JPH0360801B2 - - Google Patents

Description

[Detailed description of the invention]

The present invention relates to a novel hair growth/hair growth promoting agent, which is safe and does not cause skin irritation. Conventionally, various compounds, extracts of crude drugs, etc. have been used as hair growth/promoting agents, but few have shown significant effects, and those that have some effect may cause dermatitis. However, as a result of various experimental studies, the present inventors have developed the present invention which does not have these drawbacks. The present invention is a hair growth treatment method characterized by containing at least one type of herbal medicine extract obtained by extracting the herbal medicine of Oriental chinensis or Xinyi with a water-soluble organic solvent or a water-containing water-soluble organic solvent containing 50% by weight or more of a water-soluble organic solvent. This relates to a hair growth promoting agent. As a method for obtaining the hair growth/hair growth promoting agent applied to the present invention, 100 g of the herbal medicine of Oriental chinensis or Xinyi,
For example, methanol, ethanol, propanol,
A primary alcohol such as butanol, or an organic solvent such as acetone, tetrahydrofuran, or dioxane alone, or 50% by weight of the above primary alcohol or acetone, tetrahydrofuran, or dioxane.
Digestion extraction is carried out three times for 2 hours each using 1 of the above-contained water-containing organic solvent. These extracted extracts are combined (total 3), filtered under suction, and concentrated to dryness under reduced pressure to remove the solvent to obtain a viscous crude drug extract. The obtained crude drug extract is used as it is, or is dissolved, dispersed and diluted with an appropriate solvent, and then incorporated into a base to obtain the hair growth/hair growth promoting agent of the present invention. Here, the content of one or more of the herbal medicine extracts of Oriental chinensis and Xinyi, which are contained as active ingredients in the hair growth/hair growth promoting agent according to the present invention, is 0.1 to 5.0% by weight, preferably 0.5 to 2.0% by weight. be. The hair growth/hair growth promoting agent containing one or more of the herbal extracts extracted from Laminaria japonica and Xinyi applied to the present invention can be used in the method for measuring the density of hair growth in mice shown in Table 1 below, that is, the test method. It has been shown to be more effective than other substances that are said to promote hair growth. This is because the components of the crude drug extract extracted from the above-mentioned crude drugs stimulate the hair roots, increase blood circulation around the hair roots, and improve metabolism. Similarly, the hair growth and hair growth promoting effects of the herbal medicine extracts of Chrysanthemum elegans and Xinyi extracted with various solvents are shown below.
Shown in 2. Brief explanation of the test method Using 7-week-old DDY mice, 7 groups were made with 10 mice in each group, and 0.3 g of the sample was applied to a 2.0 cm x 2.0 cm area on the backs of which the hair was removed. On the 9th and 13th day after applying the product daily, the density of hair growth in the relevant area was measured as the degree of whiteness increase using a colorimeter, and compared with the conventional comparison substance (vitamin E) and control (95% ethanol solution). compare.

【table】

[Table] The samples applied in Table 1 are A: 95% ethanol solution containing 2% by weight of vitamin E (comparative substance);
95% ethanol solution containing 2% by weight of crude drug extract obtained by 95% ethanol extraction, D is 95
% ethanol (control).

【table】

[Table] As shown in the results of the table, the fat-soluble extract fractions of Xinyi and Chingzi, water extraction (water-soluble organic solvent 50wt%
It can be seen that the fraction containing less than or equal to 10% contains no or almost no component that promotes the hair growth effect. Next, an example of a clinical trial is shown. Production Example 1 Chrysanthemum extract Herbal medicine extract Weighed 100g of Chrysanthemum vulgaris purchased from the Osaka Herbal Medicine Market, turned it into a coarse powder of about 20 mesh using a grinder, and digested it in 1 part methanol for 2 hours. , and then filtered the extract. This extraction operation is done in 3
The extraction filtrates obtained from repeated extractions were combined and the solvent was distilled off under reduced pressure at 40°C to obtain 10.5 g of a viscous dark brown crude drug extract with a characteristic odor. Production example 2 Shinyi crude drug extract Weighed 100g of Shinyi purchased from the Osaka crude drug market, cut it into pieces about 5 mm wide, and cut it into pieces at 70V/1.
Digestion was performed in V% methanol for 2 hours, after which the extract was filtered. This extraction operation was repeated three times and the obtained extraction filtrates were combined and the solvent was distilled off at 60° C. under reduced pressure to obtain 15.1 g of a viscous dark brown crude drug extract with a characteristic odor. Production Example 3 Mixed Extraction of Herbal Medicine Extract of Prunus elegans and Xinyi Weighed 50g each of Prunus elegans and Xinyi used in Production Examples 1 and 2, powdered and cut into pieces in the same manner as in Production Examples 1 and 2, and then combined. This was digested with 1 acetone for 2 hours, and then the extract was filtered. This extraction operation was repeated three times, and the obtained extraction filtrates were combined and the acetone was distilled off at 40° C. under reduced pressure to obtain 12.2 g of a viscous dark brown crude drug extract with a characteristic odor. Example 1 A 95% ethanol solution containing 2% by weight of the herbal medicine extract prepared in Production Example 1 was used as a sample. Samples were administered three times a day (1
When 3 to 5 g of hair was applied at a time, short downy hairs appeared in the bald area after about 3 months, and after 6 months, the bald hair turned into terminal hair and the bald area disappeared. Example 2 As a sample, a 95% ethanol solution containing 2% by weight of a 1:1 mixture of the Chingophyllum medicinal herb extract of Production Example 1 and the Xin Yi crude drug extract of Production Example 2 was used. When the sample was applied three times a day (3 to 5 g at a time) to a male (age 36) patient with alopecia areata who had 2.5 cm of hair loss on the top and sides of the head, 3 months later, the hair loss on the top of the head decreased. The patient developed downy hair at the hair removal site on the side of his head, and after 6 months, terminal hair developed, but he was not completely cured. In both Examples 1 and 2, no skin damage was observed after continuous application for 6 months. Next, prescription examples will be shown. The blending ratio is in parts by weight. Example 1 Hair tonic The herbal extract obtained in Production Example 1 2.0 Menthol 0.2 95% ethanol 60.0 Purified water 37.8 Manufacturing method Dissolve the herbal extract and menthol in 95% ethanol, then add purified water. In addition, manufacture. Example 2 Hair Cream Xin Yi crude drug extract obtained in Production Example 2 1.0 Vaseline 7.0 Beeswax 8.0 Crystol 37.0 Emulsifier 5.5 Purified water 41.5 Manufacturing method Mix Xin Yi crude drug extract, petrolatum, beeswax, Crystol, and emulsifier. Melt at 80℃ and then
Gradually add purified water at 80℃ to the oil phase to make it creamy. Example 3 Ointment Herbal medicine extract obtained in Production Example 1 0.5 Herbal medicine extract obtained in Production Example 2 1.0 Isopropyl myristate 10.0 Setanol 2.0 Paraffin wax 6.0 Microcrystalline wax 10.0 Emulsifier 11.0 Purified water 59.5 Production method Melt the herbal medicine extract, isopropyl myristate, cetanol, paraffin wax, microcrystalline wax, and emulsifier by heating.
Separately, add purified water heated to 70℃ or higher and stir.
Cool with stirring to 40°C.

Claims (1)

[Claims] 1. Hair growth and hair growth characterized by containing at least one type of herbal medicine extract obtained by extracting the herbal medicine of Oriental lily or Xinyi with a water-soluble organic solvent or a water-containing water-soluble organic solvent containing 50% by weight or more of a water-soluble organic solvent. Promotion fee.