JPH0472808B2 - - Google Patents

Info

Publication number: JPH0472808B2
Authority: JP; Japan
Prior art keywords: lipopolysaccharide; serum; antitumor; fiber; immobilized
Prior art date: 1983-10-24
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

JP58197590A

Other languages

English (en)

Japanese (ja)

Other versions

JPS6089425A (ja

Inventor

Masatomo Kodama

Yutaka Katayama

Masahiro Horisawa

Tomoyuki Mizukuro

Tooru Tani

Kazuo Teramoto

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Toray Industries Inc

Original Assignee

Toray Industries Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1983-10-24

Filing date

1983-10-24

Publication date

1992-11-19

1983-10-24 Application filed by Toray Industries Inc filed Critical Toray Industries Inc

1983-10-24 Priority to JP58197590A priority Critical patent/JPS6089425A/ja

1985-05-20 Publication of JPS6089425A publication Critical patent/JPS6089425A/ja

1992-11-19 Publication of JPH0472808B2 publication Critical patent/JPH0472808B2/ja

Status Granted legal-status Critical Current

Links

239000002158 endotoxin Substances 0.000 claims description 39
229920006008 lipopolysaccharide Polymers 0.000 claims description 38
210000002966 serum Anatomy 0.000 claims description 34
230000000259 anti-tumor effect Effects 0.000 claims description 15
241000894006 Bacteria Species 0.000 claims description 6
210000002421 cell wall Anatomy 0.000 claims description 5
239000000835 fiber Substances 0.000 description 19
206010028980 Neoplasm Diseases 0.000 description 15
239000000843 powder Substances 0.000 description 9
QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 8
238000000034 method Methods 0.000 description 8
241000699670 Mus sp. Species 0.000 description 7
239000004793 Polystyrene Substances 0.000 description 7
201000011510 cancer Diseases 0.000 description 7
229920002223 polystyrene Polymers 0.000 description 7
239000000243 solution Substances 0.000 description 7
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 7
HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 6
230000000694 effects Effects 0.000 description 6
239000000203 mixture Substances 0.000 description 6
239000002504 physiological saline solution Substances 0.000 description 6
238000005406 washing Methods 0.000 description 6
-1 Polypropylene Polymers 0.000 description 5
238000000605 extraction Methods 0.000 description 5
LMDZBCPBFSXMTL-UHFFFAOYSA-N 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide Chemical compound CCN=C=NCCCN(C)C LMDZBCPBFSXMTL-UHFFFAOYSA-N 0.000 description 4
VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 4
238000006243 chemical reaction Methods 0.000 description 4
230000000295 complement effect Effects 0.000 description 4
LQNUZADURLCDLV-UHFFFAOYSA-N nitrobenzene Chemical compound [O-][N+](=O)C1=CC=CC=C1 LQNUZADURLCDLV-UHFFFAOYSA-N 0.000 description 4
108090000623 proteins and genes Proteins 0.000 description 4
102000004169 proteins and genes Human genes 0.000 description 4
239000000126 substance Substances 0.000 description 4
OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
230000004913 activation Effects 0.000 description 3
125000003277 amino group Chemical group 0.000 description 3
230000000740 bleeding effect Effects 0.000 description 3
239000003814 drug Substances 0.000 description 3
229940079593 drug Drugs 0.000 description 3
KSSNXJHPEFVKHY-UHFFFAOYSA-N phenol;hydrate Chemical compound O.OC1=CC=CC=C1 KSSNXJHPEFVKHY-UHFFFAOYSA-N 0.000 description 3
NHBKXEKEPDILRR-UHFFFAOYSA-N 2,3-bis(butanoylsulfanyl)propyl butanoate Chemical compound CCCC(=O)OCC(SC(=O)CCC)CSC(=O)CCC NHBKXEKEPDILRR-UHFFFAOYSA-N 0.000 description 2
102000000989 Complement System Proteins Human genes 0.000 description 2
108010069112 Complement System Proteins Proteins 0.000 description 2
241000588722 Escherichia Species 0.000 description 2
PIICEJLVQHRZGT-UHFFFAOYSA-N Ethylenediamine Chemical compound NCCN PIICEJLVQHRZGT-UHFFFAOYSA-N 0.000 description 2
LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical compound CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 description 2
ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 2
239000004743 Polypropylene Substances 0.000 description 2
238000002835 absorbance Methods 0.000 description 2
239000007864 aqueous solution Substances 0.000 description 2
244000052616 bacterial pathogen Species 0.000 description 2
238000009835 boiling Methods 0.000 description 2
210000004027 cell Anatomy 0.000 description 2
239000012141 concentrate Substances 0.000 description 2
229920001577 copolymer Polymers 0.000 description 2
230000008034 disappearance Effects 0.000 description 2
150000004676 glycans Chemical class 0.000 description 2
238000011081 inoculation Methods 0.000 description 2
230000001665 lethal effect Effects 0.000 description 2
150000002632 lipids Chemical class 0.000 description 2
239000012528 membrane Substances 0.000 description 2
239000011259 mixed solution Substances 0.000 description 2
238000002156 mixing Methods 0.000 description 2
239000012452 mother liquor Substances 0.000 description 2
230000017074 necrotic cell death Effects 0.000 description 2
239000008363 phosphate buffer Substances 0.000 description 2
229920001155 polypropylene Polymers 0.000 description 2
229920001282 polysaccharide Polymers 0.000 description 2
239000005017 polysaccharide Substances 0.000 description 2
238000002791 soaking Methods 0.000 description 2
YNJBWRMUSHSURL-UHFFFAOYSA-N trichloroacetic acid Chemical compound OC(=O)C(Cl)(Cl)Cl YNJBWRMUSHSURL-UHFFFAOYSA-N 0.000 description 2
210000003462 vein Anatomy 0.000 description 2
238000010792 warming Methods 0.000 description 2
TXNSZCSYBXHETP-UHFFFAOYSA-N 2-chloro-n-(hydroxymethyl)acetamide Chemical compound OCNC(=O)CCl TXNSZCSYBXHETP-UHFFFAOYSA-N 0.000 description 1
HRPVXLWXLXDGHG-UHFFFAOYSA-N Acrylamide Chemical compound NC(=O)C=C HRPVXLWXLXDGHG-UHFFFAOYSA-N 0.000 description 1
241000588832 Bordetella pertussis Species 0.000 description 1
241000700199 Cavia porcellus Species 0.000 description 1
208000035473 Communicable disease Diseases 0.000 description 1
241000588724 Escherichia coli Species 0.000 description 1
201000008808 Fibrosarcoma Diseases 0.000 description 1
241000282412 Homo Species 0.000 description 1
241000588747 Klebsiella pneumoniae Species 0.000 description 1
241000124008 Mammalia Species 0.000 description 1
PPQNQXQZIWHJRB-UHFFFAOYSA-N Methylcholanthrene Chemical compound C1=CC=C2C3=CC4=CC=C(C)C(CC5)=C4C5=C3C=CC2=C1 PPQNQXQZIWHJRB-UHFFFAOYSA-N 0.000 description 1
229930040373 Paraformaldehyde Natural products 0.000 description 1
241001494479 Pecora Species 0.000 description 1
239000002202 Polyethylene glycol Substances 0.000 description 1
241000588767 Proteus vulgaris Species 0.000 description 1
241000589517 Pseudomonas aeruginosa Species 0.000 description 1
206010037660 Pyrexia Diseases 0.000 description 1
241000293871 Salmonella enterica subsp. enterica serovar Typhi Species 0.000 description 1
241000607715 Serratia marcescens Species 0.000 description 1
241000607764 Shigella dysenteriae Species 0.000 description 1
PPBRXRYQALVLMV-UHFFFAOYSA-N Styrene Chemical compound C=CC1=CC=CC=C1 PPBRXRYQALVLMV-UHFFFAOYSA-N 0.000 description 1
241000607598 Vibrio Species 0.000 description 1
241000607447 Yersinia enterocolitica Species 0.000 description 1
239000002253 acid Substances 0.000 description 1
239000003513 alkali Substances 0.000 description 1
239000003242 anti bacterial agent Substances 0.000 description 1
229940088710 antibiotic agent Drugs 0.000 description 1
239000002246 antineoplastic agent Substances 0.000 description 1
229940041181 antineoplastic drug Drugs 0.000 description 1
239000011324 bead Substances 0.000 description 1
210000004369 blood Anatomy 0.000 description 1
239000008280 blood Substances 0.000 description 1
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 1
239000000969 carrier Substances 0.000 description 1
229920002678 cellulose Polymers 0.000 description 1
239000001913 cellulose Substances 0.000 description 1
238000005119 centrifugation Methods 0.000 description 1
230000008859 change Effects 0.000 description 1
239000003795 chemical substances by application Substances 0.000 description 1
239000002131 composite material Substances 0.000 description 1
230000034994 death Effects 0.000 description 1
210000003743 erythrocyte Anatomy 0.000 description 1
125000004185 ester group Chemical group 0.000 description 1
238000002474 experimental method Methods 0.000 description 1
125000000524 functional group Chemical group 0.000 description 1
125000005843 halogen group Chemical group 0.000 description 1
230000009931 harmful effect Effects 0.000 description 1
230000002008 hemorrhagic effect Effects 0.000 description 1
239000005457 ice water Substances 0.000 description 1
230000003100 immobilizing effect Effects 0.000 description 1
230000002779 inactivation Effects 0.000 description 1
230000003834 intracellular effect Effects 0.000 description 1
238000007918 intramuscular administration Methods 0.000 description 1
238000007912 intraperitoneal administration Methods 0.000 description 1
238000001990 intravenous administration Methods 0.000 description 1
IQPQWNKOIGAROB-UHFFFAOYSA-N isocyanate group Chemical group [N-]=C=O IQPQWNKOIGAROB-UHFFFAOYSA-N 0.000 description 1
231100000518 lethal Toxicity 0.000 description 1
231100000636 lethal dose Toxicity 0.000 description 1
239000000463 material Substances 0.000 description 1
238000000691 measurement method Methods 0.000 description 1
230000010534 mechanism of action Effects 0.000 description 1
125000000466 oxiranyl group Chemical group 0.000 description 1
229920002866 paraformaldehyde Polymers 0.000 description 1
238000010647 peptide synthesis reaction Methods 0.000 description 1
229920001223 polyethylene glycol Polymers 0.000 description 1
229920000642 polymer Polymers 0.000 description 1
238000002360 preparation method Methods 0.000 description 1
125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
229940007042 proteus vulgaris Drugs 0.000 description 1
238000004445 quantitative analysis Methods 0.000 description 1
238000011084 recovery Methods 0.000 description 1
230000009467 reduction Effects 0.000 description 1
125000000467 secondary amino group Chemical group [H]N([*:1])[*:2] 0.000 description 1
238000000926 separation method Methods 0.000 description 1
229940007046 shigella dysenteriae Drugs 0.000 description 1
150000003457 sulfones Chemical class 0.000 description 1
239000006228 supernatant Substances 0.000 description 1
230000008961 swelling Effects 0.000 description 1
231100000331 toxic Toxicity 0.000 description 1
230000002588 toxic effect Effects 0.000 description 1
231100000419 toxicity Toxicity 0.000 description 1
230000001988 toxicity Effects 0.000 description 1
239000003053 toxin Substances 0.000 description 1
231100000765 toxin Toxicity 0.000 description 1
210000004881 tumor cell Anatomy 0.000 description 1
229920002554 vinyl polymer Polymers 0.000 description 1
229940098232 yersinia enterocolitica Drugs 0.000 description 1

Landscapes

Medicines Containing Material From Animals Or Micro-Organisms (AREA)

JP58197590A 1983-10-24 1983-10-24 抗腫瘍性血清または血漿 Granted JPS6089425A (ja)

Priority Applications (1)

Application Number	Priority Date	Filing Date	Title
JP58197590A JPS6089425A (ja)	1983-10-24	1983-10-24	抗腫瘍性血清または血漿

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
JP58197590A JPS6089425A (ja)	1983-10-24	1983-10-24	抗腫瘍性血清または血漿

Publications (2)

Publication Number	Publication Date
JPS6089425A JPS6089425A (ja)	1985-05-20
JPH0472808B2 true JPH0472808B2 (fr)	1992-11-19

Family

ID=16377014

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
JP58197590A Granted JPS6089425A (ja)	1983-10-24	1983-10-24	抗腫瘍性血清または血漿

Country Status (1)

Country	Link
JP (1)	JPS6089425A (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP2009051846A (ja) *	1995-06-07	2009-03-12	Cerus Corp	血液製剤からソラレンを除去するための方法およびデバイス

1983
- 1983-10-24 JP JP58197590A patent/JPS6089425A/ja active Granted

Also Published As

Publication number	Publication date
JPS6089425A (ja)	1985-05-20

Publication	Publication Date	Title
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JPS59211458A (ja)	1984-11-30	血液処理剤
WO1990015610A1 (fr)	1990-12-27	Composition servant a eliminer ou a rendre inactifs des constituants nocifs dans le sang ou d'autres fluides corporels extra-cellulaires
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