JPH0364153B2 - - Google Patents

Info

Publication number: JPH0364153B2
Authority: JP; Japan
Prior art keywords: lipopolysaccharide; tumor; insoluble carrier; fiber; gram
Prior art date: 1982-10-04
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

JP57173321A

Other languages

English (en)

Japanese (ja)

Other versions

JPS5964053A (ja

Inventor

Masatomo Kodama

Yutaka Katayama

Tooru Tani

Kazuo Teramoto

Mutsuo Murakami

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Toray Industries Inc

Original Assignee

Toray Industries Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1982-10-04

Filing date

1982-10-04

Publication date

1991-10-04

1982-10-04 Application filed by Toray Industries Inc filed Critical Toray Industries Inc

1982-10-04 Priority to JP57173321A priority Critical patent/JPS5964053A/ja

1983-10-03 Priority to CA000438186A priority patent/CA1204667A/fr

1983-10-04 Priority to AT83109905T priority patent/ATE25337T1/de

1983-10-04 Priority to DE8383109905T priority patent/DE3369646D1/de

1983-10-04 Priority to EP83109905A priority patent/EP0107119B1/fr

1984-04-11 Publication of JPS5964053A publication Critical patent/JPS5964053A/ja

1989-08-30 Priority to US07/401,502 priority patent/US5171738A/en

1991-10-04 Publication of JPH0364153B2 publication Critical patent/JPH0364153B2/ja

Status Granted legal-status Critical Current

Links

239000002158 endotoxin Substances 0.000 claims description 28
229920006008 lipopolysaccharide Polymers 0.000 claims description 27
239000003795 chemical substances by application Substances 0.000 claims description 14
239000008280 blood Substances 0.000 claims description 11
210000004369 blood Anatomy 0.000 claims description 11
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 7
125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 7
125000000467 secondary amino group Chemical group [H]N([*:1])[*:2] 0.000 claims description 7
241000894006 Bacteria Species 0.000 claims description 6
210000002421 cell wall Anatomy 0.000 claims description 6
238000004519 manufacturing process Methods 0.000 claims description 3
230000001580 bacterial effect Effects 0.000 claims 1
239000000835 fiber Substances 0.000 description 19
206010028980 Neoplasm Diseases 0.000 description 17
238000000034 method Methods 0.000 description 16
241001465754 Metazoa Species 0.000 description 8
241000699670 Mus sp. Species 0.000 description 6
QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 6
239000000203 mixture Substances 0.000 description 6
239000000243 solution Substances 0.000 description 6
201000011510 cancer Diseases 0.000 description 5
-1 polyethylene terephthalate Polymers 0.000 description 5
LMDZBCPBFSXMTL-UHFFFAOYSA-N 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide Chemical group CCN=C=NCCCN(C)C LMDZBCPBFSXMTL-UHFFFAOYSA-N 0.000 description 4
239000004793 Polystyrene Substances 0.000 description 4
230000000259 anti-tumor effect Effects 0.000 description 4
LQNUZADURLCDLV-UHFFFAOYSA-N nitrobenzene Chemical compound [O-][N+](=O)C1=CC=CC=C1 LQNUZADURLCDLV-UHFFFAOYSA-N 0.000 description 4
238000010647 peptide synthesis reaction Methods 0.000 description 4
229920002223 polystyrene Polymers 0.000 description 4
102000004169 proteins and genes Human genes 0.000 description 4
108090000623 proteins and genes Proteins 0.000 description 4
239000000126 substance Substances 0.000 description 4
238000005406 washing Methods 0.000 description 4
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
NHBKXEKEPDILRR-UHFFFAOYSA-N 2,3-bis(butanoylsulfanyl)propyl butanoate Chemical compound CCCC(=O)OCC(SC(=O)CCC)CSC(=O)CCC NHBKXEKEPDILRR-UHFFFAOYSA-N 0.000 description 3
OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
125000003277 amino group Chemical group 0.000 description 3
210000004027 cell Anatomy 0.000 description 3
229920001577 copolymer Polymers 0.000 description 3
238000000605 extraction Methods 0.000 description 3
238000011081 inoculation Methods 0.000 description 3
230000001665 lethal effect Effects 0.000 description 3
239000002504 physiological saline solution Substances 0.000 description 3
SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 description 2
NIXOWILDQLNWCW-UHFFFAOYSA-N 2-Propenoic acid Natural products OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 2
QOSSAOTZNIDXMA-UHFFFAOYSA-N Dicylcohexylcarbodiimide Chemical compound C1CCCCC1N=C=NC1CCCCC1 QOSSAOTZNIDXMA-UHFFFAOYSA-N 0.000 description 2
241000588724 Escherichia coli Species 0.000 description 2
VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
239000004743 Polypropylene Substances 0.000 description 2
PPBRXRYQALVLMV-UHFFFAOYSA-N Styrene Natural products C=CC1=CC=CC=C1 PPBRXRYQALVLMV-UHFFFAOYSA-N 0.000 description 2
206010054094 Tumour necrosis Diseases 0.000 description 2
244000052616 bacterial pathogen Species 0.000 description 2
229920002678 cellulose Polymers 0.000 description 2
239000001913 cellulose Substances 0.000 description 2
238000006243 chemical reaction Methods 0.000 description 2
238000011049 filling Methods 0.000 description 2
150000004676 glycans Chemical class 0.000 description 2
231100000518 lethal Toxicity 0.000 description 2
KSSNXJHPEFVKHY-UHFFFAOYSA-N phenol;hydrate Chemical compound O.OC1=CC=CC=C1 KSSNXJHPEFVKHY-UHFFFAOYSA-N 0.000 description 2
229920001155 polypropylene Polymers 0.000 description 2
229920001282 polysaccharide Polymers 0.000 description 2
239000005017 polysaccharide Substances 0.000 description 2
238000002791 soaking Methods 0.000 description 2
231100000419 toxicity Toxicity 0.000 description 2
230000001988 toxicity Effects 0.000 description 2
YNJBWRMUSHSURL-UHFFFAOYSA-N trichloroacetic acid Chemical compound OC(=O)C(Cl)(Cl)Cl YNJBWRMUSHSURL-UHFFFAOYSA-N 0.000 description 2
OTLLEIBWKHEHGU-UHFFFAOYSA-N 2-[5-[[5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy]-3,4-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-3,5-dihydroxy-4-phosphonooxyhexanedioic acid Chemical compound C1=NC=2C(N)=NC=NC=2N1C(C(C1O)O)OC1COC1C(CO)OC(OC(C(O)C(OP(O)(O)=O)C(O)C(O)=O)C(O)=O)C(O)C1O OTLLEIBWKHEHGU-UHFFFAOYSA-N 0.000 description 1
TXNSZCSYBXHETP-UHFFFAOYSA-N 2-chloro-n-(hydroxymethyl)acetamide Chemical compound OCNC(=O)CCl TXNSZCSYBXHETP-UHFFFAOYSA-N 0.000 description 1
MWOOKDULMBMMPN-UHFFFAOYSA-N 3-(2-ethyl-1,2-oxazol-2-ium-5-yl)benzenesulfonate Chemical compound O1[N+](CC)=CC=C1C1=CC=CC(S([O-])(=O)=O)=C1 MWOOKDULMBMMPN-UHFFFAOYSA-N 0.000 description 1
241000588832 Bordetella pertussis Species 0.000 description 1
241000589567 Brucella abortus Species 0.000 description 1
PIICEJLVQHRZGT-UHFFFAOYSA-N Ethylenediamine Chemical compound NCCN PIICEJLVQHRZGT-UHFFFAOYSA-N 0.000 description 1
201000008808 Fibrosarcoma Diseases 0.000 description 1
241000588747 Klebsiella pneumoniae Species 0.000 description 1
PPQNQXQZIWHJRB-UHFFFAOYSA-N Methylcholanthrene Chemical compound C1=CC=C2C3=CC4=CC=C(C)C(CC5)=C4C5=C3C=CC2=C1 PPQNQXQZIWHJRB-UHFFFAOYSA-N 0.000 description 1
241000699666 Mus <mouse, genus> Species 0.000 description 1
206010028851 Necrosis Diseases 0.000 description 1
241000588652 Neisseria gonorrhoeae Species 0.000 description 1
229920002292 Nylon 6 Polymers 0.000 description 1
229920002302 Nylon 6,6 Polymers 0.000 description 1
229930040373 Paraformaldehyde Natural products 0.000 description 1
ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 1
241000588767 Proteus vulgaris Species 0.000 description 1
241000589517 Pseudomonas aeruginosa Species 0.000 description 1
206010037660 Pyrexia Diseases 0.000 description 1
241000293871 Salmonella enterica subsp. enterica serovar Typhi Species 0.000 description 1
241000607715 Serratia marcescens Species 0.000 description 1
241000607764 Shigella dysenteriae Species 0.000 description 1
108060008682 Tumor Necrosis Factor Proteins 0.000 description 1
241000607626 Vibrio cholerae Species 0.000 description 1
241000607447 Yersinia enterocolitica Species 0.000 description 1
238000002835 absorbance Methods 0.000 description 1
239000002253 acid Substances 0.000 description 1
239000003513 alkali Substances 0.000 description 1
239000007864 aqueous solution Substances 0.000 description 1
230000000740 bleeding effect Effects 0.000 description 1
210000004204 blood vessel Anatomy 0.000 description 1
238000009835 boiling Methods 0.000 description 1
229940056450 brucella abortus Drugs 0.000 description 1
125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 description 1
239000002131 composite material Substances 0.000 description 1
238000009833 condensation Methods 0.000 description 1
230000005494 condensation Effects 0.000 description 1
230000034994 death Effects 0.000 description 1
230000008260 defense mechanism Effects 0.000 description 1
230000008034 disappearance Effects 0.000 description 1
239000003814 drug Substances 0.000 description 1
229940079593 drug Drugs 0.000 description 1
230000000694 effects Effects 0.000 description 1
239000002095 exotoxin Substances 0.000 description 1
231100000776 exotoxin Toxicity 0.000 description 1
238000002474 experimental method Methods 0.000 description 1
230000009931 harmful effect Effects 0.000 description 1
239000012510 hollow fiber Substances 0.000 description 1
239000005457 ice water Substances 0.000 description 1
150000003949 imides Chemical class 0.000 description 1
231100000636 lethal dose Toxicity 0.000 description 1
150000002632 lipids Chemical class 0.000 description 1
238000000691 measurement method Methods 0.000 description 1
210000004379 membrane Anatomy 0.000 description 1
239000012528 membrane Substances 0.000 description 1
238000002156 mixing Methods 0.000 description 1
125000006203 morpholinoethyl group Chemical group [H]C([H])(*)C([H])([H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H] 0.000 description 1
239000012452 mother liquor Substances 0.000 description 1
230000017074 necrotic cell death Effects 0.000 description 1
230000001338 necrotic effect Effects 0.000 description 1
229920002866 paraformaldehyde Polymers 0.000 description 1
239000002245 particle Substances 0.000 description 1
210000003200 peritoneal cavity Anatomy 0.000 description 1
239000008363 phosphate buffer Substances 0.000 description 1
229920000139 polyethylene terephthalate Polymers 0.000 description 1
239000005020 polyethylene terephthalate Substances 0.000 description 1
229940007042 proteus vulgaris Drugs 0.000 description 1
238000004445 quantitative analysis Methods 0.000 description 1
230000009257 reactivity Effects 0.000 description 1
229940007046 shigella dysenteriae Drugs 0.000 description 1
125000001424 substituent group Chemical group 0.000 description 1
210000004881 tumor cell Anatomy 0.000 description 1
102000003390 tumor necrosis factor Human genes 0.000 description 1
229940118696 vibrio cholerae Drugs 0.000 description 1
238000010792 warming Methods 0.000 description 1
229940098232 yersinia enterocolitica Drugs 0.000 description 1

Landscapes

External Artificial Organs (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)

JP57173321A 1982-10-04 1982-10-04 血液処理剤およびその製造法 Granted JPS5964053A (ja)

Priority Applications (6)

Application Number	Priority Date	Filing Date	Title
JP57173321A JPS5964053A (ja)	1982-10-04	1982-10-04	血液処理剤およびその製造法
CA000438186A CA1204667A (fr)	1982-10-04	1983-10-03	Materiau pour le traitement du sang
AT83109905T ATE25337T1 (de)	1982-10-04	1983-10-04	Mittel zur blutbehandlung.
DE8383109905T DE3369646D1 (en)	1982-10-04	1983-10-04	Blood-treating material
EP83109905A EP0107119B1 (fr)	1982-10-04	1983-10-04	Matériau pour le traitement du sang
US07/401,502 US5171738A (en)	1982-10-04	1989-08-30	Method of treating malignant tumors

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
JP57173321A JPS5964053A (ja)	1982-10-04	1982-10-04	血液処理剤およびその製造法

Publications (2)

Publication Number	Publication Date
JPS5964053A JPS5964053A (ja)	1984-04-11
JPH0364153B2 true JPH0364153B2 (fr)	1991-10-04

Family

ID=15958262

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
JP57173321A Granted JPS5964053A (ja)	1982-10-04	1982-10-04	血液処理剤およびその製造法

Country Status (1)

Country	Link
JP (1)	JPS5964053A (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP2009051846A (ja) *	1995-06-07	2009-03-12	Cerus Corp	血液製剤からソラレンを除去するための方法およびデバイス
JP4762584B2 (ja) *	2005-03-23	2011-08-31	本田技研工業株式会社	車両用シート装置

1982
- 1982-10-04 JP JP57173321A patent/JPS5964053A/ja active Granted

Also Published As

Publication number	Publication date
JPS5964053A (ja)	1984-04-11

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