JPH02204307A - Method for generating oxygen and oxygen generating agent - Google Patents

Abstract

PURPOSE:To simplify handling and to make it possible to regulate the rate of generation of oxygen and the duration time by disintegrating tablets contg. a peroxide and a disintegrating agent and tablets contg. a catalyst and a disintegrating agent in water to generate oxygen. CONSTITUTION:Tablets A contg. a peroxide such as calcium peroxide, barium peroxide or sodium peroxide and a disintegrating agent such as starch or talc are produced. Tablets B contg. a metallic salt catalyst such as manganese dioxide or manganese sulfate and a disintegrating agent are produced. The tablets A, B are disintigrated in water to bring the peroxide and the catalyst into a catalytic reaction. The rate of generation of oxygen and the duration time are regulated by changing the amt. of the disintegrating agent, tabletting pressure and additives when the tablets are produced.

Description

DETAILED DESCRIPTION OF THE INVENTION Field of the Invention The present invention relates to an oxygen generating method for adjusting the rate and duration of oxygen generation, and an oxygen generating agent used in the method.

Prior art and its problems When there is an urgent need for oxygen supplementation, such as alleviating breathing problems caused by toxic gas in the event of a fire, a method of inhaling oxygen gas pressurized into a cylinder is exclusively used. There is. However, inhaling oxygen using a gas cylinder may have an adverse effect on the human body due to the sudden release of oxygen. Furthermore, the cylinder itself is heavy, making it inconvenient to carry.

Therefore, instead of this method, a method using an oxygen generator that uses a simpler oxygen generating agent is currently attracting attention.

The oxygen generating agent utilizes, for example, the generation of oxygen through the decomposition reaction of peroxide shown below under the catalyst of a metal salt such as manganese dioxide in water.

2Na2 CO3φ311202 2(Na2 COa Ih O) + 1120 +
1.502 Since the above reaction occurs extremely rapidly and is an exothermic reaction, the water temperature rises rapidly, and along with this, a bumping phenomenon occurs due to the generation of oxygen and water vapor. Moreover, the reaction ends in a short time and the generation of oxygen ends.

For example, with the powdered or granular oxygen generating agents currently on the market, the reaction completes in about 30 to 180 seconds;
Furthermore, due to the nature of the dosage form, the composition tends to deteriorate and there are problems in handling, such as generation of dust during use.

In order to solve these problems, research has been carried out on oxygen generating agents that can suppress rapid oxygen generation and easily control the rate and duration of oxygen generation.

For example, Japanese Patent Publication No. 60-44242 proposed an oxygen generating agent consisting of a crystalline powder of an addition compound of sodium carbonate and hydrogen peroxide and a spherical solid of a metal salt solidified with Arabic glue of different concentrations. There is. However, this oxygen generating agent is simply a mixture of a catalyst solidified with a water-soluble glue and peroxide powder, so it has poor storage stability and is difficult to handle. It has drawbacks such as the fact that it cannot be said that it can be controlled sufficiently.

Means for Solving the Problems The present inventor conducted extensive research to improve the drawbacks of conventional oxygen generating agents as described above, and as a result, the inventor developed a method to separate peroxides and catalysts using disintegrants. To control the rate and duration of oxygen generation by changing the hardness of the tablet when tabletting and manufacturing tablets containing peroxide and a disintegrant, and tablets containing a catalyst and a disintegrant. We have discovered that this is possible.

That is, the present invention provides a) a method for generating oxygen by reacting a peroxide and a metal salt, which comprises disintegrating a tablet containing a peroxide and a disintegrant and a tablet containing a catalyst and a disintegrant in water. , a method characterized by adjusting the oxygen generation rate and generation time by reacting the contents of the tablet, and b) a tablet A containing a peroxide and a disintegrant, and a metal salt and a disintegrant. Provided is an oxygen generating agent comprising a tablet B.

The present invention requires that the peroxide and catalyst be each in separate tablets. Tablets containing both peroxide and metal salt have disadvantages such as decreased storage stability and, in some cases, a risk of explosion, as both components react in the tablet. Favorable results are not obtained.

As the peroxide used in the present invention, those that are solid at room temperature and are used in known oxygen generating agents can be used. For example, hydrogen peroxide adducts such as adducts of sodium carbonate and hydrogen peroxide, adducts of potassium carbonate and hydrogen peroxide, adducts of calcium oxide and hydrogen peroxide, calcium peroxide, calcium peroxide, Examples include metal peroxides such as barium peroxide, zinc peroxide, sodium peroxide, and potassium peroxide, potassium permanganate, sodium dichromate, and sodium perborate.

As the metal salt used as a catalyst, manganese dioxide, manganese sulfate, iron oxide, iron sulfate, lead oxide, copper oxide, etc. can be used.

In the oxygen generating agent of the present invention, a disintegrant is used in order to suppress the rapid reaction between peroxide and metal salt in water and control the generation of oxygen.

Disintegrants are moisture-resistant but can be dispersed in water when in contact with a large amount of water, in order to prevent stability deterioration due to moisture absorption during storage and to disintegrate tablets in water at a predetermined rate. It needs to be something. Examples include starch, agar bundles, methyl cellulose, hydroxypropyl cellulose, calcium cellulose glycolate, sodium cellulose glycolate, and crystalline cellulose. Among these, preferred are crystalline cellulose, sodium cellulose glycolate, and calcium cellulose glycolate, and particularly preferred is calcium cellulose glycolate.

In the present invention, the oxygen generating agent may contain additives other than the disintegrant as long as they do not affect the effects of the present invention. For example, a lubricant that helps tablets separate from the die or punch of a tablet machine and increases the gloss of the tablet, and a binder that provides binding strength to tablet components to more precisely adjust disintegration properties. etc. can be contained. In particular, when oxygen generation is performed for a long period of time, it is preferable to add a binder to the preparation. Although not particularly limited, examples of lubricants include talc and adipic acid, and examples of binders include polyethylene glycol,
In the oxygen generating agent of the present invention, which includes methylcellulose, a tablet containing a peroxide and a disintegrant is referred to as a tablet A,
The tablet containing the catalyst and disintegrant is referred to as Tablet B.

In tablet A, the amount of disintegrant used is about 0.1 to 6 parts by weight, preferably 3 parts by weight, per 100 parts by weight of peroxide.
~5 parts by weight. If it is less than 0.1 part by weight, disintegration is poor and the desired amount of oxygen generated cannot be obtained, and if it exceeds 6 parts by weight, the tablet disintegrates quickly in water, resulting in rapid oxygen generation.

In tablet B, the amount of disintegrant used is about 0.1 to 6 parts by weight, preferably 1 part by weight, per 100 parts by weight of peroxide.
~3 parts by weight. If it is less than 0.1 parts by weight, the disintegration is poor, making it difficult to control the amount and time of oxygen generation. If it exceeds 6 parts by weight, the catalyst will be released quickly, resulting in bumping phenomenon due to the generation of oxygen and water vapor. occurs.

The usage ratio of tablet B to tablet A is calculated based on the amount of catalyst relative to the amount of peroxide. Generally, about 1 to 10 parts by weight of catalyst, preferably 4 parts by weight, per 100 parts by weight of peroxide.
~6 parts by weight is used. If it is less than 1 part by weight, no catalytic effect can be obtained, and therefore the desired amount of oxygen generated cannot be obtained. 1
If it exceeds 0 parts by weight, the reaction rate becomes faster and the effect of sustaining oxygen generation decreases.

Tablets A and B are manufactured by compressing powdered tablet components using a conventional compression tableting method.

Tablet A has a diameter of about 20 to 50 mm and a thickness of about 10 to 20 mm, and tablet B has a diameter of 5 to 20 mm.
The thickness should be approximately 1 to 5 mm.

The hardness of the tablets is 5kg to 30k for both tablets A and B.
g (when using a needle with a diameter of 5+m).

When the weight is less than 5 kg, the disintegration of the tablet becomes high, and oxygen is rapidly generated. When the weight exceeds 30 kg, the desired disintegration property decreases, making it impossible to obtain the desired amount of oxygen generated. The hardness of both tablets should be selected as appropriate within the above range depending on whether the purpose is to generate a relatively large amount of oxygen in a short period of time, or if the purpose is to generate a relatively small amount of oxygen continuously. Good.

The tableting pressure to obtain the above hardness varies depending on the size of the tablet. For example, the tablet has a diameter of 45 mm and a thickness of about 1 mm.
If the size is 9mm, 100-500 kg/
It is about cm2.

In addition to being applied to the human body in emergencies and pulmonary diseases, the oxygen generating agent of the present invention is also useful for seed germination, fish farming, maintaining the freshness of live fish, fruits and vegetables, plants, etc., and soil improvement, which require oxygen supplementation. It can be widely used for various purposes.

Effect of the invention According to the present invention, the following effects can be obtained.

(1) Compared to conventional oxygen generating agents, it is possible to obtain an oxygen generating agent that is easier to handle and has no scattering properties like powder or granules.

(2) During the production of the oxygen generating agent, by changing the amount of disintegrant, tableting pressure, and additives, the oxygen generation rate, oxygen generation duration, etc. can be easily controlled according to the purpose.

(3) The manufacturing method is simple, and multi-portion commercialization is easy.

(4) It is possible to obtain a formulation that does not easily deteriorate during long-term storage.

EXAMPLES The present invention will be explained in more detail with reference to Examples and Comparative Examples below.

Example 1 (1) 94 parts by weight of an adduct of sodium carbonate and hydrogen peroxide, 1 part by weight of talc, and 5 parts by weight of cellulose calcium glycolate were mixed. 40 g of the mixture was molded into a base stone-shaped circular tablet with a diameter of 45 mm at a tableting pressure of 100 or 500 kg/cd (using a 7A-8M, 5 tablet press (manufactured by Kikusui Seisakusho)). The two types of tablets obtained (each “Tablet A1”)
and "Tablet A2") were measured for thickness and hardness.

Thickness Hardness Key pressure (++im) (kg) (kg/cm2)
Tablet Al 20 9 100 Tablet A2
18 28 500 * The hardness was measured using a hardness meter (manufactured by Honya Seisakusho), and the diameter of the pressure needle was 5 mm.

(2) 94 parts by weight of manganese dioxide, 3 parts by weight of cellulose calcium glycolate, 2 parts by weight of polyethylene glycol, and 1 part by weight of adipic acid were mixed.

1 g of the mixture was compressed into stone-shaped circular tablets with a diameter of 111 m and a thickness of 3 m (Tablet B1). The tableting pressure at that time was 20
00 kg/cra2, and the obtained tablet hardness was 8
It was kg.

1 tablet of A1 or A2 obtained in (1) above, (2)
Take 3 tablets of B1 obtained in step 1 and add them to water 8001+
112 (water temperature 25℃) and the amount of oxygen generated (1/
minutes) was measured.

The results are shown in Table 1 and Figure 1.

Table 1

[Brief explanation of the drawing]

FIG. 1 shows the amount of oxygen generated versus time (minutes) when the tablet of the present invention was reacted in water. (Above) From the results shown in Table 1, it is clear that according to the present invention, the oxygen generation state can be adjusted by changing the hardness of the tablet. February 17, 1999 Director General of the Patent Office Yoshi 1) Relationship with the Moon Yi case Patent applicant Tomita Pharmaceutical Co., Ltd.

Claims (2)

[Claims] (1) In a method of reacting peroxide and a catalyst to generate oxygen, a tablet containing a peroxide and a disintegrant and a tablet containing a catalyst and a disintegrant are disintegrated in water, and the peroxide and the catalyst are disintegrated. A method characterized by adjusting the rate and duration of oxygen generation by causing a contact reaction with. (2) An oxygen generating agent consisting of tablet A containing a peroxide and a disintegrant and tablet B containing a metal salt and a disintegrant.