JPH03182598A - Lowly irritant detergent composition - Google Patents

Abstract

PURPOSE:To obtain the title composition excellent in foaming ability and detergency and lowly irritant to the skin by using a specified anionic phosphoric ester surface active agent and a specified ampholytic phosphoric ester surface active agent as effective components. CONSTITUTION:The title composition contains an anionic phosphoric ester surface active agent shown by formula I (wherein R1 is 10-18C alkyl or alkenyl; M1 is an alkali metal or alkanolamine) and an ampholytic phosphoric ester surface active agent shown by formula II (wherein R2 is 10-18C alkyl; M2 is an alkali metal) as effective components.

Description

[Detailed Description of the Invention] [Industrial Application Field] The present invention relates to a detergent composition that satisfies important requirements as a detergent such as foaming properties and detergency, and has extremely low irritation to the skin. It is.

[Conventional technology]

Conventionally, surfactants and surfactant compositions with strong protein denaturing power have caused severe roughness when used repeatedly, whereas surfactants and surfactant compositions with low protein denaturing power (for example, shampoos) ) is well known to be less likely to cause skin disorders such as rough hands even when used for a long period of time, and to have extremely low irritation to the skin.

On the other hand, anionic phosphate ester type surfactants represented by the general formula (A) below are used in detergents such as facial cleansers and shampoos because of their excellent detergency, but they have protein denaturing properties. It also has the drawback of being highly irritating to the skin and easily causing skin disorders such as rough hands. Against this background and with the increasing sophistication of living standards, there has been a strong demand for the development of low skin irritation surfactants, detergents, and products that are highly safe for the human body. The current situation is that

[Problem to be solved by the invention]

As a result of intensive research aimed at improving the drawbacks of the prior art, the present inventors discovered an appropriate amount of an amphoteric phosphate ester type surfactant represented by the general formula (B) described below in JP-A-61-141798. When mixed with an anionic phosphate ester type surfactant represented by the general formula (^) below, it satisfies essential requirements as a detergent such as foaming property and detergency, while having low protein denaturation power. The present inventors have discovered that it is possible to obtain a detergent composition that hardly causes skin disorders such as rough hands and has extremely low skin irritation, and has completed the present invention.

An object of the present invention is to provide a detergent composition that satisfies essential requirements for a detergent such as foaming properties and cleansing properties, and has extremely low irritation to the skin.

[Means to solve the problem]

The present invention is an anionic phosphate ester type surfactant represented by the general formula (A) (in the above formula, Rt is an alkyl group or alkenyl group having 10 to 18 carbon atoms, and L is an alkali metal or an alkanolamine). agent, general formula (B) (in the above formula, Rt is an alkyl group having 10 to 18 carbon atoms 1
M represents an alkali metal. ) This is a hypoallergenic detergent composition containing an amphoteric phosphate ester type surfactant represented by the following as an active ingredient.

In the present invention, the anionic phosphate ester type surfactant represented by the general formula (A) is, for example, a monosodium salt of decyl phosphate, dodecyl phosphate, tetradecyl phosphate, hexadecyl phosphate, or octadecyl phosphate, or monosodium salt of octadecyl phosphate. Potassium salts and monotriethanolamine salts may be mentioned, and among these, those in which R1 has an alkyl group having 12 to 14 carbon atoms are particularly preferred.

Further, as the amphoteric phosphate ester type surfactant represented by the general formula (B), for example, 2-[N(2-hydroxytetradecyl)-N-methylaminocoethyl phosphate heptanosodium salt (hereinafter referred to as , compound 1),
2-(N-(2-hydroxytetradecyl)-N-methylaminocoethyl phosphate heptanopotassium salt (compound 2).

2-(N-(2-hydroxydodecyl)-N-methylaminocoethyl phosphate 7nosodium salt (compound 3), 2-(N-(2-hydroxydodecyl)-N
-Methylamino]ethyl phosphate heptanopotassium salt (Compound 4), 2- (N-(2-hydroxyhexadecyl)-N-methylaminocoethyl phosphate monosodium salt (Compound 5), 2- (N -(2-hydroxyhexadecyl)-N-methylaminocoethyl phosphate monopotassium salt (compound 6), 2-(N(2-
Hydroxyoctadecyl)-N-methylamino)ethyl phosphate monosodium salt (compound 7), 2-
(N-(2-hydroxyoctadecyl)-N-methylaminocoethyl phosphate monopotassium salt (compound 8
), 2-(N(2-hydroxyeicosyl)-N-methylaminocoethyl phosphate heptanosodium salt (Compound 9), and the like.

The anionic phosphate ester type surfactant represented by the general formula (A) has sufficient surfactant properties such as foaming properties and detergent properties, but has a rather strong protein denaturing power, and when used alone does not provide the desired mild cleaning agent.

On the other hand, the amphoteric phosphate ester type surfactant represented by the general formula (B) has very low protein denaturation power and weak irritation, but only has moderate surfactant properties such as foaming and detergent properties. It is.

By combining such an anionic phosphate ester type surfactant represented by the above general formula (A) and an amphoteric phosphate ester type surfactant represented by the above general formula (B), each can be used individually. In the case of
The detergency and other surfactant properties are superior to those of the anionic phosphate ester type surfactant represented by the above general formula (A) alone, and at the same time, the protein denaturation ability is improved by the above general formula CB).
This made it possible to significantly reduce the amount of water to a level almost equivalent to that of the amphoteric phosphate ester type surfactant alone.

That is, by mixing the anionic phosphate ester type surfactant represented by the general formula (A) and the amphoteric phosphate ester type surfactant represented by the general formula (B) to form a complex, There is clearly a synergistic effect,
It has become possible to obtain a hypoallergenic detergent composition with low protein denaturation ability while maintaining excellent surfactant ability.

The mixing ratio (weight ratio) of (A):(B) is 5:
The range of 1 to 1:20 and the content of (A) + (B) is preferably 10 to 50% by weight based on the total amount of the cleaning composition. Mixing ratios outside this range or other anionic surfactants may be used. If the system is unbalanced by adding a large amount of
The desired effect of lowering protein denaturation ability cannot be obtained.

The cleaning composition of the present invention may optionally contain ingredients commonly added to cleaning agents, such as higher alcohols, lanolin derivatives, protein derivatives, oily ingredients such as fatty acid esters of polyethylene glycol, propylene glycol, glycerin, polyethylene glycol, etc. Humectant ingredients such as glycol, nonionic surfactants such as fatty acid vulcarolamide, polyoxyethylene alkyl ether and alkylamine oxide, water-soluble polymer substances (anionic, nonionic,
(including cationic ones), sequestering agents, preservatives, disinfectants, pH! [Solid agents, ultraviolet absorbers, antioxidants,
It may contain pigments, fragrances, etc.

〔Example〕

Next, the present invention will be explained in detail with examples, but the present invention is not limited thereto.Prior to the examples, the test methods adopted in each example will be explained.

(Foaming test method) Test was performed using the Ross Miles test method (ASTMD 1173-53). In addition, the evaluation criteria were set as follows.

○...Good foaming foam 1200mj! Above △... Normal foaming 1 ton of foam 150ml or more but less than 200ml ×... Poor foaming Foam volume 150mm! Less than (Cleanability test method) A chloroform solution of 7% lanolin and 0% Sudanese moss on a 5cm x 5cm wool muslin cloth.
Apply 4 ml evenly and let it dry, then remove the contaminated cloth with 3%
cleaning agent? G? fi, about 100 mj with 40 m1 in it!
Place it in a glass cylinder and heat it in a constant temperature bath at 40℃ for 1 hour.
After shaking for 5 minutes, the contaminated cloth was thoroughly rinsed under running water, dried, and the reflectance was examined to determine the cleaning rate using the following formula.

In addition, the evaluation criteria were set as follows.

0: Good cleaning efficiency Cleaning efficiency 80% or more △: Normal cleaning efficiency Washing efficiency 60% or more but less than 80% ×: Poor cleaning efficiency Cleaning efficiency less than 60% (protein denaturation rate measurement method) The ovalbumin denaturation rate when a sample was added to an albumin pH 7 buffer solution at a sample concentration of 1% was measured using an absorption peak at 220 nm.

Ho: Height of the 220 nm absorption peak of ovalbumin Hs: Height of the 220 nm absorption peak when a sample is added to the ovalbumin 11 solution The criteria for evaluation was set as follows.

◎: Ovalbumin denaturation rate less than 30% ○: Ovalbumin denaturation rate 30% or more and less than 60% Δ2 Ovalbumin denaturation rate 60% or more and less than 80% ×: Ovalbumin denaturation rate 80% or more (rough hand test method) For each sample , using a panel of 10 people, 5 men and 5 men in total, using either the left or right hand at a test concentration of 5% and a temperature of 35°C.
An operation of immersing the other hand in water at the same temperature for 10 minutes was performed twice a day for two consecutive days, and the difference in rough skin between the left and right hands was visually determined.

◎... Extremely weak hand roughness 0 to 1 out of 10 people noticed rough hands on the sample side ○... Slightly weak hand roughness 2 to 4 out of 10 people found hand roughness on the sample side △... Slightly rough hands Roughness was observed on the sample side in 5 to 7 out of 10 people x... Extremely strong roughness in hands Roughness was observed in 8 to 10 out of 10 people on the sample side Examples 1 to 6, comparative examples 1-2 Prepare a shampoo consisting of the composition listed in Table 1,
Table 1 shows the results of examining its foaming properties, cleaning properties, protein denaturation rate, and roughness.

As is clear from Table 1, the shampoo of the present invention had excellent properties. On the other hand, the general formula (B)
Comparative Example 1 lacking the amphoteric phosphate ester type surfactant represented by the protein denaturation rate 1 was undesirable due to poor hand roughness; Comparative Example 2 had poor foaming properties and cleansing properties. Preferred Example 7 A facial cleanser having the following composition was prepared.

(% by weight) Dodecyl monotriethanol phosphate 35 Amine salt Compound 7 10 Compound 8
5 Carbo Ball 941 0.5 Flavor
0.3 water
Residual foaming properties of this facial cleanser,
As a result of examining cleanability, protein denaturation rate, and hand roughness, each
, ○, ◎, ◎.

〔Effect of the invention〕

As described above, the present invention is a hypoallergenic mori detergent that is highly safe, has mild effects with little irritation to the skin and hair, and has excellent foaming and cleaning power! kIiIt
i.It is clear that it is an adversary.

Claims (1)

[Claims] General formula (A) ▲Mathematical formulas, chemical formulas, tables, etc.▼…………(A) (In the above formula, R_1 is an alkyl group or alkenyl group having 10 to 18 carbon atoms, and M_1 is an alkali group. Anionic phosphate ester type surfactant represented by general formula (B) ▲There are mathematical formulas, chemical formulas, tables, etc.▼…………(B) (In the above formula, R_2 is an alkyl group having 10 to 18 carbon atoms, and M_2 is an alkali metal.