JP4441489B2 - マクロライド系化合物の水酸化に関与するｄｎａ - Google Patents

マクロライド系化合物の水酸化に関与するｄｎａ Download PDF

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Publication number
JP4441489B2
JP4441489B2 JP2005515844A JP2005515844A JP4441489B2 JP 4441489 B2 JP4441489 B2 JP 4441489B2 JP 2005515844 A JP2005515844 A JP 2005515844A JP 2005515844 A JP2005515844 A JP 2005515844A JP 4441489 B2 JP4441489 B2 JP 4441489B2
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Japan
Prior art keywords
group
dna
hydrogen atom
formula
compound
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Expired - Fee Related
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JP2005515844A
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English (en)
Japanese (ja)
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JPWO2005052152A1 (ja
Inventor
和弘 町田
崇 中島
保秀 有徳
外志夫 土田
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Mercian Corp
Eisai R&D Management Co Ltd
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Mercian Corp
Eisai R&D Management Co Ltd
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms
    • C12P17/08—Oxygen as only ring hetero atoms containing a hetero ring of at least seven ring members, e.g. zearalenone, macrolide aglycons
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
JP2005515844A 2003-11-27 2004-11-25 マクロライド系化合物の水酸化に関与するｄｎａ Expired - Fee Related JP4441489B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2003396828 2003-11-27
JP2003396828 2003-11-27
PCT/JP2004/017906 WO2005052152A1 (fr) 2003-11-27 2004-11-25 Adn intervenant dans l'hydroxylation d'un compose macrolide

Publications (2)

Publication Number Publication Date
JPWO2005052152A1 JPWO2005052152A1 (ja) 2007-06-21
JP4441489B2 true JP4441489B2 (ja) 2010-03-31

Family

ID=34631524

Family Applications (1)

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JP2005515844A Expired - Fee Related JP4441489B2 (ja) 2003-11-27 2004-11-25 マクロライド系化合物の水酸化に関与するｄｎａ

Country Status (9)

Country Link
US (1) US7932083B2 (fr)
EP (1) EP1705247A4 (fr)
JP (1) JP4441489B2 (fr)
KR (1) KR20060110865A (fr)
CN (1) CN1886505A (fr)
AU (1) AU2004292634B2 (fr)
CA (1) CA2546614A1 (fr)
IL (1) IL175136A0 (fr)
WO (1) WO2005052152A1 (fr)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1886505A (zh) 2003-11-27 2006-12-27 美露香株式会社 参与大环内酯类化合物的羟化作用的dna
US8008049B2 (en) 2004-07-20 2011-08-30 Eisai R&D Management Co., Ltd. DNA coding for polypeptide participating in biosynthesis of pladienolide
TW200716744A (en) * 2005-05-26 2007-05-01 Eisai R&D Man Co Ltd Genetically modified microorganism and process for production of macrolide compound using the microorganism
JPWO2007043621A1 (ja) * 2005-10-13 2009-04-16 エーザイ・アール・アンド・ディー・マネジメント株式会社 プラジエノライドｂ及びプラジエノライドｄの全合成方法
LT3143016T (lt) 2014-05-15 2019-06-10 Eisai R&D Management Co., Ltd. Pladienolido piridino junginiai ir panaudojimo būdai
JP6876680B2 (ja) 2015-09-01 2021-05-26 エーザイ・アール・アンド・ディー・マネジメント株式会社 ネオモルフィックｓｆ３ｂ１変異体に関連するスプライスバリアント
BR112018009995B1 (pt) 2015-11-18 2024-04-30 Eisai R&D Management Co., Ltd Forma cristalina, composição farmacêutica, e, uso da forma cristalina
CA3056389A1 (fr) 2017-03-15 2018-09-20 Eisai R&D Management Co., Ltd. Mutations de complexes d'epissage et leurs utilisations
MX2020004179A (es) 2017-10-31 2020-08-03 Eisai R&D Man Co Ltd Combinacion que comprende al menos un modulador de espliceosomas y al menos un inhibidor elegido de inhibidores de bcl2, bcl2/bclxl y bclxl, y metodos de uso.
SG11202009906TA (en) 2018-04-09 2020-11-27 Eisai R&D Man Co Ltd Pladienolide compounds and their use
CA3096424A1 (fr) 2018-04-12 2019-10-17 Eisai R&D Management Co., Ltd. Derives de pladienolide en tant qu'agents ciblant un complexe d'epissage pour le traitement du cancer
EP3801523B1 (fr) 2018-06-01 2024-09-11 Eisai R&D Management Co., Ltd. Modulateurs d'épissage
US20240043928A1 (en) 2020-11-04 2024-02-08 Eisai R&D Management Co., Ltd. Biomarkers for myelodysplastic syndrome (mds) and methods of using the same
WO2023131866A1 (fr) 2022-01-05 2023-07-13 Eisai R&D Management Co., Ltd. Biomarqueurs pour le syndrome myélodysplasique (mds) et leurs méthodes d'utilisation

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993013663A1 (fr) 1992-01-17 1993-07-22 Abbott Laboratories Procede permettant d'effectuer la biosynthese de polycetides specifiques
US5824513A (en) * 1991-01-17 1998-10-20 Abbott Laboratories Recombinant DNA method for producing erythromycin analogs
EP0618972A1 (fr) * 1991-12-16 1994-10-12 E.I. Du Pont De Nemours And Company EXPRESSION CONSTITUTIVE DE P450SOY ET FERREDOXINE-SOY CHEZ $i(STREPTOMYCES) ET BIOTRANSFORMATION DE PRODUITS CHIMIQUES PAR DES ORGANISMES RECOMBINES
MXPA01003376A (es) * 1998-10-02 2002-11-07 Kosan Biosciences Inc Enzimas policetido sintetasa y construcciones de acido desoxirribonucleico recombinante para las mismas.
TWI312681B (en) 2001-02-01 2009-08-01 Novel physiologically active substance
AR034703A1 (es) 2001-05-16 2004-03-17 Syngenta Participations Ag Metodos y composiciones para preparar emamectina.
BR122014018568B1 (pt) 2001-10-19 2015-12-01 Sumitomo Chemical Co métodos para conferir a uma planta resistência a um herbicida, controle de ervas daninhas, bem como avaliar a resistência de uma célula ou planta a um composto herbicida
US6884608B2 (en) 2001-12-26 2005-04-26 Bristol-Myers Squibb Company Compositions and methods for hydroxylating epothilones
US20060234337A1 (en) * 2002-04-12 2006-10-19 Akira Arisawa Expression system for actinomycete-origin cytochrome p-450 in escherichia coli
TWI334866B (en) * 2002-05-29 2010-12-21 Mercian Corp Novel physiologically active substances
JP4459051B2 (ja) * 2002-07-31 2010-04-28 メルシャン株式会社 新規生理活性物質
CA2494536C (fr) 2002-07-31 2011-10-04 Mercian Corporation Substance active d'un macrolide cyclique a 12 chainons
BR0316746A (pt) 2002-11-29 2005-10-18 Mercian Corp Método de produção do composto macrolida 11107d, linhagem streptomyces sp.ab-1704 (ferm bp-8551), linhagem mortierella sp. f1529 (ferm bp-8547) ou linhagem f-1530 (ferm bp-8548), e linhagem ab-1896 (ferm bp-8550)
JP2007525148A (ja) * 2003-01-21 2007-09-06 エコピア バイオサイエンシーズ インク ポリエンポリケチド、その生成方法及び医薬品としての使用［関連出願］本出願は、２００３年１月２１日出願の米国仮出願第６０／４４１，１２３号、２００３年８月１３日出願の米国仮出願第６０／４９４，５６８号、２００３年５月１３日出願の米国仮出願第６０／４６９，８１０号及び２００３年８月１日出願の米国仮出願第６０／４９１，５１６号に対する優先権を主張するものである。
WO2004101502A1 (fr) * 2003-05-13 2004-11-25 Ecopia Biosciences Inc. Polyketides de polyene, procedes permettant de les produire et leur utilisation comme produits pharmaceutiques
CN1886505A (zh) 2003-11-27 2006-12-27 美露香株式会社 参与大环内酯类化合物的羟化作用的dna
US8008049B2 (en) * 2004-07-20 2011-08-30 Eisai R&D Management Co., Ltd. DNA coding for polypeptide participating in biosynthesis of pladienolide

Also Published As

Publication number Publication date
WO2005052152A1 (fr) 2005-06-09
CA2546614A1 (fr) 2005-06-09
EP1705247A1 (fr) 2006-09-27
KR20060110865A (ko) 2006-10-25
CN1886505A (zh) 2006-12-27
JPWO2005052152A1 (ja) 2007-06-21
US7932083B2 (en) 2011-04-26
US20080070286A1 (en) 2008-03-20
WO2005052152A8 (fr) 2005-07-14
AU2004292634A1 (en) 2005-06-09
IL175136A0 (en) 2006-09-05
AU2004292634B2 (en) 2008-11-27
EP1705247A4 (fr) 2008-08-20

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