JPH0150416B2 - - Google Patents

Info

Publication number: JPH0150416B2
Authority: JP; Japan
Prior art keywords: bioterminal; sintered; drug; terminal; skin
Prior art date: 1983-09-12
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired

Application number

JP58166502A

Other languages

English (en)

Japanese (ja)

Other versions

JPS6058154A (ja

Inventor

Hideki Aoki

Masaru Akao

Miharu Hata

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Advance KK

Original Assignee

Advance KK

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1983-09-12

Filing date

1983-09-12

Publication date

1989-10-30

1983-09-12 Application filed by Advance KK filed Critical Advance KK

1983-09-12 Priority to JP58166502A priority Critical patent/JPS6058154A/ja

1984-03-21 Priority to CA000450058A priority patent/CA1247960A/fr

1984-03-23 Priority to DE8484301977T priority patent/DE3482893D1/de

1984-03-23 Priority to EP84301977A priority patent/EP0120689B1/fr

1985-04-04 Publication of JPS6058154A publication Critical patent/JPS6058154A/ja

1989-10-30 Publication of JPH0150416B2 publication Critical patent/JPH0150416B2/ja

1990-09-05 Priority to US07/577,820 priority patent/US5035711A/en

1990-09-10 Priority to US07/581,122 priority patent/US5026397A/en

Status Granted legal-status Critical Current

Links

239000000463 material Substances 0.000 claims description 26
239000003814 drug Substances 0.000 claims description 18
229940079593 drug Drugs 0.000 claims description 18
229910052586 apatite Inorganic materials 0.000 claims description 9
VSIIXMUUUJUKCM-UHFFFAOYSA-D pentacalcium;fluoride;triphosphate Chemical compound [F-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O VSIIXMUUUJUKCM-UHFFFAOYSA-D 0.000 claims description 9
239000012530 fluid Substances 0.000 claims 1
210000003491 skin Anatomy 0.000 description 15
238000002347 injection Methods 0.000 description 12
239000007924 injection Substances 0.000 description 12
NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 description 12
229910052588 hydroxylapatite Inorganic materials 0.000 description 10
XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 description 10
210000001519 tissue Anatomy 0.000 description 10
239000011148 porous material Substances 0.000 description 8
239000010410 layer Substances 0.000 description 7
239000012528 membrane Substances 0.000 description 7
239000000243 solution Substances 0.000 description 7
102000004877 Insulin Human genes 0.000 description 6
108090001061 Insulin Proteins 0.000 description 6
230000004888 barrier function Effects 0.000 description 6
-1 fusosine Chemical class 0.000 description 6
229940125396 insulin Drugs 0.000 description 6
238000000034 method Methods 0.000 description 6
229920005989 resin Polymers 0.000 description 6
239000011347 resin Substances 0.000 description 6
239000004020 conductor Substances 0.000 description 5
238000004519 manufacturing process Methods 0.000 description 5
229910052751 metal Inorganic materials 0.000 description 5
239000002184 metal Substances 0.000 description 5
239000000203 mixture Substances 0.000 description 5
PNEYBMLMFCGWSK-UHFFFAOYSA-N aluminium oxide Inorganic materials [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 description 4
150000002500 ions Chemical class 0.000 description 4
239000000126 substance Substances 0.000 description 4
QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 4
238000005452 bending Methods 0.000 description 3
239000011575 calcium Substances 0.000 description 3
238000000502 dialysis Methods 0.000 description 3
238000001914 filtration Methods 0.000 description 3
239000007943 implant Substances 0.000 description 3
239000000843 powder Substances 0.000 description 3
238000005245 sintering Methods 0.000 description 3
210000000434 stratum corneum Anatomy 0.000 description 3
206010061218 Inflammation Diseases 0.000 description 2
229910019142 PO4 Inorganic materials 0.000 description 2
NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 2
239000004698 Polyethylene Substances 0.000 description 2
VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 2
239000004809 Teflon Substances 0.000 description 2
229920006362 Teflon® Polymers 0.000 description 2
GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 2
239000000654 additive Substances 0.000 description 2
150000001768 cations Chemical class 0.000 description 2
230000006835 compression Effects 0.000 description 2
238000007906 compression Methods 0.000 description 2
238000009792 diffusion process Methods 0.000 description 2
238000012377 drug delivery Methods 0.000 description 2
238000005370 electroosmosis Methods 0.000 description 2
230000004054 inflammatory process Effects 0.000 description 2
NUJOXMJBOLGQSY-UHFFFAOYSA-N manganese dioxide Chemical compound O=[Mn]=O NUJOXMJBOLGQSY-UHFFFAOYSA-N 0.000 description 2
210000000496 pancreas Anatomy 0.000 description 2
BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 description 2
229920003229 poly(methyl methacrylate) Polymers 0.000 description 2
229920002492 poly(sulfone) Polymers 0.000 description 2
229920000515 polycarbonate Polymers 0.000 description 2
239000004417 polycarbonate Substances 0.000 description 2
229920000573 polyethylene Polymers 0.000 description 2
239000004926 polymethyl methacrylate Substances 0.000 description 2
229920002050 silicone resin Polymers 0.000 description 2
229920002379 silicone rubber Polymers 0.000 description 2
239000004945 silicone rubber Substances 0.000 description 2
229920003002 synthetic resin Polymers 0.000 description 2
239000000057 synthetic resin Substances 0.000 description 2
238000000108 ultra-filtration Methods 0.000 description 2
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
208000035143 Bacterial infection Diseases 0.000 description 1
229910001369 Brass Inorganic materials 0.000 description 1
229910014497 Ca10(PO4)6(OH)2 Inorganic materials 0.000 description 1
BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 description 1
UNPLRYRWJLTVAE-UHFFFAOYSA-N Cloperastine hydrochloride Chemical compound Cl.C1=CC(Cl)=CC=C1C(C=1C=CC=CC=1)OCCN1CCCCC1 UNPLRYRWJLTVAE-UHFFFAOYSA-N 0.000 description 1
229920000742 Cotton Polymers 0.000 description 1
239000004641 Diallyl-phthalate Substances 0.000 description 1
WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
KKCBUQHMOMHUOY-UHFFFAOYSA-N Na2O Inorganic materials [O-2].[Na+].[Na+] KKCBUQHMOMHUOY-UHFFFAOYSA-N 0.000 description 1
239000004952 Polyamide Substances 0.000 description 1
239000004743 Polypropylene Substances 0.000 description 1
230000002159 abnormal effect Effects 0.000 description 1
239000003082 abrasive agent Substances 0.000 description 1
229920000122 acrylonitrile butadiene styrene Polymers 0.000 description 1
239000000853 adhesive Substances 0.000 description 1
230000001070 adhesive effect Effects 0.000 description 1
229910000147 aluminium phosphate Inorganic materials 0.000 description 1
208000022362 bacterial infectious disease Diseases 0.000 description 1
QUDWYFHPNIMBFC-UHFFFAOYSA-N bis(prop-2-enyl) benzene-1,2-dicarboxylate Chemical compound C=CCOC(=O)C1=CC=CC=C1C(=O)OCC=C QUDWYFHPNIMBFC-UHFFFAOYSA-N 0.000 description 1
230000000740 bleeding effect Effects 0.000 description 1
230000017531 blood circulation Effects 0.000 description 1
210000000988 bone and bone Anatomy 0.000 description 1
239000010951 brass Substances 0.000 description 1
WUKWITHWXAAZEY-UHFFFAOYSA-L calcium difluoride Chemical compound [F-].[F-].[Ca+2] WUKWITHWXAAZEY-UHFFFAOYSA-L 0.000 description 1
AXCZMVOFGPJBDE-UHFFFAOYSA-L calcium dihydroxide Chemical compound [OH-].[OH-].[Ca+2] AXCZMVOFGPJBDE-UHFFFAOYSA-L 0.000 description 1
229910001634 calcium fluoride Inorganic materials 0.000 description 1
239000000920 calcium hydroxide Substances 0.000 description 1
229910001861 calcium hydroxide Inorganic materials 0.000 description 1
ODINCKMPIJJUCX-UHFFFAOYSA-N calcium oxide Inorganic materials [Ca]=O ODINCKMPIJJUCX-UHFFFAOYSA-N 0.000 description 1
239000001506 calcium phosphate Substances 0.000 description 1
229910000389 calcium phosphate Inorganic materials 0.000 description 1
235000011010 calcium phosphates Nutrition 0.000 description 1
229920002301 cellulose acetate Polymers 0.000 description 1
239000000919 ceramic Substances 0.000 description 1
239000003795 chemical substances by application Substances 0.000 description 1
239000000460 chlorine Substances 0.000 description 1
229910052801 chlorine Inorganic materials 0.000 description 1
239000011247 coating layer Substances 0.000 description 1
229910052681 coesite Inorganic materials 0.000 description 1
239000002131 composite material Substances 0.000 description 1
238000000748 compression moulding Methods 0.000 description 1
229910052593 corundum Inorganic materials 0.000 description 1
229910052906 cristobalite Inorganic materials 0.000 description 1
239000013078 crystal Substances 0.000 description 1
210000004207 dermis Anatomy 0.000 description 1
229910003460 diamond Inorganic materials 0.000 description 1
239000010432 diamond Substances 0.000 description 1
238000001035 drying Methods 0.000 description 1
229920001971 elastomer Polymers 0.000 description 1
210000002615 epidermis Anatomy 0.000 description 1
239000003822 epoxy resin Substances 0.000 description 1
238000002474 experimental method Methods 0.000 description 1
239000007849 furan resin Substances 0.000 description 1
239000008103 glucose Substances 0.000 description 1
238000010562 histological examination Methods 0.000 description 1
210000004969 inflammatory cell Anatomy 0.000 description 1
230000002757 inflammatory effect Effects 0.000 description 1
238000001802 infusion Methods 0.000 description 1
208000014674 injury Diseases 0.000 description 1
JEIPFZHSYJVQDO-UHFFFAOYSA-N iron(III) oxide Inorganic materials O=[Fe]O[Fe]=O JEIPFZHSYJVQDO-UHFFFAOYSA-N 0.000 description 1
210000003734 kidney Anatomy 0.000 description 1
150000002605 large molecules Chemical class 0.000 description 1
231100001231 less toxic Toxicity 0.000 description 1
239000007788 liquid Substances 0.000 description 1
229920002521 macromolecule Polymers 0.000 description 1
CPLXHLVBOLITMK-UHFFFAOYSA-N magnesium oxide Inorganic materials [Mg]=O CPLXHLVBOLITMK-UHFFFAOYSA-N 0.000 description 1
VASIZKWUTCETSD-UHFFFAOYSA-N manganese(II) oxide Inorganic materials [Mn]=O VASIZKWUTCETSD-UHFFFAOYSA-N 0.000 description 1
238000001471 micro-filtration Methods 0.000 description 1
239000011812 mixed powder Substances 0.000 description 1
239000004570 mortar (masonry) Substances 0.000 description 1
230000037311 normal skin Effects 0.000 description 1
239000002504 physiological saline solution Substances 0.000 description 1
238000007750 plasma spraying Methods 0.000 description 1
229910052697 platinum Inorganic materials 0.000 description 1
229920002239 polyacrylonitrile Polymers 0.000 description 1
229920002647 polyamide Polymers 0.000 description 1
229920000647 polyepoxide Polymers 0.000 description 1
229920000728 polyester Polymers 0.000 description 1
229920000642 polymer Polymers 0.000 description 1
229920001155 polypropylene Polymers 0.000 description 1
229920002635 polyurethane Polymers 0.000 description 1
239000004814 polyurethane Substances 0.000 description 1
229910052573 porcelain Inorganic materials 0.000 description 1
239000005373 porous glass Substances 0.000 description 1
NOTVAPJNGZMVSD-UHFFFAOYSA-N potassium monoxide Inorganic materials [K]O[K] NOTVAPJNGZMVSD-UHFFFAOYSA-N 0.000 description 1
230000009257 reactivity Effects 0.000 description 1
239000004627 regenerated cellulose Substances 0.000 description 1
239000000377 silicon dioxide Substances 0.000 description 1
235000012239 silicon dioxide Nutrition 0.000 description 1
239000007858 starting material Substances 0.000 description 1
229910052682 stishovite Inorganic materials 0.000 description 1
238000001356 surgical procedure Methods 0.000 description 1
238000002560 therapeutic procedure Methods 0.000 description 1
238000002627 tracheal intubation Methods 0.000 description 1
230000008733 trauma Effects 0.000 description 1
229910052905 tridymite Inorganic materials 0.000 description 1
229910001845 yogo sapphire Inorganic materials 0.000 description 1
XLOMVQKBTHCTTD-UHFFFAOYSA-N zinc oxide Inorganic materials [Zn]=O XLOMVQKBTHCTTD-UHFFFAOYSA-N 0.000 description 1

Landscapes

Electrotherapy Devices (AREA)
External Artificial Organs (AREA)
Materials For Medical Uses (AREA)
Media Introduction/Drainage Providing Device (AREA)

JP58166502A 1983-03-24 1983-09-12 薬物治療システム用生体端子 Granted JPS6058154A (ja)

Priority Applications (6)

Application Number	Priority Date	Filing Date	Title
JP58166502A JPS6058154A (ja)	1983-09-12	1983-09-12	薬物治療システム用生体端子
CA000450058A CA1247960A (fr)	1983-03-24	1984-03-21	Implant transcutane
DE8484301977T DE3482893D1 (de)	1983-03-24	1984-03-23	Einzelteil zur transkutanen implantation.
EP84301977A EP0120689B1 (fr)	1983-03-24	1984-03-23	Elément pour implantation transcutanée
US07/577,820 US5035711A (en)	1983-03-24	1990-09-05	Transcutaneously implantable element
US07/581,122 US5026397A (en)	1983-03-24	1990-09-10	Transcutaneously implantable element

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
JP58166502A JPS6058154A (ja)	1983-09-12	1983-09-12	薬物治療システム用生体端子

Publications (2)

Publication Number	Publication Date
JPS6058154A JPS6058154A (ja)	1985-04-04
JPH0150416B2 true JPH0150416B2 (fr)	1989-10-30

Family

ID=15832544

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
JP58166502A Granted JPS6058154A (ja)	1983-03-24	1983-09-12	薬物治療システム用生体端子

Country Status (1)

Country	Link
JP (1)	JPS6058154A (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS62281954A (ja) *	1986-05-29	1987-12-07	京セラ株式会社	生体内外開通部材
JPH0677602B2 (ja) *	1988-05-20	1994-10-05	旭光学工業株式会社	経皮素子

1983
- 1983-09-12 JP JP58166502A patent/JPS6058154A/ja active Granted

Also Published As

Publication number	Publication date
JPS6058154A (ja)	1985-04-04

Publication	Publication Date	Title
US5035711A (en)	1991-07-30	Transcutaneously implantable element
US10449270B2 (en)	2019-10-22	Collagen scaffolds, medical implants with same and methods of use
US20200139099A1 (en)	2020-05-07	Apparatus and method for promoting fluid uptake into an implant
Shin et al.	1997	Tissue reactions to various percutaneous materials with different surface properties and structures
KR20200046795A (ko)	2020-05-07	생체분해성 전지, 이의 제조방법 및 이의 용도
CN220213105U (zh)	2023-12-22	一种钛材料根管塞尖及其系列
JPH0150416B2 (fr)	1989-10-30
JPH0352304B2 (fr)	1991-08-09
JPH02246986A (ja)	1990-10-02	生体内案内具
JPH0313909B2 (fr)	1991-02-25
EP0343114B1 (fr)	1993-10-06	Dispositif transdermique
JPH0611312B2 (ja)	1994-02-16	経皮インプラント体
JPH0213580B2 (fr)	1990-04-04
JPH0445190B2 (fr)	1992-07-24
JPS639435A (ja)	1988-01-16	生体用端子
JPS62298349A (ja)	1987-12-25	生体用端子
JPH06327757A (ja)	1994-11-29	生体インプラント複合材及び生体適合性複合材
JPH01164373A (ja)	1989-06-28	皮膚貫通端子
JPH0622503B2 (ja)	1994-03-30	透光性生体端子
Jeong et al.	2020	Nephrotoxicity of Chitosan-Coated Nanotube Titanium and Nanotube Titanium Eluates in Rabbits
HENCH	2012	biological acceptability and mechanical performance. Consequently, additional improvement in behavior of materials for most surgical applications is possible.
JPH01113072A (ja)	1989-05-01	経皮端子
JPS63272356A (ja)	1988-11-09	皮膚貫通端子
JPS63125265A (ja)	1988-05-28	生体用端子
JPH01256933A (ja)	1989-10-13	透光性生体端子