JPH01207232A - Preventive and therapeutic agent for hangover - Google Patents

Abstract

PURPOSE:To obtain a hangover preventing and treating agent which is composed of L-alanine and an artificial sweetening, as major ingredients, can be easily taken in any time, having the taste improved and showing large efficacy for preventing and treating hangover. CONSTITUTION:The objective preparation is obtained by formulating L-alanine, an artificial sweetening, as the major ingredients, and, when needed, other amino acids such as ornithine or tryptophan, excipients and other additives, in a usual manner. The artificial sweetening is, for example, saccharin and dipeptide sweeteners, preferably alpha-L-aspartyl-L-phenylalanine methyl ester. The amount of the sweetener is 0.1-5.0wt.% based on the L-alanine. The formulation is prepared into powder or tablets and the dose is 0.1-100mg/kg body weight.

Description

DETAILED DESCRIPTION OF THE INVENTION [Industrial Application Field] The present invention relates to a preventive and therapeutic agent for hangover, and more particularly, to a hangover preventive treatment containing an artificial sweetener and L-alanine as main ingredients. Regarding drugs.

[Conventional technology and its problems]

Since ancient times, it has been said that ``alcohol is the greatest medicine,'' and throughout the long history of mankind, various alcoholic beverages have been enjoyed. On the other hand,
Experience has taught us that if taken too far, it can cause harm and no benefit.

Efforts have been made since ancient times to eliminate the harmful effects of alcoholic beverages, such as adding legal prohibitions against drinking, and religiously and educationally promoting the idea that drinking is a bad habit. However, it is extremely difficult to break the habit of drinking that has continued for a long time, and many people who have experienced drinking have experienced this difficulty.

Although the degree of intoxication caused by drinking alcohol varies from person to person, -S exhibits symptoms such as post-intoxication headaches and hangovers, and continued drinking in large quantities can impair liver function, leading to alcohol poisoning. ing. Against this background, medical research is being conducted on alcoholic liver damage, etc.
Various medicines and treatment methods have been developed and put into practical use.

However, many people experience the so-called "
The phenomenon of a hangover causes vomiting, headache, loss of appetite, etc., creating an extremely unpleasant situation that prompts drinkers to temporarily decide not to drink alcohol again. However, regardless of this determination, some people find themselves falling back into the habit of drinking again, or drinking when forced to drink due to social necessity, resulting in a ``hangover.'' Sometimes I end up repeating myself. As an emergency measure in such cases, there are methods that have been passed down for a long time, such as egg sake and mukai sake, but each method differs from person to person, and it can be said that there is no effective method for preventing or treating hangovers. is the current situation.

(Means for Solving the Problems) The present inventors desire to effectively and appropriately prevent or treat hangovers as described above, and in particular, since the opportunity to drink alcohol may occur at any time, We have conducted extensive research into finding preventive and therapeutic agents that can be easily taken in such cases and have great preventive and therapeutic effects.

As a result, they discovered that a preventive/therapeutic agent containing and mixing L-alanine and an artificial sweetener satisfies these needs, and completed the present invention.

That is, the present invention has completed a prophylactic/therapeutic agent that uses shi-alanine and an artificial sweetener as main ingredients, improves the unique amino acid taste quality of L-alanine, has a pleasant taste, and can be easily taken. It is characterized by containing alanine and artificial sweeteners as main ingredients.

L-alanine used in the present invention is an amino acid that is also contained in all proteins, and is a substance that has been confirmed to be non-toxic.

It is already known that this L-alanine is effective for hangovers, and that it is effective for alcoholic liver damage when used in combination with ornithine.

However, although L-alanine has a relatively sweet taste, it lacks mellowness, and even when mixed with other amino acids,
Since it exhibits the bitterness characteristic of amino acids, it is not preferable to take it alone.

Therefore, for example, even a drink containing L-alanine does not have sufficient ease and convenience to take, and is not convenient enough to be carried around and taken when needed.

As described above, the monoalanine used in the present invention as an agent for preventing or treating hangover has not been improved in terms of taste and administration.

By incorporating an artificial sweetener into the L-alanine used in the present invention, the taste properties are greatly improved compared to when L-alanine alone is used, and it is usually possible to develop a taste that is easy to drink.

The amount of artificial sweetener to be used for L-alanine is not particularly limited as long as it can improve the taste of L-alanine. .1 to 5.0% by weight is often used.

As the artificial sweetener to be used, saccharin, dipeptide sweeteners, and various other sweeteners can be used.
Particularly preferably used is aspartame (hereinafter abbreviated as aspartame). This aspartame has an extremely large effect on taste improvement depending on the amount used, and can be used as a prophylactic/therapeutic agent that is easy to take.

For example, in the case of a mixture of L-alanine and aspartame, the composition is a mixture of 0.5 to 1.0% by weight of aspartame to L-alanine, and the characteristic taste of L-alanine is mellow. The weight has improved by 1 lb before drinking alcohol.
If you take only 0.5~to+mg per kg,
Prevents hangovers even when drinking heavily, and after drinking,
You can also treat hangovers by taking it in the same way.

The hangover prevention and treatment agent of the present invention is usually taken at a rate of 0.1 to 100 ml per 1 kg of body weight.

The hangover prevention and treatment agent of the present invention can be made into an easy-to-take form by directly blending alanine with an artificial sweetener such as aspartame, but it can also be used for other purposes.
The combined use of other amino acids such as ornithine, tryptophan, and other components such as fillers is also included in the embodiment of the present invention.

Further, it can be used in various forms such as powder or tablet, but is not particularly limited to these forms. However, these shapes are preferable because they have a distinct taste and are easy to take.

[Effects of the Invention] By taking the hangover prevention and treatment agent according to the present invention before, during, or after drinking alcohol, its effects can be expected with almost no individual difference.

〔Example〕

Example-1 100 g of L-alanine and 1 g of aspartame were mixed and mixed thoroughly to prepare a hangover prevention and treatment agent.

Using this treatment, 18 adult men who had a habit of drinking alcohol and had experienced hangovers were given one dose of alcoholic beverages 30 minutes before drinking alcohol.
The amount of alcohol consumed when each person experienced a hangover in the past after taking 3+ og per kg of body weight per person,
The participants were asked to drink approximately different types of alcohol (wine, Japanese sake, Western liquor, etc.), and the ease with which they could take therapeutic drugs, as well as their state of intoxication and the occurrence of hangover symptoms, were investigated.

As a result, all subjects found it easy to drink and had no hangover symptoms after drinking.

I got the impression that it was also refreshing.

These results revealed that the taste quality of L-alanine was significantly improved, and that it had a remarkable hangover preventive effect.

Example-2 The same hangover prevention and treatment agent as in Example-1 was prepared. A group of alcohol drinkers consisting of 15 adult males other than those in Example 1 was selected, and a test was conducted in the same manner as in Example 1, except that the therapeutic agent was taken while drinking alcohol. When we investigated the occurrence of hangovers after drinking alcohol, we found that there were no hangover symptoms at all. These results confirm that the drug is extremely effective in preventing hangovers even when taken while already drinking alcohol.

In addition, it can be easily taken while drinking alcohol, and the impression was received that the taste it produces has no meaning even when drinking alcohol.

Example 3 The same hangover prevention and treatment agent as in Example 1 was prepared. Select another group of 30 adult men who drink alcohol, and divide this into 15
Divide each person into two groups, and as in Example 1, after drinking enough to cause a previous hangover, one group was given the therapeutic agent 10 minutes later, and the other group The group was not given doses.

As a result, in the group that did not take the drug, four people experienced hangovers that led to vomiting, and eight people suffered from severe headaches.
All three of us had slight hangovers. However, almost no one in the group who took the drug experienced a hangover, and only three people had mild headaches. Not a single person was reluctant to take this treatment.

These results confirmed that taking the drug immediately after drinking alcohol has a hangover preventive effect.

Example 4 Twelve male adult men complaining of hangovers were given a hangover prevention and treatment agent prepared in the same manner as in Example 1, at a dose of 5 ml per Ikg of body weight.

None of the subjects experienced vomiting when taking the drug (all subjects took the drug easily, and reported that the discomfort characteristic of a hangover disappeared 1 to 3 hours later).

Patent applicant: Mitsui Toatsu Chemical Co., Ltd.

Claims (1)

[Scope of Claims] 1. A hangover prevention and treatment agent containing L-alanine and an artificial sweetener as main ingredients. 2. A hangover prevention and treatment agent containing L-alanine and α-L-aspartyl-L-phenylalanine as main ingredients.