JP6010460B2 - フィブリンおよびアガロース生体材料を用いる組織工学による、人工組織の製造 - Google Patents

フィブリンおよびアガロース生体材料を用いる組織工学による、人工組織の製造 Download PDF

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JP6010460B2
JP6010460B2 JP2012526090A JP2012526090A JP6010460B2 JP 6010460 B2 JP6010460 B2 JP 6010460B2 JP 2012526090 A JP2012526090 A JP 2012526090A JP 2012526090 A JP2012526090 A JP 2012526090A JP 6010460 B2 JP6010460 B2 JP 6010460B2
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tissue
cells
artificial
collagen
product obtained
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Expired - Fee Related
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JP2012526090A
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JP2013502915A (ja
Inventor
ミンゴランス、ミゲル アラミノス
ミンゴランス、ミゲル アラミノス
アビラ、ホセ イグナシオ ムニョス
アビラ、ホセ イグナシオ ムニョス
アンドラデス、ミゲル ゴンザレス
アンドラデス、ミゲル ゴンザレス
ムニョス、アントニオ カンポス
ムニョス、アントニオ カンポス
ベロ、イングリッド ファナ ガルソン
ベロ、イングリッド ファナ ガルソン
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Universidad de Granada
Servicio Andaluz de Salud
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Universidad de Granada
Servicio Andaluz de Salud
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Priority claimed from ES200930625A external-priority patent/ES2353990B1/es
Priority claimed from ES200930943A external-priority patent/ES2362139B1/es
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3804—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
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    • A61L27/3691—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment characterised by physical conditions of the treatment, e.g. applying a compressive force to the composition, pressure cycles, ultrasonic/sonication or microwave treatment, lyophilisation
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    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
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    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3804—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
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    • C12N2502/09—Coculture with; Conditioned medium produced by epidermal cells, skin cells, oral mucosa cells
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  • Health & Medical Sciences (AREA)
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  • Dermatology (AREA)
  • Developmental Biology & Embryology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Transplantation (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Virology (AREA)
  • Reproductive Health (AREA)
  • Immunology (AREA)
  • Botany (AREA)
  • Urology & Nephrology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Pregnancy & Childbirth (AREA)
  • Neurosurgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Neurology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
JP2012526090A 2009-08-25 2010-08-25 フィブリンおよびアガロース生体材料を用いる組織工学による、人工組織の製造 Expired - Fee Related JP6010460B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
ES200930625A ES2353990B1 (es) 2009-08-25 2009-08-25 Elaboracion de tejidos artificiales mediante ingenieria tisular utilizando biomateriales de fibrina y agarosa.
ESP200930625 2009-08-25
ES200930943A ES2362139B1 (es) 2009-11-02 2009-11-02 Elaboración de tejidos artificiales mediante ingeniería tisular utilizando biomateriales de fibrina, agarosa y colágeno.
ESP200930943 2009-11-02
PCT/ES2010/070569 WO2011023843A2 (es) 2009-08-25 2010-08-25 Elaboración de tejidos artificiales mediante ingeniería tisular utilizando biomateriales de fibrina y agarosa

Related Child Applications (1)

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JP2016042311A Division JP2016165280A (ja) 2009-08-25 2016-03-04 フィブリンおよびアガロース生体材料を用いる組織工学による、人工組織の製造

Publications (2)

Publication Number Publication Date
JP2013502915A JP2013502915A (ja) 2013-01-31
JP6010460B2 true JP6010460B2 (ja) 2016-10-19

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JP2012526090A Expired - Fee Related JP6010460B2 (ja) 2009-08-25 2010-08-25 フィブリンおよびアガロース生体材料を用いる組織工学による、人工組織の製造
JP2016042311A Withdrawn JP2016165280A (ja) 2009-08-25 2016-03-04 フィブリンおよびアガロース生体材料を用いる組織工学による、人工組織の製造

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JP2016042311A Withdrawn JP2016165280A (ja) 2009-08-25 2016-03-04 フィブリンおよびアガロース生体材料を用いる組織工学による、人工組織の製造

Country Status (8)

Country Link
US (2) US20120269776A1 (da)
EP (1) EP2471902B9 (da)
JP (2) JP6010460B2 (da)
DK (1) DK2471902T3 (da)
ES (1) ES2677945T3 (da)
PT (1) PT2471902T (da)
TR (1) TR201809713T4 (da)
WO (1) WO2011023843A2 (da)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2594295A1 (en) * 2011-11-16 2013-05-22 Servicio Andaluz De Salud Nerve implants based on a compacted biomaterial containing cells
FR2990106B1 (fr) * 2012-05-03 2014-05-09 Genoskin Systeme permettant la maintenance en survie et le transport de biospsies de peau et ses applications
RU2523342C1 (ru) * 2013-02-13 2014-07-20 федеральное государственное бюджетное учреждение "Межотраслевой научно-технический комплекс "Микрохирургия глаза" имени академика С.Н. Федорова" Министерства здравоохранения Российской Федерации Способ кератопротезирования осложненных сосудистых бельм 4-5 категории
CL2013003066A1 (es) * 2013-10-22 2014-07-25 Univ Chile Composicion para tratamiento de heridas porque comprende matriz soporte y células troncalesmesenquiámicas de gelatina de wharton; metodo para tratar heridas que comprende aplicar dicha composicion
RU2552304C1 (ru) * 2014-02-14 2015-06-10 федеральное государственное бюджетное учреждение "Межотраслевой научно-технический комплекс "Микрохирургия глаза" имени академика С.Н. Федорова" Министерства здравоохранения Российской Федерации Способ кератопротезирования ожоговых и сосудистых бельм (варианты)
EP3011981A1 (en) 2014-10-24 2016-04-27 Histocell, S.L. A biomaterial scaffold for regenerating the oral mucosa
ES2574655B1 (es) * 2014-11-21 2017-04-20 Universidad De Granada Elaboración de tejidos artificiales que comprenden partículas magnéticas
ES2667821B1 (es) * 2016-10-14 2019-02-22 Univ Granada Membranas bioartificiales de rigidez y viscoelasticidad controlada para su utilizacion en ingenieria tisular
JP2020501543A (ja) 2016-12-07 2020-01-23 メイヨ・ファウンデーション・フォー・メディカル・エデュケーション・アンド・リサーチ 網膜色素上皮移植のためのフィブリン支持体を用いた方法及び材料
US10980740B2 (en) * 2017-09-12 2021-04-20 Shilpa Medicare Limited Tranexamic acid spray for knee arthroplasty
CA3080691C (en) * 2017-11-10 2022-11-15 Regenesis Science Co., Ltd. Method for producing cultured cell, and method for producing therapeutic agent for spinal cord injury disease
EP3773765B1 (en) 2018-04-06 2022-07-27 Fundación Pública Andaluza Progreso Y Salud Hemostatic efficacy of a nanostructured fibrin agarose hydrogel
RU2714943C1 (ru) * 2019-06-04 2020-02-21 Общество с ограниченной ответственностью фирмы "Имтек" Искусственная роговица, представляющая собой мембрану гетерогенной жесткости на основе коллагена, и способ ее получения и применения
CN116194571A (zh) * 2020-07-17 2023-05-30 新加坡国立大学 牙龈组织及其制备方法

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4600533A (en) * 1984-12-24 1986-07-15 Collagen Corporation Collagen membranes for medical use
JP2858066B2 (ja) * 1993-04-06 1999-02-17 グンゼ株式会社 組織培養法並びにこれに用いる培養基材
US6933331B2 (en) * 1998-05-22 2005-08-23 Nanoproducts Corporation Nanotechnology for drug delivery, contrast agents and biomedical implants
US5844087A (en) * 1996-11-05 1998-12-01 Bayer Corporation Method and device for delivering fibrin glue
AT407117B (de) * 1997-09-19 2000-12-27 Immuno Ag Fibrinschwamm
US6056970A (en) * 1998-05-07 2000-05-02 Genzyme Corporation Compositions comprising hemostatic compounds and bioabsorbable polymers
US6946140B1 (en) * 1999-02-09 2005-09-20 The Research Foundation Of State University Of New York Methods and compositions for enhancing fibroblast migration
US6548058B1 (en) * 1999-07-20 2003-04-15 Epitech, S.A. Keratinocyte culture and uses thereof
AT500670A1 (de) * 1999-05-19 2006-02-15 Bio & Bio Licensing Sa Arzneimittel zur lokalen anwendung
US20050164388A1 (en) * 2001-02-07 2005-07-28 Young-Sook Son Method of isolating epithelial cells, method of preconditioning cells, and methods of preparing bioartificial skin and dermis with the epithelial cells and preconditioned cells
ES2173812B1 (es) * 2001-03-01 2003-12-16 Ct Investig Energeticas Ciemat Dermis artificial y metodo de obtencion.
EP1404809B1 (en) * 2001-03-02 2013-12-11 Stratatech Corporation Improved skin substitutes and uses thereof
US20030166274A1 (en) * 2001-11-15 2003-09-04 Hewitt Charles W. Three-dimensional matrix for producing living tissue equivalents
WO2003093433A2 (en) * 2002-05-02 2003-11-13 Regents Of The University Of Minnesota Fibrin-based biomatrix
AU2003257684A1 (en) * 2002-08-23 2004-03-11 Asahi Medical Co., Ltd. Fibrin-containing composition
US20040126881A1 (en) * 2002-09-06 2004-07-01 Vincent Ronfard Fibrin cell supports and methods of use thereof
US8765169B2 (en) * 2004-02-13 2014-07-01 Smith & Nephew, Inc. Wound healing profile
GB0415080D0 (en) * 2004-07-05 2004-08-04 Ucl Biomedica Plc Methods for preparing tissue equivalent implants and products thereof
PL1789534T3 (pl) * 2004-08-16 2015-03-31 Cellresearch Corp Pte Ltd Wyodrębnienie komórek macierzystych/progenitorowych z błony owodniowej pępowiny
CN103555655B (zh) * 2005-10-21 2018-02-27 细胞研究私人有限公司 自脐带羊膜分离和培养干/祖细胞及其分化的细胞的应用
FR2896506B1 (fr) * 2006-01-20 2008-04-04 Essilor Int Composition polymerisable a base de polyurethane-uree et de copolymeres a blocs et materiau transparent obtenu a partir de celle-ci
US8753670B2 (en) * 2008-03-26 2014-06-17 Baxter International Inc. Fibrin foam and process

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