JPH03131694A - Low-irritant detergent composition - Google Patents

Abstract

PURPOSE:To provide a composition extremely low in skin irritativeness while satisfying its foamability, detergency, etc., containing, as effective components, each specific anionic surfactant and amphoteric surfactant. CONSTITUTION:The objective composition containing, as effective component, pref. 10-50wt.% of a mixture of (A) an anionic surfactant of formula I and/or II (R1 is 10-20C alkyl; M1 is sodium, potassium, ammonium or alkanolamine; n is 1-8) and (B) an amphoteric surfactant of formula III (R2 is 10-18C alkyl) at the weight ratio A/B=(5:1)-(1:20).

Description

DETAILED DESCRIPTION OF THE INVENTION [Field of Industrial Application] The present invention relates to a detergent composition that satisfies essential requirements for a detergent, such as foaming properties and cleansing properties, and has extremely low irritation to the skin. It is.

[Prior Art] Conventionally, surfactants and surfactant compositions that have a strong protein denaturing power have caused severe roughness when used repeatedly, whereas surfactants and surfactant compositions that have a low protein denaturing power have been used for a long time. It is well known that even if the composition (for example, shampoo) is used continuously for a long period of time, skin IN disorders such as rough hands are unlikely to occur, and that the gf1 intensity on the skin is extremely low.

On the other hand, anionic surfactants represented by general formulas (A) and (B) below are used in detergents such as breast washes and shampoos because of their excellent detergency.
It has the disadvantage that it has strong protein'X denaturing power and skin irritation, which tends to cause skin disorders such as rough hands.

Against this background and with the advancement of living standards, there is a strong demand for the development of low skin irritation surfactants and cleaning compositions that are highly safe for the human body. is the current situation.

[Problem to be solved by the invention]

As a result of intensive research aimed at improving the drawbacks of the prior art, the present inventors determined that an appropriate amount of the amphoteric surfactant represented by the general formula (C) described below in JP-A No. 1-139588, When mixed with the anionic surfactant represented by (A) and/or (B), it satisfies the essential requirements as a detergent such as foaming properties and detergency, but has low protein denaturation power and causes rough hands. The present inventors have discovered that it is possible to obtain a detergent composition that hardly causes skin damage and has significantly low skin irritation, and has completed the present invention.

An object of the present invention is to provide a detergent composition that satisfies essential requirements for a detergent such as foaming properties and cleansing properties, and has extremely low irritation to the skin.

[Means for solving the problem] The present invention is based on the Imperial Palace style (^) and/or (B) Ill 05OJ+...
・・・・・・・・・・・・(A)R, (OCII□C
Il□)ll 0303M+ ・・・・・・・・・
・・・・・・・・・(B) (In the above formula, R has 10 to 10 carbon atoms.
20 alkyl groups.

The phylum represents sodium, potassium, ammonium, and alkanolamine, and n represents a number from 1 to 8. ) and an amphoteric surfactant represented by the general formula (C) (in the above formula, h represents an alkyl group having 10 to 18 carbon atoms) as active ingredients. It is a hypoallergenic cleaning composition.

Examples of the anionic surfactant represented by the general formula (A) in the present invention include decyl sulfate sodium salt, dodecyl sulfate potassium salt, and tetradecyl sulfate ammonium salt.

Examples include hexadecyl sulfate sodium salt and eicosyl sulfate triethanolamine salt.

The anionic surfactant represented by the general formula (B) in the present invention is, for example, polyoxyethylene (2E, O,
) Decyl ether sulfate sodium salt, polyoxyethylene (41!, O,) hexadecyl ether sulfate potassium salt, polyoxyethylene (6E, 0.
) Tetradecyl ether sulfate ammonium salt,
Polyoxyethylene (3E, O,) dodecyl ether sulfate sodium salt, polyoxyethylene (8E,
O,) eicosyl ether sulfate triethanolamine salt and the like.

didecyl) ammonio] ethyl phosphate, (hereinafter referred to as
Compound 1), 2-(dimethyl(2-hydroxydodecyl)ammonio]ethyl phosphate (Compound 2)
, 2-(dimethyl(2-hydroxytetradecyl)ammonio)ethyl phosphate (compound 3), 2-(dimethyl(2-hydroxyhexadecyl)ammonio)ethyl phosphate (compound 4), 2-(dimethyl(2-hydroxyoctadecyl) ) ammonio)ethyl phosphate (compound 5).

The anionic surfactants represented by the general formulas (A) and (B) have sufficient surfactant properties such as foaming properties and detergent properties, but have somewhat strong protein denaturing power (when used alone). The desired mild cleaning agent cannot be obtained.

On the other hand, the amphoteric surfactant represented by the general formula (C) has very low protein denaturation power and weak irritation, but has foaming and
It has only moderate surfactant ability such as detergency.

By combining such an anionic surfactant represented by the above general formula (A) and/or (11) and an amphoteric surfactant represented by the above general formula (C), when each of them is used alone, Phenomena such as an increase in viscosity and a decrease in critical micelle concentration occur, and surfactant properties such as foaming properties and detergency are superior to those of the anionic surfactants represented by the above general formulas (A) and (B) alone. At the same time, it was possible to significantly reduce the protein denaturation power to almost the same level as that of the amphoteric surfactant represented by the general formula (C) alone.

That is, by mixing the anionic surfactant represented by the general formula (^) and/or (B) and the amphoteric surfactant represented by the general formula (C) to form a complex, it is clear that A synergistic effect was exhibited, making it possible to obtain a hypoallergenic detergent composition with low protein denaturation ability while maintaining excellent surfactant ability.

The mixing ratio of (A) and/or (B): (C) (
(weight ratio) is in the range of 5:1 to 1:20, and (A)
The content of and/or (B) + (C) is preferably 10 to 50% by weight based on the total amount of the cleaning composition. If the mixing ratio is outside this range or if a large amount of other anionic surfactant is added to disrupt the balance of the system, the desired effect of lowering protein denaturation performance cannot be obtained.

The cleaning composition of the present invention may optionally contain ingredients commonly added to cleaning agents, such as higher alcohols, lanolin derivatives, protein derivatives, oily ingredients such as fatty acid esters of polyethylene glycol, propylene glycol, glycerin, polyethylene glycol, etc. Moisturizing ingredients such as glycol, nonionic surfactants such as fatty acid alkalolamide, polyoxyethylene alkyl ether, and alkylamine oxide, water-soluble polymer substances (anionic, nonionic,
(including cationic ones), sequestering agents, preservatives, bactericidal agents, pHl regulators, ultraviolet absorbers, antioxidants, pigments, fragrances, and the like.

(Example) Next, the present invention will be explained in detail with reference to Examples, but the present invention is not limited thereto. Prior to the examples, the test methods employed in each example will be explained.

(Foaming test method) Test was performed using the Ross Miles test method (ASTMD 117353). In addition, the evaluation criteria were set as follows.

O...Good foaming Foam fl! 200m1 or more Δ...
Foaming normal foam 1150mj! More than 200m1 ×...Poor foaming Foam i! Less than 150ml1 (cleaning test method) 5cm x 5 (rrl wool muslin cloth with 7% lanolin
and Sudan II [0,005% chloroform solution 0,
Apply 4 ml evenly and let it dry, then remove the contaminated cloth with 3%
40 mj of cleaning solution! Approximately 100 mj containing! The contaminated cloth was placed in a glass cylinder and shaken for 15 minutes in a constant temperature bath at 40° C., the contaminated cloth was thoroughly rinsed in raw water, dried, the reflectance was examined, and the cleaning rate was determined using the following formula.

In addition, the evaluation criteria were set as follows.

○: Good cleaning performance Washing efficiency 80% or more Δ: Average cleaning performance Washing efficiency 60% or more but less than 80% ×: Poor cleaning performance Washing efficiency less than 60% (protein denaturation rate measurement method) The ovalbumin denaturation rate when a sample was added to the albumin PHT warm solution at a sample concentration of 1% was measured using an absorption peak at 220 nm.

H,, - Height of the 220 nm absorption peak of ovalbumin H,; Ovalbumin buffer? 2 when adding sample to 8 liquid
The criteria for evaluating the height of the 20 nm absorption peak was set as follows.

◎: Ovalbumin denaturation rate less than 30% O: Ovalbumin denaturation rate 30% or more and less than 60% Δ; Ovalbumin denaturation rate 60% or more and less than 80% ×! Ovalbumin denaturation rate: 80% or more (hand roughness test method) For each sample, a panel of 10 people (5 men and 5 men in total) was used, and either the left or right hand was placed in an aqueous solution with a sample concentration of 5% and a temperature of 35°C. The other hand was immersed in water at the same temperature for 10 minutes twice a day for two consecutive days, and the difference in rough skin between the left and right hands was visually determined.

■... Hand roughness is extremely weak. Roughness of hands was observed on the sample side for 0 to 1 out of 10 people. O... Roughness of hands was observed on the sample side for 2 to 4 out of 10 people. Δ... Slightly rough hands 5-7 out of 10 people found rough hands on the sample side ×... Extremely rough hands 8-10 out of 10 people found rough hands on the sample side Examples 1-8, comparative example 1-2 Prepare a shampoo consisting of the composition listed in Table 1,
Table 1 shows the results of examining its foaming properties, cleaning properties, protein denaturation rate, and roughness.

As is clear from Table 1, the shampoo of the present invention was excellent in various properties. On the other hand, the above-mentioned version type (C)
Comparative Example 1 lacking the amphoteric surfactant represented by the above is unfavorable due to its poor protein denaturation rate 2 roughness, and Comparative Example 2 lacking the anionic surfactant represented by the above general formulas (A) and (R) Example 9 A body shampoo having the following formulation was prepared.

(Weight %) Dodecyl sulfate potassium salt 12 Compound 1
6 Compound 56 Glycerin 2 Fragrance
0.2 water
The remaining body shampoo was examined for its foaming properties, detergency, protein denaturation rate, and roughness on hands, and the results were O, O1 ◎, and ◎, respectively.

Example 10 A shampoo consisting of the following formulation was prepared.

(% by weight) Compound 2 Compound 4 Coconut fatty acid jetanolamide 5 Flavor
0.2 water
Residual As a result of examining the foaming properties, detergency, protein denaturation rate, and roughness of hands of this shampoo, each of them was O1.
They were 0, ◎, and ◎.

〔Effect of the invention〕

As described above, the present invention provides a hypoallergenic detergent composition that is highly safe, causes little irritation to the skin and hair (has a mild action, and has excellent foaming power and detergency). It is clear that

Claims (1)

[Claims] General formula (A) and/or (B) R_1OSO_3M_1......(A) R_1(OCH_2CH_2)_nOSO_3M_1...
......(B) (In the above formula, R_1 is a carbon number of 10 to 20
The alkyl group M_1 represents sodium, potassium, ammonium, or alkanolamine. n represents a number from 1 to 8. ) An anionic surfactant represented by the general formula (C) ▲There are mathematical formulas, chemical formulas, tables, etc.▼…………(C) (In the above formula, R_2 is an alkyl group having 10 to 18 carbon atoms. A mild detergent composition containing an amphoteric surfactant represented by the following as an active ingredient.