JPH0259124B2 - - Google Patents

Info

Publication number: JPH0259124B2
Authority: JP; Japan
Prior art keywords: polyacrylic acid; weight; parts; sustained release; drug
Prior art date: 1985-06-12
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired

Application number

JP12633785A

Other languages

English (en)

Japanese (ja)

Other versions

JPS61286322A (ja

Inventor

Hiroshi Igura

Yoshiki Suzuki

Tsuneji Nagai

Ryoji Machida

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Teijin Ltd

Original Assignee

Teijin Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1985-06-12

Filing date

1985-06-12

Publication date

1990-12-11

1985-06-12 Application filed by Teijin Ltd filed Critical Teijin Ltd

1985-06-12 Priority to JP12633785A priority Critical patent/JPS61286322A/ja

1986-06-10 Priority to EP86304400A priority patent/EP0205336B1/fr

1986-06-10 Priority to DE8686304400T priority patent/DE3681348D1/de

1986-06-11 Priority to US06/872,996 priority patent/US4777033A/en

1986-12-16 Publication of JPS61286322A publication Critical patent/JPS61286322A/ja

1987-07-29 Priority to MYPI87001165A priority patent/MY102459A/en

1990-12-11 Publication of JPH0259124B2 publication Critical patent/JPH0259124B2/ja

Status Granted legal-status Critical Current

Links

239000003814 drug Substances 0.000 claims description 59
229940079593 drug Drugs 0.000 claims description 58
239000008187 granular material Substances 0.000 claims description 48
229920002125 Sokalan® Polymers 0.000 claims description 40
239000004584 polyacrylic acid Substances 0.000 claims description 40
239000000203 mixture Substances 0.000 claims description 33
229920002678 cellulose Polymers 0.000 claims description 26
239000001913 cellulose Substances 0.000 claims description 26
150000003839 salts Chemical class 0.000 claims description 25
150000005215 alkyl ethers Chemical class 0.000 claims description 24
238000013268 sustained release Methods 0.000 claims description 16
239000012730 sustained-release form Substances 0.000 claims description 16
239000004604 Blowing Agent Substances 0.000 claims description 14
229920002153 Hydroxypropyl cellulose Polymers 0.000 claims description 14
239000007864 aqueous solution Substances 0.000 claims description 14
239000001863 hydroxypropyl cellulose Substances 0.000 claims description 14
235000010977 hydroxypropyl cellulose Nutrition 0.000 claims description 14
239000002775 capsule Substances 0.000 claims description 11
239000003405 delayed action preparation Substances 0.000 claims description 11
239000003795 chemical substances by application Substances 0.000 claims description 7
BVKZGUZCCUSVTD-UHFFFAOYSA-M Bicarbonate Chemical compound OC([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-M 0.000 claims description 6
239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims description 5
229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims description 5
235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims description 5
UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims description 5
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VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 5
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239000004375 Dextrin Substances 0.000 description 2
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PPBRXRYQALVLMV-UHFFFAOYSA-N Styrene Chemical compound C=CC1=CC=CC=C1 PPBRXRYQALVLMV-UHFFFAOYSA-N 0.000 description 2
KDYFGRWQOYBRFD-UHFFFAOYSA-N Succinic acid Natural products OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 description 2
MUMGGOZAMZWBJJ-DYKIIFRCSA-N Testostosterone Chemical compound O=C1CC[C@]2(C)[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 MUMGGOZAMZWBJJ-DYKIIFRCSA-N 0.000 description 2
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OROGSEYTTFOCAN-DNJOTXNNSA-N codeine Chemical compound C([C@H]1[C@H](N(CC[C@@]112)C)C3)=C[C@H](O)[C@@H]1OC1=C2C3=CC=C1OC OROGSEYTTFOCAN-DNJOTXNNSA-N 0.000 description 2
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PGZIKUPSQINGKT-UHFFFAOYSA-N dialuminum;dioxido(oxo)silane Chemical compound [Al+3].[Al+3].[O-][Si]([O-])=O.[O-][Si]([O-])=O.[O-][Si]([O-])=O PGZIKUPSQINGKT-UHFFFAOYSA-N 0.000 description 2
ZZVUWRFHKOJYTH-UHFFFAOYSA-N diphenhydramine Chemical compound C=1C=CC=CC=1C(OCCN(C)C)C1=CC=CC=C1 ZZVUWRFHKOJYTH-UHFFFAOYSA-N 0.000 description 2
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239000013618 particulate matter Substances 0.000 description 2
BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Chemical compound [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 description 2
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WFWLQNSHRPWKFK-ZCFIWIBFSA-N tegafur Chemical compound O=C1NC(=O)C(F)=CN1[C@@H]1OCCC1 WFWLQNSHRPWKFK-ZCFIWIBFSA-N 0.000 description 1
229960003604 testosterone Drugs 0.000 description 1
229940072172 tetracycline antibiotic Drugs 0.000 description 1
229960004989 tetracycline hydrochloride Drugs 0.000 description 1
229960000278 theophylline Drugs 0.000 description 1
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239000005495 thyroid hormone Substances 0.000 description 1
229940034199 thyrotropin-releasing hormone Drugs 0.000 description 1
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239000000196 tragacanth Substances 0.000 description 1
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229960000363 trapidil Drugs 0.000 description 1
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229960004813 trichlormethiazide Drugs 0.000 description 1
LMJSLTNSBFUCMU-UHFFFAOYSA-N trichlormethiazide Chemical compound C1=C(Cl)C(S(=O)(=O)N)=CC2=C1NC(C(Cl)Cl)NS2(=O)=O LMJSLTNSBFUCMU-UHFFFAOYSA-N 0.000 description 1
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UHLOVGKIEARANS-QZHINBJYSA-N tripamide Chemical compound C1=C(Cl)C(S(=O)(=O)N)=CC(C(=O)NN2C[C@@H]3[C@H]4CC[C@H](C4)[C@@H]3C2)=C1 UHLOVGKIEARANS-QZHINBJYSA-N 0.000 description 1
229950004678 tripamide Drugs 0.000 description 1
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VBEQCZHXXJYVRD-GACYYNSASA-N uroanthelone Chemical compound C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CS)C(=O)N[C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)C(C)C)[C@@H](C)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CCSC)NC(=O)[C@H](CS)NC(=O)[C@@H](NC(=O)CNC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CS)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CS)NC(=O)CNC(=O)[C@H]1N(CCC1)C(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(N)=O)C(C)C)[C@@H](C)CC)C1=CC=C(O)C=C1 VBEQCZHXXJYVRD-GACYYNSASA-N 0.000 description 1
239000002432 uterotonic agent Substances 0.000 description 1
230000002792 vascular Effects 0.000 description 1
239000005526 vasoconstrictor agent Substances 0.000 description 1
229920002554 vinyl polymer Polymers 0.000 description 1
229940088594 vitamin Drugs 0.000 description 1
239000011782 vitamin Substances 0.000 description 1
235000013343 vitamin Nutrition 0.000 description 1
229930003231 vitamin Natural products 0.000 description 1
229920003169 water-soluble polymer Polymers 0.000 description 1
239000001993 wax Substances 0.000 description 1

Landscapes

Medicinal Preparation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

JP12633785A 1985-06-11 1985-06-12 経口徐放性製剤 Granted JPS61286322A (ja)

Priority Applications (5)

Application Number	Priority Date	Filing Date	Title
JP12633785A JPS61286322A (ja)	1985-06-12	1985-06-12	経口徐放性製剤
EP86304400A EP0205336B1 (fr)	1985-06-11	1986-06-10	Préparation pharmaceutique orale à effet entretenn
DE8686304400T DE3681348D1 (de)	1985-06-11	1986-06-10	Oral-arzneizubereitung mit retardwirkung.
US06/872,996 US4777033A (en)	1985-06-11	1986-06-11	Oral sustained release pharmaceutical preparation
MYPI87001165A MY102459A (en)	1985-06-11	1987-07-29	Oral sustained release pharmaceutical preparation.

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
JP12633785A JPS61286322A (ja)	1985-06-12	1985-06-12	経口徐放性製剤

Publications (2)

Publication Number	Publication Date
JPS61286322A JPS61286322A (ja)	1986-12-16
JPH0259124B2 true JPH0259124B2 (fr)	1990-12-11

Family

ID=14932677

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
JP12633785A Granted JPS61286322A (ja)	1985-06-11	1985-06-12	経口徐放性製剤

Country Status (1)

Country	Link
JP (1)	JPS61286322A (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE102004042139B4 (de) *	2004-08-31	2009-06-10	Aristocon Verwaltungs- Gmbh	Perorale Darreichungsformen zur Erzielung eines Retardierungseffektes nach der Arzneimitteleinnahme mit einer Mahlzeit

1985
- 1985-06-12 JP JP12633785A patent/JPS61286322A/ja active Granted

Also Published As

Publication number	Publication date
JPS61286322A (ja)	1986-12-16

Legal Events

Date	Code	Title	Description
2005-06-12	EXPY	Cancellation because of completion of term

Publication	Publication Date	Title
EP0205336B1 (fr)	1991-09-11	Préparation pharmaceutique orale à effet entretenn
ES2223669T3 (es)	2005-03-01	Forma oral de dosificacion "una vez al dia" de metoprolol.
EP0797435B1 (fr)	2003-09-03	Matrice a liberation regulee pour produits pharmaceutiques
US4666705A (en)	1987-05-19	Controlled release formulation
EP1276467B1 (fr)	2008-04-09	Formulation et comprimés à libération soutenue de guaifenesine
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