JPH03503757A - タンパク質およびその誘導体 - Google Patents
タンパク質およびその誘導体Info
- Publication number
- JPH03503757A JPH03503757A JP63505229A JP50522988A JPH03503757A JP H03503757 A JPH03503757 A JP H03503757A JP 63505229 A JP63505229 A JP 63505229A JP 50522988 A JP50522988 A JP 50522988A JP H03503757 A JPH03503757 A JP H03503757A
- Authority
- JP
- Japan
- Prior art keywords
- protein
- region
- thrombin
- thrombomodulin
- human
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6456—Plasminogen activators
- C12N9/6459—Plasminogen activators t-plasminogen activator (3.4.21.68), i.e. tPA
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
- C07K14/7455—Thrombomodulin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21069—Protein C activated (3.4.21.69)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/036—Fusion polypeptide containing a localisation/targetting motif targeting to the medium outside of the cell, e.g. type III secretion
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Hematology (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Diabetes (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DK2990/87 | 1987-06-12 | ||
| DK299087A DK299087D0 (da) | 1987-06-12 | 1987-06-12 | Proteins and derivatives thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPH03503757A true JPH03503757A (ja) | 1991-08-22 |
Family
ID=8117912
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP63505229A Pending JPH03503757A (ja) | 1987-06-12 | 1988-06-09 | タンパク質およびその誘導体 |
Country Status (4)
| Country | Link |
|---|---|
| EP (1) | EP0365568A1 (de) |
| JP (1) | JPH03503757A (de) |
| DK (1) | DK299087D0 (de) |
| WO (1) | WO1988009811A1 (de) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH08289796A (ja) * | 1987-01-08 | 1996-11-05 | Asahi Chem Ind Co Ltd | トロンビンによるプロテインcの活性化を促進するペプチド |
| WO1997037018A1 (fr) * | 1996-04-03 | 1997-10-09 | Asahi Kasei Kogyo Kabushiki Kaisha | Nouveau gene |
| JP2013535211A (ja) * | 2010-08-05 | 2013-09-12 | カウンシル オブ サイエンティフィック アンド インダストリアル リサーチ | 血栓溶解及び抗凝固特性を有するタンパク質融合構築物 |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4912207A (en) * | 1987-05-06 | 1990-03-27 | Washington University | DNA clone of human thrombomodulin and portions thereof |
| WO1990010081A1 (en) * | 1989-02-17 | 1990-09-07 | Codon | Soluble analogs of thrombomodulin |
| US6063763A (en) * | 1989-04-28 | 2000-05-16 | Schering Aktiengesellschaft | Protease-resistant thrombomodulin analogs |
| US6239101B1 (en) | 1989-07-05 | 2001-05-29 | Oklahoma Medical Research Foundation | Thrombin binding polypeptides |
| CA2022713A1 (en) * | 1989-08-11 | 1991-02-12 | Nils U. Bang | Human thrombomodulin derivatives |
| JP3189052B2 (ja) * | 1990-06-27 | 2001-07-16 | 持田製薬株式会社 | 抗血液凝固活性を有するポリペプチド |
| KR930008093B1 (ko) * | 1990-08-03 | 1993-08-25 | 아사히가세이고오교 가부시끼가이샤 | 신규 폴리펩티드 및 이를 유효성분으로 하는 의약조성물 |
| EP0544826B1 (de) * | 1990-08-15 | 2002-01-02 | Paion GmbH | Überlegende thrombomodulinanaloga zur pharmazeutischen verwendung |
| ATE264913T1 (de) * | 1992-02-05 | 2004-05-15 | Paion Gmbh | Protease-resistente analoge des thrombomodulin |
| US5866543A (en) * | 1995-06-05 | 1999-02-02 | Corvas International, Inc. | Nematode-extracted anticoagulant protein |
| US5866542A (en) * | 1994-10-18 | 1999-02-02 | Corvas International, Inc. | Nematode-extracted anticoagulant protein |
| CA2202351A1 (en) * | 1994-10-18 | 1996-04-25 | George Phillip Vlasuk | Nematode-extracted serine protease inhibitors and anticoagulant proteins |
| US5872098A (en) * | 1995-06-05 | 1999-02-16 | Corvas International, Inc. | Nematode-extracted anticoagulant protein |
| US5863894A (en) * | 1995-06-05 | 1999-01-26 | Corvas International, Inc. | Nematode-extracted anticoagulant protein |
| US5945275A (en) * | 1994-10-18 | 1999-08-31 | Corvas International, Inc. | Nematode-extracted anticoagulant protein |
| EP0788546B9 (de) * | 1994-10-18 | 2007-06-13 | Dendreon Corporation | Aus nematoden extrahierte serinprotease-inhibitoren und die koagulation hemmende proteine |
| HK1080372A1 (zh) | 2002-05-01 | 2006-04-28 | Schering Aktiengesellschaft | 作为抗凝剂的新型组织因子目标抗体 |
| US7579000B2 (en) | 2002-05-01 | 2009-08-25 | Bayer Schering Pharma Ag | Tissue factor targeted antibodies as anticoagulants |
| RU2433829C2 (ru) | 2006-10-06 | 2011-11-20 | Асахи Касеи Фарма Корпорейшн | Средство для лечения и/или улучшения состояния при диссеминированном внутрисосудистом свертывании |
| CA2681294C (en) | 2007-03-23 | 2014-05-06 | Asahi Kasei Pharma Corporation | Method for producing high-purity soluble thrombomodulin |
| US20120165244A1 (en) * | 2008-10-30 | 2012-06-28 | Hua-Lin Wu | Methods for binding lewis y antigen |
| SG10201500036WA (en) | 2010-04-30 | 2015-02-27 | Asahi Kasei Pharma Corp | Highly-purified soluble thrombomodulin and method for producing same |
| DK2781221T3 (da) | 2011-11-15 | 2020-06-02 | Asahi Kasei Pharma Corp | Medicin til behandling og/eller forbedring af sepsis |
| PL2857037T3 (pl) | 2012-05-31 | 2019-12-31 | Kinki University | Środek do leczenia profilaktycznego i/lub terapeutycznego obwodowego bólu neuropatycznego wywoływanego przez środek przeciwnowotworowy |
| WO2020067389A1 (ja) | 2018-09-28 | 2020-04-02 | 旭化成ファーマ株式会社 | 抗悪性腫瘍剤による末梢神経障害の症状軽減及び/又は発症抑制のための医薬 |
| EP3871684B1 (de) | 2018-10-22 | 2024-06-26 | Asahi Kasei Pharma Corporation | Arzneimittel zur behandlung und/oder verbesserung der septikämie in zusammenhang mit einer gerinnungsstörung |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1987000050A1 (fr) * | 1985-06-28 | 1987-01-15 | Asahi Kasei Kogyo Kabushiki Kaisha | Nouvelle substance physiologiquement active limitant la coagulation du sang |
-
1987
- 1987-06-12 DK DK299087A patent/DK299087D0/da not_active Application Discontinuation
-
1988
- 1988-06-09 WO PCT/DK1988/000089 patent/WO1988009811A1/en not_active Ceased
- 1988-06-09 EP EP88905725A patent/EP0365568A1/de not_active Withdrawn
- 1988-06-09 JP JP63505229A patent/JPH03503757A/ja active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH08289796A (ja) * | 1987-01-08 | 1996-11-05 | Asahi Chem Ind Co Ltd | トロンビンによるプロテインcの活性化を促進するペプチド |
| WO1997037018A1 (fr) * | 1996-04-03 | 1997-10-09 | Asahi Kasei Kogyo Kabushiki Kaisha | Nouveau gene |
| JP2013535211A (ja) * | 2010-08-05 | 2013-09-12 | カウンシル オブ サイエンティフィック アンド インダストリアル リサーチ | 血栓溶解及び抗凝固特性を有するタンパク質融合構築物 |
Also Published As
| Publication number | Publication date |
|---|---|
| EP0365568A1 (de) | 1990-05-02 |
| DK299087D0 (da) | 1987-06-12 |
| WO1988009811A1 (en) | 1988-12-15 |
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