JP6789283B2 - 改変酵母−ブラキュリー免疫療法組成物 - Google Patents

改変酵母−ブラキュリー免疫療法組成物 Download PDF

Info

Publication number: JP6789283B2
Authority: JP; Japan
Prior art keywords: yeast; bracury; cancer; bracully; seq
Prior art date: 2015-08-03
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Active

Application number

JP2018505476A

Other languages

English (en)

Japanese (ja)

Other versions

JP2018522041A (ja

JP2018522041A5 (2

Inventor

エイチ．キング、トーマス

グオ、ジミン

シュロム、ジェフリー

パレナ、クラウディア

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

US Department of Health and Human Services

Original Assignee

US Department of Health and Human Services

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2015-08-03

Filing date

2016-08-01

Publication date

2020-11-25

2016-08-01 Application filed by US Department of Health and Human Services filed Critical US Department of Health and Human Services

2018-08-09 Publication of JP2018522041A publication Critical patent/JP2018522041A/ja

2019-09-12 Publication of JP2018522041A5 publication Critical patent/JP2018522041A5/ja

2020-11-25 Application granted granted Critical

2020-11-25 Publication of JP6789283B2 publication Critical patent/JP6789283B2/ja

Status Active legal-status Critical Current

2036-08-01 Anticipated expiration legal-status Critical

Links

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
- A61K40/41—Vertebrate antigens
- A61K40/42—Cancer antigens
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/82—Translation products from oncogenes
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
- A61K2039/521—Bacterial cells; Fungal cells; Protozoal cells inactivated (killed)
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
- A61K2039/523—Bacterial cells; Fungal cells; Protozoal cells expressing foreign proteins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/53—DNA (RNA) vaccination
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/58—Medicinal preparations containing antigens or antibodies raising an immune response against a target which is not the antigen used for immunisation
- A61K2039/585—Medicinal preparations containing antigens or antibodies raising an immune response against a target which is not the antigen used for immunisation wherein the target is cancer
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6006—Cells
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2121/00—Preparations for use in therapy

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Mycology (AREA)
Pharmacology & Pharmacy (AREA)
Organic Chemistry (AREA)
Epidemiology (AREA)
Microbiology (AREA)
Natural Medicines & Medicinal Plants (AREA)
Oncology (AREA)
Immunology (AREA)
Biophysics (AREA)
Botany (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Biochemistry (AREA)
Gastroenterology & Hepatology (AREA)
Engineering & Computer Science (AREA)
Alternative & Traditional Medicine (AREA)
Biotechnology (AREA)
Genetics & Genomics (AREA)
Medical Informatics (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Peptides Or Proteins (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

JP2018505476A 2015-08-03 2016-08-01 改変酵母−ブラキュリー免疫療法組成物 Active JP6789283B2 (ja)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US201562200497P	2015-08-03	2015-08-03
US62/200,497		2015-08-03
PCT/US2016/044977 WO2017023840A1 (en)	2015-08-03	2016-08-01	Modified yeast-brachyury immunotherapeutic compositions

Publications (3)

Publication Number	Publication Date
JP2018522041A JP2018522041A (ja)	2018-08-09
JP2018522041A5 JP2018522041A5 (2)	2019-09-12
JP6789283B2 true JP6789283B2 (ja)	2020-11-25

Family

ID=56618277

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
JP2018505476A Active JP6789283B2 (ja)	2015-08-03	2016-08-01	改変酵母−ブラキュリー免疫療法組成物

Country Status (11)

Country	Link
US (1)	US11065313B2 (2)
EP (1)	EP3331552B1 (2)
JP (1)	JP6789283B2 (2)
KR (1)	KR102833272B1 (2)
CN (1)	CN108348586B (2)
AU (1)	AU2016303525B2 (2)
CA (1)	CA2994272C (2)
HK (1)	HK1249431A1 (2)
IL (1)	IL257208B (2)
TW (1)	TWI748957B (2)
WO (1)	WO2017023840A1 (2)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU2014265873B2 (en)	2013-03-19	2019-01-17	Globeimmune, Inc.	Yeast-based immunotherapy for chordoma
CA2948803A1 (en) *	2014-04-11	2015-10-15	Globeimmune, Inc.	Yeast-based immunotherapy and type i interferon sensitivity
EP4137150A1 (en) *	2015-08-03	2023-02-22	The United States of America, as represented by the Secretary, Department of Health and Human Services	Brachyury deletion mutants, non-yeast vectors encoding brachyury deletion mutants, and their use
CN119818663A (zh) *	2018-05-15	2025-04-15	全球免疫公司	用于诱导细胞免疫应答的重组酵母裂解物
EP3886869A4 (en)	2018-11-28	2022-07-06	Forty Seven, Inc.	GENETICALLY MODIFIED ABLATION-RESISTANT HSPCS
WO2022187963A1 (en) *	2021-03-10	2022-09-15	Provincial Health Services Authority	Immunotherapy agents targeting brachyury and methods of using same
EP4489774A4 (en) *	2022-03-08	2026-04-29	Immunitybio Inc	YEAST-BASED VACCINE INJECTED INTRATUMORALLY
EP4516807A1 (en)	2023-08-28	2025-03-05	Consorcio Centro de Investigación Biomédica en Red	Compositions for use in a method of providing improved hematopoietic stem cell engraftment

Family Cites Families (38)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2486400B1 (fr)	1980-07-09	1986-05-30	Univablot	Medicaments a base de levures ou de leurs extraits insolubles
NZ199722A (en)	1981-02-25	1985-12-13	Genentech Inc	Dna transfer vector for expression of exogenous polypeptide in yeast;transformed yeast strain
US4775622A (en)	1982-03-08	1988-10-04	Genentech, Inc.	Expression, processing and secretion of heterologous protein by yeast
US5310654A (en)	1985-07-31	1994-05-10	The Board Of Trustees Of The Leland Stanford Junior University	Method for determining virulence of Yersinia
US5234830A (en)	1988-02-03	1993-08-10	Suntory Limited	DNA encoding a KEX2 endoprotease without a C-terminal hydrophobic region
IL95019A0 (en)	1989-08-09	1991-06-10	Mycogen Corp	Process for encapsulation of biologicals
US5830463A (en)	1993-07-07	1998-11-03	University Technology Corporation	Yeast-based delivery vehicles
US5413914A (en)	1993-07-07	1995-05-09	The Regents Of The University Of Colorado	Yeast assay to identify inhibitors of dibasic amino acid processing endoproteases
US5858378A (en)	1996-05-02	1999-01-12	Galagen, Inc.	Pharmaceutical composition comprising cryptosporidium parvum oocysts antigen and whole cell candida species antigen
EP1037643B1 (en)	1997-10-10	2003-12-03	Meyer Pharmaceuticals, LLC	Cancer immunotherapy using allostimulated cells in a multiple sequential implantation strategy
US5948646A (en)	1997-12-11	1999-09-07	Fordham University	Methods for preparation of vaccines against cancer comprising heat shock protein-peptide complexes
US20020044948A1 (en)	2000-03-15	2002-04-18	Samir Khleif	Methods and compositions for co-stimulation of immunological responses to peptide antigens
AU1951001A (en)	2000-04-06	2001-09-17	Panacea Pharm Llc	Microbial delivery system
AU2002225681A1 (en)	2000-11-15	2002-05-27	Globe Immune, Inc.	Yeast-dentritic cell vaccines and uses thereof
KR101455222B1 (ko)	2002-12-16	2014-10-31	글로브이뮨	면역 요법으로서의 효모계 백신
US7439042B2 (en)	2002-12-16	2008-10-21	Globeimmune, Inc.	Yeast-based therapeutic for chronic hepatitis C infection
US20060009404A1 (en)	2004-07-09	2006-01-12	Williams Jason R	Tumor ablation in combination with pharmaceutical compositions
SG163572A1 (en)	2005-07-11	2010-08-30	Globeimmune Inc	Compositions and methods for eliciting an immune response to escape mutants of targeted therapies
US20070172503A1 (en)	2005-12-13	2007-07-26	Mycologics,Inc.	Compositions and Methods to Elicit Immune Responses Against Pathogenic Organisms Using Yeast Based Vaccines
US7736642B2 (en)	2006-02-02	2010-06-15	Globeimmune, Inc.	Yeast-based vaccine for inducing an immune response
BRPI0709340A2 (pt)	2006-03-27	2013-04-16	Globeimmune, Inc.	mutaÇço ras e composiÇÕes e mÉtodos de uso da mesma
WO2008097863A2 (en)	2007-02-02	2008-08-14	Globeimmune, Inc.	Methods for producing yeast-based vaccines
WO2008106551A2 (en)	2007-02-28	2008-09-04	The Govt. Of The U.S.A. As Represented By The Secretary Of The Dept. Of Health & Human Serv.	Brachyury polypeptides and methods for use
US8501167B2 (en)	2007-03-19	2013-08-06	Globeimmune, Inc.	Compositions and methods for targeted ablation of mutational escape of targeted therapies for cancer
WO2009042645A2 (en) *	2007-09-24	2009-04-02	President And Fellows Of Harvard College	The use of mice predisposed to develop ulcerative colitis and colon cancer to develop metabolic profiles associated with same
WO2010033841A1 (en)	2008-09-19	2010-03-25	Globeimmune, Inc.	Immunotherapy for chronic hepatitis c virus infection
WO2010065626A1 (en)	2008-12-02	2010-06-10	Globeimmune, Inc.	Genotyping tools, methods and kits
MX2011010977A (es)	2009-04-17	2012-02-29	Us Health	Composiciones inmunoterapeuticas combinadas contra cancer y metodos.
CA2774326C (en)	2009-09-14	2023-11-07	Donald Bellgrau	Modulation of yeast-based immunotherapy products and responses
EP2547792A4 (en)	2010-03-14	2013-11-27	Globeimmune Inc	PHARMACOGENOMIC TREATMENT AND ADAPTATION TO THE RESPONSE OF AN INFECTIOUS DISEASE USING YEAST IMMUNOTHERAPY
GB201004575D0 (en)	2010-03-19	2010-05-05	Immatics Biotechnologies Gmbh	Composition of tumor associated peptides and related anti cancer vaccine for the treatment of gastric cancer and other cancers
WO2012019127A2 (en)	2010-08-05	2012-02-09	The Regents Of The University Of Colorado	Combination yeast-based immunotherapy and arginine therapy for the treatment of myeloid-derived supressor cell-associated diseases
US9254320B2 (en)	2010-12-17	2016-02-09	Globeimmune, Inc.	Compositions and methods for the treatment or prevention of human adenovirus-36 infection
JP5745102B2 (ja)	2011-02-12	2015-07-08	グローブイミューン，インコーポレイテッド	慢性ｂ型肝炎感染症のための酵母系免疫療法組成物
MX350661B (es) *	2011-03-17	2017-09-13	Us Health	Composiciones inmunoterapeuticas de levadura-brachyuri.
CN103732250A (zh)	2011-06-14	2014-04-16	全球免疫股份有限公司	基于酵母的治疗或预防丁型肝炎病毒感染的组合物和方法
SG10201607663YA (en)	2011-08-17	2016-11-29	Globeimmune Inc	Yeast-muc1 immunotherapeutic compositions and uses thereof
AU2014265873B2 (en) *	2013-03-19	2019-01-17	Globeimmune, Inc.	Yeast-based immunotherapy for chordoma

2016
- 2016-08-01 AU AU2016303525A patent/AU2016303525B2/en active Active
- 2016-08-01 TW TW105124349A patent/TWI748957B/zh active
- 2016-08-01 HK HK18109071.3A patent/HK1249431A1/zh unknown
- 2016-08-01 CA CA2994272A patent/CA2994272C/en active Active
- 2016-08-01 JP JP2018505476A patent/JP6789283B2/ja active Active
- 2016-08-01 KR KR1020187006157A patent/KR102833272B1/ko active Active
- 2016-08-01 US US15/749,832 patent/US11065313B2/en active Active
- 2016-08-01 EP EP16750335.8A patent/EP3331552B1/en active Active
- 2016-08-01 WO PCT/US2016/044977 patent/WO2017023840A1/en not_active Ceased
- 2016-08-01 CN CN201680056316.XA patent/CN108348586B/zh active Active
2018
- 2018-01-29 IL IL257208A patent/IL257208B/en unknown

Also Published As

Publication number	Publication date
JP2018522041A (ja)	2018-08-09
CA2994272C (en)	2023-08-22
CA2994272A1 (en)	2017-02-09
EP3331552A1 (en)	2018-06-13
IL257208B (en)	2021-10-31
EP3331552B1 (en)	2021-01-27
KR102833272B1 (ko)	2025-07-10
CN108348586B (zh)	2022-03-15
HK1249431A1 (zh)	2018-11-02
US11065313B2 (en)	2021-07-20
AU2016303525B2 (en)	2021-01-21
IL257208A (en)	2018-03-29
KR20180054587A (ko)	2018-05-24
US20180214525A1 (en)	2018-08-02
TWI748957B (zh)	2021-12-11
AU2016303525A1 (en)	2018-03-15
WO2017023840A1 (en)	2017-02-09
TW201716574A (zh)	2017-05-16
CN108348586A (zh)	2018-07-31

Legal Events

Date	Code	Title	Description
2019-07-31	A521	Request for written amendment filed	Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20190731
2019-07-31	A621	Written request for application examination	Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20190731
2020-06-23	A131	Notification of reasons for refusal	Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20200623
2020-09-17	A521	Request for written amendment filed	Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20200917
2020-09-29	TRDD	Decision of grant or rejection written
2020-10-06	A01	Written decision to grant a patent or to grant a registration (utility model)	Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20201006
2020-11-05	A61	First payment of annual fees (during grant procedure)	Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20201102
2020-11-05	R150	Certificate of patent or registration of utility model	Ref document number: 6789283 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150
2023-10-26	R250	Receipt of annual fees	Free format text: JAPANESE INTERMEDIATE CODE: R250
2024-11-08	R250	Receipt of annual fees	Free format text: JAPANESE INTERMEDIATE CODE: R250
2025-11-12	R250	Receipt of annual fees	Free format text: JAPANESE INTERMEDIATE CODE: R250

Publication	Publication Date	Title
JP6571822B2 (ja)	2019-09-04	酵母−ｍｕｃ１免疫療法用組成物およびその使用
JP6580733B2 (ja)	2019-09-25	酵母−ブラキュリ免疫治療組成物
JP6789283B2 (ja)	2020-11-25	改変酵母−ブラキュリー免疫療法組成物
NZ724797B2 (en)	2020-09-29	Yeast-brachyury immunotherapeutic compositions
HK1192141B (en)	2018-02-15	Yeast-brachyury immunotherapeutic compositions
HK1192141A (en)	2014-08-15	Yeast-brachyury immunotherapeutic compositions