JP4257573B2 - Ｒ（＋）α−リポ酸の製造方法 - Google Patents

Ｒ（＋）α−リポ酸の製造方法 Download PDF

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Publication number
JP4257573B2
JP4257573B2 JP2002534304A JP2002534304A JP4257573B2 JP 4257573 B2 JP4257573 B2 JP 4257573B2 JP 2002534304 A JP2002534304 A JP 2002534304A JP 2002534304 A JP2002534304 A JP 2002534304A JP 4257573 B2 JP4257573 B2 JP 4257573B2
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Japan
Prior art keywords
range
acid
solvent
lipoic acid
salt
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Expired - Fee Related
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JP2002534304A
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English (en)
Japanese (ja)
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JP2004511476A (ja
Inventor
ヴィルラニ・フラヴィオ
ナルディ・アントニオ
サルヴィ・アンニバーレ
ファラベッラ・ジオヴァンナ
Original Assignee
ラボラトリオ チミコ インターナジオナーレ ソシエタ ペル アチオニ
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D339/00—Heterocyclic compounds containing rings having two sulfur atoms as the only ring hetero atoms
    • C07D339/02—Five-membered rings
    • C07D339/04—Five-membered rings having the hetero atoms in positions 1 and 2, e.g. lipoic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
    • C07C319/02—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of thiols
    • C07C319/06—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of thiols from sulfides, hydropolysulfides or polysulfides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2002534304A 2000-10-10 2001-10-08 Ｒ（＋）α−リポ酸の製造方法 Expired - Fee Related JP4257573B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT2000MI002187A IT1319195B1 (it) 2000-10-10 2000-10-10 Processo per la produzione dell'acido r(+)alfa-lipoico.
PCT/EP2001/011575 WO2002030918A2 (en) 2000-10-10 2001-10-08 PROCESS FOR THE PRODUCTION OF R(+)α-LIPOIC ACID

Publications (2)

Publication Number Publication Date
JP2004511476A JP2004511476A (ja) 2004-04-15
JP4257573B2 true JP4257573B2 (ja) 2009-04-22

Family

ID=11445936

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2002534304A Expired - Fee Related JP4257573B2 (ja) 2000-10-10 2001-10-08 Ｒ（＋）α−リポ酸の製造方法

Country Status (11)

Country Link
US (1) US6670484B2 (cs)
EP (1) EP1330450B1 (cs)
JP (1) JP4257573B2 (cs)
KR (1) KR100838922B1 (cs)
AT (1) ATE316082T1 (cs)
AU (1) AU2002223603A1 (cs)
CZ (1) CZ302932B6 (cs)
DE (1) DE60116796T2 (cs)
ES (1) ES2254522T3 (cs)
IT (1) IT1319195B1 (cs)
WO (1) WO2002030918A2 (cs)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1319196B1 (it) * 2000-10-10 2003-09-26 Laboratorio Chimico Int Spa Sintesi dell'acido r(+)alfa-lipoico.
DE10137381A1 (de) * 2001-07-31 2003-02-13 Viatris Gmbh Neue Modifikationen des Trometamolsalzes der R-Thioctsäure sowie Verfahren zu ihrer Herstellung
ITMI20030831A1 (it) 2003-04-22 2004-10-23 Laboratorio Chimico Int Spa Sale basico dell'acido tiottico con la l-carnitina.
ITMI20061024A1 (it) 2006-05-25 2007-11-26 Eurand Pharmaceuticals Ltd Pellet a base di acido lipoico
WO2010047717A1 (en) * 2008-10-24 2010-04-29 Biolink Life Sciences, Inc. Stable, water-insoluble r-(+)-alpha-lipoic acid salt useful for the treatment of diabetes mellitus and its co-morbidities
CN106959348A (zh) * 2017-05-12 2017-07-18 苏州富士莱医药股份有限公司 一种(r)‑硫辛酸的光学异构体含量的检测方法
CN108003134A (zh) * 2018-01-19 2018-05-08 华东师范大学 一种r-（+）-硫辛酸的制备方法
CN112390779B (zh) * 2019-08-16 2022-09-06 南京海润医药有限公司 一种右旋硫辛酸的制备方法
CN114163418A (zh) * 2021-12-24 2022-03-11 山东龙辰药业有限公司 一种右旋硫辛酸的合成方法

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1374015A (en) * 1920-08-17 1921-04-05 Jerruss Joseph Safety lock-bolt
US1413024A (en) * 1920-12-04 1922-04-18 Annie L Harrell Lock nut and bolt
US2456234A (en) * 1945-06-20 1948-12-14 Panhandle Eastern Pipe Line Co Bolt protector
US2728895A (en) * 1954-10-04 1955-12-27 Whitney Blake Co Self-locking coupling device
US2966187A (en) * 1958-10-14 1960-12-27 Cock Chars Ter Pawl and ratchet bolt and nut lock
FR4630M (cs) * 1965-06-09 1966-11-28
US3670795A (en) * 1970-06-29 1972-06-20 Wright Barry Corp Self-locking fastener
US3877672A (en) * 1972-06-21 1975-04-15 Trw Inc Fastener
US4784555A (en) * 1985-09-09 1988-11-15 Cantrell Roger M Protective and ornamental cover for nuts and bolts
US4875819A (en) * 1988-10-11 1989-10-24 Kevin Wilkinson Wheel lock system apparatus
US5042880A (en) * 1990-04-10 1991-08-27 Garuti Raymond R Quick change wheel assembly
DE4137773A1 (de) * 1991-11-16 1993-05-19 Degussa Herstellung und verwendung von salzen der reinen enantiomere der (alpha)-liponsaeure
US5360304A (en) * 1993-05-11 1994-11-01 Mcgard, Inc. Fastener construction
US5380070A (en) * 1993-08-09 1995-01-10 Wheel Masters, Inc. Lug nut covers
US5463093A (en) * 1993-11-26 1995-10-31 Garnett; Merrill Palladium complexes and methods for using same in the treatment of tumors or Psoriasis
DE4427079C2 (de) * 1994-07-30 2002-12-19 Viatris Gmbh Verfahren zur Racemisierung von Enantiomeren der alpha-Liponsäure
DE4433764A1 (de) 1994-09-22 1996-03-28 Asta Medica Ag Darreichungsformen enthaltend alpha-Liponsäure, feste Salze von R-Thioctsäure mit verbesserter Freisetzung und Bioverfügbarkeit
CZ96798A3 (cs) * 1997-04-02 1998-10-14 Sankyo Company Limited Deriváty dithiolanu, jejich příprava a jejich terapeutické účinky
FR2768055A1 (fr) * 1997-09-11 1999-03-12 Synthelabo Utilisation de derives de sulfonanilide pour obtenir un medicament destine au traitement de l'ejaculation retrograde ou de l'aspermie
US5965618A (en) * 1997-11-17 1999-10-12 Perricone; Nicholas V. Treatment of scar tissue using lipoic acid
US6146070A (en) * 1998-03-09 2000-11-14 Mts Co. Ltd. Bolt/nut unfastening preventing structure
DE19834608A1 (de) * 1998-07-31 2000-02-03 Basf Ag Kristallmodifikation der Liponsäure
DE19938621A1 (de) * 1999-08-14 2001-02-22 Sueddeutsche Kalkstickstoff Verfahren zur Herstellung von lösemittelfreier alpha-Liponsäure
US6036420A (en) * 1999-09-21 2000-03-14 Horizon Technology, Llp Capped wheel nut assembly

Also Published As

Publication number Publication date
DE60116796D1 (de) 2006-04-06
ATE316082T1 (de) 2006-02-15
EP1330450A2 (en) 2003-07-30
EP1330450B1 (en) 2006-01-18
ITMI20002187A0 (it) 2000-10-10
WO2002030918A2 (en) 2002-04-18
CZ302932B6 (cs) 2012-01-18
IT1319195B1 (it) 2003-09-26
DE60116796T2 (de) 2006-11-30
US20030187279A1 (en) 2003-10-02
ITMI20002187A1 (it) 2002-04-10
ES2254522T3 (es) 2006-06-16
AU2002223603A1 (en) 2002-04-22
WO2002030918A3 (en) 2002-08-01
KR100838922B1 (ko) 2008-06-16
KR20030070000A (ko) 2003-08-27
JP2004511476A (ja) 2004-04-15
US6670484B2 (en) 2003-12-30

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