JPH0363208A - Cosmetic - Google Patents

Abstract

PURPOSE:To obtain an ascorbic acid phosphate ester-containing cosmetic providing excellent antiseptic and mildewproofing effects without damaging stability, etc., of the ester by blending the ascorbic acid phosphoric ester-containing cosmetic with phenoxyethanol as an antiseptic mildewproofing agent. CONSTITUTION:A cosmetic which contains preferably >=0.01wt.% ascorbic acid phosphoric ester being more stable than ascorbic acids which have been used as an active ingredient of cosmetic for fair skin and beauty and having beautifying effects but requires alkalinity of cosmetic because of instability of aqueous solution in a range of pH of neutrality to acidity, further contains preferably >=1wt.% water and has pH>=7.0, especially pH7.0-9.0 is blended with preferably 0.01-2.0wt.% phenoxyethanol as an antiseptic mildewproofing agent to give the above-mentioned cosmetic which has excellent stability in a range of alkalinity and provides antiseptic and mildewproofing effects and high stability to the skin without damaging solubility and stability of the ester and touch of cosmetic in use.

Description

DETAILED DESCRIPTION OF THE INVENTION [Industrial Field of Application] The present invention relates to a cosmetic composition in which the ascorbic acid phosphate ester contained therein is stable and has excellent antiseptic and antifungal effects.

[Prior art and its problems] Ascorbic acid and its fatty acid esters have been known to have a whitening effect and have been used as active ingredients in whitening cosmetics. However, these compounds have problems in that they are unstable and do not have sufficient whitening effects.

Therefore, ascorbic acid phosphate ester has been developed which is more stable and has excellent whitening effect and can be preferably used as a cosmetic ingredient (Japanese Patent Publication No. 44-31237, Japanese Patent Application Laid-open No. 62-129212, Japanese Patent Application Laid-open No. 62-129212, Japanese Patent Application Laid-Open No. 62-129212, -2985
No. 08, JP-A No. 63-243014, etc.). However, this ascorbic acid phosphate ester is also unstable when the pH of the aqueous solution is in the neutral to acidic range, and cosmetics containing it have to be alkaline.

On the other hand, as a preservative and antifungal agent for cosmetics, it is required to be stable in cosmetics, not have a negative effect on other ingredients, have high skin groove safety, and be sufficiently effective with a small amount. .

However, among the preservatives and fungicides commonly used in cosmetics, benzoic acid, dehydroacetic acid, salicylic acid, and their salts are effective in the acidic range and are not effective in the alkaline range. It cannot be applied to the above ascorbic acid phosphate-containing cosmetics. In addition, roseoxybenzoic acid esters have excellent antiseptic and antifungal effects and are the most frequently used ones, but they are susceptible to hydrolysis in alkaline regions (J, Soc.

Cosmet, Chem, 25.495-506
(1974)), and in systems containing a large amount of polar oil, etc., there are problems such as dissolving in the polar oil and lowering the concentration in the aqueous system, resulting in insufficient effectiveness. Furthermore, when glycols such as ethanol and propylene glycol are used as preservatives, there are problems such as precipitation of ascorbic acid phosphate ester and impairing the feel of the product when used in an amount sufficient to achieve a sufficient effect.

[Means for Solving the Problems] Under these circumstances, the present inventors have developed a method that has high skin safety and
As a result of intensive research into a preservative and fungicide that is stable in an alkaline region and has a high preservative and antifungal effect, and does not have a negative effect on the solubility and stability of ascorbic acid phosphate ester or the feel of cosmetics, we found that phenoxyethanol is a highly effective preservative and antifungal agent. The present invention was completed based on the discovery that the above conditions were satisfied.

That is, the present invention provides a cosmetic material containing ascorbic acid phosphate ester or a salt thereof and phenoxyethanol.

In the present invention, examples of salts of ascorbic acid phosphate include magnesium salts, sodium salts, potassium salts, calcium salts, triethanolamine salts, etc., and particularly preferred ones include L-ascorbic acid-2-
Examples include magnesium phosphate ester salts. The content of ascorbic acid phosphate or its salt in the cosmetic of the present invention is not particularly limited, but is preferably 0.01% by weight or more.

The content of phenoxyethanol in the cosmetics of the present invention is not particularly limited, but from the viewpoint of skin safety and antiseptic and antifungal effects, the content is 0. A range of 1 to 2.0% by weight of O is preferred.

The dosage form of the cosmetic of the present invention is not particularly limited, and examples thereof include various cosmetic dosage forms such as liquid, milky lotion, cream, etc., skin cosmetics, makeup cosmetics, hair cosmetics, packs, etc. Cosmetics containing water, particularly those containing 1% by weight or more of water, are preferred. In addition, the pH of cosmetics is 7.
．． It is preferably 0 or more, particularly 7.0 to 9.0.

In addition, the cosmetics of the present invention further contain ingredients used in ordinary cosmetics, such as oils, surfactants, water-soluble polymers, pigments, fragrances, ultraviolet absorbers, antioxidants, alcohols, and skin-beautifying ingredients. Can be blended. Incidentally, if necessary, a conventionally used preservative and fungicide may be used in combination without impairing the effects of the present invention.

[Examples] Hereinafter, the present invention will be described in more detail with reference to Examples, but the present invention is not limited thereto.

Example 1 and Comparative Examples 1 to 5 Cream (pH approximately 8.5) Creams having the formulations shown in Table 1 were prepared according to conventional methods, and tested for antiseptic effect and stability over time as described below.

(Preservation test) Each of the pre-cultured test bacteria (mold: 1 strain, yeast: 3 strains, bacteria = 3 strains) was prepared in Example 1 at a concentration of 10'cells/g.
The creams of Comparative Examples 1 to 5 were inoculated, and the number of viable bacteria was checked over time. Those that met all of the following criteria were rated 0, and those that did not meet at least one were rated x.

Mold: The number of viable bacteria after 4 weeks is less than 10'cells/g Yeast: The number of viable bacteria after 4 weeks is less than IO'cells/g Bacteria = The number of viable bacteria after 2 weeks is less than 10'calls/g (over time) Stability test) The creams of Example 1 and Comparative Examples 1 to 5 were left in a constant temperature bath at 40°C for one month and then visually observed. No change was marked as ○, and changes such as crystal precipitation were marked as ×. did.

These results are shown in Table 1.

(Margins below) Table 1 Example 2 Emulsion (pH approx. 82) (Ingredients) (Weight %) (1
) Squalane 30 (2) Jojobaura 20 (3) Dimethylpolysiloxane (1oocs) 0.5 (4)
Setanol 0.5 (5)
Behenyl alcohol 05 (6) Glyceryl monostearate 1.0 (7) Polyethylene glycol monostearate (40E, 0.) 0
．． 5(8) Vitamin E acetate 0.
05 (9) L-ascorbic acid-2-phosphate magnesium salt 30 (10) Sodium citrate 1.0 (11) Xanthan gum 0.2 (12) Elastin hydrolyzate 0.1 (1303-butylene glycol 90 <14 ) Phenoxyethanol 0.3 (15) Kisei Ice
A milky lotion was prepared according to a conventional method using the remaining amounts of each of the above components, and the preservative effect and stability over time were evaluated in the same manner as in Example 1, and both results were satisfactory.

Example 3 Cosmetics (pH approx. 8.3) (Ingredients) (Weight %) (
1) Jojoba oil 01(2)
Polyoxyethylene hydrogenated castor oil (60E, 0.) 1
．． 0(3) Hydrogenated soybean phospholipid 0.
1 (4) S-Riki Roll 507 (manufactured by Van Dyke) O2
(5) L-ascorbic acid-2-phosphate magnesium salt (6) Ginseng extract (7) Xanthan gum (8) Quince extract (9) Potassium dihydrogen phosphate (10) Disodium hydrogen phosphate (11) Hydroxylation Sodium (120,3-butylene glycol (13) Glycerin 5 1 O02 20 mouths 0.01 5 0.04 5.0 0 (14) Phenoxyethanol 05 (
15) Remaining amount of water made from pure water A cosmetic lotion was manufactured according to a conventional method using each of the above ingredients, and Example 1
When the preservative effect and stability over time were evaluated in the same manner as above, both were found to be satisfactory.

Example 4 Lotion CpH approx. 80) (Ingredients) (Weight%) (
2) Sorbitan sesquioleate 0.05 (
4) 2-Ethylhexanoic acid triglyceride (5) S-Ryki Roll 507 (manufactured by Vandyke) 4 1 (7) Lactic acid (8) Sodium lactate 0.01 0.2 (9) 2-Amino-2-methyl-13 -Propanediol 025 (lO) Hamamelis extract 0.1
(11) Sorbitol 0.1 (
12) Ethanol 5.0 (
13) Glycerin 5.0 (
14) Phenoxyethanol 0.3 (
15) Purified water Remaining amount Using each of the above ingredients, a lotion was manufactured according to a conventional method, and Example 1
When the preservative effect and stability over time were evaluated in the same manner as above, both were found to be satisfactory.

[Effect of the invention] As described above, by using phenoxyethanol as a preservative and antifungal agent in cosmetic rice containing ascorbic acid phosphate, a cosmetic product in which the ascorbic acid phosphate ester is stable and has an excellent preservative and antifungal effect can be obtained. is provided.

that's all

Claims (1)

[Claims] (1) A cosmetic containing ascorbic acid phosphate or a salt thereof and phenoxyethanol.