JPH03212365A - Cap for chemical liquid bottle - Google Patents

Abstract

(57) [Summary] This bulletin contains application data before electronic filing, so abstract data is not recorded.

Description

DETAILED DESCRIPTION OF THE INVENTION (Field of Industrial Application) The present invention relates to a cap for a medicine bottle in which a specific synthetic resin layer is provided on the outer surface of the cap body made of aluminum. Concerning caps for chemical liquid bottles that are resistant to deformation or attack by sterilization or chemicals.

(Prior art and its problems) Normally, glass chemical containers (vials) filled with various chemical solutions are sealed with a rubber stopper at the seed opening and then sealed with a metal cap, and then sealed with ethylene oxide, formaldehyde, etc. The entire body is sterilized using a sterilizing gas.

The above-mentioned cap is obtained by drawing a thin plate made of aluminum alone, but there is a problem that the aluminum surface is easily corroded by the above-mentioned sterilization process, and as a countermeasure, the surface is alumite-processed after the cap is formed. Previously, an aluminum plate coated with epoxy resin was used.

However, among the above methods, alumite processing is time-consuming and uneconomical, and when drawing an aluminum plate coated with epoxy resin, the area between the eyebrows tends to peel off when the degree of drawing becomes large, and the resulting cap However, there are problems with deformation and surface corrosion due to sterilization and chemicals.

(Means for Solving the Problems) The present invention is based on the discovery that the above problems can be solved by providing a specific synthetic resin layer on the outer surface of an aluminum cap and subjecting it to heat treatment. However, after drawing a laminate in which one side of an aluminum plate is coated with a crystalline thermoplastic resin layer so that the crystalline thermoplastic resin layer is on the outer surface, the weight loss is reduced by heating above the melting point of the crystalline thermoplastic resin. The present invention relates to a cap for a liquid medicine bottle which is heat-treated in a heating temperature range of 10% by weight or less.

The aluminum plate used for the cap of the present invention includes:
1000 series or 3000 series by JISHOOOOI can be used, and those with a thickness of about 0.2 to 0.4 mm can be suitably used.

If a chemical conversion layer made of a chromate treatment film is further provided on the surface of the aluminum plate, the adhesion between the layers can be further improved.

The chromate treatment method uses a treatment solution containing chromic anhydride, phosphoric acid, fluoride or a complex salt thereof, etc.
The treatment may be carried out by a spray method or a dipping method at a treatment temperature of about 50° C., and it is preferable that the amount of chromate film on the aluminum plate after treatment is in the range of 5 to 150 mg/rrr.

If the above chromate film amount is less than 5 mg/rd, the effect of improving the adhesion with the crystalline thermoplastic resin provided on the surface is small, and if it exceeds 150 mg/rrf, peeling between the eyebrows may occur when drawing the laminate. is observed, and the drawing processability tends to be poor.

In the laminate used for the cap of the present invention, it is necessary to coat one side of the aluminum plate with a crystalline thermoplastic resin layer. As the crystalline thermoplastic resin, various thermoplastic resins having a melting point can be used, such as 6-nylon, 6-row nylon, a copolymer of 6-nylon and 6-row nylon, and meta-xylene diamine and adipic acid. Examples include polyamide resins such as aromatic crystalline thermoplastic resins, polyolefin resins such as polyethylene and polypropylene, and modified polyolefin resins obtained by graft copolymerizing unsaturated carboxylic acids or derivatives thereof. A laminate formed by appropriately laminating layers can also be used. The thickness of the crystalline thermoplastic resin layer is preferably 3 to 100 μm, preferably 5 to 50 μm from the viewpoint of drawing workability and chemical resistance.

Various methods can be considered for laminating the crystalline thermoplastic resin layer, but the melt lamination method, in which a film formed in a separate process is pressure-bonded onto an aluminum plate heated above the melting point of the film, has the highest productivity, etc. It is preferable from the point of view.

The laminated plate having the above structure is drawn using a normal drawing machine so that the resin layer is on the outer surface, so that caps of various shapes can be formed. In particular, the laminates used in the present invention can be deep drawn. For example, a cap is provided with a cylindrical protrusion formed outward by deep drawing in the center of the cap, and a half cut is carved on the peripheral edge of the base of the protrusion,
A type of cap that can be easily separated from the cap body and opened by pressing this protrusion with your finger (for example,
-89856) can be suitably used.

The cap obtained by the drawing process described above needs to be heat-treated in a heating temperature range that is higher than the melting point of the crystalline thermoplastic resin and has a heating loss of 10% by weight or less.

Heat treatment has the advantage of improving glabella adhesion, appearance, and chemical resistance.

Here, the method for measuring the melting point is differential scanning calorimetry (DSC).
The loss on heating can be measured using the thermogravimetric method (TGA).
The measurement can be carried out at a heating rate of 10° C./min.

If the heat treatment temperature is below the melting point of the resin, there will be no improvement in glabella adhesion or chemical resistance, and if the heating loss exceeds 10% by weight, thermal decomposition of the resin will progress and discoloration will occur. be. Note that the heat treatment time can be appropriately determined depending on the heating temperature and the like.

Furthermore, in the cap for a drug solution bottle of the present invention, it is easy to print on the round surface coated with resin on the outer surface, and by applying various types of printing to the top surface of the re-cap 1, it is easy to classify and identify the filled drug solution. Can be done.

Hereinafter, the present invention will be explained in detail with reference to Examples.

(Example) Example 1 Aluminum plate (A 1100 P-H2S thickness 0°3
mm) was subjected to chromate treatment using a treatment solution containing phosphoric acid, chromic anhydride, and fluoride at a treatment temperature of 40 to 50°C to obtain a surface-treated aluminum plate with a chromate coating amount of 10 mg/m2. . A 6-nylon film having a thickness of 20 μm was melt-laminated on one side of the treated surface to obtain a laminate sample. Each laminate was subjected to 7 stages of drawing using a lance progressive drawing machine to form a 161IlφX with a protrusion < 7 onφX1Bnn height) in the center.
We created caps for chemical liquid bottles with a temperature of 711 and heated them to 250℃.
The sample was heat-treated for 1 minute. (Melting point of nylon 6 used = 2
15°C, temperature at 10% weight loss on heating = 375°C).

Using the above heat-treated cap, 0.1% at 25°C
After being immersed in an aqueous hydrochloric acid solution for 24 hours, it was washed with water and air-dried, and its appearance was observed, but no changes were observed. Also,
When the state of peeling between the eyebrows was observed, there was no peeling between the layers at all.

Furthermore, when the drug solution bottle body and the cap obtained by the above method were fitted with a seamer, the state of interlayer peeling was observed, and no interlayer peeling was observed.

Example 2 Carboxylic acid modified polypropylene (10μ)/6-nylon (10μ) was used instead of the 6-nylon film of Example 1.
A cap was made in the same manner as in Example 1, except that a laminated film made of a laminated film was used, and a laminated plate was laminated so that the carboxylic acid-modified polypropylene was on the outer surface. When the cap was evaluated after heat treatment, no abnormality was found. There was no.

Comparative Example Same shape as the example, epoxy resin on the outer surface (thickness 8 μm)
When the same evaluation as above was performed using a cap coated with , the epoxy resin on the side surface peeled off, and corrosion of the aluminum was observed from that area during sterilization.

(Effects of the Invention) As described above, the cap of the present invention has excellent adhesion, especially between the eyebrows, and is less likely to be deformed or eroded by sterilization or chemicals, making it highly usable as a cap for a medicine bottle. It is.

Claims (1)

[Claims] 1. After drawing a laminate in which one side of an aluminum plate is coated with a crystalline thermoplastic resin layer so that the crystalline thermoplastic resin layer is on the outer surface, A cap for a liquid medicine bottle that is heat-treated in a heating temperature range above the melting point and with a heating loss of 10% by weight or less. 2. The cap for a drug solution bottle according to claim 1, wherein the top surface of the cap is printed for identification.