JPH0149499B2 - - Google Patents

Info

Publication number: JPH0149499B2
Authority: JP; Japan
Prior art keywords: iodine; solution; adhesive; antimicrobial; activity
Prior art date: 1979-07-31
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired

Application number

JP55104947A

Other languages

English (en)

Other versions

JPS5622727A (en

Inventor

Debitsudo Rotsuso Hooru

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

3M Co

Original Assignee

Minnesota Mining and Manufacturing Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1979-07-31

Filing date

1980-07-30

Publication date

1989-10-25

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22041975&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=JPH0149499(B2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1980-07-30 Application filed by Minnesota Mining and Manufacturing Co filed Critical Minnesota Mining and Manufacturing Co

1981-03-03 Publication of JPS5622727A publication Critical patent/JPS5622727A/ja

1989-10-25 Publication of JPH0149499B2 publication Critical patent/JPH0149499B2/ja

Status Granted legal-status Critical Current

Links

ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 description 29
239000011630 iodine Substances 0.000 description 29
229910052740 iodine Inorganic materials 0.000 description 29
239000000243 solution Substances 0.000 description 18
239000000203 mixture Substances 0.000 description 16
FVAUCKIRQBBSSJ-UHFFFAOYSA-M sodium iodide Chemical compound [Na+].[I-] FVAUCKIRQBBSSJ-UHFFFAOYSA-M 0.000 description 15
239000000853 adhesive Substances 0.000 description 14
230000001070 adhesive effect Effects 0.000 description 14
239000004599 antimicrobial Substances 0.000 description 13
238000000034 method Methods 0.000 description 13
239000004820 Pressure-sensitive adhesive Substances 0.000 description 11
WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 description 10
230000000845 anti-microbial effect Effects 0.000 description 9
239000000126 substance Substances 0.000 description 8
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 7
230000000694 effects Effects 0.000 description 6
PNDPGZBMCMUPRI-UHFFFAOYSA-N iodine Chemical compound II PNDPGZBMCMUPRI-UHFFFAOYSA-N 0.000 description 6
-1 polyethylene Polymers 0.000 description 6
229920001817 Agar Polymers 0.000 description 5
239000004698 Polyethylene Substances 0.000 description 5
239000008272 agar Substances 0.000 description 5
230000000844 anti-bacterial effect Effects 0.000 description 5
239000003795 chemical substances by application Substances 0.000 description 5
238000009472 formulation Methods 0.000 description 5
230000005764 inhibitory process Effects 0.000 description 5
229920000573 polyethylene Polymers 0.000 description 5
235000009518 sodium iodide Nutrition 0.000 description 5
239000002904 solvent Substances 0.000 description 5
102000008186 Collagen Human genes 0.000 description 4
108010035532 Collagen Proteins 0.000 description 4
238000003556 assay Methods 0.000 description 4
229920001436 collagen Polymers 0.000 description 4
229940075894 denatured ethanol Drugs 0.000 description 4
239000000463 material Substances 0.000 description 4
239000007787 solid Substances 0.000 description 4
DXPPIEDUBFUSEZ-UHFFFAOYSA-N 6-methylheptyl prop-2-enoate Chemical compound CC(C)CCCCCOC(=O)C=C DXPPIEDUBFUSEZ-UHFFFAOYSA-N 0.000 description 3
XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 3
229920002472 Starch Polymers 0.000 description 3
239000002253 acid Substances 0.000 description 3
239000002313 adhesive film Substances 0.000 description 3
239000012790 adhesive layer Substances 0.000 description 3
XMBWDFGMSWQBCA-UHFFFAOYSA-N hydrogen iodide Chemical compound I XMBWDFGMSWQBCA-UHFFFAOYSA-N 0.000 description 3
244000005700 microbiome Species 0.000 description 3
239000000178 monomer Substances 0.000 description 3
NLKNQRATVPKPDG-UHFFFAOYSA-M potassium iodide Chemical compound [K+].[I-] NLKNQRATVPKPDG-UHFFFAOYSA-M 0.000 description 3
239000003755 preservative agent Substances 0.000 description 3
230000002335 preservative effect Effects 0.000 description 3
239000008107 starch Substances 0.000 description 3
235000019698 starch Nutrition 0.000 description 3
238000012360 testing method Methods 0.000 description 3
230000000699 topical effect Effects 0.000 description 3
OZAIFHULBGXAKX-UHFFFAOYSA-N 2-(2-cyanopropan-2-yldiazenyl)-2-methylpropanenitrile Chemical compound N#CC(C)(C)N=NC(C)(C)C#N OZAIFHULBGXAKX-UHFFFAOYSA-N 0.000 description 2
CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 2
229920000178 Acrylic resin Polymers 0.000 description 2
239000004925 Acrylic resin Substances 0.000 description 2
IMNFDUFMRHMDMM-UHFFFAOYSA-N N-Heptane Chemical compound CCCCCCC IMNFDUFMRHMDMM-UHFFFAOYSA-N 0.000 description 2
ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 2
206010040880 Skin irritation Diseases 0.000 description 2
241000191967 Staphylococcus aureus Species 0.000 description 2
230000002378 acidificating effect Effects 0.000 description 2
SHGAZHPCJJPHSC-YCNIQYBTSA-N all-trans-retinoic acid Chemical compound OC(=O)\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C SHGAZHPCJJPHSC-YCNIQYBTSA-N 0.000 description 2
239000003242 anti bacterial agent Substances 0.000 description 2
BLFLLBZGZJTVJG-UHFFFAOYSA-N benzocaine Chemical compound CCOC(=O)C1=CC=C(N)C=C1 BLFLLBZGZJTVJG-UHFFFAOYSA-N 0.000 description 2
230000015572 biosynthetic process Effects 0.000 description 2
239000005018 casein Substances 0.000 description 2
239000011248 coating agent Substances 0.000 description 2
238000000576 coating method Methods 0.000 description 2
238000010668 complexation reaction Methods 0.000 description 2
230000021615 conjugation Effects 0.000 description 2
229920001577 copolymer Polymers 0.000 description 2
239000012153 distilled water Substances 0.000 description 2
239000000835 fiber Substances 0.000 description 2
239000003999 initiator Substances 0.000 description 2
239000011159 matrix material Substances 0.000 description 2
239000012528 membrane Substances 0.000 description 2
244000000010 microbial pathogen Species 0.000 description 2
229920000728 polyester Polymers 0.000 description 2
229920000036 polyvinylpyrrolidone Polymers 0.000 description 2
239000001267 polyvinylpyrrolidone Substances 0.000 description 2
235000013855 polyvinylpyrrolidone Nutrition 0.000 description 2
230000036556 skin irritation Effects 0.000 description 2
231100000475 skin irritation Toxicity 0.000 description 2
230000001954 sterilising effect Effects 0.000 description 2
238000004659 sterilization and disinfection Methods 0.000 description 2
239000000758 substrate Substances 0.000 description 2
MGSRCZKZVOBKFT-UHFFFAOYSA-N thymol Chemical compound CC(C)C1=CC=C(C)C=C1O MGSRCZKZVOBKFT-UHFFFAOYSA-N 0.000 description 2
238000004448 titration Methods 0.000 description 2
JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 description 2
229960001727 tretinoin Drugs 0.000 description 2
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 description 1
SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 description 1
NIXOWILDQLNWCW-UHFFFAOYSA-N 2-Propenoic acid Natural products OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 1
244000063299 Bacillus subtilis Species 0.000 description 1
241000894006 Bacteria Species 0.000 description 1
NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 description 1
206010073306 Exposure to radiation Diseases 0.000 description 1
GHASVSINZRGABV-UHFFFAOYSA-N Fluorouracil Chemical compound FC1=CNC(=O)NC1=O GHASVSINZRGABV-UHFFFAOYSA-N 0.000 description 1
241000233866 Fungi Species 0.000 description 1
108010010803 Gelatin Proteins 0.000 description 1
WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
229920000153 Povidone-iodine Polymers 0.000 description 1
241000589517 Pseudomonas aeruginosa Species 0.000 description 1
239000005844 Thymol Substances 0.000 description 1
241000700605 Viruses Species 0.000 description 1
206010052428 Wound Diseases 0.000 description 1
208000027418 Wounds and injury Diseases 0.000 description 1
239000013543 active substance Substances 0.000 description 1
229910052783 alkali metal Inorganic materials 0.000 description 1
150000008044 alkali metal hydroxides Chemical class 0.000 description 1
150000001412 amines Chemical group 0.000 description 1
230000002421 anti-septic effect Effects 0.000 description 1
239000002246 antineoplastic agent Substances 0.000 description 1
238000013096 assay test Methods 0.000 description 1
239000002585 base Substances 0.000 description 1
229960005274 benzocaine Drugs 0.000 description 1
230000004071 biological effect Effects 0.000 description 1
KGBXLFKZBHKPEV-UHFFFAOYSA-N boric acid Chemical compound OB(O)O KGBXLFKZBHKPEV-UHFFFAOYSA-N 0.000 description 1
239000004327 boric acid Substances 0.000 description 1
239000007853 buffer solution Substances 0.000 description 1
229940041514 candida albicans extract Drugs 0.000 description 1
238000012993 chemical processing Methods 0.000 description 1
238000004140 cleaning Methods 0.000 description 1
239000002131 composite material Substances 0.000 description 1
150000001875 compounds Chemical class 0.000 description 1
239000003431 cross linking reagent Substances 0.000 description 1
230000003247 decreasing effect Effects 0.000 description 1
238000000502 dialysis Methods 0.000 description 1
238000009792 diffusion process Methods 0.000 description 1
239000012895 dilution Substances 0.000 description 1
238000010790 dilution Methods 0.000 description 1
238000005553 drilling Methods 0.000 description 1
238000001704 evaporation Methods 0.000 description 1
230000008020 evaporation Effects 0.000 description 1
239000004744 fabric Substances 0.000 description 1
229960002949 fluorouracil Drugs 0.000 description 1
239000008273 gelatin Substances 0.000 description 1
229920000159 gelatin Polymers 0.000 description 1
235000019322 gelatine Nutrition 0.000 description 1
235000011852 gelatine desserts Nutrition 0.000 description 1
239000008103 glucose Substances 0.000 description 1
230000009036 growth inhibition Effects 0.000 description 1
239000001963 growth medium Substances 0.000 description 1
239000012456 homogeneous solution Substances 0.000 description 1
239000012535 impurity Substances 0.000 description 1
208000015181 infectious disease Diseases 0.000 description 1
229910001505 inorganic iodide Inorganic materials 0.000 description 1
XMBWDFGMSWQBCA-UHFFFAOYSA-M iodide Chemical compound [I-] XMBWDFGMSWQBCA-UHFFFAOYSA-M 0.000 description 1
229940006461 iodide ion Drugs 0.000 description 1
239000010410 layer Substances 0.000 description 1
239000006210 lotion Substances 0.000 description 1
238000004519 manufacturing process Methods 0.000 description 1
239000002609 medium Substances 0.000 description 1
229940041616 menthol Drugs 0.000 description 1
238000002816 microbial assay Methods 0.000 description 1
230000000813 microbial effect Effects 0.000 description 1
239000012299 nitrogen atmosphere Substances 0.000 description 1
231100000344 non-irritating Toxicity 0.000 description 1
231100000252 nontoxic Toxicity 0.000 description 1
230000003000 nontoxic effect Effects 0.000 description 1
239000002674 ointment Substances 0.000 description 1
150000007524 organic acids Chemical class 0.000 description 1
244000052769 pathogen Species 0.000 description 1
230000001717 pathogenic effect Effects 0.000 description 1
229960003742 phenol Drugs 0.000 description 1
229920000642 polymer Polymers 0.000 description 1
230000000379 polymerizing effect Effects 0.000 description 1
229920001296 polysiloxane Polymers 0.000 description 1
238000002360 preparation method Methods 0.000 description 1
230000005855 radiation Effects 0.000 description 1
229930002330 retinoic acid Natural products 0.000 description 1
150000003839 salts Chemical class 0.000 description 1
239000012047 saturated solution Substances 0.000 description 1
210000003786 sclera Anatomy 0.000 description 1
230000001235 sensitizing effect Effects 0.000 description 1
238000007493 shaping process Methods 0.000 description 1
230000006641 stabilisation Effects 0.000 description 1
238000011105 stabilization Methods 0.000 description 1
239000003381 stabilizer Substances 0.000 description 1
239000007858 starting material Substances 0.000 description 1
238000003756 stirring Methods 0.000 description 1
239000011550 stock solution Substances 0.000 description 1
238000003860 storage Methods 0.000 description 1
125000001424 substituent group Chemical group 0.000 description 1
230000002459 sustained effect Effects 0.000 description 1
238000013268 sustained release Methods 0.000 description 1
239000012730 sustained-release form Substances 0.000 description 1
238000003786 synthesis reaction Methods 0.000 description 1
229960000790 thymol Drugs 0.000 description 1
239000012137 tryptone Substances 0.000 description 1
125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 1
229920002554 vinyl polymer Polymers 0.000 description 1
230000029663 wound healing Effects 0.000 description 1
239000012138 yeast extract Substances 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N59/00—Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds
- A01N59/12—Iodine, e.g. iodophors; Compounds thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/46—Deodorants or malodour counteractants, e.g. to inhibit the formation of ammonia or bacteria
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/58—Adhesives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F2013/00361—Plasters
- A61F2013/00655—Plasters adhesive
- A61F2013/0071—Plasters adhesive containing active agent
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/10—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing inorganic materials
- A61L2300/106—Halogens or compounds thereof, e.g. iodine, chlorite
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Hematology (AREA)
Materials Engineering (AREA)
Epidemiology (AREA)
Plant Pathology (AREA)
Inorganic Chemistry (AREA)
Pest Control & Pesticides (AREA)
Agronomy & Crop Science (AREA)
Dentistry (AREA)
Wood Science & Technology (AREA)
Zoology (AREA)
Environmental Sciences (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Preparation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Materials For Medical Uses (AREA)

Description

【発明の詳細な説明】

本発明は皮膚医学的に許容しうる沃素を含む感
圧性粘着物の製造方法に関する。本発明の一面は
調整され且持続的仕方で防腐性広スペクトルの抗
菌活性を示す生成組成物の能力に関する。多くの病原微生物が人の皮膚に存在する。病院
環境では病原微生物の生育は阻止されることおよ
び好ましくはこれらの微生物は患者の感染を抑制
し傷の回復を増進するように殺滅されることが一
般に望ましい。その結果局所的殺菌活性剤の皮膚
表面への適用は病院の防腐技術の標準的要素とな
つた。しばしば使用される１抗菌剤は沃素であるが、
その固有の化学的および物理的制限のために、防
腐性広スペクトル抗菌剤としてのその使用は限定
された。沃素元素は高蒸気圧を有し、それは抗菌
剤として沃素を含む抗菌製剤から沃素含量が揮発
するので殺菌効力に大きなロスを生じる。更に沃
素は皮膚の腐食破壊性の可能性であるために一般
に包帯に含ませることはない。沃素の抗菌活性を保有させ、同時に腐食性およ
び蒸気圧を減少させるためにポリビニルピロリド
ンと沃素の複合物が形成された。このようなポリ
ビニルピロリドン−沃素複合物（PVP−）の
１つの合成例が米国特許第4128633号明細書に開
示される。広スペクトル抗菌剤の局所適用は手術前皮膚適
用物、外科用清浄テイツシユペーパー例えば米国
特許第4054364号明細書、洗滌剤、傷清浄剤、ロ
ーシヨンおよび軟膏の形であつた。ある場合には
このような受渡しは制限時間の特別目的に対し有
効である。抗菌剤の初めの適用で生き残ることが
できる微生物は種として作用してある場合には病
原菌数を初めのレベルまで上昇させる。局所への
抗菌剤の連続的適用は個体群の増加を阻止する方
法である。多数の他の生物学的活性剤は基質上の粘着層に
添加され、その剤を身体に連続的に適用された
が、広スペクトル抗菌剤の安定性および不変の活
性を特徴とした広スペクトル抗菌剤の粘着層への
添加は全く成功しなかつた。粘着物に添加した各
種の他の剤の例はフエノール、チモール、メント
ールなどを澱粉粘着物に添加する米国特許第
2137169号明細書、ベンゾカインを粘着性ゼラチ
ンに添加する米国特許第3249109号明細書、カル
チコステロイドを粘着物に添加する米国特許第
3632740号明細書、マイクロカプセル化抗腫瘍剤
を粘着物に添加する米国特許第3734097号明細書、
トレチノイン（Tretinoin）を粘着物に添加する
米国特許第4073291号明細書、５−フルオロウラ
シルを粘着物に添加する米国特許第3769071号明
細書、レチノン酸を感圧性テープに添加する米国
特許第3896789号明細書である。粘着物に広スペ
クトル抗菌剤を添加することの従来の試みは生物
学的活性の減少およびある患者の場合皮膚刺激を
生ずる制御できない遊離により挫折した。広スペクトルなる用語は抗菌剤が１タイプ以上
の微生物、すなわちグラム陽性菌およびグラム陰
性菌の両者に対し活性を示し、かびおよびウイル
スに対しても活性を恐らく有するであろうことを
意味するために本明細書で使用される（参照：
Tederal Register、39巻、179号）。本発明は皮膚と接触させておく時に、均一に且
制御できるように広スペクトル抗菌剤沃素を遊離
する化学的且貯蔵安定性組成物の形成方法として
一般に記載することができる。この遊離は照射殺
菌にかけた後でさえ実質的に不変の広スペクトル
抗菌活性を有したまま起こる。この防腐抗菌活性
は実質的に皮膚刺激なしに本発明により達成され
る。本発明方法の生成組成物は沃素、沃化物イオン
および皮膚医学的に許容しうる通常室温で粘着性
感圧性粘着物（PSA）の安定な化学複合物であ
る。「安定」とはポリエチレンシートに付着する
24平方インチにつき11グレンの組成物被覆は、
120〓の温度および９％の相対湿度に２週間もし
くは澱粉テストで試験する時に物理的外観もしく
は化学的活性の実質的変化なしにおよびゾーンイ
ンヒビシヨンアセイ（Zone Inhibition
Assay）で試験する時に微生物活性の実質的変化
なしに2.5メガラドのガンマー照射の照射量を曝
露することができることを意味する。ゾーンインヒビシヨンアセイテストは次
のように行なわれる：アセイ細菌バチルスサブ
チリス（Bacillus subtilis）は約６時間37℃で回
転振盪培地（200rpm）で生育させる。生育培地
Ｌ−ブロスは１の蒸溜水に溶解し、PH7.0に調
整した次の成分より成る：トリプトン10g、酵母
エキス5g、食塩10g、グルコース1g。このカルチ
ヤーは滅菌Ｌ−ブロスに660muで50％Ｔまで稀釈
され、更に１：10に稀釈され、45〜50℃に維持さ
れた融解大豆−カゼイン消化寒天培地（Inolex）
に１：100の割合で接種される。アセイプレート
は大豆−カゼイン消化寒天培地（TSA）の５ml
基底層を最初にピペツトでとり、これを室温で任
意に使用できるペトリ皿中で硬化させ、次に５ml
の接種TSAで覆うことにより製造される。これ
らの調製物はその日に使用される。被覆ポリエチレンフイルム（以下の例で教示す
る方法で製造）は粘着層に添加する抗菌剤と無関
係に同じ方法で試験される。10個の６mmデイスク
は丈夫な紙穴あけ器（Master Products、
Series25）により均一被覆された区域（すなわち
目に見える傷の全くない）から切り取られる。紙
支持体は鉗子および小へらにより被覆デイスクか
ら除去される。次に被覆デイスクは１プレートに
つき４個が接種寒天表面に粘着物側面を下にして
入れる。次に沃素参考デイスクが製造される。10％沃素
を含む溶液は1gの沃素および1gの沃化ソーダを
10ml容量フラスコを使用し10％水性アセトンに溶
解して製造される。新しく製造され且同じ溶媒の
この貯蔵溶液は0.25、0.5、0.75および1.0％沃素
溶液を製造するために使用される。これらの稀釈
液から、10μ試料は接種寒天表面上においた６
mmポリエステル地デイスクに適用され、25、50、
75および100μg沃素をそれぞれ含むデイスクが供
される。（ポリエステル地は一夜溶媒中にさらし、
穴あけ前に固有の抗菌活性を除去すべきである。）
各参考デイスクは２mlポリエチレンの１インチ平
方により被覆し、下層寒天中に拡散する前の蒸散
を阻止する。被覆デイスクおよび参考デイスクアセイプ
レートは一夜室温でインキユベートされる。デイ
スクの回りの阻止ゾーンは双眼実体顕微鏡により
もつとも近い0.5mmまで測定された。沃素抗菌剤
の場合には、被覆デイスクも除去されデイスク下
の生育阻止面積に対しプレートが調査される。上記方法を使用する参考抗菌剤に対するアセイ
結果は、mmで測定した阻止ゾーンの直径は試験範
囲では各剤に対しLog₁₀濃度に直線的に比例する
ことを証明する。本発明の粘着物から抗菌剤の遊
離は阻止値の図式内挿法により評価することがで
きる。でん粉テストは次のように行なわれる：指示薬
溶液はパラゴンアイオデインタイトレーシヨ
ンインデイケーター（paragon Indine
Titration Indicator）（Eastern Chemical、
Division of Guardian Chemical Corp.、
Hanppauge、NY）62.5gを250mlの蒸溜水に撹拌
しながら溶解して製造する。それからのパラゴン
インデイケーター溶液の１滴は粘着物表面にお
かれる。その小滴中の青色形成は沃素の有効性を
示す。本発明組成物の形成方法は感圧性粘着物を形成
し、それに沃素、沃化物および溶媒より成る抗菌
剤処理溶液を混合することを含む。生成組成物は
好ましくは感圧性粘着物の本体に沃素の複合化に
供するＮ−ビニルピロリドン（NVP）を含む。
複合化は安定化を供し、一方適当な平衡を維持し
て沃素の持続性遊離を供すると信じられる。上記方法の生成化学複合物である組成物は安定
で、刺激性がなく、感作性がなく、無毒で且皮膚
もしくは他の組織に対し全く損傷性がない。酸性
媒体は多くの広−スペクトル抗菌剤、すなわち
PVP−を一層安定化することが一般に認めら
れるが、かなりの酸含量を有する感圧性粘着物は
本システムでは沃素の安定性に負の変化を生ず
る。従つて本組成物のベースとして作用する通常
室温で粘着性感圧性粘着物モノマーは実質的に酸
成分を含まないことが望ましい。「実質的に酸成
分を含まない」とは感圧性粘着物モノマーは機能
的に酸性を示す例えばアクリル酸などの置換基を
実質的に含まないことを意味する。抗菌組成物
PSAを含む調製物に使用することができる粘着
物モノマーの例はアクリル樹脂およびビニル／ア
クリル樹脂を含む。これら粘着物の処方は当業者
には周知で例えば米国特許RE24906、米国特許第
2973286号、同第3307544号、同第3728148号各号
明細書などである。上記粘着物タイプは状況によ
り指令された効用を有することができるように各
種の化学加工剤例えば粘着剤、架橋剤、安定剤、
開始剤などを含むことができることは当業者には
認められるであろう。本発明に使用する好ましい
感圧性粘着物はＮ−ビニルピロリドン（NVP）
およびイソオクチルアクリレート（IOA）より成
るコポリマーである。沃素の遊離は粘着物本体に低レベルのNVPを
コポリマー化することにより制御されることが信
じられる。粘着物マトリツクスから沃素の遊離は
粘着物本体はコポリマー化されたNVPレベルの
函数である。一定沃素含量に対してはNVPレベ
ルの高い程抗菌活性は低下する。本発明に対し有
用なNVPコモノマーレベルは全粘着物固形の30
％（選択的には５〜10％）より少ない。より高い
NVPレベルでは皮膚粘着および抗菌活性が減少
する。抗菌剤溶液は感圧性粘着物に沃素を添加するた
めに使用される。この溶液は沃素、無機沃化物
（例えば沃化カリ）および粘着物と相溶性の適当
な溶媒を含む。上記５〜10％NVPコポリマー粘
着物と共に使用する推奨溶液は変性エタノールに
溶解した0.5：１〜４：１モル比の沃化物：沃素
（好ましい溶液は２：１モル比の沃化物：沃素）
を有するであろう。たとえば、沃化ソーダを使用
する溶液は１〜20重量％沃素、1.2〜24重量％沃
化ソーダおよび97.8〜56重量％エタノールを有す
るであろう。本発明の粘着物マトリツクスへの沃素の複合化
機作は完全に理解されないが、沃素とポリビニル
ピロリドンの複合化にはいくつかの相似性を有す
ることが信じられる。次は本発明の複合物の１つ
の可能な表現である：式中ｍ、ｎ、ｏおよびｐは整数である。本発明方法の組成物は屈撓性支持体基質上に直
接付着するか、もしくは後の使用のために遊離ラ
イナー上に形成させることができる。支持体は医
療用に使用する既知の任意の材料を使用すること
ができるが、好ましい材料はポリエチレンフイル
ムである。次に溶媒は当業者に既知の方法により
蒸発させ、それによつてテープ、滅菌布
（drape）および他の医療用装置に使用すること
ができる粘着フイルムが形成される。本発明は更に次の非限定例により例示される。イソオクチルアクリレート／Ｎ−ビニルピロリ
ドン／−メタクリルオキシプロピルトリメトキシ
シラン（94.95／５／0.05）組成の溶液ポリマー
粘着物をエチルアセテート／ヘプタン／エタノー
ル（48／47／５）中で重合させて製造する（条
件：窒素雰囲気、アゾビスイソブチロニトリル開
始剤、53℃６時間；性質：全固形45％、固有粘度
0.8）。次の処方物を製造する：上記粘着物 500g 20重量％沃素を含む溶液／変性エタノール中の24
重量％の沃化ソーダ 11g 付加変性エタノール 78g 10重量％ｐ−トルエンスルホン酸（ｐ−TSA）
変性エタノール溶液（粘着物固形について0.1重
量％ｐ−TSA） 2.3％処方物は室温でへらにより撹拌し、粘着物固形
について１重量％沃素／1.2重量％沃化ソーダの
均一溶液を得る。この溶液はシリコン遊離ライナ
ー上に被覆し、乾燥（10分、175〓）して、11グ
レン／24平方インチに等しい被覆重量の均質沃度
色粘着物フイルムを形成させる。粘着物フイルム
はコロナ（corona）および４級アミン帯電防止
剤処理ポリエチレンの支持体にラミネートし、抗
菌剤沃素を含む構造物を形成させる。この構造物
は接種した人の皮膚で生体に適用した時に、１時
間後にスタフイロコツカスアウレウス
（Staphylococcus aureus）およびシユードモナ
スエアルギノサ（Pseudomonas aeruginosa）
を4log減少させる活性を示した。構造物は照射滅
菌後満足すべき粘着および安定性を示した。

【特許請求の範囲】

１眼科用コラーゲンカバーを製造するに当た
り、アルカリ金属塩の飽和溶液中で動物の眼球繊
維膜を水酸化アルカリ金属により処理し、次いで
得られた組織を6.0〜7.0のPHに中和し、有機酸の
水溶液に溶解し、得られたコラーゲンの溶液をコ
ラーゲンの溶液のPHを4.5〜7.5にしながら緩衝溶
液に対して透析することにより、低分子量不純物
から精製し、得られたコラーゲンの溶液を乾燥す
ると同時に目の前部の曲面に合わせて球面のカバ
ーを成形することを含む方法。２出発材料の動物の眼球繊維膜として、強膜が
用いられる、特許請求の範囲第１項記載の方法。３組織の中和がホウ酸の２％溶液により行われ
る、特許請求の範囲第１項または第２項記載の方

JP10494780A 1979-07-31 1980-07-30 Pressure sensitive adhesive containing iodine Granted JPS5622727A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US06/062,362 US4323557A (en)	1979-07-31	1979-07-31	Pressure-sensitive adhesive containing iodine

Related Child Applications (1)

Application Number	Title	Priority Date	Filing Date
JP1114896A Division JPH0643298B2 (ja)	1979-07-31	1989-05-08	医療用材料

Publications (2)

Publication Number	Publication Date
JPS5622727A JPS5622727A (en)	1981-03-03
JPH0149499B2 true JPH0149499B2 (ja)	1989-10-25

Family

ID=22041975

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
JP10494780A Granted JPS5622727A (en)	1979-07-31	1980-07-30	Pressure sensitive adhesive containing iodine
JP1114896A Expired - Lifetime JPH0643298B2 (ja)	1979-07-31	1989-05-08	医療用材料

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
JP1114896A Expired - Lifetime JPH0643298B2 (ja)	1979-07-31	1989-05-08	医療用材料

Country Status (8)

Country	Link
US (1)	US4323557A (ja)
EP (1)	EP0024107B2 (ja)
JP (2)	JPS5622727A (ja)
AU (1)	AU537351B2 (ja)
CA (1)	CA1151548A (ja)
DE (1)	DE3065603D1 (ja)
ES (1)	ES493775A0 (ja)
ZA (1)	ZA804631B (ja)

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1980
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- 1980-07-30 JP JP10494780A patent/JPS5622727A/ja active Granted
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1989
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Also Published As

Publication number	Publication date
JPH0643298B2 (ja)	1994-06-08
AU537351B2 (en)	1984-06-21
JPH0257262A (ja)	1990-02-27
ES8106655A1 (es)	1981-09-01
EP0024107B2 (en)	1991-01-16
AU6087180A (en)	1981-02-05
US4323557A (en)	1982-04-06
JPS5622727A (en)	1981-03-03
ES493775A0 (es)	1981-09-01
DE3065603D1 (en)	1983-12-22
EP0024107B1 (en)	1983-11-16
CA1151548A (en)	1983-08-09
ZA804631B (en)	1981-07-29
EP0024107A1 (en)	1981-02-25

Publication	Publication Date	Title
JPH0149499B2 (ja)	1989-10-25
CA1151547A (en)	1983-08-09	Pressure-sensitive adhesive having a broad spectrum antimicrobial therein
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KR950003697B1 (ko)	1995-04-17	항미생물성 드레싱 및 그의 제조방법
US6102205A (en)	2000-08-15	Prepolymer compositions comprising an antimicrobial agent
JP2001525344A (ja)	2001-12-11	１段階の手術用調整及びドレープを提供するのに有用な組成物
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EP1689338B1 (en)	2013-01-16	Antimicrobial adhesive system
AU2012200831A1 (en)	2012-03-01	Antimicrobial adhesive system