JPH04235165A - 鎮痛性抗炎症剤として有効な２−オキシインドール−１−カルボキサミド化合物製造用中間体 - Google Patents

鎮痛性抗炎症剤として有効な２−オキシインドール−１−カルボキサミド化合物製造用中間体

Info

Publication number
JPH04235165A
JPH04235165A JP3132826A JP13282691A JPH04235165A JP H04235165 A JPH04235165 A JP H04235165A JP 3132826 A JP3132826 A JP 3132826A JP 13282691 A JP13282691 A JP 13282691A JP H04235165 A JPH04235165 A JP H04235165A
Authority
JP
Japan
Prior art keywords
oxindole
formula
carboxamide
acid
carbon atoms
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP3132826A
Other languages
English (en)
Japanese (ja)
Other versions
JPH0561269B2 (2
Inventor
Saul B Kadin
サウル・バーナード・カディン
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Corp Belgium
Pfizer Inc
Original Assignee
Pfizer Corp Belgium
Pfizer Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Corp Belgium, Pfizer Inc filed Critical Pfizer Corp Belgium
Publication of JPH04235165A publication Critical patent/JPH04235165A/ja
Publication of JPH0561269B2 publication Critical patent/JPH0561269B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/34—Oxygen atoms in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
JP3132826A 1984-03-19 1991-06-04 鎮痛性抗炎症剤として有効な２−オキシインドール−１−カルボキサミド化合物製造用中間体 Granted JPH04235165A (ja)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US59065984A 1984-03-19 1984-03-19
US590659 1984-03-19
US684634 1984-12-21
US06/684,634 US4556672A (en) 1984-03-19 1984-12-21 3-Substituted 2-oxindole-1-carboxamides as analgesic and anti-inflammatory agents

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
JP60055627A Division JPS60209564A (ja) 1984-03-19 1985-03-19 鎮痛性抗炎症剤として有効な、２‐オキシインドール‐１‐カルボキサミド化合物

Publications (2)

Publication Number Publication Date
JPH04235165A true JPH04235165A (ja) 1992-08-24
JPH0561269B2 JPH0561269B2 (2) 1993-09-06

Family

ID=27080909

Family Applications (1)

Application Number Title Priority Date Filing Date
JP3132826A Granted JPH04235165A (ja) 1984-03-19 1991-06-04 鎮痛性抗炎症剤として有効な２−オキシインドール−１−カルボキサミド化合物製造用中間体

Country Status (36)

Country Link
US (1) US4556672A (2)
EP (1) EP0156603B1 (2)
JP (1) JPH04235165A (2)
KR (1) KR860001873B1 (2)
AT (1) ATE45731T1 (2)
AU (1) AU549927B2 (2)
BG (1) BG60347B2 (2)
CA (2) CA1251441A (2)
CS (1) CS249539B2 (2)
CY (1) CY1668A (2)
DE (1) DE3572481D1 (2)
DK (1) DK162090C (2)
EG (1) EG17795A (2)
ES (1) ES8603408A1 (2)
FI (2) FI82042C (2)
GR (1) GR850668B (2)
HK (1) HK78392A (2)
HU (1) HU196178B (2)
IE (1) IE57743B1 (2)
IL (3) IL74631A (2)
LV (1) LV5618A3 (2)
MA (1) MA20380A1 (2)
MY (1) MY101987A (2)
NL (1) NL940025I2 (2)
NO (1) NO165799C (2)
NZ (2) NZ224134A (2)
OA (1) OA07966A (2)
PH (2) PH21323A (2)
PL (1) PL145951B1 (2)
PT (1) PT80117B (2)
RO (1) RO90952B (2)
SI (1) SI8510440A8 (2)
SU (1) SU1445556A3 (2)
UA (1) UA6343A1 (2)
YU (1) YU43870B (2)
ZW (1) ZW4785A1 (2)

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Also Published As

Publication number Publication date
EP0156603B1 (en) 1989-08-23
PH21323A (en) 1987-09-28
IL74631A (en) 1988-07-31
IL85130A (en) 1988-07-31
FI82042C (fi) 1991-01-10
CA1251441A (en) 1989-03-21
FI851069L (fi) 1985-09-20
PT80117A (en) 1985-04-01
IL85130A0 (en) 1988-06-30
LV5618A3 (lv) 1994-05-10
MY101987A (en) 1992-02-29
FI82449B (fi) 1990-11-30
NZ211486A (en) 1988-10-28
KR850006173A (ko) 1985-10-02
IE57743B1 (en) 1993-03-24
ES541372A0 (es) 1985-12-16
NZ224134A (en) 1988-10-28
FI894540L (fi) 1989-09-26
BG60347B2 (bg) 1994-09-30
DK162090B (da) 1991-09-16
FI82449C (fi) 1991-03-11
US4556672A (en) 1985-12-03
YU44085A (en) 1988-02-29
HK78392A (en) 1992-10-23
HU196178B (en) 1988-10-28
PL145951B1 (en) 1988-12-31
DK162090C (da) 1992-02-24
YU43870B (en) 1989-12-31
JPH0561269B2 (2) 1993-09-06
PL252434A1 (en) 1985-12-03
NO851054L (no) 1985-09-20
DK121385A (da) 1985-09-20
UA6343A1 (uk) 1994-12-29
GR850668B (2) 1985-07-16
CS249539B2 (en) 1987-03-12
ZW4785A1 (en) 1985-06-19
ATE45731T1 (de) 1989-09-15
KR860001873B1 (ko) 1986-10-24
CY1668A (en) 1993-05-14
NO165799B (no) 1991-01-02
RO90952A (ro) 1987-02-27
PT80117B (pt) 1987-10-20
EP0156603A2 (en) 1985-10-02
IE850684L (en) 1985-09-19
SI8510440A8 (sl) 1996-06-30
DK121385D0 (da) 1985-03-18
CA1288422C (en) 1991-09-03
PH21470A (en) 1987-10-28
FI851069A0 (fi) 1985-03-18
MA20380A1 (fr) 1985-10-01
RO90952B (ro) 1987-03-01
EG17795A (en) 1990-08-30
FI82042B (fi) 1990-09-28
NL940025I2 (nl) 2000-01-03
NL940025I1 (nl) 1995-02-01
NO165799C (no) 1991-04-10
EP0156603A3 (en) 1986-02-12
AU549927B2 (en) 1986-02-20
IL74631A0 (en) 1985-06-30
OA07966A (fr) 1987-01-31
DE3572481D1 (en) 1989-09-28
HUT37398A (en) 1985-12-28
ES8603408A1 (es) 1985-12-16
AU4005985A (en) 1985-09-26
FI894540A0 (fi) 1989-09-26
SU1445556A3 (ru) 1988-12-15

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