JP4167302B2 - 新規ｎ―置換ピロリジン誘導体及びその製造法 - Google Patents

新規ｎ―置換ピロリジン誘導体及びその製造法 Download PDF

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Publication number
JP4167302B2
JP4167302B2 JP52543998A JP52543998A JP4167302B2 JP 4167302 B2 JP4167302 B2 JP 4167302B2 JP 52543998 A JP52543998 A JP 52543998A JP 52543998 A JP52543998 A JP 52543998A JP 4167302 B2 JP4167302 B2 JP 4167302B2
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JP
Japan
Prior art keywords
general formula
same
novel
halogen atom
compound represented
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
JP52543998A
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English (en)
Japanese (ja)
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JPWO1998024431A1 (ja
Inventor
弘幸 宮地
正人 星野
尚基 安藤
文義 小林
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kyorin Pharmaceutical Co Ltd
Original Assignee
Kyorin Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Kyorin Pharmaceutical Co Ltd filed Critical Kyorin Pharmaceutical Co Ltd
Publication of JPWO1998024431A1 publication Critical patent/JPWO1998024431A1/ja
Application granted granted Critical
Publication of JP4167302B2 publication Critical patent/JP4167302B2/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/12—Oxygen or sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
JP52543998A 1996-12-02 1997-11-26 新規ｎ―置換ピロリジン誘導体及びその製造法 Expired - Fee Related JP4167302B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP8-336353 1996-12-02
JP33635396 1996-12-02
PCT/JP1997/004306 WO1998024431A1 (en) 1996-12-02 1997-11-26 Novel n-substituted pyrrolidine derivatives and process for preparing the same

Publications (2)

Publication Number Publication Date
JPWO1998024431A1 JPWO1998024431A1 (ja) 2000-04-11
JP4167302B2 true JP4167302B2 (ja) 2008-10-15

Family

ID=18298258

Family Applications (1)

Application Number Title Priority Date Filing Date
JP52543998A Expired - Fee Related JP4167302B2 (ja) 1996-12-02 1997-11-26 新規ｎ―置換ピロリジン誘導体及びその製造法

Country Status (12)

Country Link
US (1) US6071950A (de)
EP (1) EP0948964B1 (de)
JP (1) JP4167302B2 (de)
KR (1) KR100483221B1 (de)
CN (1) CN1104239C (de)
AT (1) ATE235903T1 (de)
AU (1) AU733209B2 (de)
CA (1) CA2273253C (de)
DE (1) DE69720518T2 (de)
HU (1) HUP0001118A3 (de)
TW (1) TW429249B (de)
WO (1) WO1998024431A1 (de)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2006293618B9 (en) * 2005-09-21 2009-10-29 Pfizer Limited Carboxamide derivatives as muscarinic receptor antagonists
JP2010504316A (ja) * 2006-09-22 2010-02-12 ファイザー・リミテッド ムスカリン様受容体アンタゴニストとしてのアゼチジン誘導体
DK2125714T3 (da) * 2007-03-16 2011-07-25 Pfizer Ltd Hydrochloridsalt af 5-[3-(3-hydroxyphenoxy)azetidin-1-yl]-5-methyl-2,2-diphenylhexanamid

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8906166D0 (en) * 1989-03-17 1989-05-04 Pfizer Ltd Therapeutic agents
CA2069912A1 (en) * 1989-10-25 1991-04-26 The Regents Of The University Of California Method of inhibiting the transport of l-glutamate
GB8928042D0 (en) * 1989-12-12 1990-02-14 Pfizer Ltd Muscarinic receptor antagonists
SE9203318D0 (sv) * 1992-11-06 1992-11-06 Kabi Pharmacia Ab Novel 3,3-diphenylpropylamines, their use and preparation
IL117440A0 (en) * 1995-03-31 1996-07-23 Pfizer Pyrrolidinyl hydroxamic acid compounds and their production process
DE19523502A1 (de) * 1995-06-28 1997-01-02 Merck Patent Gmbh Kappa-Opiatagonisten für entzündliche Darmerkrankungen
NZ502866A (en) * 1997-09-08 2001-12-21 Univ Georgetown Substituted 2-pyrrolidinone activators of PKC
JPH11100366A (ja) * 1997-09-29 1999-04-13 Kyorin Pharmaceut Co Ltd 新規ｎ−置換環状アミン誘導体及びその製造法

Also Published As

Publication number Publication date
DE69720518T2 (de) 2004-02-26
CA2273253C (en) 2003-09-16
WO1998024431A1 (en) 1998-06-11
AU5066998A (en) 1998-06-29
KR100483221B1 (ko) 2005-04-15
TW429249B (en) 2001-04-11
CA2273253A1 (en) 1998-06-11
CN1239428A (zh) 1999-12-22
EP0948964A4 (de) 2001-04-04
ATE235903T1 (de) 2003-04-15
AU733209B2 (en) 2001-05-10
EP0948964A1 (de) 1999-10-13
US6071950A (en) 2000-06-06
KR20000069260A (ko) 2000-11-25
DE69720518D1 (de) 2003-05-08
HUP0001118A3 (en) 2001-06-28
CN1104239C (zh) 2003-04-02
HUP0001118A2 (hu) 2000-10-28
EP0948964B1 (de) 2003-04-02

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