JPH03109497A - Detergent composition having low stimulating property - Google Patents

Abstract

PURPOSE:To obtain the title composition containing an anionic phosphoric acid ester type surfactant and amphoteric phosphoric acid ester type surfactant as active ingredients and being extremely low in stimulating properties to skin while satisfying foaming properties and cleaning properties. CONSTITUTION:The aimed composition containing (A) an anionic phosphoric acid ester type surfactant expressed by formula I (R1 is 8-18C alkyl or alkenyl; M1 is alkali metal or alkanolamine; n is 1-5) and (B) amphoteric phosphoric acid ester type surfactant expressed by formula II (R2 is 10-18C alkyl; M2 is alkali metal) as active ingredients, preferably at weight ratio of ingredient A: ingredient B of 5:1-1:20 and at an amount of total amount of the ingredients A and B of 10-50wt.%.

Description

DETAILED DESCRIPTION OF THE INVENTION [Field of Industrial Application] The present invention relates to a detergent composition that satisfies essential requirements for a detergent, such as foaming properties and cleansing properties, and has extremely low irritation to the skin. It is.

[Conventional technology]

Conventionally, surfactants and surfactant compositions with strong protein denaturing power have caused severe roughness when used repeatedly, whereas surfactants and surfactant compositions with low protein denaturing power (for example, shampoos) ) is well known to be less likely to cause skin disorders such as rough hands even when used for a long period of time, and to have extremely low irritation to the skin.

On the other hand, anionic phosphate ester surfactants represented by the general formula (^) below are used in detergents such as facial cleansers and shampoos due to their excellent detergency, but they have a high degree of protein denaturation. Against this background and with the advancement of living standards, surfactants with low skin irritation and a high degree of safety for the human body have been developed. At present, there is a strong demand for the development of cleaning compositions.

[Problem to be solved by the invention]

As a result of intensive research aimed at improving the drawbacks of the above-mentioned conventional techniques, the inventors of the present invention have discovered the following.
2-71528, an appropriate amount of the amphoteric phosphate ester type surfactant represented by the general formula (B) described below is mixed with the anionic phosphate ester type surfactant represented by the general formula (A) described below. In this case, it is possible to obtain a detergent composition that satisfies the essential requirements for a detergent such as foaming properties and cleansing properties, has low protein denaturation power, is less likely to cause skin disorders such as rough hands, and has extremely low skin irritation. The present invention was completed based on the discovery that the present invention is possible.

An object of the present invention is to provide a detergent composition that satisfies essential requirements for a detergent such as foaming properties and cleansing properties, and has extremely low irritation to the skin.

[Means to solve the problem]

The present invention is based on the general formula (A) (in the above formula, R represents an alkyl group having 8 to 18 carbon atoms or an alkenyl group, 1M-, an alkali metal, or an alkanolamine, and n represents a number from 1 to 5). An anionic phosphate ester type surfactant represented by the general formula (B) (in the above formula, Rt is an alkyl group having 10 to 18 carbon atoms,
This is a hypoallergenic detergent composition containing as an active ingredient an amphoteric phosphate ester type surfactant represented by (L represents an alkali metal).

In the present invention, the anionic phosphate ester type surfactant represented by the general formula (A) is, for example, polyoxyethylene (3E, O,) dodecyl ether phosphate monosodium salt, polyoxyethylene (3E, O, )
Decyl ether phosphate monosodium salt, polyoxyethylene (2E, O,) tetradecyl ether phosphate monotriethanolamine salt, polyoxyethylene (4E, O,) hexadecyl ether phosphate monotriethanolamine salt , polyoxyethylene (2E, O,) octadecyl ether phosphate monopotassium salt, polyoxyethylene (5E, O,) octyl ether phosphate monosodium salt, polyoxyethylene (IE, O,) tetotadecyl ether phosphate Acid ester heptanosodium salt, polyoxyethylene (
4E, 0. ) dodecyl ether phosphate monotriethanolamine salt, among others, those in which L has an alkyl group having 12 to 14 carbon atoms are particularly preferred.

Further, as the amphoteric phosphate ester type surfactant represented by the general formula (B), for example, 2-(N-(2-hydroxytetradecyl)-N-methylaminocoethyl phosphate monosodium salt (hereinafter referred to as , compound 1)
, 2- (N-(2-hydroxytetradecyl)-N-
Methylaminocoethyl phosphate monopotassium salt (
Compound 2), 2- (N-(2-hydroxydodecyl)
-N-methylaminocoethyl phosphate monosodium salt (compound 3), 2-(N-(2-hydroxydodecyl)-N-methylaminocoethyl phosphate heptanopotassium salt (compound 4), 2-(N -(2-hydroxyhexadecyl)-N-methylaminocoethyl phosphate monosodium salt (compound 5), 2- (N-(
2-hydroxyhexadecyl)-N-methylaminocoethyl phosphate heptanopotassium salt (compound 6), 2-
(N-(2-hydroxyoctadecyl)-N-methylaminocoethyl phosphate monosodium salt (compound 7), 2-(N-(2-hydroxyoctadecyl)
-N-methylamino]ethyl phosphate monopotassium salt (compound 8), 2-(N(2-hydroxyeicosyl)-N-methylamino]ethyl phosphate heptanosodium salt (compound 9), 2-[N -(2-hydroxyeicosyl)-N-methylamino]ethyl phosphate monopotassium salt (Compound 10) and the like.

The anionic phosphate ester type surfactant represented by the general formula (A) has sufficient surfactant properties such as foaming properties and detergent properties, but has a rather strong protein denaturing power, and when used alone does not provide the desired mild cleaning agent.

On the other hand, the amphoteric phosphate ester type surfactant represented by the general formula (B) has very low protein denaturation power and weak irritation, but only has moderate surfactant properties such as foaming and detergent properties. It is.

By combining such an anionic phosphate ester type surfactant represented by the above general formula (A) and an amphoteric phosphate ester type surfactant represented by the above general formula (B), each of them can be used individually. Phenomena such as an increase in viscosity and a decrease in critical micelle concentration occur than in the case of , and surfactant abilities such as foaming properties and detergent properties are lower than when using the anionic phosphate ester type surfactant represented by the above general formula (^) alone. The protein denaturation power is as good as that of the above general formula (B).
This made it possible to significantly reduce the amount of water to a level almost equivalent to that of the amphoteric phosphate ester type surfactant alone.

That is, by mixing the anionic phosphate ester type surfactant represented by the general formula (8) and the amphoteric phosphate ester type surfactant represented by the general formula (B) to form a composite, There is clearly a synergistic effect,
It has become possible to obtain a hypoallergenic detergent composition with low protein denaturation ability while maintaining excellent surfactant ability.

The mixing ratio (weight ratio) of (^):(B) is in the range of 5:1 to 1:20, and the content of (A) + (B) is 10 to 50% of the total amount of the cleaning composition. If the mixing ratio is outside the preferred weight percent range or if a large amount of other anionic surfactant is added to disrupt the balance of the system, the desired effect of lowering protein denaturation performance cannot be obtained.

The cleaning composition of the present invention may optionally contain ingredients commonly added to cleaning agents, such as higher alcohols, lanolin derivatives, protein derivatives, oily ingredients such as fatty acid esters of polyethylene glycol, propylene glycol, glycerin, polyethylene glycol, etc. Moisturizing ingredients such as glycol, nonionic surfactants such as fatty acid alkalolamide, polyoxyethylene alkyl ether, and alkylamine oxide, water-soluble polymer substances (anionic, nonionic,
(including cationic ones), metal ion sequestrants, preservatives, whitening agents, pH adjusters, ultraviolet absorbers, antioxidants,
It may contain pigments, fragrances, etc.

〔Example〕

Next, the present invention will be explained in detail with examples, but the present invention is not limited thereto.Prior to the examples, the test methods adopted in each example will be explained.

(Foaming test method) Test was performed using the Ross Miles test method (ASTMD 1173-53). In addition, the evaluation criteria were set as follows.

O...Good foaming Foam 11200m42 or more Δ...
Foaming is normal, foam volume is over 150ml and 200mj! Less than ×...Poor foaming Foam volume 150mj! Less than (Cleanability test method) A chloroform solution of 7% lanolin and 5% Sudan III O,000 on a 5cm x 5cm wool muslin cloth.
Apply ml evenly and let it dry, then wash the contaminated cloth with 40ml of 3% detergent solution! Approximately 100 mJ containing! The contaminated cloth was placed in a glass cylinder and shaken for 15 minutes in a constant temperature bath at 40°C.The contaminated cloth was thoroughly rinsed under running water and dried.The reflectance was examined and the cleaning rate was determined using the following formula.

In addition, the evaluation criteria were set as follows.

O: Good cleaning performance Washing efficiency 80% or more Δ: Normal cleaning performance Washing efficiency 60% or more but less than 80% The ovalbumin denaturation rate when a sample was added to the albumin pH 7 iJi solution at a sample concentration of 1% was calculated at 220n
It was measured using the absorption peak of m.

Ho: Height of the 220 nm absorption peak of ovalbumin Hl: 2 when the sample is added to the ovalbumin buffer solution
The criteria for evaluating the height of the 20 nm absorption peak was set as follows.

O: Ovalbumin denaturation rate less than 30% ○: Ovalbumin denaturation rate 30% or more and less than 60% Δ2 Ovalbumin denaturation rate 60% or more and less than 80% ×: Ovalbumin denaturation rate 80% or more (rough hand test method) For each sample , using a panel of 10 people, 5 men and 5 men in total, with either the left or right hand at a sample concentration of 5% and a temperature of 35°.
An operation of immersing the other hand in the aqueous solution of C and water at the same temperature for 10 minutes was performed twice a day for 2 consecutive days, and the difference in rough skin between the left and right hands was visually determined.

O: Extremely weak hand roughness O-1 out of 10 people found rough hands on the sample side O: Slightly weak hand roughness 2-4 out of 10 people found hand roughness on the sample side Δ... Slightly rough hands 5-7 out of 10 people found rough hands on the sample side ×... Extremely rough hands 8-10 out of 10 people found rough hands on the sample side Examples 1-8, comparative example 1-2 Prepare a shampoo consisting of the composition listed in Table 1,
Table 1 shows the results of examining its foaming properties, cleaning properties, protein denaturation rate, and roughness.

As is clear from Table 1, the shampoo of the present invention had excellent properties. On the other hand, the general formula (B)
Comparative Example 1, which lacks the amphoteric phosphate ester type surfactant represented by the formula (A), has a protein denaturation rate of 9 and is undesirable due to poor roughness. Comparative Example 2 had poor foaming properties and cleansing properties.Good Example 9 A facial cleanser having the following composition was prepared.

(Weight%) Compound 1 10 Compound 75 Carbopol 941 0.5 Fragrance
0.3 water
The remaining face wash was examined for foaming properties, cleansing properties, protein denaturation rate, and roughness on hands, and the results were 01○, ◎, and ◎, respectively.

Example 10 A facial cleanser having the following composition was prepared.

(% by weight) Compound 8 Compound 10 Coconut fatty acid jetanolamide 5 Flavoring
0.3 water
Residual As a result of examining the foaming properties, cleansing properties, protein denaturation rate, and roughness of hands of this facial cleanser, it was found that the results were O1○,
It was ◎, ◎.

〔Effect of the invention〕

As described above, the present invention provides a hypoallergenic detergent composition that is highly safe, has mild effects with little irritation to the skin and hair, and has excellent foaming and detergent powers. That is clear.

Claims (1)

[Claims] (1) General formula (A) ▲There are mathematical formulas, chemical formulas, tables, etc.▼………………(A) (In the above formula, R_1 is an alkyl group or alkenyl group having 8 to 18 carbon atoms, M_1 is an alkali metal or Anionic phosphate ester type surfactant represented by alkanolamine (n is a number from 1 to 5) and general formula (B) ▲There are mathematical formulas, chemical formulas, tables, etc.▼………… (B) (In the above formula, R_2 is an alkyl group having 10 to 18 carbon atoms, and M_2 is an alkali metal.) A low irritation product containing an amphoteric phosphate ester type surfactant as an active ingredient. Cleaning composition.