|
US3773919A
(en)
|
1969-10-23 |
1973-11-20 |
Du Pont |
Polylactide-drug mixtures
|
|
US4560655A
(en)
|
1982-12-16 |
1985-12-24 |
Immunex Corporation |
Serum-free cell culture medium and process for making same
|
|
US4657866A
(en)
|
1982-12-21 |
1987-04-14 |
Sudhir Kumar |
Serum-free, synthetic, completely chemically defined tissue culture media
|
|
US4767704A
(en)
|
1983-10-07 |
1988-08-30 |
Columbia University In The City Of New York |
Protein-free culture medium
|
|
GB8516415D0
(en)
|
1985-06-28 |
1985-07-31 |
Celltech Ltd |
Culture of animal cells
|
|
US4927762A
(en)
|
1986-04-01 |
1990-05-22 |
Cell Enterprises, Inc. |
Cell culture medium with antioxidant
|
|
US4965195A
(en)
|
1987-10-26 |
1990-10-23 |
Immunex Corp. |
Interleukin-7
|
|
US4968607A
(en)
|
1987-11-25 |
1990-11-06 |
Immunex Corporation |
Interleukin-1 receptors
|
|
AU632065B2
(en)
|
1988-09-23 |
1992-12-17 |
Novartis Vaccines And Diagnostics, Inc. |
Cell culture medium for enhanced cell growth, culture longevity and product expression
|
|
GB8823869D0
(en)
|
1988-10-12 |
1988-11-16 |
Medical Res Council |
Production of antibodies
|
|
WO1990005183A1
(en)
|
1988-10-31 |
1990-05-17 |
Immunex Corporation |
Interleukin-4 receptors
|
|
US5530101A
(en)
|
1988-12-28 |
1996-06-25 |
Protein Design Labs, Inc. |
Humanized immunoglobulins
|
|
DE3920358A1
(de)
|
1989-06-22 |
1991-01-17 |
Behringwerke Ag |
Bispezifische und oligospezifische, mono- und oligovalente antikoerperkonstrukte, ihre herstellung und verwendung
|
|
US6673986B1
(en)
|
1990-01-12 |
2004-01-06 |
Abgenix, Inc. |
Generation of xenogeneic antibodies
|
|
EP1690934A3
(en)
|
1990-01-12 |
2008-07-30 |
Abgenix, Inc. |
Generation of xenogeneic antibodies
|
|
US6713610B1
(en)
|
1990-01-12 |
2004-03-30 |
Raju Kucherlapati |
Human antibodies derived from immunized xenomice
|
|
US5486472A
(en)
|
1990-03-17 |
1996-01-23 |
Takeda Chemical Industries, Ltd. |
Monoclonal antibodies to PACAP
|
|
US5427908A
(en)
|
1990-05-01 |
1995-06-27 |
Affymax Technologies N.V. |
Recombinant library screening methods
|
|
AU651596B2
(en)
|
1990-06-05 |
1994-07-28 |
Immunex Corporation |
Type II interleukin-1 receptors
|
|
GB9015198D0
(en)
|
1990-07-10 |
1990-08-29 |
Brien Caroline J O |
Binding substance
|
|
US5770429A
(en)
|
1990-08-29 |
1998-06-23 |
Genpharm International, Inc. |
Transgenic non-human animals capable of producing heterologous antibodies
|
|
US6300129B1
(en)
|
1990-08-29 |
2001-10-09 |
Genpharm International |
Transgenic non-human animals for producing heterologous antibodies
|
|
US5874299A
(en)
|
1990-08-29 |
1999-02-23 |
Genpharm International, Inc. |
Transgenic non-human animals capable of producing heterologous antibodies
|
|
US5661016A
(en)
|
1990-08-29 |
1997-08-26 |
Genpharm International Inc. |
Transgenic non-human animals capable of producing heterologous antibodies of various isotypes
|
|
US5545806A
(en)
|
1990-08-29 |
1996-08-13 |
Genpharm International, Inc. |
Ransgenic non-human animals for producing heterologous antibodies
|
|
US6255458B1
(en)
|
1990-08-29 |
2001-07-03 |
Genpharm International |
High affinity human antibodies and human antibodies against digoxin
|
|
ATE300615T1
(de)
|
1990-08-29 |
2005-08-15 |
Genpharm Int |
Transgene mäuse fähig zur produktion heterologer antikörper
|
|
US5633425A
(en)
|
1990-08-29 |
1997-05-27 |
Genpharm International, Inc. |
Transgenic non-human animals capable of producing heterologous antibodies
|
|
US5877397A
(en)
|
1990-08-29 |
1999-03-02 |
Genpharm International Inc. |
Transgenic non-human animals capable of producing heterologous antibodies of various isotypes
|
|
US5625126A
(en)
|
1990-08-29 |
1997-04-29 |
Genpharm International, Inc. |
Transgenic non-human animals for producing heterologous antibodies
|
|
US5814318A
(en)
|
1990-08-29 |
1998-09-29 |
Genpharm International Inc. |
Transgenic non-human animals for producing heterologous antibodies
|
|
US5789650A
(en)
|
1990-08-29 |
1998-08-04 |
Genpharm International, Inc. |
Transgenic non-human animals for producing heterologous antibodies
|
|
US5122469A
(en)
|
1990-10-03 |
1992-06-16 |
Genentech, Inc. |
Method for culturing Chinese hamster ovary cells to improve production of recombinant proteins
|
|
JPH06508035A
(ja)
|
1991-06-14 |
1994-09-14 |
ディーエヌエックス コーポレーション |
トランスジェニックブタにおけるヒトヘモグロビンの生産
|
|
DE69224906T2
(de)
|
1991-07-08 |
1998-10-29 |
Univ Massachusetts |
Thermotropes flüssig-kristallines segment-blockcopolymer
|
|
DE69232137T2
(de)
|
1991-11-25 |
2002-05-29 |
Enzon Inc |
Multivalente antigen-bindende proteine
|
|
ATE179210T1
(de)
|
1992-03-17 |
1999-05-15 |
Novartis Erfind Verwalt Gmbh |
Gentechnologisch hergestellte antikörper
|
|
NZ255101A
(en)
|
1992-07-24 |
1997-08-22 |
Cell Genesys Inc |
A yeast artificial chromosome (yac) vector containing an hprt minigene expressible in murine stem cells and genetically modified rodent therefor
|
|
EP0618291A3
(en)
|
1993-02-26 |
1997-12-03 |
Takeda Chemical Industries, Ltd. |
PACAP receptor protein, method for preparing said protein, and use thereof
|
|
US6399316B1
(en)
|
1994-02-25 |
2002-06-04 |
Takeda Chemical Industries, Ltd. |
PACAP receptor protein, method for preparing said protein, and use thereof
|
|
DE69433747D1
(de)
|
1994-08-16 |
2004-06-03 |
Human Genome Sciences Inc |
Calcitoninrezeptor
|
|
US5731168A
(en)
|
1995-03-01 |
1998-03-24 |
Genentech, Inc. |
Method for making heteromultimeric polypeptides
|
|
US6130364A
(en)
|
1995-03-29 |
2000-10-10 |
Abgenix, Inc. |
Production of antibodies using Cre-mediated site-specific recombination
|
|
US6096871A
(en)
|
1995-04-14 |
2000-08-01 |
Genentech, Inc. |
Polypeptides altered to contain an epitope from the Fc region of an IgG molecule for increased half-life
|
|
CA2219361C
(en)
|
1995-04-27 |
2012-02-28 |
Abgenix, Inc. |
Human antibodies derived from immunized xenomice
|
|
US6462016B1
(en)
|
1995-10-06 |
2002-10-08 |
Shiseido Company, Ltd. |
Method for screening agonist or antagonist of the maxadilan receptor participating in vasodilating action, and compound found by the method
|
|
JP4046354B2
(ja)
|
1996-03-18 |
2008-02-13 |
ボード オブ リージェンツ，ザ ユニバーシティ オブ テキサス システム |
増大した半減期を有する免疫グロブリン様ドメイン
|
|
US6017533A
(en)
|
1996-04-25 |
2000-01-25 |
Shiseido Company, Ltd. |
Peptides having specific affinity to pituitary adenylate cyclase activating polypeptide type 1 receptors
|
|
WO1998003534A1
(en)
|
1996-07-23 |
1998-01-29 |
Smithkline Beecham Corporation |
Calcitonin gene-related peptide receptor component factor (houdc44)
|
|
US6255455B1
(en)
|
1996-10-11 |
2001-07-03 |
The Trustees Of The University Of Pennsylvania |
Rh(D)-binding proteins and magnetically activated cell sorting method for production thereof
|
|
EP1500329B1
(en)
|
1996-12-03 |
2012-03-21 |
Amgen Fremont Inc. |
Human antibodies that specifically bind human TNF alpha
|
|
US6171586B1
(en)
|
1997-06-13 |
2001-01-09 |
Genentech, Inc. |
Antibody formulation
|
|
HUP0104934A3
(en)
|
1998-07-20 |
2002-05-28 |
Sod Conseils Rech Applic |
Peptide analogues of pacap, pharmaceutical compositions comprising thereof and their use
|
|
US6242563B1
(en)
|
1998-07-20 |
2001-06-05 |
Societe De Conseils De Recherches Et D'applications Scientifiques, Sas |
Peptide analogues
|
|
US6210924B1
(en)
|
1998-08-11 |
2001-04-03 |
Amgen Inc. |
Overexpressing cyclin D 1 in a eukaryotic cell line
|
|
US6660843B1
(en)
|
1998-10-23 |
2003-12-09 |
Amgen Inc. |
Modified peptides as therapeutic agents
|
|
US20020155533A1
(en)
|
1998-11-30 |
2002-10-24 |
Takeda Chemical |
PACAP receptor protein, method for preparing said protein, and use thereof
|
|
US20020182729A1
(en)
|
2001-01-11 |
2002-12-05 |
Dicicco-Bloom Emanuel |
Pituitary adenylate cyclase-activating polypeptide (PACAP) is an anti-mitogenic signal for selected neuronal precursors in vivo
|
|
US7829084B2
(en)
|
2001-01-17 |
2010-11-09 |
Trubion Pharmaceuticals, Inc. |
Binding constructs and methods for use thereof
|
|
US20030133939A1
(en)
|
2001-01-17 |
2003-07-17 |
Genecraft, Inc. |
Binding domain-immunoglobulin fusion proteins
|
|
FR2821080B1
(fr)
|
2001-02-20 |
2003-12-19 |
Sanofi Synthelabo |
Anticorps specifique de l'adrenomedulline humaine, composition pharmaceutique le contenant, ses applications therapeutiques
|
|
CA2454587C
(en)
|
2001-07-25 |
2012-11-13 |
Protein Design Labs, Inc. |
Stable lyophilized pharmaceutical formulation of igg antibodies
|
|
EP1433793A4
(en)
|
2001-09-13 |
2006-01-25 |
Inst Antibodies Co Ltd |
METHOD FOR CREATING A CAMEL ANTIBODY LIBRARY
|
|
ATE453661T1
(de)
|
2001-09-27 |
2010-01-15 |
Merck & Co Inc |
Isolierte dna-moleküle, die für einen humanisierten calcitonin gene-related peptide receptor kodieren, damit verwandte, nichthumane transgene tiere und assayverfahren
|
|
US7658924B2
(en)
|
2001-10-11 |
2010-02-09 |
Amgen Inc. |
Angiopoietin-2 specific binding agents
|
|
AR039067A1
(es)
|
2001-11-09 |
2005-02-09 |
Pfizer Prod Inc |
Anticuerpos para cd40
|
|
US20040132101A1
(en)
|
2002-09-27 |
2004-07-08 |
Xencor |
Optimized Fc variants and methods for their generation
|
|
US7317091B2
(en)
|
2002-03-01 |
2008-01-08 |
Xencor, Inc. |
Optimized Fc variants
|
|
US20040110170A1
(en)
|
2002-05-18 |
2004-06-10 |
The Regents Of The University Of California |
Cloning and characterization of calcitonin gene related peptide receptors
|
|
WO2005056606A2
(en)
|
2003-12-03 |
2005-06-23 |
Xencor, Inc |
Optimized antibodies that target the epidermal growth factor receptor
|
|
CA2495498C
(en)
|
2002-08-12 |
2014-04-15 |
Birkir Sveinsson |
Use of cgrp antagonist compounds for treatment of psoriasis
|
|
US20040176577A1
(en)
|
2002-09-10 |
2004-09-09 |
Eva Rojer |
Immunoassays for specific determination of SCCA isoforms
|
|
US7615219B2
(en)
|
2003-01-16 |
2009-11-10 |
Life Sciences Research Partners Vzw |
Inhibition of PACAP signalling for the prevention and treatment of thrombocytopenia
|
|
WO2004097421A2
(en)
|
2003-04-29 |
2004-11-11 |
Bayer Healthcare Ag |
Diagnostics and therapeutics for diseases associated with calcitonin receptor-like receptor (calcrl)
|
|
US20050129687A1
(en)
|
2003-11-03 |
2005-06-16 |
University Of Vermont And State Agricultural College |
Use of inhibitors of PACAP receptor activity for treatment of overactive bladder and pelvic floor pain syndrome
|
|
CA2554735A1
(en)
|
2004-01-30 |
2005-08-11 |
Peplin Biolipids Pty Ltd |
Therapeutic and carrier molecules
|
|
EP1718665B1
(en)
|
2004-02-11 |
2013-04-10 |
Amylin Pharmaceuticals, LLC |
Hybrid polypeptides with selectable properties
|
|
US7423128B2
(en)
|
2004-11-03 |
2008-09-09 |
Amgen Fremont Inc. |
Anti-properdin antibodies, and methods for making and using same
|
|
BRPI0519596B1
(pt)
|
2004-12-21 |
2022-01-18 |
Astrazeneca Ab |
Agente de ligação alvejado, anticorpo monoclonal que se liga a angiopoietina-2, molécula de ácido nucleico, vetor, e, uso do agente de ligação alvejado
|
|
EP3050963B1
(en)
|
2005-03-31 |
2019-09-18 |
Chugai Seiyaku Kabushiki Kaisha |
Process for production of polypeptide by regulation of assembly
|
|
US9072777B2
(en)
|
2005-06-16 |
2015-07-07 |
Takayuki Shindo |
Method for screening substance having proangiogenic effect
|
|
US8008453B2
(en)
|
2005-08-12 |
2011-08-30 |
Amgen Inc. |
Modified Fc molecules
|
|
CA2620202C
(en)
|
2005-08-26 |
2016-10-04 |
The Board Of Trustees Of The Leland Stanford Junior University |
Therapy procedure for drug delivery for trigeminal pain
|
|
GB0521139D0
(en)
|
2005-10-18 |
2005-11-23 |
Univ Sheffield |
Therapeutic agent
|
|
US8168592B2
(en)
|
2005-10-21 |
2012-05-01 |
Amgen Inc. |
CGRP peptide antagonists and conjugates
|
|
MY153249A
(en)
*
|
2005-11-14 |
2015-01-29 |
Rinat Neuroscience Corp |
Antagonist antibodies directed against calcitonin gene-related peptide and methods using same
|
|
WO2007076336A1
(en)
|
2005-12-22 |
2007-07-05 |
Eli Lilly And Company |
Treatment of migraine with anti-cgrp antibodies
|
|
KR101516823B1
(ko)
|
2006-03-17 |
2015-05-07 |
바이오겐 아이덱 엠에이 인코포레이티드 |
안정화된 폴리펩티드 조성물
|
|
TW200815474A
(en)
|
2006-08-03 |
2008-04-01 |
Astrazeneca Ab |
Antibodies alphaVbeta6 and uses thereof
|
|
US20100112601A1
(en)
|
2006-08-08 |
2010-05-06 |
Kyoto University |
Novel monoclonal antibody and use of the same
|
|
IN2009DN05758A
(2)
|
2007-03-12 |
2015-07-24 |
Esbatech Ag |
|
|
GB0708002D0
(en)
|
2007-04-25 |
2007-06-06 |
Univ Sheffield |
Antibodies
|
|
US8793074B2
(en)
|
2007-06-21 |
2014-07-29 |
Saint Louis University |
Sequence covariance networks, methods and uses therefor
|
|
US20090074780A1
(en)
|
2007-06-25 |
2009-03-19 |
David Urech |
Methods of modifying antibodies, and modified antibodies with improved functional properties
|
|
WO2009033489A2
(en)
|
2007-09-11 |
2009-03-19 |
Glostrup Hospital |
Selective pacl inhibitors for use in the treatment of migraine and headaches
|
|
ES2563027T3
(es)
|
2008-01-07 |
2016-03-10 |
Amgen Inc. |
Método para fabricación de moléculas heterodímeras Fc de anticuerpos utilizando efectos de conducción electrostática
|
|
DK2265288T3
(en)
|
2008-03-04 |
2016-06-06 |
Labrys Biologics Inc |
Methods for the treatment of inflammatory pain
|
|
FR2934597B1
(fr)
|
2008-07-31 |
2013-04-19 |
Univ Aix Marseille Ii |
Anticorps se liant aux recepteurs de l'adrenomedulline et leurs utilisations comme medicament.
|
|
CN101434649B
(zh)
|
2008-12-12 |
2012-04-25 |
余榕捷 |
一种环七肽及其制备方法和应用
|
|
JO3382B1
(ar)
|
2008-12-23 |
2019-03-13 |
Amgen Inc |
أجسام مضادة ترتبط مع مستقبل cgrp بشري
|
|
US9676845B2
(en)
*
|
2009-06-16 |
2017-06-13 |
Hoffmann-La Roche, Inc. |
Bispecific antigen binding proteins
|
|
SG10201406930UA
(en)
|
2009-07-27 |
2014-11-27 |
Nocicepta Llc |
Methods For Treatment Of Pain
|
|
KR101519192B1
(ko)
|
2009-08-28 |
2015-05-11 |
리나트 뉴로사이언스 코프. |
칼시토닌 유전자-관련된 펩티드에 대해 지시된 길항제 항체의 투여에 의한 내장 통증의 치료 방법
|
|
AU2010334974A1
(en)
|
2009-12-22 |
2012-07-12 |
Novartis Ag |
Tetravalent CD47-antibody constant region fusion protein for use in therapy
|
|
US20140038285A1
(en)
|
2011-03-11 |
2014-02-06 |
Amgen Inc. |
Method of correlated mutational analysis to improve therapeutic antibodies
|
|
EP2686345B1
(en)
|
2011-03-16 |
2018-04-25 |
Amgen Inc. |
Fc variants
|
|
AU2012258980B8
(en)
*
|
2011-05-20 |
2017-06-15 |
H. Lundbeck A/S |
Use of anti-CGRP antibodies and antibody fragments to prevent or inhibit photophobia or light aversion in subjects in need thereof, especially migraine sufferers
|
|
JP2015502397A
(ja)
|
2011-12-23 |
2015-01-22 |
ファイザー・インク |
部位特異的コンジュゲーションのための操作された抗体定常領域、ならびにそのための方法および使用
|
|
AU2013266611B2
(en)
|
2012-05-21 |
2016-08-11 |
Genentech, Inc. |
Methods for improving safety of blood-brain barrier transport
|
|
UY35148A
(es)
|
2012-11-21 |
2014-05-30 |
Amgen Inc |
Immunoglobulinas heterodiméricas
|
|
US9580486B2
(en)
|
2013-03-14 |
2017-02-28 |
Amgen Inc. |
Interleukin-2 muteins for the expansion of T-regulatory cells
|
|
CA2906737C
(en)
|
2013-03-15 |
2023-08-15 |
Amgen Inc. |
Human pac1 antibodies
|