JPH0429680B2 - - Google Patents
Info
- Publication number
- JPH0429680B2 JPH0429680B2 JP58044509A JP4450983A JPH0429680B2 JP H0429680 B2 JPH0429680 B2 JP H0429680B2 JP 58044509 A JP58044509 A JP 58044509A JP 4450983 A JP4450983 A JP 4450983A JP H0429680 B2 JPH0429680 B2 JP H0429680B2
- Authority
- JP
- Japan
- Prior art keywords
- blood coagulation
- factor
- polyethylene glycol
- molecular weight
- coagulation factor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Landscapes
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP58044509A JPS59172425A (ja) | 1983-03-18 | 1983-03-18 | 新規な血液凝固因子誘導体およびその製造法ならびにそれを含有する血液凝固促進剤 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP58044509A JPS59172425A (ja) | 1983-03-18 | 1983-03-18 | 新規な血液凝固因子誘導体およびその製造法ならびにそれを含有する血液凝固促進剤 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS59172425A JPS59172425A (ja) | 1984-09-29 |
| JPH0429680B2 true JPH0429680B2 (2) | 1992-05-19 |
Family
ID=12693520
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP58044509A Granted JPS59172425A (ja) | 1983-03-18 | 1983-03-18 | 新規な血液凝固因子誘導体およびその製造法ならびにそれを含有する血液凝固促進剤 |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS59172425A (2) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE9503380D0 (sv) * | 1995-09-29 | 1995-09-29 | Pharmacia Ab | Protein derivatives |
| US7173003B2 (en) | 2001-10-10 | 2007-02-06 | Neose Technologies, Inc. | Granulocyte colony stimulating factor: remodeling and glycoconjugation of G-CSF |
| US7214660B2 (en) | 2001-10-10 | 2007-05-08 | Neose Technologies, Inc. | Erythropoietin: remodeling and glycoconjugation of erythropoietin |
| WO2004075923A2 (en) | 2003-02-26 | 2004-09-10 | Nektar Therapeutics Al, Corporation | Polymer-factor viii moiety conjugates |
| EP2055189A1 (en) | 2003-04-09 | 2009-05-06 | Neose Technologies, Inc. | Glycopegylation methods and proteins/peptides produced by the methods |
| WO2005012484A2 (en) | 2003-07-25 | 2005-02-10 | Neose Technologies, Inc. | Antibody-toxin conjugates |
| US20080305992A1 (en) | 2003-11-24 | 2008-12-11 | Neose Technologies, Inc. | Glycopegylated erythropoietin |
| AU2004296860B2 (en) * | 2003-12-03 | 2010-04-22 | Novo Nordisk A/S | Glycopegylated factor IX |
| AU2014280936B2 (en) * | 2004-06-30 | 2016-12-15 | Nektar Therapeutics | Polymer-factor ix moiety conjugates |
| KR101146160B1 (ko) | 2004-06-30 | 2012-07-16 | 넥타르 테라퓨틱스 | 중합체인자 ｉｘ 부분의 접합체 |
| WO2006010143A2 (en) | 2004-07-13 | 2006-01-26 | Neose Technologies, Inc. | Branched peg remodeling and glycosylation of glucagon-like peptide-1 [glp-1] |
| US20080176790A1 (en) | 2004-10-29 | 2008-07-24 | Defrees Shawn | Remodeling and Glycopegylation of Fibroblast Growth Factor (Fgf) |
| KR101468345B1 (ko) * | 2004-11-12 | 2014-12-03 | 바이엘 헬스케어 엘엘씨 | Ｆｖｉｉｉ의 부위 지향 변형 |
| CA2591852A1 (en) * | 2004-12-27 | 2006-07-06 | Baxter International Inc. | Polymer-von willebrand factor-conjugates |
| US9029331B2 (en) | 2005-01-10 | 2015-05-12 | Novo Nordisk A/S | Glycopegylated granulocyte colony stimulating factor |
| US20070154992A1 (en) | 2005-04-08 | 2007-07-05 | Neose Technologies, Inc. | Compositions and methods for the preparation of protease resistant human growth hormone glycosylation mutants |
| US20070105755A1 (en) | 2005-10-26 | 2007-05-10 | Neose Technologies, Inc. | One pot desialylation and glycopegylation of therapeutic peptides |
| WO2007056191A2 (en) | 2005-11-03 | 2007-05-18 | Neose Technologies, Inc. | Nucleotide sugar purification using membranes |
| ES2516694T3 (es) | 2006-07-21 | 2014-10-31 | Ratiopharm Gmbh | Glicosilación de péptidos a través de secuencias de glicosilación con unión en O |
| US8969532B2 (en) | 2006-10-03 | 2015-03-03 | Novo Nordisk A/S | Methods for the purification of polypeptide conjugates comprising polyalkylene oxide using hydrophobic interaction chromatography |
| KR20100016160A (ko) | 2007-04-03 | 2010-02-12 | 바이오제너릭스 에이지 | 글리코페길화 ｇ―ｃｓｆ를 이용하는 치료 방법 |
| WO2008154639A2 (en) | 2007-06-12 | 2008-12-18 | Neose Technologies, Inc. | Improved process for the production of nucleotide sugars |
| KR101582841B1 (ko) | 2008-02-27 | 2016-01-11 | 노보 노르디스크 에이/에스 | 콘쥬게이트된 인자 ｖｉｉｉ 분자 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5959629A (ja) * | 1982-09-27 | 1984-04-05 | Nippon Chem Res Kk | 効力持続性組成物 |
| JPS6042087A (ja) * | 1983-08-19 | 1985-03-06 | Nec Corp | プリンタ |
-
1983
- 1983-03-18 JP JP58044509A patent/JPS59172425A/ja active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| JPS59172425A (ja) | 1984-09-29 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JPH0429680B2 (2) | ||
| JP4171526B2 (ja) | ２，２′−ジチオ−ビス（エタンスルホネート）（ジメスナ）と組み合わせたシスプラチン組成物 | |
| JPH0525470B2 (2) | ||
| JPH0534337B2 (2) | ||
| CN1926155B (zh) | 羟乙基淀粉 | |
| JPS5931713A (ja) | オキシカム誘導体含有医薬組成物 | |
| KR840001798B1 (ko) | 서방출성 조성물의 제조방법 | |
| JPH01500997A (ja) | ヒアルロニダーゼの使用 | |
| RU2136291C1 (ru) | Полифункциональный кровезаменитель для лечения кровопотери и шока | |
| GB2221907A (en) | Superoxide dismutase composition. | |
| JP2003339853A (ja) | 安定な透析用剤 | |
| JPS6058927A (ja) | 放射能標識血小板製剤 | |
| US20060016752A1 (en) | Compositions capable of inhibiting reactive oxygen and carbonyl species | |
| JP2766303B2 (ja) | グリコサミノグリカンで修飾されたスーパーオキシドジスムターゼ及びその製造法 | |
| US5439894A (en) | Dextrin derivatives for the treatment of acidic conditions | |
| EP1210944A1 (en) | Blood plasma replacement solution | |
| POLEC et al. | Protective effect of ascorbic acid, isoascorbic acid and mannitol against tetracycline-induced nephrotoxicity | |
| US4271150A (en) | Urokinase preparation for oral administration | |
| JPH04225923A (ja) | エリスロポイエチンの水性医薬製剤及びその使用 | |
| JPH0215193B2 (2) | ||
| JPH02231076A (ja) | デキストラン修飾スーパーオキシドジスムターゼ | |
| JPS5995221A (ja) | 食細胞機能調節作用を有する医薬組成物 | |
| JPH09194371A (ja) | 皮膚疾患の治療のための局所組成物 | |
| JPS59204130A (ja) | 新規プラスミノ−ゲンアクチベ−タ誘導体を含有してなる経口投与薬剤 | |
| JPS59167520A (ja) | 新規プラスミノ−ゲンアクチベ−タ誘導体およびその製造法ならびにそれを含有する医薬品 |