JPH03212364A - Cap for liquid chemical bottle - Google Patents

Abstract

(57) [Summary] This bulletin contains application data before electronic filing, so abstract data is not recorded.

Description

DETAILED DESCRIPTION OF THE INVENTION (Field of Industrial Application) The present invention relates to a cap for a medicine bottle in which a specific synthetic resin layer is provided on the outer surface of the cap body made of aluminum. Concerning caps for chemical liquid bottles that are resistant to sterilization and attack by chemicals.

(Prior art and its problems) Normally, a glass chemical solution station (vial station) filled with various chemical solutions is sealed with a rubber stopper at the mouth and then sealed with a metal cap, and then sealed with ethylene oxide, formaldehyde, etc. The entire body is sterilized using a sterilizing gas. The above-mentioned cap is obtained by drawing a thin plate made of aluminum alone, but there is a problem that the aluminum surface is easily corroded by the above-mentioned sterilization process.
As a countermeasure, the cap has been molded and then its surface treated with alumite, or an aluminum plate coated with epoxy resin has been used.

However, among the above methods, alumite processing is time-consuming and uneconomical, and when drawing an aluminum plate coated with epoxy resin, there are problems in that the area between the eyebrows tends to peel off when the degree of drawing becomes large, and the resulting cap However, there was a problem in that the surface was attacked by sterilization and chemicals.

(Means for Solving the Problems) The present invention has discovered that the above problems can be solved by providing a specific synthetic resin layer on the outer surface of an aluminum cap, and the gist thereof is as follows: A cap for a drug solution bottle is obtained by drawing a laminated plate coated with an acid-modified polyolefin resin layer on one side of which is graft-copolymerized with an unsaturated carboxylic acid or a derivative thereof so that the acid-modified polyolefin resin layer is on the outer surface. .

The aluminum plate used for the cap of the present invention includes:
1000 series and 300-0 series by JISHOOOOI can be used, and those having a thickness of about 0.2 to 0.4 mm can be suitably used.

If a chemical conversion treatment layer made of a chromate treatment or an organic titanate treatment film is further provided on the surface of the aluminum plate, the adhesion between the layers is further improved.

The chromate treatment method uses a treatment solution containing chromic anhydride, phosphoric acid, fluoride or a complex salt thereof, etc.
The treatment can be carried out by spraying or dipping at a treatment temperature of about 50°C, and the amount of chromate film on the aluminum plate after treatment is 5 to 150 mg/rr? It is preferable to set it as the range of.

If the above chromate film amount is 5 mg/nf without groove, the effect of improving the adhesion with the acid-modified polyolefin resin provided on the surface is small, and if it exceeds 150 mg/nf, peeling between the eyebrows occurs when drawing the laminate. is observed, and drawing workability tends to decrease.

In addition, the above-mentioned organic titanate treatment method includes diluting the organic titanate [general formula T I (OR) 4...R is an alkyl group, an allyl group, etc.] with a solvent such as hexane or isopropanol, and using the usual gravure roll method. , reverse roll method, etc. may be used. The amount of this organic titanate film is preferably in the range of 3 mg/rd to 300 mg/rd. If the coating amount is less than 3 mg1rd, the effect of improving the adhesive force with the acid-modified polyolefin resin provided on the surface is small, and if it exceeds 300 mg/nf, there is a problem that the drawability of the laminate is poor.

In the laminate used for the cap of the present invention, it is necessary to coat one side of the aluminum plate with an acid-modified polyolefin resin layer obtained by graft copolymerizing an unsaturated carboxylic acid or a derivative thereof. The above-mentioned unsaturated carboxylic acids include acrylic acid, methacrylic acid, crotonic acid, maleic acid, etc., and derivatives thereof include maleic anhydride, itaconic anhydride, etc., and polyolefin resins include polyethylene,
Examples include polypropylene, poly-1-butene, poly-4-methyl-1-pentene, and ethylene-propylene copolymer.

The thickness range of the acid-modified polyolefin resin layer is 3 to 10
The thickness is preferably 0 μm, preferably in the range of 5 to 50 μm from the viewpoint of drawability and chemical resistance. Further, a polyamide resin layer such as 6-nylon may be laminated on the aluminum plate side of the acid-modified polyolefin resin layer to improve interlayer adhesion with the aluminum plate.

Various methods can be considered for laminating the acid-modified polyolefin resin layer, but the melt lamination method, in which a film formed in a separate process is pressure-bonded onto an aluminum plate heated above the melting point of the film, is the most efficient method. Preferable from this point of view.

The laminate with the above structure is drawn using a normal drawing machine so that the acid-modified polyolefin resin layer is on the outer surface.
Caps of various shapes can be molded.

In particular, the laminate used in the present invention can be deep drawn.
For example, a cap is provided with a cylindrical protrusion formed outward by deep drawing in the center of the cap, and a half cut is carved on the periphery of the base of the protrusion, and this protrusion can be pressed with a finger. A type of cap that can be easily separated from the cap body and opened (for example, Utility Model No. 59-89856)
It can be suitably used for the cap shown in No.

If the cap obtained by the above-described drawing process is heat-treated in a heating temperature range that is above the melting point of the acid-modified polyolefin resin and has a heating loss of 10% by weight or less, there is an advantage that the glabella adhesiveness and appearance can be further improved.

Here, the heating loss may be measured by a thermobalance analysis (TGA) at a heating rate of 10° C./min.

Hereinafter, the present invention will be explained in detail with reference to Examples.

(Example) Example 1 Aluminum plate (A 1100 P-H2S thickness 0°3
mm) was subjected to chromate treatment using a treatment solution containing phosphoric acid, chromic anhydride, and fluoride at a treatment temperature of 40 to 50°C to obtain a surface-treated aluminum plate with a chromate coating amount of 10 mg/m2.

A maleic anhydride-modified polypropylene film having a thickness of 20 μm was melt-laminated on one side of the treated surface to obtain a laminate sample. Using the obtained samples, "drawability", "secondary workability" and "chemical resistance" were evaluated.

Here, regarding drawing workability, each laminate was drawn in 7 stages using a lance progressive drawing machine, and a 16n+nφ with a protrusion (7IIIφX13nn height) in the center was used.
A cap for a medicine bottle with a height of X711 was prepared, and when the state of peeling between the eyebrows was observed, there was no H separation between the layers.

Regarding "secondary processability", when the main body of the medicinal liquid and the cap obtained by the above method were fitted with a seamer, the state of peeling between the eyebrows was observed, and no peeling between the layers was observed.

Regarding "chemical resistance", the above cap was tested at 25°C.
After immersing it in a 2% aqueous hydrochloric acid solution for 24 hours, it was washed with water and air-dried, and its appearance was observed, but no changes were observed.

Example 2 The cap obtained in Example 1 was further heat-treated at 250°C for 1 minute. Melting point of maleic anhydride-modified polypropylene used was 160'C. Temperature at the time of 110% weight loss on heating = 280'C). Using the above heat-treated cap, we evaluated the chemical resistance of Example 1 at a higher concentration of 0.3%.
When a hydrochloric acid aqueous solution was used, no change in appearance was observed.

Comparative Example Same shape as the example, epoxy resin on the outer surface (thickness 8 μm)
When the same evaluation as above was performed using a cap coated with , the epoxy resin on the side surface peeled off and corrosion of the aluminum occurred from that part during sterilization.

(Effects of the Invention) As described above, the cap of the present invention has excellent adhesion, especially between the eyebrows, and is not easily attacked by sterilization or chemicals, so it is highly usable as a cap for a medicine bottle.

Claims (1)

[Claims] A cap for a drug bottle made by drawing a laminate in which one side of an aluminum plate is coated with an acid-modified polyolefin resin layer made by graft copolymerizing an unsaturated carboxylic acid or its derivative, so that the acid-modified polyolefin resin layer is on the outer surface.