JP5155177B2 - リン酸塩模倣物を含むポリヌクレオチド - Google Patents
リン酸塩模倣物を含むポリヌクレオチド Download PDFInfo
- Publication number
- JP5155177B2 JP5155177B2 JP2008541599A JP2008541599A JP5155177B2 JP 5155177 B2 JP5155177 B2 JP 5155177B2 JP 2008541599 A JP2008541599 A JP 2008541599A JP 2008541599 A JP2008541599 A JP 2008541599A JP 5155177 B2 JP5155177 B2 JP 5155177B2
- Authority
- JP
- Japan
- Prior art keywords
- group
- acc
- nucleotide
- oligonucleotide
- electron acceptor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C247/00—Compounds containing azido groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
- C09B62/00—Reactive dyes, i.e. dyes which form covalent bonds with the substrates or which polymerise with themselves
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Biochemistry (AREA)
- Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Saccharide Compounds (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP05025499A EP1801114B8 (fr) | 2005-11-23 | 2005-11-23 | Polynucléotides contenant des phosphates mimétiques |
| EP05025499.4 | 2005-11-23 | ||
| PCT/EP2006/008842 WO2007059816A1 (fr) | 2005-11-23 | 2006-09-12 | Polynucleotide contenant un mimetique de phosphate |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2009516521A JP2009516521A (ja) | 2009-04-23 |
| JP5155177B2 true JP5155177B2 (ja) | 2013-02-27 |
Family
ID=36128618
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008541599A Active JP5155177B2 (ja) | 2005-11-23 | 2006-09-12 | リン酸塩模倣物を含むポリヌクレオチド |
| JP2008541627A Expired - Fee Related JP5364380B2 (ja) | 2005-11-23 | 2006-11-21 | ポリヌクレオチド標識試薬 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008541627A Expired - Fee Related JP5364380B2 (ja) | 2005-11-23 | 2006-11-21 | ポリヌクレオチド標識試薬 |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US7741472B2 (fr) |
| EP (3) | EP1801114B8 (fr) |
| JP (2) | JP5155177B2 (fr) |
| KR (2) | KR101028980B1 (fr) |
| CN (2) | CN101312985B (fr) |
| AT (2) | ATE443072T1 (fr) |
| AU (1) | AU2006317195B2 (fr) |
| BR (2) | BRPI0618833B1 (fr) |
| CA (2) | CA2627208C (fr) |
| DE (2) | DE502005008153D1 (fr) |
| ES (2) | ES2332139T3 (fr) |
| WO (1) | WO2007059816A1 (fr) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2213737B1 (fr) | 2002-02-01 | 2012-11-07 | Life Technologies Corporation | Oligonucleotides double brin |
| US20060009409A1 (en) | 2002-02-01 | 2006-01-12 | Woolf Tod M | Double-stranded oligonucleotides |
| US20030166282A1 (en) | 2002-02-01 | 2003-09-04 | David Brown | High potency siRNAS for reducing the expression of target genes |
| EP1801114B8 (fr) | 2005-11-23 | 2009-12-02 | Roche Diagnostics GmbH | Polynucléotides contenant des phosphates mimétiques |
| EP2147010A1 (fr) * | 2007-04-18 | 2010-01-27 | Roche Diagnostics GmbH | Nucléotide à mimétique alpha-phosphate |
| US8906306B2 (en) | 2009-04-09 | 2014-12-09 | Roche Molecular Systems, Inc. | Fluid transfer control for real-time PCR |
| US8674080B2 (en) | 2009-04-09 | 2014-03-18 | Roche Molecular Systems, Inc. | Dye composition for liquid transfer control |
| EP2459743B1 (fr) | 2009-07-30 | 2017-09-13 | Roche Diagnostics GmbH | Ensemble de sondes oligonucléotides ainsi que procédés et utilisations associées |
| KR20120108967A (ko) | 2009-09-16 | 2012-10-05 | 제넨테크, 인크. | 코일드 코일 및/또는 테더 함유 단백질 복합체 및 그의 용도 |
| TW201138821A (en) | 2010-03-26 | 2011-11-16 | Roche Glycart Ag | Bispecific antibodies |
| WO2012052181A1 (fr) | 2010-10-22 | 2012-04-26 | Roche Diagnostics Gmbh | Conjugué entre une phase solide thiophilique et un oligonuclélotide comprenant un thiooxonucléotide |
| JP5766296B2 (ja) | 2010-12-23 | 2015-08-19 | エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft | ポリペプチド−ポリヌクレオチド複合体、およびエフェクター成分の標的化された送達におけるその使用 |
| WO2012085069A2 (fr) | 2010-12-23 | 2012-06-28 | Roche Diagnostics Gmbh | Détection d'un dimère polypeptidique par un agent de liaison bivalent |
| CA2817448C (fr) | 2010-12-23 | 2019-01-22 | F. Hoffmann-La Roche Ag | Agent de liaison |
| WO2012085064A1 (fr) | 2010-12-23 | 2012-06-28 | Roche Diagnostics Gmbh | Détection d'un polypeptide à modification post-translationnelle par un agent de liaison bivalent |
| EP2495336B8 (fr) | 2011-03-04 | 2014-07-23 | Roche Diagnostics GmbH | Nouveau type de sondes universelles pour la détection des variantes génomiques |
| KR101411013B1 (ko) | 2011-12-01 | 2014-06-23 | 제일모직주식회사 | (메타)아크릴로일 이미노포스파젠계 화합물, 그 제조방법 및 이를 포함한 공중합체 |
| WO2013119966A2 (fr) | 2012-02-10 | 2013-08-15 | Genentech, Inc. | Anticorps et autres hétéromultimères monocaténaires |
| WO2014001325A1 (fr) | 2012-06-27 | 2014-01-03 | F. Hoffmann-La Roche Ag | Méthode de fabrication de conjugués d'anticorps à région fc comprenant au moins une entité de liaison qui se lie spécifiquement à une cible et leurs utilisations |
| MX354862B (es) | 2012-06-27 | 2018-03-23 | Hoffmann La Roche | Método para la producción de entidades dirigidas altamente selectivas hechas a la medida y biespecíficas que contienen dos entidades de unión diferentes. |
| CA2871386A1 (fr) | 2012-06-27 | 2014-01-03 | F. Hoffmann-La Roche Ag | Procede de selection et de production de molecules therapeutiques multi-specifiques, selectives et personnalisees comprenant au moins deux entites de ciblage differentes et leursutilisations |
| US9382581B2 (en) * | 2012-12-13 | 2016-07-05 | Roche Molecular Systems, Inc. | Primers with modified phosphate and base in allele-specific PCR |
| RU2708237C2 (ru) | 2014-08-22 | 2019-12-05 | Общество с ограниченной ответственностью "НооГен" | Модифицированные олигонуклеотиды и способ их получения |
| CN107001482B (zh) | 2014-12-03 | 2021-06-15 | 豪夫迈·罗氏有限公司 | 多特异性抗体 |
| JPWO2017111137A1 (ja) | 2015-12-22 | 2018-10-18 | 味の素株式会社 | オリゴヌクレオチドの製造方法 |
| RU2740501C2 (ru) * | 2017-02-21 | 2021-01-14 | Федеральное государственное бюджетное учреждение науки Институт химической биологии и фундаментальной медицины Сибирского отделения Российской академии наук (ИХБФМ СО РАН) | МОДИФИЦИРОВАННЫЕ ОЛИГОНУКЛЕОТИДЫ, АКТИВИРУЮЩИЕ РНКазу Н |
| US11603532B2 (en) | 2017-06-02 | 2023-03-14 | Wave Life Sciences Ltd. | Oligonucleotide compositions and methods of use thereof |
| US11597927B2 (en) | 2017-06-02 | 2023-03-07 | Wave Life Sciences Ltd. | Oligonucleotide compositions and methods of use thereof |
| IL277889B2 (en) | 2018-04-12 | 2025-01-01 | Wave Life Sciences Ltd | Oligonucleotide preparations and methods of using them |
| WO2019217459A1 (fr) | 2018-05-07 | 2019-11-14 | Alnylam Pharmaceuticals, Inc. | Administration extra-hépatique |
| EP3790596A4 (fr) | 2018-05-11 | 2022-04-06 | Wave Life Sciences Ltd. | Compositions d'oligonucléotides et leurs procédés d'utilisation |
| US11384376B2 (en) | 2018-05-31 | 2022-07-12 | Roche Molecular Systems, Inc. | Reagents and methods for post-synthetic modification of nucleic acids |
| EP4013767A4 (fr) * | 2019-08-15 | 2023-10-25 | Ionis Pharmaceuticals, Inc. | Composés oligomères modifiés par liaison et leurs utilisations |
| US20260085087A1 (en) * | 2020-10-12 | 2026-03-26 | Maxim Sergeevich Kupryushkin | Chemical compound comprising a triazine group and method for producing same |
| WO2025070241A1 (fr) * | 2023-09-25 | 2025-04-03 | 藤本化学製品株式会社 | Composé ou sel de celui-ci et son procédé de production |
| CN121909203A (zh) * | 2023-10-31 | 2026-04-21 | 科罗生物公司 | 包含氨基磷酸酯核苷酸间键的寡核苷酸 |
Family Cites Families (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3792025A (en) * | 1972-12-15 | 1974-02-12 | Upjohn Co | Novel compounds and process |
| US4031068A (en) * | 1976-07-26 | 1977-06-21 | Uniroyal Inc. | Non-migratory sulfonyl azide antioxidants |
| US5260433A (en) | 1982-06-23 | 1993-11-09 | Enzo Diagnostics, Inc. | Saccharide specific binding system labeled nucleotides |
| US5241060A (en) | 1982-06-23 | 1993-08-31 | Enzo Diagnostics, Inc. | Base moiety-labeled detectable nucleatide |
| US4948882A (en) | 1983-02-22 | 1990-08-14 | Syngene, Inc. | Single-stranded labelled oligonucleotides, reactive monomers and methods of synthesis |
| US5002885A (en) | 1984-01-30 | 1991-03-26 | Enzo Biochem, Inc. | Detectable molecules, method preparation and use |
| US5585481A (en) | 1987-09-21 | 1996-12-17 | Gen-Probe Incorporated | Linking reagents for nucleotide probes |
| US5231191A (en) | 1987-12-24 | 1993-07-27 | Applied Biosystems, Inc. | Rhodamine phosphoramidite compounds |
| WO1989009221A1 (fr) | 1988-03-25 | 1989-10-05 | University Of Virginia Alumni Patents Foundation | N-alkylphosphoramidates oligonucleotides |
| US4997928A (en) | 1988-09-15 | 1991-03-05 | E. I. Du Pont De Nemours And Company | Fluorescent reagents for the preparation of 5'-tagged oligonucleotides |
| US5118801A (en) | 1988-09-30 | 1992-06-02 | The Public Health Research Institute | Nucleic acid process containing improved molecular switch |
| US5141813A (en) | 1989-08-28 | 1992-08-25 | Clontech Laboratories, Inc. | Multifunctional controlled pore glass reagent for solid phase oligonucleotide synthesis |
| US5177198A (en) | 1989-11-30 | 1993-01-05 | University Of N.C. At Chapel Hill | Process for preparing oligoribonucleoside and oligodeoxyribonucleoside boranophosphates |
| US5210015A (en) | 1990-08-06 | 1993-05-11 | Hoffman-La Roche Inc. | Homogeneous assay system using the nuclease activity of a nucleic acid polymerase |
| US5290925A (en) | 1990-12-20 | 1994-03-01 | Abbott Laboratories | Methods, kits, and reactive supports for 3' labeling of oligonucleotides |
| JPH06102267A (ja) * | 1992-09-18 | 1994-04-15 | Japan Organo Co Ltd | 非イオン界面活性剤の分析方法 |
| US5538848A (en) | 1994-11-16 | 1996-07-23 | Applied Biosystems Division, Perkin-Elmer Corp. | Method for detecting nucleic acid amplification using self-quenching fluorescence probe |
| US5624711A (en) | 1995-04-27 | 1997-04-29 | Affymax Technologies, N.V. | Derivatization of solid supports and methods for oligomer synthesis |
| CA2253969A1 (fr) | 1996-05-15 | 1997-11-20 | Rajkumar Siva Iyer | Reactifs de liaison non nucleotidiques |
| JP4281877B2 (ja) | 1996-06-04 | 2009-06-17 | ユニバーシティ オブ ユタ リサーチ ファウンデーション | 生物学的プロセスを実行し且つモニタリングするためのシステムと方法 |
| DE19650252C2 (de) | 1996-12-04 | 2002-01-17 | Univ Dresden Tech | Verfahren zum Färben von Filamenten, Fasern und Garnen, natürlicher oder synthetischer Herkunft und von Kunststoffen in Folienform |
| JPH11140488A (ja) * | 1997-11-05 | 1999-05-25 | Nippon Shokubai Co Ltd | 洗剤ビルダーおよび洗剤組成物 |
| US6255476B1 (en) | 1999-02-22 | 2001-07-03 | Pe Corporation (Ny) | Methods and compositions for synthesis of labelled oligonucleotides and analogs on solid-supports |
| US6303774B1 (en) * | 1999-08-20 | 2001-10-16 | Sri International | Nucleoside pyrophosphate and triphosphate analogs and related compounds |
| TWI287536B (en) * | 2000-04-18 | 2007-10-01 | Ind Tech Res Inst | Method for preparing azide photo-initiators |
| ATE332398T1 (de) | 2000-08-11 | 2006-07-15 | Univ Utah Res Found | Einfach markierte oligonukleotidsonden |
| US20030138797A1 (en) | 2001-06-29 | 2003-07-24 | Micrologix Biotech Inc. | Nucleic acid-based compounds |
| CN101160399A (zh) * | 2002-04-22 | 2008-04-09 | 拜奥尼茨生命科学公司 | 寡核苷酸组合物及其在调节免疫应答中的应用 |
| EP1801114B8 (fr) | 2005-11-23 | 2009-12-02 | Roche Diagnostics GmbH | Polynucléotides contenant des phosphates mimétiques |
-
2005
- 2005-11-23 EP EP05025499A patent/EP1801114B8/fr not_active Expired - Lifetime
- 2005-11-23 ES ES05025499T patent/ES2332139T3/es not_active Expired - Lifetime
- 2005-11-23 AT AT05025499T patent/ATE443072T1/de not_active IP Right Cessation
- 2005-11-23 DE DE502005008153T patent/DE502005008153D1/de not_active Expired - Lifetime
-
2006
- 2006-09-12 CA CA2627208A patent/CA2627208C/fr not_active Expired - Fee Related
- 2006-09-12 JP JP2008541599A patent/JP5155177B2/ja active Active
- 2006-09-12 AU AU2006317195A patent/AU2006317195B2/en not_active Ceased
- 2006-09-12 DE DE602006016325T patent/DE602006016325D1/de active Active
- 2006-09-12 BR BRPI0618833-8A patent/BRPI0618833B1/pt not_active IP Right Cessation
- 2006-09-12 KR KR1020087012000A patent/KR101028980B1/ko not_active Expired - Fee Related
- 2006-09-12 EP EP06791985A patent/EP1954707B1/fr active Active
- 2006-09-12 AT AT06791985T patent/ATE478087T1/de not_active IP Right Cessation
- 2006-09-12 CN CN200680043667.3A patent/CN101312985B/zh active Active
- 2006-09-12 ES ES06791985T patent/ES2349129T3/es active Active
- 2006-09-12 WO PCT/EP2006/008842 patent/WO2007059816A1/fr not_active Ceased
- 2006-11-21 EP EP06818687A patent/EP1954671B1/fr not_active Not-in-force
- 2006-11-21 KR KR1020087012296A patent/KR101032008B1/ko not_active Expired - Fee Related
- 2006-11-21 BR BRPI0618855-9A patent/BRPI0618855A2/pt not_active Application Discontinuation
- 2006-11-21 JP JP2008541627A patent/JP5364380B2/ja not_active Expired - Fee Related
- 2006-11-21 CN CN2006800434199A patent/CN101312941B/zh not_active Expired - Fee Related
- 2006-11-21 CA CA2627216A patent/CA2627216C/fr not_active Expired - Fee Related
-
2008
- 2008-05-16 US US12/121,842 patent/US7741472B2/en active Active
- 2008-05-20 US US12/123,656 patent/US7795423B2/en not_active Expired - Fee Related
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