JPH04145016A - シメチジン含有固形医薬組成物 - Google Patents
シメチジン含有固形医薬組成物Info
- Publication number
- JPH04145016A JPH04145016A JP2400217A JP40021790A JPH04145016A JP H04145016 A JPH04145016 A JP H04145016A JP 2400217 A JP2400217 A JP 2400217A JP 40021790 A JP40021790 A JP 40021790A JP H04145016 A JPH04145016 A JP H04145016A
- Authority
- JP
- Japan
- Prior art keywords
- cimetidine
- dosage form
- release
- tablet
- coated
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 229960001380 cimetidine Drugs 0.000 title claims abstract description 109
- 239000000203 mixture Substances 0.000 title claims abstract description 46
- CCGSUNCLSOWKJO-UHFFFAOYSA-N cimetidine Chemical compound N#CNC(=N/C)\NCCSCC1=NC=N[C]1C CCGSUNCLSOWKJO-UHFFFAOYSA-N 0.000 title claims abstract 19
- 229940126589 solid medicine Drugs 0.000 title 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims abstract description 34
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims abstract description 30
- 239000000872 buffer Substances 0.000 claims abstract description 20
- 239000000126 substance Substances 0.000 claims abstract description 19
- 239000002253 acid Substances 0.000 claims abstract description 15
- 239000006172 buffering agent Substances 0.000 claims abstract description 12
- 239000007864 aqueous solution Substances 0.000 claims abstract description 10
- 229910000402 monopotassium phosphate Inorganic materials 0.000 claims abstract description 10
- 235000019796 monopotassium phosphate Nutrition 0.000 claims abstract description 10
- GNSKLFRGEWLPPA-UHFFFAOYSA-M potassium dihydrogen phosphate Chemical compound [K+].OP(O)([O-])=O GNSKLFRGEWLPPA-UHFFFAOYSA-M 0.000 claims abstract description 10
- LWIHDJKSTIGBAC-UHFFFAOYSA-K potassium phosphate Substances [K+].[K+].[K+].[O-]P([O-])([O-])=O LWIHDJKSTIGBAC-UHFFFAOYSA-K 0.000 claims abstract description 10
- 210000000936 intestine Anatomy 0.000 claims abstract description 6
- 229920002845 Poly(methacrylic acid) Polymers 0.000 claims abstract description 5
- 229920001577 copolymer Polymers 0.000 claims abstract description 5
- 229920003132 hydroxypropyl methylcellulose phthalate Polymers 0.000 claims abstract description 5
- 229940031704 hydroxypropyl methylcellulose phthalate Drugs 0.000 claims abstract description 5
- 239000006186 oral dosage form Substances 0.000 claims abstract description 4
- 239000011248 coating agent Substances 0.000 claims description 83
- 239000002552 dosage form Substances 0.000 claims description 41
- 239000012729 immediate-release (IR) formulation Substances 0.000 claims description 31
- 239000003795 chemical substances by application Substances 0.000 claims description 23
- 230000003111 delayed effect Effects 0.000 claims description 21
- QJHCNBWLPSXHBL-UHFFFAOYSA-N cimetidine hydrochloride Chemical compound [H+].[Cl-].N#C/N=C(/NC)NCCSCC=1N=CNC=1C QJHCNBWLPSXHBL-UHFFFAOYSA-N 0.000 claims description 19
- 229960002908 cimetidine hydrochloride Drugs 0.000 claims description 18
- 239000003814 drug Substances 0.000 claims description 18
- 150000003839 salts Chemical class 0.000 claims description 14
- -1 alkali metal salt Chemical class 0.000 claims description 10
- 239000000463 material Substances 0.000 claims description 10
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 9
- 238000007922 dissolution test Methods 0.000 claims description 7
- 229940124597 therapeutic agent Drugs 0.000 claims description 7
- 239000007884 disintegrant Substances 0.000 claims description 6
- 235000019262 disodium citrate Nutrition 0.000 claims description 6
- 239000002526 disodium citrate Substances 0.000 claims description 6
- CEYULKASIQJZGP-UHFFFAOYSA-L disodium;2-(carboxymethyl)-2-hydroxybutanedioate Chemical compound [Na+].[Na+].[O-]C(=O)CC(O)(C(=O)O)CC([O-])=O CEYULKASIQJZGP-UHFFFAOYSA-L 0.000 claims description 6
- 239000012530 fluid Substances 0.000 claims description 6
- 239000000314 lubricant Substances 0.000 claims description 6
- 235000018342 monosodium citrate Nutrition 0.000 claims description 6
- 239000002524 monosodium citrate Substances 0.000 claims description 6
- 239000004014 plasticizer Substances 0.000 claims description 6
- 102220570135 Histone PARylation factor 1_L30D_mutation Human genes 0.000 claims description 5
- 238000004090 dissolution Methods 0.000 claims description 5
- 230000002496 gastric effect Effects 0.000 claims description 5
- HWPKGOGLCKPRLZ-UHFFFAOYSA-M monosodium citrate Chemical compound [Na+].OC(=O)CC(O)(C([O-])=O)CC(O)=O HWPKGOGLCKPRLZ-UHFFFAOYSA-M 0.000 claims description 5
- 230000000979 retarding effect Effects 0.000 claims description 5
- 229920000623 Cellulose acetate phthalate Polymers 0.000 claims description 4
- NIXOWILDQLNWCW-UHFFFAOYSA-N acrylic acid group Chemical group C(C=C)(=O)O NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims description 4
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 claims description 4
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- 229940100467 polyvinyl acetate phthalate Drugs 0.000 claims description 4
- 210000002784 stomach Anatomy 0.000 claims description 4
- 229910052783 alkali metal Inorganic materials 0.000 claims description 3
- 239000005711 Benzoic acid Substances 0.000 claims description 2
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical class [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 claims description 2
- 239000001856 Ethyl cellulose Substances 0.000 claims description 2
- ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 claims description 2
- 229910000318 alkali metal phosphate Inorganic materials 0.000 claims description 2
- 229940069428 antacid Drugs 0.000 claims description 2
- 239000003159 antacid agent Substances 0.000 claims description 2
- 230000001458 anti-acid effect Effects 0.000 claims description 2
- 239000012736 aqueous medium Substances 0.000 claims description 2
- 235000010233 benzoic acid Nutrition 0.000 claims description 2
- BEFDCLMNVWHSGT-UHFFFAOYSA-N ethenylcyclopentane Chemical compound C=CC1CCCC1 BEFDCLMNVWHSGT-UHFFFAOYSA-N 0.000 claims description 2
- 235000019325 ethyl cellulose Nutrition 0.000 claims description 2
- 229920001249 ethyl cellulose Polymers 0.000 claims description 2
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- 150000002734 metacrylic acid derivatives Chemical class 0.000 claims description 2
- 229940117841 methacrylic acid copolymer Drugs 0.000 claims description 2
- 229920003145 methacrylic acid copolymer Polymers 0.000 claims description 2
- 239000004334 sorbic acid Substances 0.000 claims description 2
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- 208000006558 Dental Calculus Diseases 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 150000003840 hydrochlorides Chemical class 0.000 claims 1
- 238000012360 testing method Methods 0.000 abstract description 20
- 239000008194 pharmaceutical composition Substances 0.000 abstract description 2
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- 230000001747 exhibiting effect Effects 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- 230000004936 stimulating effect Effects 0.000 abstract 1
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- AQIXAKUUQRKLND-UHFFFAOYSA-N cimetidine Chemical compound N#C/N=C(/NC)NCCSCC=1N=CNC=1C AQIXAKUUQRKLND-UHFFFAOYSA-N 0.000 description 90
- 238000000576 coating method Methods 0.000 description 60
- 239000000243 solution Substances 0.000 description 30
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 24
- 239000000725 suspension Substances 0.000 description 23
- 238000011282 treatment Methods 0.000 description 22
- 239000008213 purified water Substances 0.000 description 20
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 18
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 18
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 18
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 18
- 238000009492 tablet coating Methods 0.000 description 18
- 239000002700 tablet coating Substances 0.000 description 18
- 239000004615 ingredient Substances 0.000 description 17
- 239000008188 pellet Substances 0.000 description 17
- GDCRSXZBSIRSFR-UHFFFAOYSA-N ethyl prop-2-enoate;2-methylprop-2-enoic acid Chemical compound CC(=C)C(O)=O.CCOC(=O)C=C GDCRSXZBSIRSFR-UHFFFAOYSA-N 0.000 description 15
- 239000008187 granular material Substances 0.000 description 13
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 12
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 11
- 239000002775 capsule Substances 0.000 description 11
- 235000019333 sodium laurylsulphate Nutrition 0.000 description 11
- 229920002472 Starch Polymers 0.000 description 10
- 239000008107 starch Substances 0.000 description 10
- 229940032147 starch Drugs 0.000 description 10
- 235000019698 starch Nutrition 0.000 description 10
- VVQNEPGJFQJSBK-UHFFFAOYSA-N Methyl methacrylate Chemical compound COC(=O)C(C)=C VVQNEPGJFQJSBK-UHFFFAOYSA-N 0.000 description 9
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- 229960004291 sucralfate Drugs 0.000 description 8
- MNQYNQBOVCBZIQ-JQOFMKNESA-A sucralfate Chemical compound O[Al](O)OS(=O)(=O)O[C@@H]1[C@@H](OS(=O)(=O)O[Al](O)O)[C@H](OS(=O)(=O)O[Al](O)O)[C@@H](COS(=O)(=O)O[Al](O)O)O[C@H]1O[C@@]1(COS(=O)(=O)O[Al](O)O)[C@@H](OS(=O)(=O)O[Al](O)O)[C@H](OS(=O)(=O)O[Al](O)O)[C@@H](OS(=O)(=O)O[Al](O)O)O1 MNQYNQBOVCBZIQ-JQOFMKNESA-A 0.000 description 8
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- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
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- 229940082500 cetostearyl alcohol Drugs 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
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- 239000003086 colorant Substances 0.000 description 1
- 238000007906 compression Methods 0.000 description 1
- 230000006835 compression Effects 0.000 description 1
- 238000012937 correction Methods 0.000 description 1
- 229960000913 crospovidone Drugs 0.000 description 1
- 235000010947 crosslinked sodium carboxy methyl cellulose Nutrition 0.000 description 1
- 230000009089 cytolysis Effects 0.000 description 1
- 235000014113 dietary fatty acids Nutrition 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 239000003937 drug carrier Substances 0.000 description 1
- 230000002183 duodenal effect Effects 0.000 description 1
- 238000010410 dusting Methods 0.000 description 1
- 201000006549 dyspepsia Diseases 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 238000005538 encapsulation Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 239000002702 enteric coating Substances 0.000 description 1
- 238000009505 enteric coating Methods 0.000 description 1
- 208000006881 esophagitis Diseases 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- CCIVGXIOQKPBKL-UHFFFAOYSA-M ethanesulfonate Chemical compound CCS([O-])(=O)=O CCIVGXIOQKPBKL-UHFFFAOYSA-M 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 230000008020 evaporation Effects 0.000 description 1
- 239000000194 fatty acid Substances 0.000 description 1
- 229930195729 fatty acid Natural products 0.000 description 1
- 239000001530 fumaric acid Substances 0.000 description 1
- 235000011087 fumaric acid Nutrition 0.000 description 1
- 210000001035 gastrointestinal tract Anatomy 0.000 description 1
- 229920000159 gelatin Polymers 0.000 description 1
- 239000008273 gelatin Substances 0.000 description 1
- 235000019322 gelatine Nutrition 0.000 description 1
- 235000011852 gelatine desserts Nutrition 0.000 description 1
- 235000011187 glycerol Nutrition 0.000 description 1
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 description 1
- 229940075507 glyceryl monostearate Drugs 0.000 description 1
- 238000005469 granulation Methods 0.000 description 1
- 230000003179 granulation Effects 0.000 description 1
- 239000003485 histamine H2 receptor antagonist Substances 0.000 description 1
- 239000001863 hydroxypropyl cellulose Substances 0.000 description 1
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 238000003780 insertion Methods 0.000 description 1
- 230000037431 insertion Effects 0.000 description 1
- 229960000829 kaolin Drugs 0.000 description 1
- 239000004310 lactic acid Substances 0.000 description 1
- 235000014655 lactic acid Nutrition 0.000 description 1
- 229960001375 lactose Drugs 0.000 description 1
- 235000019388 lanolin Nutrition 0.000 description 1
- 229940039717 lanolin Drugs 0.000 description 1
- 239000007942 layered tablet Substances 0.000 description 1
- 230000009063 long-term regulation Effects 0.000 description 1
- VTHJTEIRLNZDEV-UHFFFAOYSA-L magnesium dihydroxide Chemical compound [OH-].[OH-].[Mg+2] VTHJTEIRLNZDEV-UHFFFAOYSA-L 0.000 description 1
- 239000000347 magnesium hydroxide Substances 0.000 description 1
- 229910001862 magnesium hydroxide Inorganic materials 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 description 1
- 239000011976 maleic acid Substances 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
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- 239000011859 microparticle Substances 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
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- 235000010446 mineral oil Nutrition 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 239000001788 mono and diglycerides of fatty acids Substances 0.000 description 1
- 229920005690 natural copolymer Polymers 0.000 description 1
- GLDOVTGHNKAZLK-UHFFFAOYSA-N octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 description 1
- 235000006408 oxalic acid Nutrition 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- PNJWIWWMYCMZRO-UHFFFAOYSA-N pent‐4‐en‐2‐one Natural products CC(=O)CC=C PNJWIWWMYCMZRO-UHFFFAOYSA-N 0.000 description 1
- 230000002688 persistence Effects 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 description 1
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 1
- 229940068968 polysorbate 80 Drugs 0.000 description 1
- 229920000053 polysorbate 80 Polymers 0.000 description 1
- 235000013809 polyvinylpolypyrrolidone Nutrition 0.000 description 1
- 229920000523 polyvinylpolypyrrolidone Polymers 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 239000003223 protective agent Substances 0.000 description 1
- 229910052710 silicon Inorganic materials 0.000 description 1
- 239000010703 silicon Substances 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000007909 solid dosage form Substances 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
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- 239000011975 tartaric acid Chemical class 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- OULAJFUGPPVRBK-UHFFFAOYSA-N tetratriacontyl alcohol Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCO OULAJFUGPPVRBK-UHFFFAOYSA-N 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
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- WEAPVABOECTMGR-UHFFFAOYSA-N triethyl 2-acetyloxypropane-1,2,3-tricarboxylate Chemical compound CCOC(=O)CC(C(=O)OCC)(OC(C)=O)CC(=O)OCC WEAPVABOECTMGR-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
- A61K9/209—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/284—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
- A61K9/2846—Poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4808—Preparations in capsules, e.g. of gelatin, of chocolate characterised by the form of the capsule or the structure of the filling; Capsules containing small tablets; Capsules with outer layer for immediate drug release
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5084—Mixtures of one or more drugs in different galenical forms, at least one of which being granules, microcapsules or (coated) microparticles according to A61K9/16 or A61K9/50, e.g. for obtaining a specific release pattern or for combining different drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR8916056 | 1989-12-05 | ||
| FR8916056A FR2655266B1 (fr) | 1989-12-05 | 1989-12-05 | Compositions pharmaceutiques a base de cimetidine. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPH04145016A true JPH04145016A (ja) | 1992-05-19 |
Family
ID=9388166
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2400217A Pending JPH04145016A (ja) | 1989-12-05 | 1990-12-03 | シメチジン含有固形医薬組成物 |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US5229134A (de) |
| EP (1) | EP0431877B1 (de) |
| JP (1) | JPH04145016A (de) |
| KR (1) | KR910011257A (de) |
| AT (1) | ATE112961T1 (de) |
| AU (1) | AU629071B2 (de) |
| CA (1) | CA2031066A1 (de) |
| DE (1) | DE69013473T2 (de) |
| DK (1) | DK0431877T3 (de) |
| ES (1) | ES2062417T3 (de) |
| FR (1) | FR2655266B1 (de) |
| IE (1) | IE904364A1 (de) |
| NZ (1) | NZ236326A (de) |
| PT (1) | PT96078A (de) |
| ZA (1) | ZA909685B (de) |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| JP2001500885A (ja) * | 1996-09-23 | 2001-01-23 | デュファル インターナショナル リサーチ ベスローテン ベノートスハップ | 経口遅延型即時放出製剤及びその製造方法 |
| JP2002508311A (ja) * | 1997-12-12 | 2002-03-19 | アンドルックス ファーマスーティカルズ インコーポレーテッド | ＨＭＧ−ＣｏＡ還元酵素阻害剤の徐放性改良製剤 |
| JP2008546830A (ja) * | 2005-06-28 | 2008-12-25 | サノフイ−アベンテイス | ｐＨ依存性の溶解度を有する有効成分の持続放出製剤 |
| JP2012503609A (ja) * | 2008-09-24 | 2012-02-09 | エボニック レーム ゲゼルシャフト ミット ベシュレンクテル ハフツング | エタノールの影響に対する耐性を有するオピオイドではないｐＨ依存の制御放出の医薬組成物 |
| JP2012520832A (ja) * | 2009-03-18 | 2012-09-10 | エボニック レーム ゲゼルシャフト ミット ベシュレンクテル ハフツング | ポリマー混合物と賦形剤とを含むコーティングを使用するエタノールの影響に対する耐性を有する制御放出性医薬組成物 |
| JP5257070B2 (ja) * | 2006-06-13 | 2013-08-07 | 日本新薬株式会社 | 被覆錠剤 |
| JP5524624B2 (ja) * | 2007-11-16 | 2014-06-18 | 旭化成ケミカルズ株式会社 | 水系フィルムコーティング液、および、フィルムコーティング顆粒、ならびに、これを用いた錠剤 |
| CN111991364A (zh) * | 2020-09-03 | 2020-11-27 | 四川省百草生物药业有限公司 | 一种盐酸洛美利嗪渗透泵片及其制备方法 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZA919510B (en) * | 1990-12-05 | 1992-10-28 | Smithkline Beecham Corp | Pharmaceutical compositions |
| US6224911B1 (en) * | 1993-03-16 | 2001-05-01 | Syntex (U.S.A.) Llc | Process for the preparation of enteric coated pharmaceutical dosage forms |
| FR2723586A1 (fr) * | 1994-08-11 | 1996-02-16 | Seth Pawan | Nouvelles compositions contenant de la cimetidine et associations en derivant |
| CN1183044A (zh) * | 1995-04-03 | 1998-05-27 | 中外制药株式会社 | 含有硫糖铝的制剂组合物 |
| US5789014A (en) * | 1995-12-25 | 1998-08-04 | Shin-Etsu Chemical Co., Ltd. | Method of manufacturing a solid preparation coated with non-solvent coating |
| US5773031A (en) * | 1996-02-27 | 1998-06-30 | L. Perrigo Company | Acetaminophen sustained-release formulation |
| US8071128B2 (en) | 1996-06-14 | 2011-12-06 | Kyowa Hakko Kirin Co., Ltd. | Intrabuccally rapidly disintegrating tablet and a production method of the tablets |
| US5768140A (en) * | 1996-06-21 | 1998-06-16 | Symbol Technologies, Inc. | RF-interrogatable processing system |
| JP2002529503A (ja) | 1998-11-17 | 2002-09-10 | ニトロメッド，インク． | ニトロソ化及びニトロシル化ｈ２リセプターアンタゴニスト化合物及び組成物並びにその利用方法 |
| US6270807B1 (en) | 1999-03-02 | 2001-08-07 | L. Perrigo Company | Taste-masked pharmaceutical composition |
| SE0100200D0 (sv) | 2001-01-24 | 2001-01-24 | Astrazeneca Ab | New film coating |
| CA2447984A1 (en) * | 2001-09-28 | 2003-04-03 | Mcneil-Ppc, Inc. | Dosage forms having an inner core and outer shell with different shapes |
| US6837696B2 (en) * | 2001-09-28 | 2005-01-04 | Mcneil-Ppc, Inc. | Apparatus for manufacturing dosage forms |
| US9358214B2 (en) | 2001-10-04 | 2016-06-07 | Adare Pharmaceuticals, Inc. | Timed, sustained release systems for propranolol |
| US6663888B2 (en) | 2001-12-14 | 2003-12-16 | Eurand Pharmaceuticals Ltd. | Pulsatile release histamine H2 antagonist dosage form |
| SK9132003A3 (en) | 2001-12-19 | 2004-02-03 | Astrazeneca Ab | A film coating composition, a coating film, pharmaceutical formulation comprising same and a process for its production |
| AU2002357366A1 (en) * | 2001-12-20 | 2003-07-09 | Pharmacia Corporation | Multiple-pulse extended release formulations of clindamycin |
| MY148805A (en) * | 2002-10-16 | 2013-05-31 | Takeda Pharmaceutical | Controlled release preparation |
| US8367111B2 (en) | 2002-12-31 | 2013-02-05 | Aptalis Pharmatech, Inc. | Extended release dosage forms of propranolol hydrochloride |
| US7632521B2 (en) * | 2003-07-15 | 2009-12-15 | Eurand, Inc. | Controlled release potassium chloride tablets |
| AR045330A1 (es) * | 2003-08-07 | 2005-10-26 | Sb Pharmco Inc | Forma de dosificacion oral, procedimiento para su preparacion y uso del compuesto 5-(4-(2-(n-metil-n- (2-piridil)amino)etoxi )bencil) tiazolidin-2,4-diona o una sal o solvato farmaceuticamente aceptable del mismo para prepararla |
| EP1753405A4 (de) * | 2004-06-10 | 2008-09-17 | Glatt Air Tech Inc | Pharmazeutische formulierung mit kontrollierter freisetzung |
| EP1768668A2 (de) | 2004-06-16 | 2007-04-04 | Tap Pharmaceutical Products, Inc. | Multi-ppi-dosierform |
| US8747895B2 (en) | 2004-09-13 | 2014-06-10 | Aptalis Pharmatech, Inc. | Orally disintegrating tablets of atomoxetine |
| US9884014B2 (en) | 2004-10-12 | 2018-02-06 | Adare Pharmaceuticals, Inc. | Taste-masked pharmaceutical compositions |
| AU2005299490C1 (en) | 2004-10-21 | 2012-01-19 | Adare Pharmaceuticals, Inc. | Taste-masked pharmaceutical compositions with gastrosoluble pore-formers |
| US20070298098A1 (en) * | 2005-02-16 | 2007-12-27 | Elan Pharma International Limited | Controlled Release Compositions Comprising Levetiracetam |
| WO2006103702A2 (en) * | 2005-04-01 | 2006-10-05 | Mccullough Ricky W | Enhanced bio-adherent polymeric compositions for coating mucosal and epidermal epithelium |
| US9161918B2 (en) | 2005-05-02 | 2015-10-20 | Adare Pharmaceuticals, Inc. | Timed, pulsatile release systems |
| KR20080039876A (ko) * | 2005-07-22 | 2008-05-07 | 미리어드 제네틱스, 인크. | 높은 약물 충진 제형 및 투여형 |
| CN104161736A (zh) * | 2006-06-01 | 2014-11-26 | Msd消费保健品公司 | 包含去氧肾上腺素的缓释药物制剂 |
| NZ573174A (en) * | 2006-06-01 | 2012-01-12 | Msd Consumer Care Inc | Sustained release pharmaceutical dosage form containing phenylephrine |
| JP5121824B2 (ja) * | 2006-06-01 | 2013-01-16 | メルク・シャープ・アンド・ドーム・コーポレーション | フェニレフリンの徐放のための薬学的組成物 |
| CN102014638A (zh) | 2007-10-12 | 2011-04-13 | 武田制药北美公司 | 与食物摄入无关的治疗胃肠病症的方法 |
| KR101765357B1 (ko) | 2009-12-02 | 2017-08-04 | 아데어 파마수티컬스 에스.알.엘. | 펙소페나딘 마이크로캡슐 및 그것을 함유하는 조성물 |
| US20140251181A1 (en) * | 2011-11-03 | 2014-09-11 | Wincoat Colours And Coatings Private Limited | Novel Film Composition |
| CA2936741C (en) | 2014-10-31 | 2018-11-06 | Purdue Pharma | Methods and compositions particularly for treatment of attention deficit disorder |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4968507A (en) * | 1984-06-20 | 1990-11-06 | Merck & Co., Inc. | Controlled porosity osmotic pump |
| US4851228A (en) * | 1984-06-20 | 1989-07-25 | Merck & Co., Inc. | Multiparticulate controlled porosity osmotic |
| IE58110B1 (en) * | 1984-10-30 | 1993-07-14 | Elan Corp Plc | Controlled release powder and process for its preparation |
| GB8518301D0 (en) * | 1985-07-19 | 1985-08-29 | Fujisawa Pharmaceutical Co | Hydrodynamically explosive systems |
| US4976949A (en) * | 1985-10-25 | 1990-12-11 | The University Of Michigan | Controlled release dosage form |
| SE461891B (sv) * | 1986-11-19 | 1990-04-09 | Roland Palm | Medel foer utvaertes behandling av husdjur, foerfarande foer framstaellning av naemnda medel samt anvaendning daerav foer behandling av juver och spenar hos kor |
| US4800087A (en) * | 1986-11-24 | 1989-01-24 | Mehta Atul M | Taste-masked pharmaceutical compositions |
| JP2646251B2 (ja) * | 1987-10-20 | 1997-08-27 | 富士写真フイルム株式会社 | 多層同時塗布方法及び装置 |
| GB8724763D0 (en) * | 1987-10-22 | 1987-11-25 | Aps Research Ltd | Sustained-release formulations |
-
1989
- 1989-12-05 FR FR8916056A patent/FR2655266B1/fr not_active Expired - Lifetime
-
1990
- 1990-11-28 CA CA002031066A patent/CA2031066A1/en not_active Abandoned
- 1990-12-03 JP JP2400217A patent/JPH04145016A/ja active Pending
- 1990-12-03 AU AU67704/90A patent/AU629071B2/en not_active Ceased
- 1990-12-03 ZA ZA909685A patent/ZA909685B/xx unknown
- 1990-12-04 DE DE69013473T patent/DE69013473T2/de not_active Expired - Fee Related
- 1990-12-04 ES ES90313123T patent/ES2062417T3/es not_active Expired - Lifetime
- 1990-12-04 PT PT96078A patent/PT96078A/pt not_active Application Discontinuation
- 1990-12-04 EP EP90313123A patent/EP0431877B1/de not_active Expired - Lifetime
- 1990-12-04 NZ NZ236326A patent/NZ236326A/en unknown
- 1990-12-04 DK DK90313123.3T patent/DK0431877T3/da active
- 1990-12-04 AT AT90313123T patent/ATE112961T1/de not_active IP Right Cessation
- 1990-12-04 IE IE436490A patent/IE904364A1/en unknown
- 1990-12-05 KR KR1019900020230A patent/KR910011257A/ko not_active Withdrawn
- 1990-12-05 US US07/622,895 patent/US5229134A/en not_active Expired - Fee Related
Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2001500885A (ja) * | 1996-09-23 | 2001-01-23 | デュファル インターナショナル リサーチ ベスローテン ベノートスハップ | 経口遅延型即時放出製剤及びその製造方法 |
| JP2002508311A (ja) * | 1997-12-12 | 2002-03-19 | アンドルックス ファーマスーティカルズ インコーポレーテッド | ＨＭＧ−ＣｏＡ還元酵素阻害剤の徐放性改良製剤 |
| JP2010229150A (ja) * | 1997-12-12 | 2010-10-14 | Andrx Pharmaceuticals Inc | ＨＭＧ−ＣｏＡ還元酵素阻害剤の徐放性改良製剤 |
| JP2008546830A (ja) * | 2005-06-28 | 2008-12-25 | サノフイ−アベンテイス | ｐＨ依存性の溶解度を有する有効成分の持続放出製剤 |
| JP5257070B2 (ja) * | 2006-06-13 | 2013-08-07 | 日本新薬株式会社 | 被覆錠剤 |
| US8617603B2 (en) | 2006-06-13 | 2013-12-31 | Nippon Shinyaku Co., Ltd. | Coated tablet |
| JP5524624B2 (ja) * | 2007-11-16 | 2014-06-18 | 旭化成ケミカルズ株式会社 | 水系フィルムコーティング液、および、フィルムコーティング顆粒、ならびに、これを用いた錠剤 |
| JP2012503609A (ja) * | 2008-09-24 | 2012-02-09 | エボニック レーム ゲゼルシャフト ミット ベシュレンクテル ハフツング | エタノールの影響に対する耐性を有するオピオイドではないｐＨ依存の制御放出の医薬組成物 |
| US10933024B2 (en) | 2008-09-24 | 2021-03-02 | Evonik Operations Gmbh | PH-dependent controlled release pharmaceutical composition for non-opioids with resistance against the influence of ethanol |
| JP2012520832A (ja) * | 2009-03-18 | 2012-09-10 | エボニック レーム ゲゼルシャフト ミット ベシュレンクテル ハフツング | ポリマー混合物と賦形剤とを含むコーティングを使用するエタノールの影響に対する耐性を有する制御放出性医薬組成物 |
| CN111991364A (zh) * | 2020-09-03 | 2020-11-27 | 四川省百草生物药业有限公司 | 一种盐酸洛美利嗪渗透泵片及其制备方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| KR910011257A (ko) | 1991-08-07 |
| ZA909685B (en) | 1992-07-29 |
| FR2655266B1 (fr) | 1992-04-03 |
| EP0431877B1 (de) | 1994-10-19 |
| ES2062417T3 (es) | 1994-12-16 |
| DK0431877T3 (da) | 1995-04-03 |
| DE69013473D1 (de) | 1994-11-24 |
| EP0431877A1 (de) | 1991-06-12 |
| AU6770490A (en) | 1991-06-27 |
| US5229134A (en) | 1993-07-20 |
| CA2031066A1 (en) | 1991-06-06 |
| ATE112961T1 (de) | 1994-11-15 |
| AU629071B2 (en) | 1992-09-24 |
| NZ236326A (en) | 1993-05-26 |
| FR2655266A1 (fr) | 1991-06-07 |
| DE69013473T2 (de) | 1995-03-16 |
| PT96078A (pt) | 1991-09-30 |
| IE904364A1 (en) | 1991-06-05 |
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