553T2/hu unknown
- 2015-10-06 US US15/517,290 patent/US10106539B2/en active Active
- 2015-10-06 NZ NZ731323A patent/NZ731323A/en unknown
- 2015-10-06 EP EP15782033.3A patent/EP3204375B1/en active Active
- 2015-10-06 AU AU2015329778A patent/AU2015329778B2/en active Active
- 2015-10-06 RS RS20190515A patent/RS58706B1/sr unknown
- 2015-10-06 MX MX2017004425A patent/MX373233B/es active IP Right Grant
- 2015-10-06 PL PL15782033T patent/PL3204375T3/pl unknown
- 2015-10-06 HR HRP20190808TT patent/HRP20190808T1/hr unknown
- 2015-10-06 LT LTEP15782033.3T patent/LT3204375T/lt unknown
- 2015-10-06 SG SG11201702766YA patent/SG11201702766YA/en unknown
- 2015-10-07 TW TW104133092A patent/TWI718107B/zh active
-
2017
- 2017-04-06 CL CL2017000839A patent/CL2017000839A1/es unknown
- 2017-05-05 CO CONC2017/0004603A patent/CO2017004603A2/es unknown
-
2019
- 2019-04-11 CY CY20191100403T patent/CY1121564T1/el unknown
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