JPH0215092A - 求核性三級有機ホスフインによる特異的ペプチド結合切断 - Google Patents

求核性三級有機ホスフインによる特異的ペプチド結合切断

Info

Publication number: JPH0215092A
Authority: JP; Japan
Prior art keywords: cleavage; phosphine; proteins; formula; tertiary
Prior art date: 1988-04-01
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Pending

Application number

JP1083848A

Other languages

English (en)

Japanese (ja)

Inventor

Lois M Hinman

ロイス・エム・ヒンマン

Libby S Miller

リビイ・エス・ミラー

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Wyeth Holdings LLC

Original Assignee

American Cyanamid Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-04-01

Filing date

1989-04-01

Publication date

1990-01-18

1989-04-01 Application filed by American Cyanamid Co filed Critical American Cyanamid Co

1990-01-18 Publication of JPH0215092A publication Critical patent/JPH0215092A/ja

Status Pending legal-status Critical Current

Links

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- G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
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- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/572—Five-membered rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
- C07F9/6503—Five-membered rings
- C07F9/6506—Five-membered rings having the nitrogen atoms in positions 1 and 3
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/12—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by hydrolysis, i.e. solvolysis in general
- C07K1/128—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by hydrolysis, i.e. solvolysis in general sequencing

Landscapes

Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Medicinal Chemistry (AREA)
Hematology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Urology & Nephrology (AREA)
Physics & Mathematics (AREA)
Biophysics (AREA)
Analytical Chemistry (AREA)
Immunology (AREA)
Biomedical Technology (AREA)
Bioinformatics & Cheminformatics (AREA)
Cell Biology (AREA)
Biotechnology (AREA)
Bioinformatics & Computational Biology (AREA)
Microbiology (AREA)
Genetics & Genomics (AREA)
Food Science & Technology (AREA)
General Physics & Mathematics (AREA)
Pathology (AREA)
Peptides Or Proteins (AREA)
Investigating Or Analysing Biological Materials (AREA)

JP1083848A 1988-04-01 1989-04-01 求核性三級有機ホスフインによる特異的ペプチド結合切断 Pending JPH0215092A (ja)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date
US17657188A	1988-04-01	1988-04-01
US17657388A	1988-04-01	1988-04-01
US176571		1988-04-01
US176573		1988-04-01

Publications (1)

Publication Number	Publication Date
JPH0215092A true JPH0215092A (ja)	1990-01-18

Family

ID=26872381

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
JP1083848A Pending JPH0215092A (ja)	1988-04-01	1989-04-01	求核性三級有機ホスフインによる特異的ペプチド結合切断

Country Status (6)

Country	Link
EP (1)	EP0339217B1 (fr)
JP (1)	JPH0215092A (fr)
AT (1)	ATE111918T1 (fr)
CA (1)	CA1330800C (fr)
DE (1)	DE68918323T2 (fr)
ES (1)	ES2064374T3 (fr)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
PL213309B1 (pl)	2006-02-09	2013-02-28	Polska Akademia Nauk Inst Biochemii I Biofizyki	Sposób hydrolizy wiazania peptydowego
CA2756244A1 (fr)	2009-04-02	2010-10-07	Roche Glycart Ag	Anticorps multispecifiques renfermant des anticorps de longueur entiere et des fragments fab a chaine unique
EP2478013B1 (fr)	2009-09-16	2018-10-24	F.Hoffmann-La Roche Ag	Complexes protéiques contenant une super-hélice et/ou une attache et leurs utilisations
TW201138821A (en)	2010-03-26	2011-11-16	Roche Glycart Ag	Bispecific antibodies
CN103068846B9 (zh)	2010-08-24	2016-09-28	弗·哈夫曼-拉罗切有限公司	包含二硫键稳定性Fv片段的双特异性抗体
SG191153A1 (en)	2010-12-23	2013-07-31	Hoffmann La Roche	Polypeptide-polynucleotide-complex and its use in targeted effector moiety delivery
CA2861124A1 (fr)	2012-02-10	2013-08-15	Genentech, Inc.	Anticorps et autres heteromultimeres monocatenaires
KR20150030744A (ko)	2012-06-27	2015-03-20	에프. 호프만-라 로슈 아게	표적에 특이적으로 결합하는 하나 이상의 결합 단위를 포함하는 항체 Ｆｃ－영역 접합체의 제조 방법 및 그의 용도
RU2639287C2 (ru)	2012-06-27	2017-12-20	Ф. Хоффманн-Ля Рош Аг	Способ отбора и получения высокоселективных и мультиспецифичных нацеливающих групп с заданными свойствами, включающих по меньшей мере две различные связывающие группировки, и их применения
EP3227332B1 (fr)	2014-12-03	2019-11-06	F.Hoffmann-La Roche Ag	Anticorps multi-spécifiques

Citations (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR1522660A (fr) *	1966-05-02	1968-04-26	American Cyanamid Co	Nouvelles compositions permettant de déformer les fibres kératiniques
FR1574239A (fr) *	1967-07-12	1969-07-11
US3754035A (en) *	1970-01-29	1973-08-21	American Cyanamid Co	Tertiary organophosphines
DE2601520A1 (de) *	1975-01-16	1976-07-22	Borg Warner	Verfahren zur herstellung von 2-hydroxyalkylphosphinen

1989
- 1989-03-06 EP EP89103906A patent/EP0339217B1/fr not_active Expired - Lifetime
- 1989-03-06 AT AT89103906T patent/ATE111918T1/de not_active IP Right Cessation
- 1989-03-06 ES ES89103906T patent/ES2064374T3/es not_active Expired - Lifetime
- 1989-03-06 DE DE68918323T patent/DE68918323T2/de not_active Expired - Fee Related
- 1989-03-30 CA CA000595161A patent/CA1330800C/fr not_active Expired - Fee Related
- 1989-04-01 JP JP1083848A patent/JPH0215092A/ja active Pending

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR1522660A (fr) *	1966-05-02	1968-04-26	American Cyanamid Co	Nouvelles compositions permettant de déformer les fibres kératiniques
FR1574239A (fr) *	1967-07-12	1969-07-11
US3754035A (en) *	1970-01-29	1973-08-21	American Cyanamid Co	Tertiary organophosphines
DE2601520A1 (de) *	1975-01-16	1976-07-22	Borg Warner	Verfahren zur herstellung von 2-hydroxyalkylphosphinen

Also Published As

Publication number	Publication date
ATE111918T1 (de)	1994-10-15
DE68918323T2 (de)	1995-05-18
EP0339217B1 (fr)	1994-09-21
CA1330800C (fr)	1994-07-19
DE68918323D1 (de)	1994-10-27
ES2064374T3 (es)	1995-02-01
EP0339217A3 (en)	1990-01-03
EP0339217A2 (fr)	1989-11-02

Publication	Publication Date	Title
KR950000300B1 (ko)	1995-01-13	융합 단백질의 제조방법
Tam et al.	1998	Methionine ligation strategy in the biomimetic synthesis of parathyroid hormones
MX2014010348A (es)	2015-08-20	Composiciones de conjugados de xten y métodos para realizarlas.
Schofield et al.	1973	Procollagen-a precursor form of collagen
JPH0215092A (ja)	1990-01-18	求核性三級有機ホスフインによる特異的ペプチド結合切断
CN1149876A (zh)	1997-05-14	弹性蛋白酶的全氟烷基酮抑制剂及其制备方法
KR20160048122A (ko)	2016-05-03	아미노 2산을 함유한 펩타이드 변형제
Hörlein et al.	1979	Amino Acid Sequence of the Aminoterminal Segment of Dermatosparactic Calf‐Skin Procollagen Type I
JPH07507051A (ja)	1995-08-03	新規なパラトルモンフラグメント，その調製およびそれを含む医薬
CN1484651A (zh)	2004-03-24	重组体bmp-2的生产
EA009771B1 (ru)	2008-04-28	Полипептид нейбластина, способы его получения и применения
Wallner et al.	2004	Lab scale and medium scale production of recombinant allergens in Escherichia coli
JP3011274B2 (ja)	2000-02-21	組み換え技術により産生した、３−デス−ヒドロキシ−シスタチンｃポリペプチドまたはその修飾物
Pesciotta et al.	1980	Purification and characterization of the amino-terminal propeptide of pro. alpha. 1 (I) chains from embryonic chick tendon procollagen
Bassuk et al.	1996	Expression of biologically active human SPARC inEscherichia coli
US4956467A (en)	1990-09-11	Nucleophilic tertiary organophosphines
Ahmed et al.	1986	Identification of three sites of proteolytic cleavage in the hinge region between the two domains of the. beta. 2 subunit of tryptophan synthase of Escherichia coli or Salmonella typhimurium
DK149457B (da)	1986-06-16	Fremgangsmaade til fremstilling af humant insulin eller b30-estere deraf
WO1993019084A1 (fr)	1993-09-30	Repliement et purification de facteurs de croissance i ressemblant a l'insuline
JPS6041697A (ja)	1985-03-05	活性蛋白質誘導体の新規合成法
JP2008531482A (ja)	2008-08-14	Ｃ末端がｐｅｇ化された成長ホルモン
Tou et al.	1990	Chemical synthesis of bovine transforming growth factor-α: synthesis, characterization and biological activity
JPS61112099A (ja)	1986-05-30	新規ポリペプチド及びその製造法
JPH0780906B2 (ja)	1995-08-30	Ｇｍ―ｃｓｆの酸化型変異体
Curran et al.	1984	Isolation and partial characterization of the carboxy-terminal propeptide of type II procollagen from chick embryos