JP3704348B2 - アポトーシスプロセスを改変する化合物を同定する方法 - Google Patents
アポトーシスプロセスを改変する化合物を同定する方法 Download PDFInfo
- Publication number
- JP3704348B2 JP3704348B2 JP50097895A JP50097895A JP3704348B2 JP 3704348 B2 JP3704348 B2 JP 3704348B2 JP 50097895 A JP50097895 A JP 50097895A JP 50097895 A JP50097895 A JP 50097895A JP 3704348 B2 JP3704348 B2 JP 3704348B2
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- Prior art keywords
- bcl
- cells
- cell
- protein
- disease
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- Expired - Lifetime
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0271—Chimeric vertebrates, e.g. comprising exogenous cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/37—Digestive system
- A61K35/39—Pancreas; Islets of Langerhans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/82—Translation products from oncogenes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/105—Murine
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/01—Animal expressing industrially exogenous proteins
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/02—Animal zootechnically ameliorated
- A01K2267/025—Animal producing cells or organs for transplantation
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
- A01K2267/0306—Animal model for genetic diseases
- A01K2267/0318—Animal model for neurodegenerative disease, e.g. non- Alzheimer's
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2840/00—Vectors comprising a special translation-regulating system
- C12N2840/20—Vectors comprising a special translation-regulating system translation of more than one cistron
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2840/00—Vectors comprising a special translation-regulating system
- C12N2840/20—Vectors comprising a special translation-regulating system translation of more than one cistron
- C12N2840/203—Vectors comprising a special translation-regulating system translation of more than one cistron having an IRES
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Biomedical Technology (AREA)
- Public Health (AREA)
- Genetics & Genomics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Biotechnology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Cell Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Biodiversity & Conservation Biology (AREA)
- Animal Husbandry (AREA)
- Oncology (AREA)
- Virology (AREA)
- Epidemiology (AREA)
- Psychology (AREA)
- Hematology (AREA)
- Microbiology (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/066,556 | 1993-05-26 | ||
| US08/066,556 US5550019A (en) | 1993-05-26 | 1993-05-26 | Methods of identifying compounds which alter apoptosis |
| PCT/US1994/005980 WO1994027426A1 (en) | 1993-05-26 | 1994-05-26 | Methods of using bcl-2 for the therapeutic treatment and prevention of diseases |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002263443A Division JP3867033B2 (ja) | 1993-05-26 | 2002-09-09 | 疾患の治療的処置および予防のためにbcl−2を用いる方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPH09502083A JPH09502083A (ja) | 1997-03-04 |
| JP3704348B2 true JP3704348B2 (ja) | 2005-10-12 |
Family
ID=22070248
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP50097895A Expired - Lifetime JP3704348B2 (ja) | 1993-05-26 | 1994-05-26 | アポトーシスプロセスを改変する化合物を同定する方法 |
| JP2002263443A Expired - Lifetime JP3867033B2 (ja) | 1993-05-26 | 2002-09-09 | 疾患の治療的処置および予防のためにbcl−2を用いる方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002263443A Expired - Lifetime JP3867033B2 (ja) | 1993-05-26 | 2002-09-09 | 疾患の治療的処置および予防のためにbcl−2を用いる方法 |
Country Status (10)
| Country | Link |
|---|---|
| US (4) | US5550019A (da) |
| EP (2) | EP1130087A3 (da) |
| JP (2) | JP3704348B2 (da) |
| AT (1) | ATE204704T1 (da) |
| CA (1) | CA2163439C (da) |
| DE (1) | DE69428130T3 (da) |
| DK (1) | DK0751709T3 (da) |
| ES (1) | ES2160124T3 (da) |
| PT (1) | PT751709E (da) |
| WO (1) | WO1994027426A1 (da) |
Families Citing this family (51)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5831066A (en) * | 1988-12-22 | 1998-11-03 | The Trustees Of The University Of Pennsylvania | Regulation of bcl-2 gene expression |
| US6841541B1 (en) | 1992-02-21 | 2005-01-11 | The Trustees Of The University Of Pennsylvania | Regulation of BCL-2-gene expression |
| US5539085A (en) * | 1993-08-20 | 1996-07-23 | Onyx Pharmaceuticals, Inc. | Bcl-2 and R-ras complex |
| US6231852B1 (en) | 1993-11-18 | 2001-05-15 | The Regents Of The University Of California | Method for reducing BCL-2 expressing cells resistance to death |
| FR2739561B1 (fr) * | 1995-10-06 | 1997-12-26 | Inst Nat Sante Rech Med | Utilisation d'un vecteur assurant l'expression ou l'augmentation transitoire de l'activite bc1-2 |
| US5972622A (en) * | 1996-02-08 | 1999-10-26 | Desjardins; Louise | Method of detecting apoptosis using an anti-human GP46 monoclonal anti-body |
| US5744460A (en) * | 1996-03-07 | 1998-04-28 | Novartis Corporation | Combination for treatment of proliferative diseases |
| AUPN896596A0 (en) * | 1996-03-27 | 1996-04-26 | Walter And Eliza Hall Institute Of Medical Research, The | Therapeutic molecules |
| US6558900B2 (en) * | 1996-07-12 | 2003-05-06 | Emory University | Regulation of apoptosis and in vitro model for studies thereof |
| CA2260766A1 (en) * | 1996-07-12 | 1998-01-22 | Emory University | Regulation of apoptosis and in vitro model for studies thereof |
| WO1998002178A1 (en) * | 1996-07-12 | 1998-01-22 | Massachusetts Institute Of Technology | Methods of controlling axonal growth |
| US6180402B1 (en) | 1996-11-20 | 2001-01-30 | Qlt Inc. | Method for inhibiting apoptosis induced by photodynamic therapy using a cysteine or serine protease inhibitor |
| US6337184B1 (en) | 1997-04-01 | 2002-01-08 | Jeffrey B. Miller | Molecular marker for muscle stem cells |
| US6720311B2 (en) | 1997-12-18 | 2004-04-13 | David Tsai | Polypeptide for the treatment of cancer and a method for preparation thereof |
| US7238662B2 (en) * | 1997-12-18 | 2007-07-03 | Ambryx Biotechnology, Inc. | Alpha 2HS glycoprotein for treatment of cancer and a method for preparation thereof |
| US6737402B2 (en) | 1997-12-18 | 2004-05-18 | David Tsai | Method of preparing fetuin to induce apoptosis |
| US20010041342A1 (en) * | 1998-04-01 | 2001-11-15 | The General Hospital Corporation, A Massachusetts Corporation | Molecular marker for muscle stem cells |
| US7381413B1 (en) * | 1998-04-17 | 2008-06-03 | University Of Vermont And State Agricultural College | Methods and products related to metabolic interactions in disease |
| KR20010071798A (ko) * | 1998-07-10 | 2001-07-31 | 무라마쯔 다카시 | 세포자멸사 관련질환 치료제 |
| CA2379264A1 (en) | 1999-07-09 | 2001-01-18 | The Burnham Institute | A method for determining the prognosis of cancer patients by measuring levels of bag expression |
| US6277974B1 (en) * | 1999-12-14 | 2001-08-21 | Cogent Neuroscience, Inc. | Compositions and methods for diagnosing and treating conditions, disorders, or diseases involving cell death |
| AU2001231009A1 (en) | 2000-01-21 | 2001-07-31 | Beth Israel Deaconess Medical Center | Use of pro-apoptotic factors in treatment of atherosclerosis |
| US6773894B1 (en) * | 2000-01-21 | 2004-08-10 | Biochain Institute, Inc. | Isolation and extraction of subcellularly compartmentalized protein |
| US20030044413A1 (en) * | 2000-08-15 | 2003-03-06 | Regents Of The University Of Minnesota | Methods of limiting apoptosis of cells |
| US7795232B1 (en) | 2000-08-25 | 2010-09-14 | Genta Incorporated | Methods of treatment of a bcl-2 disorder using bcl-2 antisense oligomers |
| ATE420101T1 (de) * | 2001-04-20 | 2009-01-15 | Children S Hospital Of Orange | Isolierung von nervenstammzellen unter verwendung von gangliosiden und anderen oberflächenmarkern |
| DE10228187A1 (de) * | 2002-06-24 | 2004-01-22 | MedInnova Gesellschaft für medizinische Innovationen aus akademischer Forschung mbH | Testsystem zum Nachweis von Krebserkrankungen |
| US8017323B2 (en) * | 2003-03-26 | 2011-09-13 | President And Fellows Of Harvard College | Free reactant use in nucleic acid-templated synthesis |
| WO2005014017A1 (ja) * | 2003-08-08 | 2005-02-17 | Yuji Shino | 癌治療用医薬組成物 |
| JP2005305107A (ja) * | 2004-03-25 | 2005-11-04 | Sei Matsuoka | 価値的情報値の測定装置およびこれを使用した測定方法 |
| US7608425B2 (en) * | 2004-07-23 | 2009-10-27 | Immunomedics, Inc. | Methods for protein expression in mammalian cells in serum-free medium |
| US7531327B2 (en) * | 2004-07-23 | 2009-05-12 | Immunomedics, Inc. | Methods and compositions for increasing longevity and protein yield from a cell culture |
| US7537930B2 (en) | 2004-07-23 | 2009-05-26 | Immunomedics, Inc. | Mammalian cell lines for increasing longevity and protein yield from a cell culture |
| US20060159681A1 (en) * | 2004-12-14 | 2006-07-20 | Functional Neuroscience Inc. | Compositions and methods to inhibit cell loss by using inhibitors of BAG |
| US20070092947A1 (en) * | 2005-10-20 | 2007-04-26 | Immunomedics, Inc. | Methods and compositions for increasing longevity and protein yield from a cell culture |
| US9005974B2 (en) | 2005-12-09 | 2015-04-14 | Academish Medisch Centrum Bij De Universiteit Van Amsterdam | Means and methods for influencing the stability of cells |
| NZ592159A (en) * | 2005-12-09 | 2012-12-21 | Amc Amsterdam | Means and methods for influencing the stability of antibody producing cells |
| ITMI20060384A1 (it) * | 2006-03-03 | 2007-09-04 | Umberto Cornelli | Composizioni comprendenti chitosano atte al trattamento terapeutico complessivo o alla prevenzione complessiva della sindrome metabolica |
| US20100189802A1 (en) * | 2007-08-21 | 2010-07-29 | Scott And White Memorial Hospital And Scott, Sherwood, And Brindley Foundation | Method for treatment of vascular hyperpermeability |
| US20090069223A1 (en) * | 2007-08-21 | 2009-03-12 | Childs Ed W | Method for treatment of vascular hyperpermeability |
| US8192420B2 (en) | 2007-12-20 | 2012-06-05 | Acclarent, Inc. | Iontophoresis methods |
| US8497092B2 (en) | 2008-04-03 | 2013-07-30 | Tsumura & Co. | Method of bioassaying yokukansan |
| MX2010011032A (es) | 2008-04-11 | 2011-03-01 | Cytotech Labs Llc Star | Metodos y uso de induccion de apoptosis en celulas cancerigenas. |
| KR20100135887A (ko) | 2008-05-23 | 2010-12-27 | 유겐가이샤 니시하라 | Bcl-2 단백질 발현제, 아포토시스 억제제 및 표피 세포의 자외선 dna 장해 방지제 |
| US9273118B2 (en) | 2009-07-15 | 2016-03-01 | Aimm Therapeutics B.V. | Means and methods for producing high affinity antibodies |
| CN103429615B (zh) | 2010-12-02 | 2018-03-16 | 埃姆医疗有限公司 | 用于生产高亲和力抗体的方式和方法 |
| MX2014001073A (es) | 2011-07-25 | 2014-03-21 | Acclarent Inc | Sistema y metodo personalizable para anestesiar la membrana timpanica. |
| CA2938193C (en) | 2014-01-31 | 2023-05-02 | Aimm Therapeutics B.V. | Means and methods for producing stable antibodies |
| US10016304B2 (en) | 2015-07-16 | 2018-07-10 | Tusker Medical, Inc. | Earplug assembly for iontophoresis system |
| US20220204575A1 (en) * | 2019-04-23 | 2022-06-30 | The Regents Of The University Of California | Modulating survival of therapeutic cells and methods, cells and nucleic acids related thereto |
| CN118055944A (zh) * | 2021-08-11 | 2024-05-17 | 宾夕法尼亚大学董事会 | 调节Bcl-2增强嵌合抗原受体癌症免疫疗法功效 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4271145A (en) * | 1979-10-22 | 1981-06-02 | The Massachusetts General Hospital | Process for producing antibodies to hepatitis virus and cell lines therefor |
| US5202429A (en) * | 1986-07-09 | 1993-04-13 | The Wistar Institute | DNA molecules having human BCL-2 gene sequences |
| US4997764A (en) | 1987-04-23 | 1991-03-05 | New York University | Transformation of human B-lympocytes with Epstein Barr virus and c-myc containing vectors |
| US5024947A (en) | 1987-07-24 | 1991-06-18 | Cetus Corporation | Serum free media for the growth on insect cells and expression of products thereby |
| US5149628A (en) * | 1989-11-15 | 1992-09-22 | Temple University | Methods for detecting bcl-3 gene in human leukemias |
| US5328844A (en) | 1990-05-09 | 1994-07-12 | University Of Colorado Foundation, Inc. | Culture media for mammalian cells |
| WO1992022640A1 (en) * | 1991-06-10 | 1992-12-23 | Research Development Foundation | Rb TRANSFERRED CELLS AND METHOD |
| WO1993020200A1 (en) * | 1992-04-02 | 1993-10-14 | Imperial Cancer Research Technology Limited | Modified cells and method of treatment |
-
1993
- 1993-05-26 US US08/066,556 patent/US5550019A/en not_active Expired - Lifetime
-
1994
- 1994-05-26 CA CA2163439A patent/CA2163439C/en not_active Expired - Lifetime
- 1994-05-26 JP JP50097895A patent/JP3704348B2/ja not_active Expired - Lifetime
- 1994-05-26 EP EP01107435A patent/EP1130087A3/en not_active Ceased
- 1994-05-26 DE DE69428130T patent/DE69428130T3/de not_active Expired - Lifetime
- 1994-05-26 AT AT94919263T patent/ATE204704T1/de not_active IP Right Cessation
- 1994-05-26 DK DK94919263T patent/DK0751709T3/da active
- 1994-05-26 ES ES94919263T patent/ES2160124T3/es not_active Expired - Lifetime
- 1994-05-26 PT PT94919263T patent/PT751709E/pt unknown
- 1994-05-26 WO PCT/US1994/005980 patent/WO1994027426A1/en not_active Ceased
- 1994-05-26 EP EP94919263A patent/EP0751709B2/en not_active Expired - Lifetime
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1998
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2002
- 2002-09-09 JP JP2002263443A patent/JP3867033B2/ja not_active Expired - Lifetime
- 2002-11-01 US US10/285,853 patent/US7427495B2/en not_active Expired - Fee Related
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2007
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Also Published As
| Publication number | Publication date |
|---|---|
| JP3867033B2 (ja) | 2007-01-10 |
| ATE204704T1 (de) | 2001-09-15 |
| CA2163439C (en) | 2011-01-04 |
| JPH09502083A (ja) | 1997-03-04 |
| DK0751709T3 (da) | 2002-03-04 |
| US20030069201A1 (en) | 2003-04-10 |
| PT751709E (pt) | 2001-12-28 |
| US20080102060A1 (en) | 2008-05-01 |
| US7427495B2 (en) | 2008-09-23 |
| JP2003176236A (ja) | 2003-06-24 |
| EP1130087A3 (en) | 2003-10-29 |
| WO1994027426A1 (en) | 1994-12-08 |
| DE69428130T3 (de) | 2006-10-12 |
| DE69428130D1 (de) | 2001-10-04 |
| EP0751709B2 (en) | 2006-03-29 |
| DE69428130T2 (de) | 2002-05-02 |
| EP0751709A4 (en) | 1997-09-24 |
| CA2163439A1 (en) | 1994-12-08 |
| US7910370B2 (en) | 2011-03-22 |
| EP1130087A2 (en) | 2001-09-05 |
| EP0751709A1 (en) | 1997-01-08 |
| EP0751709B1 (en) | 2001-08-29 |
| ES2160124T3 (es) | 2001-11-01 |
| US5550019A (en) | 1996-08-27 |
| US6514761B1 (en) | 2003-02-04 |
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