JP5063860B2 - 抗寄生虫活性を有する化合物及びそれを含有する医薬 - Google Patents

抗寄生虫活性を有する化合物及びそれを含有する医薬 Download PDF

Info

Publication number: JP5063860B2
Authority: JP; Japan
Prior art keywords: mmol; bis; water; nmr; mhz
Prior art date: 2002-07-18
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Fee Related

Application number

JP2004522264A

Other languages

English (en)

Japanese (ja)

Other versions

JP2006504652A (ja

Inventor

ヴィアル，アンリ

カラ，ミッシェル

エスカール，ロジェール

ヴィダル，ヴァレリ

ブルゾール，フランソワーズ

アンスラーン，マリ−ロール

Original Assignee

サーントルナシオナルドゥラルシェルシェシャーンティフィク（セーエンヌエールエス）

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-07-18

Filing date

2003-07-18

Publication date

2012-10-31

2003-07-18 Application filed by サーントルナシオナルドゥラルシェルシェシャーンティフィク（セーエンヌエールエス） filed Critical サーントルナシオナルドゥラルシェルシェシャーンティフィク（セーエンヌエールエス）

2006-02-09 Publication of JP2006504652A publication Critical patent/JP2006504652A/ja

2012-10-31 Application granted granted Critical

2012-10-31 Publication of JP5063860B2 publication Critical patent/JP5063860B2/ja

2023-07-18 Anticipated expiration legal-status Critical

Status Expired - Fee Related legal-status Critical Current

Links

0 CC*N=C(C)*(*)* Chemical compound CC*N=C(C)*(*)* 0.000 description 3

Images

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4245—Oxadiazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A61P33/06—Antimalarials
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
General Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Tropical Medicine & Parasitology (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Plural Heterocyclic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

JP2004522264A 2002-07-18 2003-07-18 抗寄生虫活性を有する化合物及びそれを含有する医薬 Expired - Fee Related JP5063860B2 (ja)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
FR0209156A FR2842423B1 (fr)	2002-07-18	2002-07-18	Composes a activite anti-parasitaire et medicaments les renfermant
FR02/09156		2002-07-18
PCT/FR2003/002283 WO2004009068A2 (fr)	2002-07-18	2003-07-18	Composes a activite anti-parasitaire et medicaments les renfermant

Publications (2)

Publication Number	Publication Date
JP2006504652A JP2006504652A (ja)	2006-02-09
JP5063860B2 true JP5063860B2 (ja)	2012-10-31

Family

ID=29797562

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
JP2004522264A Expired - Fee Related JP5063860B2 (ja)	2002-07-18	2003-07-18	抗寄生虫活性を有する化合物及びそれを含有する医薬

Country Status (17)

Country	Link
US (1)	US8012985B2 (de)
EP (5)	EP2260840A3 (de)
JP (1)	JP5063860B2 (de)
CN (2)	CN1668288B (de)
AP (1)	AP2098A (de)
AR (1)	AR040504A1 (de)
AU (2)	AU2003269035A1 (de)
BR (1)	BR0312719A (de)
CA (1)	CA2491989C (de)
FR (1)	FR2842423B1 (de)
IL (1)	IL166036A0 (de)
MX (1)	MXPA05000751A (de)
OA (1)	OA12888A (de)
PL (1)	PL374308A1 (de)
TW (1)	TW200412932A (de)
WO (1)	WO2004009068A2 (de)
ZA (1)	ZA200500250B (de)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP6013364B2 (ja) *	2010-12-23	2016-10-25	アルカーメスファーマアイルランドリミテッド	マルチプルａｐｉローディングプロドラッグ
FR3017240B1 (fr) *	2014-02-04	2016-01-29	Ncs Pyrotechnie Et Tech Sas	Coupe-circuit pyrotechnique

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CH214041A (fr)	1938-04-14	1941-03-31	May & Baker Ltd	Verfahren zur Herstellung von 4.4'-Diamidino-a, y-diphenoxypropan.
US2364075A (en) *	1942-10-15	1944-12-05	Du Pont	Disinfectant compounds
US2744116A (en) *	1953-12-04	1956-05-01	Purdue Research Foundation	Bis-(aminotriazolyl-)-hydrocarbons
US3020283A (en) *	1958-10-20	1962-02-06	Abbott Lab	Bis-lepidines
US3222285A (en) *	1962-07-23	1965-12-07	Union Oil Co	Non-corrosive detergent compositions
US3471509A (en) *	1965-06-17	1969-10-07	William J Mckillip	Oxadiazoles
FR1542163A (fr) *	1966-10-31	1968-10-11	Toyo Jozo Kk	Procédé de fabrication de composés bisamidino substitués et composés obtenus par le procédé précédent ou similaire
GB1197929A (en) *	1966-10-31	1970-07-08	Toyo Jozo Kk	Process for the Manufacture of Substituted Bis-AmidinoCompounds
US3639478A (en) *	1968-06-24	1972-02-01	Sterling Drug Inc	N n-alkylenebis(2-lower alkoxy) - 2-sub-stituted-alkanamidines) and their preparation
JPS5235300A (en) *	1975-09-12	1977-03-17	Sakai Chem Ind Co Ltd	Curing agents for epoxy resins
US4178253A (en) *	1977-04-05	1979-12-11	Ciba-Geigy Corporation	Corrosion inhibited lubricant compositions
JPS5748902A (en)	1980-09-10	1982-03-20	Dainippon Ink & Chem Inc	Agricultural and horticultural germicide
EP0338372A3 (de) *	1988-04-22	1991-10-09	American Cyanamid Company	Solubilisierte Vorstufen von Medikamenten
DE4026473A1 (de) *	1990-08-22	1992-02-27	Basf Ag	Bis-guanidine und diese enthaltende fungizide
US5387600A (en) *	1992-07-30	1995-02-07	Fuji Photo Film Co., Ltd.	Treating arteriosclerosis using benzimidazole compositions
US5654451B1 (en) *	1993-01-14	2000-02-22	Magainin Pharma	Amino acids and peptides having modified c-terminals and modified n-terminals
CA2153987A1 (en) *	1993-01-14	1994-07-21	U. Prasad Kari	Amino acids and peptides having modified terminals
KR960703856A (ko) *	1994-06-06	1996-08-31	가와노 다케히코	축합 고리를 갖는 카르복실산 화합물, 이의 염 및 이의 약학적 용도(novel fused-ring carboxylic acid compound or salt thereof, and medicinal use thereof)
GB9515720D0 (en) *	1995-08-01	1995-10-04	Zeneca Ltd	Bacterial coating compositions
US5874438A (en) *	1996-10-11	1999-02-23	Bayer Aktiengesellschaft	2,2'-bridged bis-2,4-diaminoquinazolines
EP0836851A1 (de) *	1996-10-21	1998-04-22	Virbac S.A.	Amidin-Verbindungen zur Behandlung von durch Ekto- oder Endoparasiten hervorgerufenen Erkrankungen und systemische Zusammensetzungen zur Parasitenkontrolle
JPH10237761A (ja) *	1997-02-21	1998-09-08	Lion Corp	柔軟仕上げ剤組成物
US6420354B1 (en) *	1998-06-08	2002-07-16	Advanced Medicine, Inc.	Sodium channel drugs and uses
JP4090133B2 (ja) *	1998-12-28	2008-05-28	富士フイルム株式会社	抗マラリア剤
JP3459189B2 (ja) *	1999-03-01	2003-10-20	科学技術振興事業団	フェブリフジンおよびイソフェブリフジンとその製造方法
US6544541B1 (en) *	1999-06-02	2003-04-08	Cardiovascular Solutions, Inc.	Devices and compounds for treating arterial restenosis
EP1545544A2 (de) *	2002-07-11	2005-06-29	Combinatorx, Incorporated	Kombinationen von medikamenten für die behandlung von neoplasien

2002
- 2002-07-18 FR FR0209156A patent/FR2842423B1/fr not_active Expired - Fee Related
2003
- 2003-07-18 CA CA2491989A patent/CA2491989C/fr not_active Expired - Fee Related
- 2003-07-18 JP JP2004522264A patent/JP5063860B2/ja not_active Expired - Fee Related
- 2003-07-18 IL IL16603603A patent/IL166036A0/xx unknown
- 2003-07-18 TW TW092119712A patent/TW200412932A/zh not_active IP Right Cessation
- 2003-07-18 EP EP10185288A patent/EP2260840A3/de not_active Withdrawn
- 2003-07-18 EP EP10185580A patent/EP2266555A3/de not_active Withdrawn
- 2003-07-18 BR BR0312719-2A patent/BR0312719A/pt not_active IP Right Cessation
- 2003-07-18 CN CN03817278XA patent/CN1668288B/zh not_active Expired - Fee Related
- 2003-07-18 EP EP03750822A patent/EP1524972A2/de not_active Withdrawn
- 2003-07-18 PL PL03374308A patent/PL374308A1/xx unknown
- 2003-07-18 EP EP10185289A patent/EP2260841A3/de not_active Withdrawn
- 2003-07-18 AU AU2003269035A patent/AU2003269035A1/en not_active Abandoned
- 2003-07-18 US US10/521,329 patent/US8012985B2/en not_active Expired - Fee Related
- 2003-07-18 AP AP2005003224A patent/AP2098A/en active
- 2003-07-18 CN CN2011100275528A patent/CN102079729B/zh not_active Expired - Fee Related
- 2003-07-18 OA OA1200500015A patent/OA12888A/fr unknown
- 2003-07-18 EP EP10185599A patent/EP2275100A3/de not_active Withdrawn
- 2003-07-18 MX MXPA05000751A patent/MXPA05000751A/es active IP Right Grant
- 2003-07-18 AR AR20030102593A patent/AR040504A1/es unknown
- 2003-07-18 WO PCT/FR2003/002283 patent/WO2004009068A2/fr not_active Ceased
2005
- 2005-01-11 ZA ZA200500250A patent/ZA200500250B/xx unknown
2009
- 2009-10-09 AU AU2009225272A patent/AU2009225272B2/en not_active Ceased

Also Published As

Publication number	Publication date
EP2266555A2 (de)	2010-12-29
CN102079729B (zh)	2013-04-24
AR040504A1 (es)	2005-04-06
TW200412932A (en)	2004-08-01
JP2006504652A (ja)	2006-02-09
EP2275100A3 (de)	2013-01-09
EP2260841A3 (de)	2013-01-02
US8012985B2 (en)	2011-09-06
AU2009225272B2 (en)	2012-08-23
OA12888A (fr)	2006-10-13
IL166036A0 (en)	2006-01-15
EP2260841A2 (de)	2010-12-15
AU2003269035A1 (en)	2004-02-09
US20050176819A1 (en)	2005-08-11
CA2491989A1 (fr)	2004-01-29
EP2260840A2 (de)	2010-12-15
EP1524972A2 (de)	2005-04-27
FR2842423B1 (fr)	2005-07-08
TWI369979B (de)	2012-08-11
WO2004009068A3 (fr)	2004-08-12
CN102079729A (zh)	2011-06-01
EP2260840A3 (de)	2013-01-02
ZA200500250B (en)	2006-05-31
AP2098A (en)	2010-02-02
EP2266555A3 (de)	2013-01-09
AU2009225272A1 (en)	2009-10-29
AP2005003224A0 (en)	2005-03-31
MXPA05000751A (es)	2005-04-28
CA2491989C (fr)	2012-03-20
PL374308A1 (pl)	2005-10-03
EP2275100A2 (de)	2011-01-19
WO2004009068A2 (fr)	2004-01-29
CN1668288B (zh)	2013-07-17
FR2842423A1 (fr)	2004-01-23
CN1668288A (zh)	2005-09-14
BR0312719A (pt)	2005-04-26

Legal Events

Date	Code	Title	Description
2006-06-24	A621	Written request for application examination	Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20060623
2009-05-19	A131	Notification of reasons for refusal	Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20090518
2009-08-19	A601	Written request for extension of time	Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20090818
2009-08-26	A602	Written permission of extension of time	Free format text: JAPANESE INTERMEDIATE CODE: A602 Effective date: 20090825
2009-10-17	A601	Written request for extension of time	Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20091016
2009-10-26	A602	Written permission of extension of time	Free format text: JAPANESE INTERMEDIATE CODE: A602 Effective date: 20091023
2009-11-19	A521	Request for written amendment filed	Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20091118
2010-11-16	A131	Notification of reasons for refusal	Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20101115
2011-02-11	A601	Written request for extension of time	Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20110210
2011-02-21	A602	Written permission of extension of time	Free format text: JAPANESE INTERMEDIATE CODE: A602 Effective date: 20110218
2011-05-14	A521	Request for written amendment filed	Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20110513
2012-03-29	A131	Notification of reasons for refusal	Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20120328
2012-06-29	A521	Request for written amendment filed	Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20120628
2012-07-23	TRDD	Decision of grant or rejection written
2012-07-27	A01	Written decision to grant a patent or to grant a registration (utility model)	Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20120726
2012-08-02	A01	Written decision to grant a patent or to grant a registration (utility model)	Free format text: JAPANESE INTERMEDIATE CODE: A01
2012-08-16	A61	First payment of annual fees (during grant procedure)	Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20120808
2012-08-17	R150	Certificate of patent or registration of utility model	Free format text: JAPANESE INTERMEDIATE CODE: R150
2012-08-20	FPAY	Renewal fee payment (event date is renewal date of database)	Free format text: PAYMENT UNTIL: 20150817 Year of fee payment: 3
2015-08-17	LAPS	Cancellation because of no payment of annual fees

Publication	Publication Date	Title
ES2565229T3 (es)	2016-04-01	Derivados 2-amino-4-(piridin-2-il)-5,6-dihidro-4H-1,3-oxazina y su uso como inhibidores de BACE-1 y/o BACE-2
JP2020524703A (ja)	2020-08-20	がん、炎症性疾患、ラソパシー、及び線維性疾患の治療のためのｒａｓスーパーファミリーと相互作用する化合物
CN105541836A (zh)	2016-05-04	激酶抑制剂的前药形式及其在治疗中的用途
CN1446217A (zh)	2003-10-01	用作磷酸二酯酶抑制剂的β－咔啉衍生物
HUT77735A (hu)	1998-07-28	Triazinszármazékok és ezeket tartalmazó gyógyászati készítmények
RU2436786C1 (ru)	2011-12-20	Замещенные индолы, противовирусный активный компонент, способ получения и применения
JP5063860B2 (ja)	2012-10-31	抗寄生虫活性を有する化合物及びそれを含有する医薬
AU2011271480B2 (en)	2014-09-11	Riminophenazines with 2-(heteroaryl)amino substituents and their anti-microbial activity
CN102796121B (zh)	2014-08-13	3-芳基-7H-噻唑并[3,2-b]-1,2,4-三嗪-7-酮类衍生物及其应用
JP3873173B2 (ja)	2007-01-24	ビス−２−アミノピリジン類、その製造方法及び寄生虫感染を制御するためのその用途
JPWO2006082821A1 (ja)	2008-06-26	ヘルペスウイルスが関与する疾患の予防若しくは治療剤
CN100467440C (zh)	2009-03-11	双季铵盐前体及其作为抗寄生物前药的用途
JP4152576B2 (ja)	2008-09-17	抗がん剤
KR20180020119A (ko)	2018-02-27	새로운 5형포스포디에스테라아제 억제제 및 그 용도
US20050107439A1 (en)	2005-05-19	Composition and method for treating emesis
KR20260030140A (ko)	2026-03-05	헤테로방향족 dhodh 억제제
HK1152495A (en)	2012-03-02	Compounds with antiparasitic activity and medicines containing same
HK1151978A (en)	2012-02-17	Compounds with antiparasitic activity and medicines containing same
JP2008543770A (ja)	2008-12-04	（５ｚ）−５−（６−キノキサリニルメチリデン）−２−［（２，６−ジクロロフェニル）アミノ］−１，３−チアゾール−４（５ｈ）−オン
JP2002536448A (ja)	2002-10-29	治療用ヌクレオシド化合物
HK1151977A (en)	2012-02-17	Compounds with antiparasitic activity and medicines containing same
HK1153387A (en)	2012-03-30	Compounds with anti-parasitic activity and drugs containing said compounds
JP2000095737A (ja)	2000-04-04	キノンメチド化合物
JPS61249988A (ja)	1986-11-07	新規ピリミドピリミジン誘導体、その製法並びに該化合物を含有する医薬組成物